| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The interferon induced protein kinase ( PKR ) , triggers apoptosis through FADD mediated activation of caspase 8 in a manner independent of Fas and TNF alpha receptors . ^^^ We showed the involvement of the FADD caspase 8 pathway on PKR induced apoptosis based on four experimental findings : upregulation of caspase 8 activity during PKR induced apoptosis , blocking of PKR induced apoptosis by the use of a chemical inhibitor of caspase 8 , and inhibition of PKR induced apoptosis by expression of both a FADD dominant negative or a viral FLIP molecule . ^^^ Taken together , our observations establish the involvement of caspase 8 in PKR induced apoptosis and suggest that death receptors other than Fas or TNFR 1 or , alternatively , a novel mechanism involving FADD independently of death receptors , are responsible for PKR induced apoptosis . . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The pathway of PKR induced apoptosis involves FADD activation of caspase 8 by a mechanism independent of Fas and TNFR . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| PKR in turn can activate caspase 8 independently of death receptor ligation . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The double stranded RNA dependent protein kinase ( PKR ) induces apoptosis by activation of the FADD / caspase 8 pathway . ^^^ During PKR induced apoptosis , caspase 9 is activated downstream of caspase 8 . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| These include TNF alpha related apoptosis inducing ligand ( TRAIL / Apo2L ) , Fas / FasL , XIAP associated factor 1 ( XAF 1 ) , caspase 4 , caspase 8 , dsRNA activated protein kinase ( PKR ) , 2 ' 5 ' A oligoadenylate synthetase ( OAS ) , death activating protein kinases ( DAP kinase ) , phospholipid scramblase , galectin 9 , IFN regulatory factors ( IRFs ) , promyelocytic leukemia gene ( PML ) and regulators of IFN induced death ( RIDs ) . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Calcium release from the endoplasmic reticulum and activation of caspase 8 are the upstream signals modulating the caspase 3 mediated activation of PKR by Abeta peptide . ^^^ |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
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