| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| The heat shock protein 90 ( Hsp 90 ) inhibitor , geldanamycin , and the proteasome inhibitor , MG 132 , both inhibited tumor necrosis factor receptor 1 ( TNF R 1 ) but not TRAIL induced apoptosis in Kym 1 cells , suggesting that TNF R 1 induced cell death is dependent on NF kappaB activation in this model . ^^^ |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| We conclude that inhibition of HSP 90 may alter the composition of the TNFR 1 complex , favoring the caspase 8 dependent apoptotic pathway . ^^^ In the absence of geldanamycin , certain HSP 90 client proteins may be preferentially recruited to the TNFR 1 complex , promoting necrosis . ^^^ |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| Cleavage and degradation of TNF pathway components TNFR 1 , RIP , and Hsp 90 were observed in l mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL 1beta induced IKK activation . . ^^^ |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P19438 and P07900 |
Pubmed |
SVM Score :0.0 |
| NA |
|