| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.60591148 |
| PKR is directly regulated by physical association with the specific inhibitor , P58IPK , a cellular protein of the tetratricopeptide repeat ( TPR ) family , and K3L , the product of the corresponding vaccinia virus gene . 0.60591148^^^ Interaction of the interferon induced PKR protein kinase with inhibitory proteins P58IPK and vaccinia virus K3L is mediated by unique domains : implications for kinase regulation . 0.50411883^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| The molecular chaperone hsp 40 regulates the activity of P58IPK , the cellular inhibitor of PKR . ^^^ We previously found that influenza virus avoids the translational inhibitory effects of activated PKR by activating a cellular inhibitory protein , termed P58IPK , based on its Mr of 58 , 000 . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| RESULTS : PKR protein levels were consistently increased in HCV related HCC compared with NT ( p=0 . 001 ) ; similar increases were seen in total eIF2alpha and the PKR inhibitor p58IPK in T compared with NT ( p=0 . 022 , p=0 . 048 , respectively ) . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| Regulation of interferon induced protein kinase PKR : modulation of P58IPK inhibitory function by a novel protein , P52rIPK . ^^^ Like many protein kinases , PKR is regulated through direct interactions with activator and inhibitory molecules , including P58IPK , a cellular PKR inhibitor . ^^^ P58IPK functions to represses PKR mediated phosphorylation of the eukaryotic initiation factor 2alpha subunit ( eIF 2alpha ) through a direct interaction , thereby relieving the PKR imposed block on mRNA translation and cell growth . ^^^ To further define the molecular mechanism underlying regulation of PKR , we have utilized an interaction cloning strategy to identify a novel cDNA encoding a P58IPK interacting protein . ^^^ When coexpressed with PKR in yeast , P58IPK repressed PKR mediated eIF 2alpha phosphorylation , inhibiting the normally toxic and growth suppressive effects associated with PKR function . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| Double stranded RNA independent dimerization of interferon induced protein kinase PKR and inhibition of dimerization by the cellular P58IPK inhibitor . ^^^ Curiously , PKR aa 244 to 296 contain the binding site for a select group of specific inhibitors , including the cellular protein P58IPK . ^^^ We demonstrated , utilizing both the yeast and lambda systems , that P58IPK , a member of the tetratricopeptide repeat protein family , can block kinase activity by preventing PKR dimerization . ^^^ In contrast , a nonfunctional form of P58IPK lacking a TPR motif did not inhibit kinase activity or perturb PKR dimers . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| The influenza virus can repress PKR activity through the use of at least two factors , the cellular P58IPK protein and the viral NS 1 protein . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| These features are best exemplified by the P58IPK protein , an influenza virus activated cellular inhibitor of the PKR protein kinase , whose different TPR motifs mediate interactions with distinct proteins . ^^^ Here we review recent progress on the structural and functional characterization of P58IPK , and discuss the possible mechanisms by which P58IPK modulates PKR and induces tumorigenesis in view of present knowledge of TPR proteins and molecular chaperones . . ^^^ |
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| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13217 and P19525 |
Pubmed |
SVM Score :0.0 |
| NA |
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