| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Here we show that the TNF R 2 signal transducers TRAF 2 and c IAP 1 are a part of the TNF R 1 signaling complex . ^^^ The recruitment of TRAF 2 and c IAP 1 to TNF R 1 is TNF dependent , is mediated by TRADD , and is independent of TNF R 2 . ^^^ These data establish the physiological involvement of TRAF 2 and c IAP 1 in TNF R 1 signaling and help provide a molecular explanation for both the overlapping and distinct signals generated by the two TNF receptors . . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF RI and TNF RII signalling complexes also contain the anti apoptotic ( ' inhibitor of apoptosis ' ) molecules c IAP 1 and c IAP 2 ( refs 5 , 6 ) , which also have RING domain dependent ubiquitin protein ligase ( E 3 ) activity . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| BLM exposure had no marked effect on AM expression of TNF R 1 or caspase 8 activation , but significantly increased the expression of TNF R 2 that was accompanied by a rise in c IAP 1 and a decrease in TRAF 2 . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF alpha induced transcriptional activation of a heterologous promoter construct harboring the AP 1 binding site was also mediated by the type 1 p 55 TNF R . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| In addition , both Tnfr 1 and Tnfr 2 mediated independently the activation of the transcription factor Ap 1 albeit with parallel activation kinetics . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Binding of AP 1 after PH was decreased in TNFR 1 knockout mice compared with animals with the intact receptor whereas C / EBP binding was not modified . ^^^ Injection of interleukin 6 in TNFR 1 deficient animals 30 min before PH corrected the defect in DNA synthesis and restored STAT 3 and AP 1 binding to normal levels but had no effect on NF kappaB binding in the regenerating liver . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Despite being unable to activate JNK / SAPK and mitogen activated protein kinase , NIK strongly activated AP 1 and was required for TNF R 1 induced AP 1 activation . ^^^ Therefore , NIK links TNF R 1 to a novel , JNK / SAPK independent , AP 1 activation pathway . . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Although AP 1 binding was induced in WT TNFR 1 and TNFR 2 knockout mice , binding in TNFR 2 knockouts was lower than in WT mice . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| We investigated the mechanism by which TNFR 1 recruits the stress activated protein kinases ( SAPKs ) and the p38s , two mitogen activated protein kinase ( MAPK ) families that together regulate AP 1 . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using OA synovial fibroblasts , we investigated the effects of interleukin 8 ( IL 8 ) , leukaemia inhibitory factor ( LIF ) and IL 11 on the level of TNF alpha induced PGE ( 2 ) , and their impact on the TNF alpha induced cellular signalling cascades including the TNF receptor ( TNF R ) , soluble TNF R ( TNF sR ) , cytoplasmic phospholipase A 2 ( cPLA 2 ) , cyclooxygenase 2 ( COX 2 ) , and the transcription factors NF kappaB , C / EBP , CREB and AP 1 . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| To determine the mechanism of inhibition of these pathways by the adenovirus E 3 10 . 4K / 14 . 5K proteins , we have examined the effects of this viral complex on the inhibition of AP 1 and NF kappaB activation by TNF and found a reduction in assembly of the TNF receptor 1 ( TNFR 1 ) signaling complex at the plasma membrane accompanied by downregulation of surface levels of TNFR1 . . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Furthermore , a marked reduction in procollagen and TGF beta synthesis was observed in TNFR 1 KO mice , which also had little detectable NF kappa B , STAT 3 , and AP 1 binding , and reduced levels of liver interleukin 6 ( IL 6 ) mRNA compared to WT and TNFR 2 KO mice . ^^^ In conclusion , our results indicate the possibility that NF kappa B , STAT 3 , and AP 1 binding by signals transduced through TNFR 1 plays an important role in liver fibrosis formation . . ^^^ |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNFalpha induced activation of NF kappaB and AP 1 was decreased in the primary dermal fibroblasts with the C43S TNFRSF1A mutation . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using embryonic fibroblasts lacking TAK 1 , TAB 1 , or TAB 2 , we have found that TNFR 1 , IL 1R , TLR 3 , and TLR 4 mediated NF kappaB and AP 1 activation are severely impaired in Tak 1 ( m / m ) cells , but they are normal in Tab 1 ( / ) and Tab 2 ( / ) cells . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| RIP 2 interacted with other members of the TNFR 1 signaling complex , including inhibitor of apoptosis protein cIAP 1 and with members of the TNFR associated factor ( TRAF ) family , specifically TRAF 1 , TRAF 5 , and TRAF 6 , but not with TRAF 2 , TRAF 3 , or TRAF 4 . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Life cell imaging and confocal microscopy revealed that both TNF R 1 and TNF R 2 recruited the anti apoptotic factor cIAP 1 in a TRAF 2 dependent manner . ^^^ |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| Increased apoptosis was associated with an increased expression of TNFR 1 , TNFR 2 , and CD95L and decreased expression of cIAP 1 and FLIP ( L ) . ^^^ |
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| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| This was established by showing that CIN 85 was co precipitated with TNFR 1 , TRADD , cIAP 1 and TARF1 / 2 , but not with FADD , RIP , caspase 8 or TRAF 6 . ^^^ |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|