Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.87488275
TNF alpha has been shown to interact with two distinct membrane receptors ( TNF R ) : p55R and p75R . 0.87488275^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.63531393
In addition , the results suggest some overlap between the TNFR 1 binding sites for TNF alpha and TNF beta , despite low amino acid sequence homology between these cytokines . . 0.63531393^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.74021805
The TNF R 55 was found to be the major receptor species responsible for ligand binding activity , such as COX 2 induction and PGE 2 synthesis , since a specific antireceptor TNF R 55 blocking antibody inhibited about 76 % of TNF alpha binding and TNF alpha stimulated COX 2 induction and PGE 2 production . 0.74021805^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.60969485
These findings suggest that TNF alpha transiently phosphorylates and activates the three members of the MAPK family , namely p 42 ( mapk / erk2 ) , p 46 c Jun amino terminal kinase / stress activated protein kinase ( JNK / SAPK ) , and p38mapk following cross linking of CD120a ( p 55 ) , and that MKK 3 and MKK 4 are capable of phosphorylating p38mapk . . 0.60969485^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.94220636
Last , our radioligand binding experiments demonstrate that TNF alpha binds TNFRI with high affinity ( K ( d ) of 0 . 6 nm ) , whereas TNFRII shows lower binding affinity ( K ( d ) of 1 . 14 nm ) to TNF alpha in NT 2 transfected cells . 0.94220636^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.69642191
Different soluble human TNFR 80 derivatives , a solubilized form of the complete TNFR 80 , the TNFR 80 extracellular domain , a secretory TNFR 80 mutant ( TR80TM ) with a deleted transmembrane region , and a TNFR 80 immunoadhesin were produced in insect cells and characterized side by side with a recombinant human TNFR 60 extracellular domain with respect to TNF binding affinity and neutralization of TNF bioactivity . 0.69642191^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.53679028
We used TNFRI ( / ) mice to study adaptive antilisterial immunity in the absence of interactions between TNF and TNFRI . 0.53679028^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , the ratios of TNF alpha / s TNF R 55 and 75 were not higher in the cases of cerebral malaria or fatal outcome . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Phorbol ester upregulated and TNF alpha down regulated the TNF R gene expression in A 549 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , the interaction between TNF alpha and its 55 kDa receptor ( TNF R ) was investigated by the same approach . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
No significant changes in CD4 / CD8 count , activation markers , TNF alpha , or TNFR 1 were observed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha / s TNF RI correlated with % best of PEF ( r = 0 . 691 , n = 9 , p 0 . 0373 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neither diacerhein nor rhein significantly affected the level of synthesis of TNF alpha or the level of TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
They constitute a death receptor family ( DR 1 to DR 5 ) whose first member is the TNFR 1 receptor for TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Prosaptide prevents hyperalgesia and reduces peripheral TNFR 1 expression following TNF alpha nerve injection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The same can be said about the tumor necrosis factor receptor 1 ( TNFR 1 ) and its ligand , TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced apoptosis has been largely attributed to the p 60 TNF R 1 receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
But , the level of the 1 kappa B alpha and the TNF alpha receptor , TNF R 1 , were not obviously affected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Use of receptor specific TNF alpha mutants showed that activation of MAPK is entirely mediated by the TNFR 1 receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) signals though two receptors , TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of TNF alpha and TNF R 1 was not affected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 6 , TNF alpha , IL 10 and TNF R 1 were not different between both groups , however . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha exerts its biological effects via TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Anti TNF alpha therapy in TNFR 1 KO mice significantly reduced chemokine production and liver injury . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological effects of TNF alpha are mediated via the cell surface TNF receptors TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , the mutant forms of surface expressed deltasig TNFRSF1A were defective in binding TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
SM elevated the expressions of TNF R 1 and R 2 and overcame the resistance of A 549 cells to TNF alpha and beta . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha receptor 1 ( TNFRI ) and IL 6 knock out mice were also used to study CNT 1 regulation in vivo . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Positive TNF alpha and TNFR 1 immunostainings were observed in hepatocytes and Kupffer cells in LEC rats . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha exerts a variety of effects that are mediated mainly by TNF receptor 1 ( TNF R 1 ) in cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSION : The sensitivity and specificity of ascitic fluid CRP , TNF alpha and TNF r values were found to be similar . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , TRAF 2 is absent from TNFR 1 complexes under stress conditions even after TNF alpha treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced TNF alpha production by microglia through ligation of TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast with Fas and TNFR 1 , expression of TNF alpha and FasL did not predict recovery of LV function . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These effects were absent when TNF alpha receptor 1 ( TNFR 1 ) was selectively ablated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Chronic TNF alpha exposure impairs TCR signaling via TNF RII but not TNF RI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutralizing antibody to TNFR 1 could diminish the effect of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Leukocyte infiltration and mRNA expression of IL 20 , IL 8 and TNF R P 60 in psoriatic skin is driven by TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The gene for the type 1 tumor necrosis factor receptor ( TNF R 1 ) is localized on band 12p13 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Many diverse activities of tumor necrosis factor ( TNF ) are signaled through TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 95 ( Fas / APO 1 ) and tumor necrosis factor receptor 1 ( TNFR 1 ) are related molecules that signal apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Identification and characterization of an RNA specific primer for human tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 is a 48 kDa glycosylated phospoprotein that is a member of the tumor necrosis factor receptor ( TNF R ) superfamily . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The type 1 receptor ( CD120a ) is the high affinity receptor for soluble tumor necrosis factor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor p 55 receptor ( TNF RI ) mediates the in vitro inhibition of hepatic erythropoietin production . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor 2 ( TNF RII , CD120b , TNF R p75 / 80 ) gene has recently been characterised . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OX 40 is a member of the tumor necrosis factor receptor ( TNF R ) superfamily . