| Interacting proteins: Q96C24 and P20336 |
Pubmed |
SVM Score :0.0 |
| Although Rab3a , another exocytotic Rab protein , has some similarities with Rab27a in primary sequence , intracellular distribution , and affinity toward granuphilin , overexpression of Rab3a caused different effects on insulin secretion . ^^^ |
|
| Interacting proteins: Q96C24 and P20336 |
Pubmed |
SVM Score :0.0 |
| The GTPases Rab3a and Rab27a and their effectors Granuphilin / Slp4 and Noc 2 are essential regulators of neuroendocrine secretion . ^^^ ICER overexpression diminished the level of Granuphilin , Noc 2 , Rab3a and Rab27a by binding to cAMP responsive elements located in the promoters of these genes and inhibited exocytosis of beta cells in response to secretagogues . ^^^ |
|