Involvement of the Ras Ras activated Rab 5 guanine nucleotide exchange factor RIN 2 Rab5 pathway in the hepatocyte growth factor induced endocytosis of E cadherin . ^^^ HGF induced activation of Ras small G protein , which then bound to RIN 2 , a Rab 5 GDP / GTP exchange factor with the Vps9p like guanine nucleotide exchange factor and Ras association domains , and activated it . ^^^ Activated RIN 2 then activated Rab 5 , eventually inducing the endocytosis of E cadherin . ^^^ These results indicate that RIN 2 connects Ras to Rab 5 in the HGF induced endocytosis of E cadherin . . ^^^ |