| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) induced apoptosis is mediated by the interaction of FADD with caspase 8 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and 1 , which are activated by ligation of the CD 95 and TNF R 1 death receptors , are not involved . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The cytoplasmic tail of human TNFRI was found to be susceptible to caspase cleavage but not by caspase 8 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 activity was increased in B 6 PTCs , but not in Fas mutant PTCs and TNFR 1 deficient PTCs . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 mediates the extrinsic pathway of apoptosis triggered by signaling through TNF R 1 family receptors . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| CASP 8 and CASP 10 , members of a cysteine protease family that participates in apoptosis , interact with MORT1 / FADD , an adapter protein in the CD120a ( p 55 tumor necrosis factor receptor ) , and CD 95 ( Fas / Apo 1 ) death inducing signaling pathways , through a shared N terminal sequence motif , the death effector domain . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The death signaling pathways induced by TNF R 1 and CD 95 involve a group of death domain containing proteins , including caspase 8 , a member of the interleukin 1beta converting enzyme family . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 is recruited to Fas and TNF receptor 1 ( TNF R 1 ) through interaction of its prodomain with the death effector domain ( DED ) of the receptor associating FADD . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Upon activation , cell surface death receptors , Fas / APO 1 / CD95 and tumor necrosis factor receptor 1 ( TNFR 1 ) , are attached to cytosolic adaptor proteins , which in turn recruit caspase 8 ( MACH / FLICE / Mch5 ) to activate the interleukin 1 beta converting enzyme ( ICE ) / CED 3 family protease ( caspase ) cascade . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the Fas or tumor necrosis factor receptor 1 ( TNFR 1 ) cell surface receptors leads to the activation of the death effector protease , caspase 8 , and subsequent apoptosis . ^^^ To address the effect of Bcl xL on caspase 8 processing , Fas and TNFR 1 mediated apoptosis were studied in the MCF 7 breast carcinoma cell line stably transfected with human Fas cDNA ( MCF7 / F ) or double transfected with Fas and human Bcl xL cDNAs ( MCF7 / FB ) . ^^^ Thus , at least in some cells , caspase 8 signaling in response to Fas or TNFR 1 stimulation is regulated by a Bcl xL inhibitable step . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Depending on the DNA virus and the viral proteins , the following mechanisms to prevent TNF receptor and Fas induced apoptosis are used : ( 1 ) absorption of extracellular TNF by secreted homologs of the TNF receptor ; ( 2 ) degradation of Fas ; ( 3 ) inhibition of the assembly of FADD and Caspase 8 with TNFR 1 and Fas ; ( 4 ) direct inhibition of proapoptotic caspase enzymatic activity ; and ( 5 ) inhibition of the proapoptotic members of the Bcl 2 family . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| UV irradiation stimulated the aggregation mediated activation of TNFR 1 which was coupled with activation of caspase 8 , the most proximal caspase in TNF alpha signaling pathway . ^^^ CrmA and the dominant negative versions of FADD , caspase 8 and caspase 10 , that block the apoptotic axis of TNFR 1 at different levels , also independently inhibited the UV induced apoptosis . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| In particular , the TNF R 55 associated protein FADD seems to be responsible for recruitment and subsequent activation of caspase 8 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The phosphoprotein protein PEA 15 inhibits Fas but increases TNF R 1 mediated caspase 8 activity and apoptosis . ^^^ Furthermore , the differential effect is evident at the level of caspase 8 activity which is inhibited via Fas activation , but increased via TNF R 1 activation upon PEA 15 expression . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas associated death domain protein ( FADD ) , caspase 8 related protein ( Casper ) , and caspase 8 are components of the tumor necrosis factor receptor type 1 ( TNF R 1 ) and Fas signaling complexes that are involved in TNF R 1 and Fas induced apoptosis . ^^^ A mutant of Casper and the caspase specific inhibitors crmA and BD fmk partially inhibit TNF R 1 , TRADD , and TNF induced NF kappaB activation , suggesting that FADD , Casper , and caspase 8 function downstream of TRADD and contribute to TNF R 1 induced NF kappaB activation . ^^^ These data indicate that FADD , Casper , and pro caspase 8 are parts of the TNF R 1 induced NF kappaB activation pathways , whereas activated caspase 8 can negatively regulate TNF R 1 induced NF kappaB activation by proteolytically inactivating NIK . