| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.52985261 |
| Catalytic domain of the p 120 Ras GAP binds to RAb 5 and stimulates its GTPase activity . 0.52985261^^^ This study demonstrates that the catalytic domain of p 120 GTPase activating protein ( GAP ) , a well known Ras GAP , is able to interact physically with Rab 5 and stimulate its GTPase activity . 0.52955917^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| The tuberous sclerosis 2 gene product , tuberin , functions as a Rab 5 GTPase activating protein ( GAP ) in modulating endocytosis . ^^^ Tuberin GAP activity was specific for Rab 5 and showed no cross reactivity with Rab3a or Rab 6 . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| TSC 2 encodes tuberin , a putative GTPase activating protein for rap 1 and rab 5 . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| We show that RN tre is a Rab 5 GTPase activating protein , whose activity is regulated by the EGFR . ^^^ |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| We further showed that wortmannin reduced the membrane association of p 120 Ras GTPase activating protein ( GAP ) and inhibited the interaction between Rab 5 and p 120 Ras GAP . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| On the other hand , RN tre , a Rab 5 GTPase activating protein , by entering in a complex with Eps 8 , inhibits EGFR internalization . ^^^ |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| Endocytosis of epidermal growth factor receptor regulated by Grb 2 mediated recruitment of the Rab 5 GTPase activating protein RN tre . ^^^ Grb 2 functions through association with RN tre , a GTPase activating protein for Rab 5 . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| A beta generation was dependent on endocytosis and was reduced after expression of the dynamin mutant K44A and the Rab 5 GTPase activating protein , RN tre . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| Rab 5 signals to the actin cytoskeleton through RN tre , a previously identified Rab 5 specific GTPase activating protein ( GAP ) . ^^^ Here we demonstrate that RN tre has the dual function of Rab 5 GAP and Rab 5 effector . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that p85alpha has GAP activity toward Rab 5 , Rab 4 , Cdc 42 , Rac 1 and to a lesser extent Rab 6 , with little GAP activity toward Rab 11 . ^^^ Purified recombinant Rab 5 and p85alpha can bind directly to each other and not surprisingly , the p85alpha encoded GAP activity is present in the BH domain . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we identify a Rab 5 specific GAP ( RabGAP 5 ) , and show that RN Tre ( previously described as a Rab 5 GAP ) acts on Rab 41 . ^^^ A GTPase activating protein controls Rab 5 function in endocytic trafficking . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| RAP 6 contains a Rab 5 GEF and a Ras GAP domain . ^^^ This study is the first to show that RAP 6 is a novel regulator of endocytosis that exhibits GEF activity specific for Rab 5 and GAP activity specific for Ras . . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| We found that the p 85 alpha subunit of PI 3 kinase binds directly to Rab 5 and possesses GTPase activating protein ( GAP ) activity toward Rab 5 . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have found that the p 85 alpha subunit of PI3K binds directly to Rab 5 and possesses GTPase activating protein ( GAP ) activity toward Rab 5 . ^^^ We describe two methods used to characterize the GAP activity of p 85 toward the Rab 5 protein . ^^^ The first method is a steady state GAP assay , used to show that the p 85 alpha protein has GAP activity toward Rab 5 . ^^^ The second method is a single turnover GAP assay and measures changes in the catalytic rate of Rab 5 GTP hydrolysis with or without the p 85 alpha protein . . ^^^ |
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| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| The TSC 2 product , tuberin , has a region of homology with the GTPase activating protein rap1GAP and stimulates the GTPase activity of rap1a and rab5a in vitro . ^^^ |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| Instead , we speculate that yeast may contain a GTPase activating protein ( GAP ) activity that stimulates Rab5a but not Rab5b . ^^^ In contrast , pig brain cytosol was found to contain a GAP activity that stimulates the GTPase activity of Rab5b in preference to that of Rab5a . ^^^ |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P20339 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|