| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Signal transduction by DR 3 , a death domain containing receptor related to TNFR 1 and CD 95 . ^^^ Tumor necrosis factor receptor 1 ( TNFR 1 ) and CD 95 ( also called Fas or APO 1 ) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology , designated the `` death domain . ' ' Another death domain containing member of the TNFR family , death receptor 3 ( DR 3 ) , was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Unlike Fas , TNFR 1 , and DR 3 , DR 4 could not use FADD to transmit the death signal , suggesting the use of distinct proximal signaling machinery . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| The Fas receptor is a member of a family of cell death receptors , including tumor necrosis factor receptor 1 ( TNFR 1 ) , death receptor 3 and 4 ( DR 3 and DR 4 ) , and cytopathic avian receptor 1 ( CAR 1 ) . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| CD 95 , tumor necrosis factor receptor type 1 ( TNFR 1 ) , and death receptor 3 ( DR 3 ) did not induce apoptosis in FADD deficient embryonic fibroblasts , whereas DR 4 , oncogenes E1A and c myc , and chemotherapeutic agent adriamycin did . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| In addition , Apo 3 resembles TNFR 1 and CD 95 in that it contains a cytoplasmic death domain . ^^^ CrmA , a poxvirus inhibitor of Ced 3 like proteases which blocks death signaling by TNFR 1 and CD 95 , inhibited Apo 3 induced apoptosis . ^^^ CONCLUSIONS : These results identify Apo 3 as a third member of the TNFR family that activates apoptosis , and suggest that Apo 3 , TNFR 1 and CD 95 engage a common apoptotic cell death machinery . ^^^ Apo 3 resembles TNFR 1 because it can stimulate NF kappa B activity and regulate apoptosis . ^^^ |
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| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| The expression of LARD is more tightly regulated than that of either Fas or TNF R 1 as it is found predominantly on lymphocytes ( T and B cells ) but not on macrophages or a number of transformed lymphocyte cell lines . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| These include Fas , TNF R 1 , lymphocyte associated receptor of death ( LARD ) , DR 4 , and TNF related apoptosis inducing ligand receptor inducer of cell killing 2 ( TRICK 2 ) . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| In particular , MVL ( DR 1 ) , Akiba ( DR 2 ) , QBL ( DR 3 ) , FPF ( DR 5 ) , and APD ( DR 6 ) have polymorphisms that distinguish them from other members of their DR haplotype . . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Recently , several tumor necrosis factor receptor 1 ( TNF R 1 ) and Fas related death receptors have been discovered and include DR 3 , DR 4 , DR 5 and DR 6 . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| However , TGF beta treatment of BL 41 cells was found not to affect the cell surface expression of Fas , TNF R 1 , DR 3 , DR 4 , or DR 5 , or the steady state expression levels of Fas ligand , TNF R 1 , DR 3 , DR 4 , and DR 5 . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Transcripts for the 14 receptors to which the ligands bind , six of which contain death domains ( TNFR 1 , Fas , DR 3 , DR 4 , DR 5 , DR 6 ) , were also identified using RT PCR . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| FADD is a death domain containing protein that binds to certain members of the tumor necrosis factor receptor family , namely TNFR 1 , Fas , and DR 3 . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Apoptotic signals are transduced by five death domain containing receptors TNFR 1 , Fas , DR 3 , DR 4 , and DR 5 by binding to their ligands . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Recently , researchers have discovered several novel homologues of Fas and TNFR 1 : DR 3 , 4 , 5 , and 6 function as death receptors that signal apoptosis , whereas DcR 1 , 2 , and 3 act as decoys that compete with specific death receptors for ligand binding . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| For TNF R 1 , Fas / APO 1 , DR 3 , DR 6 , TRAIL R 1 and TRAIL R 2 , a conserved ' death domain ' in the intracellular region couples these receptors to activation of caspases . