| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.74883103 |
| In order to identify the domain ( s ) of the GTPase that is important for this interaction , protein chimeras were constructed between Rab3a , which binds Mss 4 , and Rab5a , which does not bind Mss 4 . 0.74883103^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| The Mss 4 protein also stimulates GDP release from Ypt 1 and from the mammalian protein Rab3a , but not from Ras 2 . ^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| Rab3A small GTP binding protein and its associated proteins , such as Rabphilin 3A , a putative target protein for Rab3A , MSS 4 , a stimulatory GDP / GTP exchange protein for Rab3A , and Rab GDI , a translocator for the Rab family members including Rab3A , are implicated in neurotransmitter release . ^^^ Neither Rab3A , MSS 4 , nor Rab GDI was phosphorylated , but Rabphilin 3A was phosphorylated Rab GDI was phosphorylated , but Rabphilin 3A was phosphorylated at its N terminal region . ^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| Accordingly , Mss 4 co precipitates from a brain extract with Rab3a but not Rab 5 . ^^^ Recombinant Mss 4 and Rab3a form a stable complex in solution that is dissociated with either GDP or GTP gamma S . ^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| Comparison of kinetic properties between MSS 4 and Rab3A GRF GDP / GTP exchange proteins . ^^^ The kinetic properties of MSS 4 are studied in comparison with those of Rab3A GRF . ^^^ MSS 4 stimulates the dissociation of [ 3H ] GDP from the lipid modified and lipid unmodified forms of Rab3A to the same extent , although Rab3A GRF is more effective on the lipid modified form than on the lipid unmodified form . ^^^ Both MSS 4 and Rab3A GRF are inactive on other Rab / Sec / Ypt family members including at least Rab 2 , Rab 5 , and Rab 11 . ^^^ Rab GDI inhibits the MSS 4 and Rab3A GRF effects on the lipid modified form of Rab3A , but the doses of Rab GDI necessary for this inhibitory effect on Rab3A GRF are lower than those on MSS 4 . ^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| An equivalent Rab3A mutant ( Rab3A [ N135I ] ) , a Rab protein specifically involved in regulated secretion at the cell surface , associates with Mss 4 as efficiently as the Rab1A [ N124I ] mutant . ^^^ Although Rab3A [ N135I ] prevents the ability of Mss 4 to neutralize the inhibitory effects of Rab1A mutants on transport , it has no effect on Rab 1 function or endoplasmic reticulum to Golgi transport . ^^^ |
|
| Interacting proteins: P47224 and P20336 |
Pubmed |
SVM Score :0.0 |
| The spatial disposition of these residues with respect to the structure of Rab3A correlates with the dimensions of the elongated Rab interaction epitope in Mss 4 and supports a mode of interaction similar to that of other exchange factor GTPase complexes . ^^^ |
|