| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| Taken together , these results suggest that the third basic region of PKR is required for PKR induced apoptosis , the process is initiated upstream of bcl 2 and involves activation of a cellular protease , CPP 32 , or its family members that cleave PARP . . ^^^ |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| Analysis of PKR induced activation of caspases 3 and 9 revealed that LANA 2 abrogated activation of caspase 3 but not of caspase 9 . ^^^ |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| We report here that inhibition of caspase 3 activity reduces phosphorylation of PKR and to a certain extent , cleavage of PKR and eIF2alpha in neurons exposed to Abeta peptide . ^^^ Calcium release from the endoplasmic reticulum and activation of caspase 8 are the upstream signals modulating the caspase 3 mediated activation of PKR by Abeta peptide . ^^^ Although in other systems HSP 90 serves as a repressor for PKR , it is unlikely the candidate for caspase 3 to affect PKR activation in neurons after Abeta peptide exposure . ^^^ |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| TNFalpha treatment induced eIF2alpha phosphorylation and activation of caspase 3 primarily through the dsRNA activated eIF2alpha kinase PKR . ^^^ |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|