| Interacting proteins: P49815 and P20339 |
Pubmed |
SVM Score :0.0 |
| The tuberous sclerosis 2 gene product , tuberin , functions as a Rab 5 GTPase activating protein ( GAP ) in modulating endocytosis . ^^^ Immune complexes of native tuberin , as well as recombinant protein , possessed activity to stimulate GTP hydrolysis of Rab 5 . ^^^ Tuberin GAP activity was specific for Rab 5 and showed no cross reactivity with Rab3a or Rab 6 . ^^^ These findings suggest that tuberin functions as a Rab5GAP in vivo to negatively regulate Rab 5 GTP activity in endocytosis . . ^^^ |
|
| Interacting proteins: P49815 and P20339 |
Pubmed |
SVM Score :0.0 |
| The TSC 2 product , tuberin , has a region of homology with the GTPase activating protein rap1GAP and stimulates the GTPase activity of rap1a and rab5a in vitro . ^^^ |
|
| Interacting proteins: P49815 and P20339 |
Pubmed |
SVM Score :0.0 |
| TSC 2 encodes tuberin , a putative GTPase activating protein for rap 1 and rab 5 . ^^^ |
|
| Interacting proteins: P49815 and P20339 |
Pubmed |
SVM Score :0.0 |
| Immunoisolation of tuberin bound vesicles using magnetic beads showed an enrichment of rap 1 , rab 5 , and caveolin 1 , all of which have been found in specialized lipid microdomains , caveolae . ^^^ |
|
| Interacting proteins: P49815 and P20339 |
Pubmed |
SVM Score :0.0 |
| NA |
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