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| These studies showed that CD120a and DR 3 are significantly phosphorylated by p 42 ( mapk / erk2 ) but Fas , DR 4 and DR 5 are not . ^^^ Additionally , we demonstrated that ( 1 ) the p 42 ( mapk / erk2 ) dependent phosphorylation of CD120a and DR 3 occurred on Ser and Thr residues , ( 2 ) p 42 ( mapk / erk2 ) phosphorylated residues located in the membrane proximal regions but not the death domains of CD120a and DR 3 , ( 3 ) Ser 253 is a preferred site of phosphorylation on CD120a , and ( 4 ) the p 42 ( mapk / erk2 ) dependent phosphorylation of the DR 3 cytoplasmic domain occurred exclusively at non p42 / 44 ( mapk / erk2 / 1 ) consensus sites . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Besides TNFR 1 , death receptor 3 ( DR 3 ) , Hsp70 / Hsc70 , and Bcl 2 have been characterized as binding partners of SODD . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Death receptors [ Fas / Apo 1 / CD95 , TNF R 1 [ tumour necrosis factor ( TNF ) receptor 1 ] , DR 3 [ death receptor 3 ] , TRAIL R 1 [ TNF related apoptosis inducing ligand receptor 1 ] , TRAIL R 2 , DR 6 , p 75 NGFR [ p 75 nerve growth factor receptor ] , EDAR [ ectodermal dysplasia receptor ] ] form a subgroup of the TNF R superfamily that can induce apoptosis ( programmed cell death ) via a conserved cytoplasmic signalling module termed the death domain . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| The apoptotic signals by these cytokines are transduced by eight different death domain ( DD ) containing receptors ( TNFR 1 , also called DR 1 ; Fas , also called DR 2 ; DR 3 , DR 4 , DR 5 , DR 6 , NGFR , and EDAR ) . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| To date six bona fide death receptors ( DRs ) have been discovered and include tumor necrosis factor receptor 1 ( TNF R 1 ) , Fas , DR 3 , DR 4 , DR 5 and DR 6 . ^^^ For example , TNFalpha activates TNF R 1 while FasL and TL1A activate Fas and DR 3 respectively . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| The results showed that MEM induced cell apoptosis involved up regulation of Fas and down regulation of Bcl 2 , DR 3 , DR 4 , TNFRI , and TNFRII in HepG 2 cells , while no changes on the levels of Bax , Bid , Bad , and Bak protein were observed . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Differential regulation of interleukin 8 gene transcription by death receptor 3 ( DR 3 ) and type 1 TNF receptor ( TNFRI ) . ^^^ Overexpression of its cognate receptor DR 3 can induce a higher amount of IL 8 protein secretion than that induced by TNFRI even though both receptors activate IL 8 gene transcription in a similar fashion . ^^^ Although both DR 3 and TNFRI activated TRAF 2 and NF kappaB to induce IL 8 gene transcription , the kinase cascades that transduce signals for DR 3 and TNFRI induced IL 8 gene transcription are different . ^^^ The axis TAK1 / ASK1 MKK4 / MKK7 JNK 2 is responsible for DR 3 mediated IL 8 gene expression whereas the axis ASK 1 MKK4 JNK1 / JNK2 / p38MAPK is the choice for TNFRI mediated activation of IL 8 gene expression . ^^^ This indicates that the downstream signaling pathways of DR 3 and TNFRI for IL 8 secretion are divergent even though both receptors contain death domain and induce IL 8 secretion via TRAF2 . . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| These data suggest that despite some similarity between the death domains of TR 3 and TNFR 1 the nature of the interaction with TRADD differs from that reported for TNFR1 . . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Thus , TRAIL receptors can signal both death and gene transcription , functions reminiscent of those of TNFR 1 and TRAMP , two other members of the death receptor family . . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| A comparative examination of HVS transformed T cell clones and their native parental clones revealed that the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and members of the tumor necrosis factor receptor ( TNF R ) superfamily with a death domain , namely , TNF RI , CD 95 , and TRAMP , were not modulated by HVS . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| Eight human DRs ( Fas , TNF R 1 , TRAMP , TRAIL R 1 , TRAIL R 2 , DR 6 , EDA R and NGF R ) have been identified . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| This protein , WSL 1 , is most similar to TNFR 1 itself , particularly in the death domain region . ^^^ Like TNFR 1 , WSL 1 will homodimerize in yeast . ^^^ WSL 1 also interacts specifically with the TNFR 1 associated molecule TRADD . ^^^ |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q93038 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|