| Interacting proteins: P20396 and P16870 |
Pubmed |
SVM Score :0.0 |
| The change in steady state levels of TRH precursor peptides in the hearts of the ZD1+T rats was consistent with a reduction in the activity of the zinc dependent carboxypeptidase H enzyme . ^^^ We conclude that severe zinc deficiency inhibits TRH biosynthesis in reproductive tissues of the male rat due to the combined effects of hypogonadism and inhibition of the zinc dependent carboxypeptidase H . . ^^^ |
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| Interacting proteins: P20396 and P16870 |
Pubmed |
SVM Score :0.0 |
| To test whether pro thyrotropin releasing hormone ( TRH ) conversion to TRH involves CPE , processing was examined in the Cpe ( fat / fat ) mouse . ^^^ TRH [ Gly ( 4 ) Lys ( 5 ) Arg ( 6 ) ] and TRH [ Gly ( 4 ) Lys ( 5 ) ] represent approximately 45 % of the total TRH like immunoreactivity in Cpe ( fat / fat ) mice ; they constitute approximately 1 % in controls . ^^^ Immunocytochemical studies indicate that TRH neurons contain CPE and carboxypeptidase D like immunoreactivity . ^^^ Recombinant CPE or carboxypeptidase D can convert synthetic TRH [ Gly ( 4 ) Lys ( 5 ) ] and TRH [ Gly ( 4 ) Lys ( 5 ) Arg ( 6 ) ] to TRH [ Gly ( 4 ) ] . ^^^ When Cpe ( fat / fat ) mice are exposed to cold , they can not maintain their body temperatures , and this loss is associated with hypothalamic TRH depletion and reduction in thyroid hormone . ^^^ |
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| Interacting proteins: P20396 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20396 and P16870 |
Pubmed |
SVM Score :0.0 |
| NA |
|