| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein kinases Erk 1 and Erk 2 were found to be tyrosine phosphorylated and activated by Tnf treatment in all wt , tnfr 1 ( o ) , and tnfr 2 ( o ) fibroblasts ; the activation was down regulated 60 min after the start of steady state Tnf treatment . ^^^ Distinct kinetics of Erk 1 and Erk 2 activation were detected ; the Tnfr 1 mediated activation of Erk 1 and Erk 2 started more slowly and persisted for more prolonged times as compared with Tnfr 2 activation . ^^^ |
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| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| Our findings show that : ( 1 ) TNF RII is able to activate two members of the MAP kinase family : extracellular regulated kinase ( ERK ) and c jun N terminal kinase ( JNK ) ; ( 2 ) TRAF 2 , a molecule that binds TNF RII and associates indirectly with TNF RI , is sufficient to activate JNK upon overexpression ; ( 3 ) dominant negative TRAF 2 blocks TNF alpha mediated JNK activation and ( 4 ) TRAF 2 signals the activation of JNK and NF kappaB through different pathways . ^^^ |
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| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| Hierarchical phosphorylation of the TNF alpha receptor , TNF R 1 , by p42Mapk / Erk at basic Pro directed kinase sites . ^^^ |
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| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the membrane proximal region of tumor necrosis factor receptor CD120a ( p 55 ) at ERK consensus sites . ^^^ |
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| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| Earlier results had suggested that a pathway involving the p 55 TNF receptor ( TNF R 55 ) , neutral sphingomyelinase ( N SMase ) , and c Raf 1 activates ERK and cPLA ( 2 ) . ^^^ Furthermore , we provide evidence that the TNF dependent activation of ERK and cPLA ( 2 ) requires the intact death domain of TNF R 55 . ^^^ Finally , we demonstrate that in murine fibroblasts cPLA ( 2 ) is phosphorylated in response to TNF solely by ERK , but not by p 38 mitogen activated protein kinase , suggesting a signaling pathway from TNF R 55 via the death domain to ERK and cPLA ( 2 ) . . ^^^ |
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| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|