| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| Similar to RN Tre , we found that PRC 17 protein interacts directly with Rab 5 and stimulates its GTP hydrolysis . ^^^ |
|
| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of epidermal growth factor receptor regulated by Grb 2 mediated recruitment of the Rab 5 GTPase activating protein RN tre . ^^^ Grb 2 functions through association with RN tre , a GTPase activating protein for Rab 5 . ^^^ Overexpression of RN tre blocks the internalization of both proteins , consistent with its function as a negative regulator of Rab 5 and endocytosis . ^^^ These results 1 ) suggest that the ability of RN tre to inhibit internalization of the EGFR requires Grb 2 mediated binding to the receptor and 2 ) identify Grb 2 as a critical regulator of Rab 5 and EGFR endocytosis . . ^^^ |
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| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| A beta generation was dependent on endocytosis and was reduced after expression of the dynamin mutant K44A and the Rab 5 GTPase activating protein , RN tre . ^^^ |
|
| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| Here , we identify a Rab 5 specific GAP ( RabGAP 5 ) , and show that RN Tre ( previously described as a Rab 5 GAP ) acts on Rab 41 . ^^^ |
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| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| We show that RN tre is a Rab 5 GTPase activating protein , whose activity is regulated by the EGFR . ^^^ By entering in a complex with Eps 8 , RN tre acts on Rab 5 and inhibits internalization of the EGFR . ^^^ |
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| Interacting proteins: Q92738 and P20339 |
Pubmed |
SVM Score :0.0 |
| On the other hand , RN tre , a Rab 5 GTPase activating protein , by entering in a complex with Eps 8 , inhibits EGFR internalization . ^^^ |
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