| Interacting proteins: Q9UKG1 and P20339 |
Pubmed |
SVM Score :0.55831993 |
| Adiponectin stimulates the interaction between APPL 1 and Rab 5 ( a small GTPase ) interaction , leading to increased GLUT 4 membrane translocation . 0.55831993^^^ |
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| Interacting proteins: Q9UKG1 and P20339 |
Pubmed |
SVM Score :0.0 |
| APPL proteins link Rab 5 to nuclear signal transduction via an endosomal compartment . ^^^ This pathway operates via APPL 1 and APPL 2 , two Rab 5 effectors , which reside on a subpopulation of endosomes . ^^^ Both APPL 1 and APPL 2 are essential for cell proliferation and their function requires Rab 5 binding . ^^^ Our findings identify an endosomal compartment bearing Rab 5 and APPL proteins as an intermediate in signaling between the plasma membrane and the nucleus . . ^^^ |
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| Interacting proteins: Q9UKG1 and P20339 |
Pubmed |
SVM Score :0.0 |
| For example , the BAR domain family includes Endophilins , GTPase activating proteins of the Centaurinbeta family and Oligophrenins , the adaptor proteins APPL 1 and APPL 2 that were recently shown to interact with the small GTPase Rab 5 , as well as members of the Sorting nexin family . ^^^ |
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