| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| The gene encoding mouse LT beta R , Ltbr , contains 10 exons spanning 6 . 9 kb and maps to mouse chromosome 6 , which is closely linked to Tnfr 1 , consistent with the tight linkage of the human homologue of these genes on chromosome 12p13 . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Cellular responses are initiated by a corresponding family of specific receptors that includes two distinct TNFR ( TNFR 60 and TNFR 80 ) , Fas ( CD 95 ) , CD 40 , p75NTF , and the recently identified lymphotoxin beta receptor ( LT beta R ) , among others . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ TNF , LT alpha and LT beta and their receptors ( CD120a , CD120b , TNFR RP ) interact in a complex fashion . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| In this report we have compared the effects of ligand engagement of TNF R and LT beta R by evaluating the ability of soluble LT alpha beta complexes to initiate activities of human umbilical vein endothelial cells which are characteristically signalled by TNF . ^^^ Thus , the ability of LT alpha beta complexes to efficiently initiate tumoricidal but not inflammatory activities distinguishes the LT / LT beta R from the LT / TNF R pathways and suggest novel strategies for exploiting the LT ligands in tumor therapy and for inhibiting TNF R mediated inflammatory sequellae . . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Thus , certain actions of LT alpha to regulate spleen white pulp architecture are mediated by receptors other than TNFR 1 , most likely by the LT beta R or a closely related receptor . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Here we have used soluble receptor Ig forms of LT beta R and TNF R 55 and mAbs specific for murine LT alpha , LT beta , and LT beta R to characterize the appearance of surface LT alpha beta complexes and LT beta R on several common murine cell lines . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| To determine the role of the various ligands and their receptors in LT induced inflammation , mice deficient in either TNFR 1 , TNFR 2 , or LT beta were crossed to RIPLT transgenic mice . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of TNF , LT alpha ( the soluble form of LT ) , LT beta ( the beta chain of LT alpha beta , the membrane bound form of LT ) , TNF RI , TNF RII , LT beta R , FasL , and Fas receptor in MS lesions has been examined by immunohistochemistry for protein and by RT PCR for mRNA . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays demonstrated that TRAF 4 interacts with the cytosolic domain of the lymphotoxin beta receptor ( LT beta R ) and weakly with the p 75 nerve growth factor receptor ( NGFR ) but not with TNFR 1 , TNFR 2 , Fas , or CD 40 . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Mice deficient in either TNFR 1 or LT beta R also fail to develop splenic FDC clusters and germinal centers , indicating that signaling through both TNFR 1 and LT beta R is required for the development of these structures . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Expression of three members of the TNF R family of receptors ( 4 1BB , lymphotoxin beta receptor , and Fas ) in human lung . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Among them are also molecules belonging to superfamily of tumor necrosis factor receptor ( TNFR ) which beside CD 30 include CD 27 , CD 40 , TNFR 1 and 2 , Fas ( CD 95 ) , OX 40 , 4 1BB ( CDw 137 ) , nerve growth factor receptor , lymphotoxin beta receptor , Apo3 / DR3 / Ws1 1 / lymphocyte associated receptor of death , DR 4 , DR5 / TNF related apoptosis inducing ligand , osteoprotegerin , and TNFR related 2 . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| It may bind to the death domain of tumor necrosis factor receptor 1 ( TNFR 1 ) and to the cytoplasmic tail of lymphotoxin beta receptor , implying that it may be involved in the apoptosis and anti apoptosis signaling pathways . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Gene knockout study , however , suggests that NIK is dispensable for TNF R 1 but required for lymphotoxin beta receptor induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| Cells from mice defective in tumor necrosis factor ( TNF ) alpha , TNF beta , lymphotoxin beta , or TNFR 1 , TNFR 2 , Fas , or death receptor 6 were as susceptible to apoptosis signaling as wild type cells . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| We now show that mice made deficient in both LTbeta and TNFR type 1 ( TNFR 1 ) lack all LNs , revealing redundancy or synergism between TNFR 1 and LTbeta , acting presumably via LTbetaR . ^^^ A complete lack of only PPs in mice heterozygous for both ltalpha and ltbeta , but not ltalpha or ltbeta alone , suggests a similar two ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr 1 / mice . . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| The Tlx 1 , Bapx 1 , Tcf 21 , Wt 1 and Dh genes are essential for development of the spleen , while mutations of Nkx 2 3 , Lta , Ltb , Ltbr , Map3k14 , Relb , Tnf , Tnfrsf1a , Cxcl 13 , Blr 1 ( Cxcr 5 ) , or cpdm genes result in disruption of normal splenic microarchitecture . ^^^ Here we review abnormalities of lymphoid organ development in immunodeficient mutant mice , including spontaneous and targeted mutations of Id 2 , Rorc , Tnf , Tnfrsf1a , Lta , Ltb , Ltbr , Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , IL7r , Blr 1 , and Cxcl 13 genes . . ^^^ |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q06643 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|