| Interacting proteins: Q9NZ08 and P19438 |
Pubmed |
SVM Score :0.0 |
| Identification of ARTS 1 as a novel TNFR 1 binding protein that promotes TNFR 1 ectodomain shedding . ^^^ Using a yeast two hybrid approach , we identified ARTS 1 ( aminopeptidase regulator of TNFR 1 shedding ) as a type 2 integral membrane protein that binds to the TNFR 1 extracellular domain . ^^^ In vivo binding of membrane associated ARTS 1 to TNFR 1 was confirmed by coimmunoprecipitation experiments using human pulmonary epithelial and umbilical vein endothelial cells . ^^^ A direct relationship exists between membrane associated ARTS 1 protein levels and concordant changes in TNFR 1 shedding . ^^^ Cells overexpressing ARTS 1 demonstrated increased TNFR 1 shedding and decreased membrane associated TNFR 1 , while cells expressing antisense ARTS 1 mRNA demonstrated decreased membrane associated ARTS 1 , decreased TNFR 1 shedding , and increased membrane associated TNFR 1 . ^^^ |
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| Interacting proteins: Q9NZ08 and P19438 |
Pubmed |
SVM Score :0.0 |
| Aminopeptidase regulator of TNFR 1 shedding ( ARTS 1 ) binds to the type 1 tumor necrosis factor receptor ( TNFR 1 ) and promotes receptor shedding . ^^^ Because hydroxamic acid based metalloprotease inhibitors prevent shedding of both TNFR 1 and the interleukin 6 receptor ( IL 6Ralpha ) , we hypothesized that ARTS 1 might also regulate shedding of IL 6Ralpha , a member of the type 1 cytokine receptor superfamily that is structurally different from TNFR 1 . ^^^ Thus , ARTS 1 promotes the shedding of two cytokine receptor superfamilies , the type 1 cytokine receptor superfamily ( IL 6Ralpha ) and the TNF receptor superfamily ( TNFR 1 ) . ^^^ We propose that ARTS 1 is a multifunctional aminopeptidase that may modulate inflammatory events by promoting IL 6Ralpha and TNFR 1 shedding . . ^^^ |
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| Interacting proteins: Q9NZ08 and P19438 |
Pubmed |
SVM Score :0.0 |
| In this study we report that an aminopeptidase , aminopeptidase regulator of TNFR 1 shedding ( ARTS 1 ) , is required for IL 1RII shedding . ^^^ |
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| Interacting proteins: Q9NZ08 and P19438 |
Pubmed |
SVM Score :0.0 |
| Extracellular TNFR 1 release requires the calcium dependent formation of a nucleobindin 2 ARTS 1 complex . ^^^ TNFR 1 release from HUVEC is known to involve the association between ARTS 1 ( aminopeptidase regulator of TNFR 1 shedding ) , an integral membrane aminopeptidase , and TNFR 1 . ^^^ The goal of this study was to identify ARTS 1 binding partners that modulate TNFR 1 release to the extracellular space . ^^^ ARTS 1 complex that associated with a subset of total cellular TNFR 1 . ^^^ RNA interference was utilized to specifically knock down NUCB 2 and ARTS 1 expression , which demonstrated that both are required for the constitutive release of a full length 55 kDa TNFR 1 within exosome like vesicles as well as the inducible proteolytic cleavage of soluble TNFR 1 ectodomains . ^^^ |
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