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas ( APO 1 / CD95 ) and tumor necrosis factor receptor 1 ( TNFR 1 ) trigger apoptosis by recruiting the apoptosis initiator caspase 8 through the adaptor FADD . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Taken together , our observations establish the involvement of caspase 8 in PKR induced apoptosis and suggest that death receptors other than Fas or TNFR 1 or , alternatively , a novel mechanism involving FADD independently of death receptors , are responsible for PKR induced apoptosis . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The C terminal fragment of RIP also enhanced the association between TNFR 1 and death domain proteins including TNFR 1 associated death domain ( TRADD ) and Fas associated death domain ( FADD ) , resulting in the activation of caspase 8 and stimulation of apoptosis . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Under the conditions where HIPK2 / TRADD association was found , no direct interaction of HIPK 2 with CD 95 , TNF R 1 , FADD or caspase 8 could be detected . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Changes in the activation of caspase 8 that parallel changes in regulatory light chain phosphorylation levels reveal that myosin 2 motor activities regulate TNF receptor 1 ( TNFR 1 ) signaling at an early step in the TNF death signaling pathway . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Gel shift assay and Western blot analysis supported microarray results , showing that 5 PYRRO / NO suppressed GlaN / LPS induced activation of nuclear factor kappaB and GlaN / LPS induced increases in caspase 1 , caspase 8 , tumor necrosis factor receptor 1 ( TNFR 1 ) associated death domain , and TNF related apoptosis inducing ligand . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 ( TNFR 1 ) and TNFR 2 mediated apoptosis in HIV infection : relation to expression of Bcl 2 and active caspase 8 and caspase 3 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Because of the intimate role of caspase 8 in apoptosis signaling pathways from FAS , TNFR 1 , and other death receptors , the enzyme is a potentially important therapeutic target . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Among induced genes , four ( TNFR 1 , TNFSF 7 , caspase 8 , and DAPK 1 ) were associated with the tumor necrosis factor ligand receptor death pathway . ^^^ Induction of TNFR 1 , TNFSF 7 , and caspase 8 were confirmed by Northern and Western analyses . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Apoptotic crosstalk of TNF receptors : TNF R 2 induces depletion of TRAF 2 and IAP proteins and accelerates TNF R 1 dependent activation of caspase 8 . ^^^ Compared with FasL induced cell death TNF R 1 induced activation of caspase 8 was significantly weaker and delayed . ^^^ Thus , TNF R 2 may compete with TNF R 1 for the recruitment of newly synthesized TRAF 2 bound anti apoptotic factors , thereby promoting the formation of a caspase 8 activating TNF R 1 complex . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| RNase protection assay revealed that IFN gamma up regulated the mRNA levels of two pro apoptotic molecules , tumor necrosis factor alpha receptor 1 ( TNFR 1 ) and caspase 8 , in THP 1 cells . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| We conclude that inhibition of HSP 90 may alter the composition of the TNFR 1 complex , favoring the caspase 8 dependent apoptotic pathway . ^^^ Thus , the availability of proteins such as receptor interacting protein , Fas associated death domain , and caspase 8 can determine whether TNFR 1 activation will lead to apoptosis or to necrosis . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Death receptor ( DR ) dependency was analyzed by examining expression of DRs ( Fas , DR 4 , DR 5 , TNFR 1 , and R 2 ) , and interaction of Fas associated death domain and caspase 8 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expressions of T cell apoptosis promoting and inhibiting genes , including Fas , FasL , Bcl 2 , Bax , TNFR 1 and TNFR 2 , as well as activity of cysteine proteinase in cascade connection , such as Caspase 8 and Caspase 3 were determined by TUNEL labeled flow cytometry and fluorescence real time quantitative RT PCR technique . ^^^ RESULTS : The two compound prescriptions for Kidney tonifying could effectively lower T cell over apoptosis in old rats , down regulate FasL and TNFR 1 gene transcription , and decrease the activity of Caspase 8 and Caspase 3 , while the compound prescription for blood circulation activating showed insignificant effect on T cell over apoptosis . