| Interacting proteins: Q8WXG6 and P19438 |
Pubmed |
SVM Score :0.0 |
| Furthermore , overexpression of MADD ( MAP kinase activating death domain protein ) , an adapter protein that binds to the death domain of TNFR 1 and activates MAP kinase cascades , results in CRE dependent induction of TNF alpha gene expression . ^^^ |
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| Interacting proteins: Q8WXG6 and P19438 |
Pubmed |
SVM Score :0.0 |
| Antisense abrogation of DENN expression culminated in upregulated expression of TNFR 2 , TRAIL and Fas , but downregulation of TNFalpha , TNFR 1 and cyclin D 3 . ^^^ The participation of TNFalpha , TNFR 1 , TNFR 2 and Fas in the inhibition of DENN expression was also demonstrated . ^^^ |
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| Interacting proteins: Q8WXG6 and P19438 |
Pubmed |
SVM Score :0.0 |
| We have used the yeast interaction trap to isolate a protein , MADD , that associates with the death domain of TNFR 1 through its own C terminal death domain . ^^^ MADD interacts with TNFR 1 residues that are critical for signal generation and coimmunoprecipitates with TNFR 1 , implicating MADD as a component of the TNFR 1 signaling complex . ^^^ These data indicate that MADD links TNFR 1 with MAP kinase activation and arachidonic acid release and provide further insight into the mechanisms by which TNF exerts its pleiotropic effects . . ^^^ |
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| Interacting proteins: Q8WXG6 and P19438 |
Pubmed |
SVM Score :0.0 |
| We found that actinomycin D treatment of KS cells selectively abolished expression of mitogen activated protein kinase activating death domain protein ( MADD ) , a novel TNFR 1 associated death domain protein . ^^^ MADD may couple TNFR 1 with the ERK1 / 2 signaling pathway required for KS cell proliferation . . ^^^ |
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