| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :1.1273715 |
| Here we show that PKR physically interacts with Stat 3 and is required for PDGF induced phosphorylation of Stat 3 at Tyr 705 and Ser 727 , resulting in DNA binding and transcriptional activation . 1.1273715^^^ |
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| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| The catalytic activity of the eukaryotic initiation factor 2alpha kinase PKR is required to negatively regulate Stat 1 and Stat 3 via activation of the T cell protein tyrosine phosphatase . ^^^ Previous data have implicated PKR in cell signaling via regulation of Stat 1 and Stat 3 , but the molecular mechanisms underlying these events have remained elusive . ^^^ Using PKR ( / ) mouse embryonic fibroblasts and a conditionally active form of human PKR , we demonstrate herein that tyrosine ( but not serine ) phosphorylation of either Stat 1 or Stat 3 is impaired in cells with activated kinase . ^^^ This reduction in Stat 1 and Stat 3 tyrosine phosphorylation by active PKR proceeds through TC PTP , which is a substrate of the eukaryotic initiation factor 2alpha kinase both in vitro and in vivo . ^^^ These data reveal a novel function of PKR as a negative regulator of Stat 1 and Stat 3 with important implications in cell signaling . . ^^^ |
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| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19525 and P40763 |
Pubmed |
SVM Score :0.0 |
| NA |
|