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 activation is an upstream event in the apoptotic pathway triggered by the activation of cytokines receptors such as TNF alpha receptor 1 ( TNFR 1 ) , and the presence of caspase 8 activation in fibroblast like cells in the aseptic interface membranes of THAs suggests a possible TNF alpha dependent apoptosis . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Because cellular FLICE / caspase 8 inhibitory protein ( cFLIP ) is a recently identified intracellular inhibitor of caspase 8 activation that potently inhibits death signaling mediated by all known death receptors , including Fas , TNF receptor ( TNF R ) , and TNF related apoptosis inducing ligand receptors ( TRAIL Rs ) , we investigated the expression and function of cFLIP in human HCCs . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced by TNF receptor 1 ( TNFR 1 ) is thought to proceed via recruitment of the adaptor FADD and caspase 8 to the receptor complex . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 activity may be suppressed because the loss of TNFalpha and TNFR 1 gene and protein expression inhibits the initial formation of a death signaling complex . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| In aged coronary arteries there was an increased expression of TNFalpha , TNFbeta , and caspase 9 ( microarray , real time PCR ) , as well as increased caspase 9 and caspase 3 activity , whereas expression of TNFR 1 , TNFalpha converting enzyme ( TACE ) , Bcl 2 , Bcl 10 ( L ) , Bid , Bax , caspase 8 , and caspase 3 were unchanged . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| This apoptotic process involved the cytoplasmic pathway from a death receptor ( DR 6 , Fas , TNF R 1 ) through caspase 8 , and the mitochondrial pathway though Bad and caspase 9 activation . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that within minutes internalized TNF R 1 ( TNF receptosomes ) recruits TRADD , FADD , and caspase 8 to establish the `` death inducing signaling complex ' ' ( DISC ) . ^^^ In contrast , aggregation of TRADD , FADD , and caspase 8 to establish the TNF R 1 associated DISC is critically dependent on receptor endocytosis . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| BLM exposure had no marked effect on AM expression of TNF R 1 or caspase 8 activation , but significantly increased the expression of TNF R 2 that was accompanied by a rise in c IAP 1 and a decrease in TRAF 2 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Down regulating the expression of FasL and TNFR 1 and up regulating the expression of Bcl 2 as well as decreasing the activities of caspase 8 and caspase 3 may be the unique regulating pattern of tonifying kidney method with respect to T cell apoptosis related genes in corticosterone treated rats . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| CONCLUSION : In the initiation phase of pulmonary oxygen toxicity , an increase of TNFalpha and its receptor TNFR 1 leads to the activation of caspase 8 and 3 in TIIcells . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The effects of age and CR on muscle mass , myocyte area , fiber number , myocyte TNF alpha expression , plasma TNF alpha levels , and specific elements linked with the TNF alpha signaling cascade ( TNF R 1 , IKKgamma , IkappaBalpha , p 65 , NF kappaB binding activity , FADD , caspase 8 , and DNA fragmentation ) were investigated in soleus ( predominately Type 1 fiber ) , and superficial vastus lateralis ( SVL , predominately Type 2 fiber ) , of 6 month old ad libitum fed ( 6AL ) , 26 month old ad libitum fed ( 26AL ) , and 26 month old calorie restricted ( 26CR ) male Fischer 344 rats ( CR = 40 % restriction compared with ad libitum ) . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| This was established by showing that CIN 85 was co precipitated with TNFR 1 , TRADD , cIAP 1 and TARF1 / 2 , but not with FADD , RIP , caspase 8 or TRAF 6 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The expression of TNF alpha , TNF R 1 , TRAIL , NF ( kappa ) B and caspase 8 were studied in muscle biopsy specimens from 14 patients with a dystrophinopathy [ 10 Duchenne muscular dystrophies ( DMD ) , 2 Becker MD , and 2 DMD carriers ] by immunohistochemistry and Western blotting . