| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| Alsin is a Rab 5 and Rac 1 guanine nucleotide exchange factor . ^^^ We found that the Vps9p domain of alsin has Rab 5 guanine nucleotide exchange activity . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| Our results further demonstrate the requirement of the Alsin VPS 9 domain for occurrence of the vacuolation process and the role of Alsin as a guanine nucleotide exchange factor for Rab 5 . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| Biochemical characterization of Alsin , a Rab 5 and Rac 1 guanine nucleotide exchange factor . ^^^ Sequence motif searches within Alsin predict the presence of Vps 9 , DH , and PH domains , implying that Alsin may function as a guanine nucleotide exchange factor ( GEF ) for Rab 5 and a member of the Rho GTPase family . ^^^ The presence of both Rac 1 and Rab 5 GEF activities makes Alsin a unique dual exchange factor that may couple endocytosis ( via Rab 5 activation ) to cytoskeletal modulation ( via Rac 1 activation ) . . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| ALS 2 gene encodes a protein termed alsin , containing multiple guanine nucleotide exchange factor domains , specifically binding to small GTPase Rab 5 and acting as a GEF for Rab 5 . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| ALS 2 is an autosomal recessive form of spastic paraparesis ( motor neuron disease ) with juvenile onset and slow progression caused by loss of function of alsin , an activator of Rac 1 and Rab 5 small GTPases . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Recessive mutations in alsin , a guanine nucleotide exchange factor for the GTPases Rab 5 and Rac 1 , cause juvenile amyotrophic lateral sclerosis ( ALS 2 ) and related motoneuron disorders . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| ALS 2 , a novel guanine nucleotide exchange factor for the small GTPase Rab 5 , is implicated in endosomal dynamics . ^^^ Here we show that the ALS 2 protein specifically binds to small GTPase Rab 5 and functions as a GEF for Rab 5 . ^^^ Ectopically expressed ALS 2 protein localizes with Rab 5 and early endosome antigen 1 ( EEA 1 ) onto early endosomal compartments and stimulates the enlargement of endosomes in cultured cortical neurons . ^^^ The carboxy terminus of ALS 2 protein carrying a VPS 9 domain mediates not only the activation of Rab 5 via a guanine nucleotide exchanging reaction but also the endosomal localization of the ALS 2 protein , while the amino terminal half containing RLD acts suppressive in its membranous localization . ^^^ Taken together , the ALS 2 protein as a novel Rab 5 GEF , ALS2rab5GEF seems to be implicated in the endosomal dynamics in vivo . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| Homo oligomerization of ALS 2 through its unique carboxyl terminal regions is essential for the ALS 2 associated Rab 5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking . ^^^ Recently , we have demonstrated that the ALS 2 protein specifically binds to the small GTPase Rab 5 and acts as a GEF ( guanine nucleotide exchange factor ) for Rab 5 . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.0 |
| ALS2CL , the novel protein highly homologous to the carboxy terminal half of ALS 2 , binds to Rab 5 and modulates endosome dynamics . ^^^ ALS 2 , the causative gene product for juvenile recessive amyotrophic lateral sclerosis ( ALS 2 ) , is a guanine nucleotide exchange factor for the small GTPase Rab 5 . ^^^ |
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| Interacting proteins: Q96Q42 and P20339 |
Pubmed |
SVM Score :0.69585384 |
| In vitro , ALS 2 specifically binds to the small GTPase Rab 5 and functions as a GEF for Rab 5 . 0.69585384^^^ |
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