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Tissue specimens of 10 tooth germs , 40 benign ameloblastomas , and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry to determine the expression of TNFalpha , TNF receptor 1 ( TNFRI ) , TRAIL , TRAIL receptor 1 ( TRAIL R 1 ) , TRAIL R 2 , caspase 8 , and nuclear factor kappaB ( NF kappaB ) . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Activation of caspase 8 can occur via a death receptor dependent mechanism ( e . g . , TNF alpha binding to TNF alpha receptor 1 ( TNF R 1 ) ) . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the present study , we show that caspase 8 activation in these cells is mediated through ER stress associated elevation of death receptor DR 5 and the C / EBP homologous protein ( GADD153 / CHOP ) , an ER stress initiated transcription factor , rather than through TNFalpha and TNF R 1 interactions on the cell surface . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Remarkably , both CD 95 and TNFR 1 death receptors initiate apoptosis by recruiting a novel ICE / CED 3 family member , designated FLICE / MACH , to the receptor signaling complex . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| FADD and FLICE participate in generating the death signal from both tumor necrosis factor receptor 1 ( TNFR 1 ) and the CD 95 receptor . ^^^ The flow of death signals from TNFR 1 occurs through the adaptor molecule tumor necrosis factor receptor associated death domain protein ( TRADD ) to FADD to FLICE , whereas for CD 95 the receptor directly communicates with FADD and then FLICE . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that select genes from several important apoptosis related gene families are induced by IFN gamma , including the apoptosis signaling receptors CD 95 ( Fas / APO 1 ) and TNFR 1 and interleukin 1beta converting enzyme ( Ice ) family members Ice , CPP 32 ( Yama , apopain ) , ICErel 2 ( TX , Ich 2 ) , Mch 3 ( ICE LAP 3 , CMH 1 ) , Mch 4 , and Mch 5 ( MACH , FLICE ) . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas and TNFR 1 belong to a family of cytokine activated receptors that share key components in their signaling pathways , Fas associating protein with death domain ( FADD ) and FADD like interleukin 1beta converting enzyme ( FLICE ) , to induce an apoptotic response . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| In contrast , transcripts representing Fas , TNFR 1 , FADD ( Fas associated death domain ) , FLICE , Bad and Bax were ablated in cells expressing PKRdelta 6 . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using the ribonuclease ( RNase ) protection assay and the reverse transcriptase polymerase chain reaction ( RT PCR ) method , we confirmed that TNF receptor 1 ( TNFR 1 ) , TNFR 1 associated death domain protein ( TRADD ) , Fas receptor associated intracellular protein with death domain ( FADD ) , and FADD like interleukin 1beta converting enzyme ( FLICE ) were expressed in the pancreatic beta cell line , MIN 6 cells . ^^^ These results suggest that TNF alpha can cause apoptosis in pancreatic beta cells through TNFR 1 linked apoptotic factors , TRADD , FADD , and FLICE , and TNF induced ceramide production may be involved in the pathways . . ^^^ |
|
| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^ |
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| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Myocardial biopsies from 17 patients at the time of LVAD implantation and after explantation , at the time of heart transplantation ( HTx ) , were examined by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) reaction and with antibodies against Fas ligand ( FasL ) , Fas , tumor necrosis factor ( TNF ) alpha receptor 1 ( TNF R 1 ) , TNF alpha receptor 2 ( TNF R 2 ) , TNF alpha , TNF alpha converting enzyme ( TACE ) , poly ( ADP ribose ) polymerase ( PARP ) , poly ( ADP ribose ) ( PAR ) , caspase 3 and FLICE inhibitory protein ( FLIP ) . ^^^ |
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| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| These cytokines induce cell death through sequential recruitment by the death receptors TNFR 1 associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , FADD like interleukin 1beta converting enzyme ( FLICE ) , and downstream caspases . ^^^ |
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| Interacting proteins: Q14790 and P19438 |
Pubmed |
SVM Score :0.0 |
| Expression of MACH isoforms that contain an incomplete ICE / CED 3 region provides effective protection against the cytotoxicity induced by Fas / APO 1 or p 55 R triggering . ^^^ These findings suggest that MACH is the most upstream enzymatic component in the Fas / APO 1 and p 55 R induced cell death signaling cascades . . ^^^ |
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