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among the virus encoded immuno modulators is M T 2 , a tumor necrosis factor receptor ( TNF R ) homologue . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This phenomenon was accompanied by enhanced clustering of tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The p 55 tumor necrosis factor receptor ( TNF RI ) is the main receptor by which TNF exerts its effects . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : Tumor necrosis factor alpha ( TNFalpha ) binds the receptors TNFRI and TNFRII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined the gene coding for the tumor necrosis factor receptor TNFRSF1A in all first degree family members . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Herein , we demonstrate that , in contrast to TNF R expression , both resting and IL 2 activated lymphocytes express Fas . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We observed that the induction of tolerance is mediated by TNF R 55 triggering . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 55 or TNFR 75 transformed colon cancer cells were killed by recombinant TNF . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recovery of TNF R occupancy and TNF internalization were subsequently noted . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Surprisingly , no TNF R was detectable on nonlymphoid tissues . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast IL 1beta affected neither its own receptors nor the TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The demonstration that a subunit of the 26S protease binds TNFR 1 may identify a novel TNF signaling pathway . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It exerts its action through the adherence to cellular receptors , known as the TNF R 55 und TNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFalpha exerts its functions by engaging two receptors ( TNF RI and TNF RII ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , we could enhance the survival of TRAF 2 deficient mice by eliminating either TNF or TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutralization of TNF or disruption of TNF R 1 leads to fatal Mycobacterium bovis BCG infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
All responses were blocked by pretreating alveoli with a mAb against TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSION : 41 . 8 degrees C WBH results in transient increases in TNF RI and RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of TNF receptor 1 ( TNFR 1 ) was assessed by flow cytometry and quantitative RT PCR . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using TNF receptor specific antibodies and flow cytometry , we showed that MRC 5 cells express mainly TNFRI . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Older adult ( 6 to 8 month old ) TNF receptor 1 knockout ( TNFR 1 ( / ) ) mice displayed decreased relative liver weight . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These include induction of endothelial cell apoptosis and upregulation of TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MemTNF induced apoptosis was mediated through both TNF R 1 and TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This TNF effect was mediated by TNFR 2 ( p 75 ) but not by TNFR 1 ( p 55 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TRAPS is caused by dominant mutations in the 55 kDa TNF receptor gene ( TNFRSF1A ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF : TNF R T Cell costimulatory pathways in transplantation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Therefore , TNF is a key mediator of LPS induced ARF , acting through its receptor TNFR 1 in the kidney . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , infection decreased the level of TNF membrane receptors , but had no effect on TNFR 1 and TNFR 2 mRNA levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
GH + / LPS was administered to TNF receptor 1 ( TNFR 1 ) or IL 6 null mice and wild type ( WT ) controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 1 was expressed by mononuclear cells and basal and suprabasal keratinocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The kinetics of apoptosis and the expression of Fas and TNF R 1 were also assessed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
There is extensive crosstalk between the apoptotic and NF kappaB signaling pathways that emanate from TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 1 ( p 55 ) serves as the principal receptor responsible for MCP 1 synthesis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 1 ( p 55 ) , TRAIL receptor 1 and 2 ( DR 4 and 5 ) , and Fas were expressed ; RANK was undetectable . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Further , we show that this activity of TNF is independent of TNF receptors ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The mRNA of TNF receptor ( TNF R ) 2 but not of TNF R 1 was also increased . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) induces apoptosis in a range of cell types via its two receptors , TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This is the first report to show the relationship between Notch activation and TNF R 1 signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
No difference was found in TNF RI mRNA levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSIONS : The results confirm that TNFalpha can induce RGC death by TNF R 1 activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
One of the 2 TNFalpha receptors is TNF receptor superfamily 1A ( TNFRSF1A ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast the evaluation of both serum and urinary TNF RI and 2 seems to have no predictive value . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
No significant changes in the levels of TNFalpha or TNF RI transcripts were detected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Antibodies that inhibit TNFalpha TNFR 1 or Fas FasL interactions were not able to block PKR induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Further , hepatotoxicity was ameliorated in mice lacking either the TNFR 1 or the TNFR 2 TNFalpha receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Double fluorescence labeling demonstrated co localization of TUNEL with caspase 3 and TNFalpha receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We studied the role of TNFalpha in this setting by using TNFR 1 knockout mice ( C 57 BL / 6 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , IFNgamma up regulated TNFR 1 expression and amplified TNFalpha induced protein leakage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Competitive binding experiments showed that sTNF R 1 has a 50 60 fold higher affinity for TNF alpha than for TNF beta , in contrast to the equal affinities of TNF alpha and TNF beta for the full length TNF R 1 transiently expressed in mammalian cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Since TNF alpha acts via two membrane receptors , we have extended those studies to investigate the distribution of the p 55 and p 75 TNF receptors ( TNF R ) in RA tissue . ^^^ These results , therefore , indicate that in RA synovial joint tissue there is up regulation of both p 55 and p 75 TNF R mRNA and surface protein expression , and with the presence of TNF alpha in RA tissues , these results provide support to our hypothesis that TNF alpha is of critical importance in the pathogenesis of RA . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Accordingly , a specific inhibition of phycoerythrin ( PE ) conjugated TNF alpha binding was demonstrated by the anti p 75 TNF R utr 1 MoAb , but not by the anti p 55 htr 9 MoAb . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To further understand the local actions of TNF alpha , we investigated the expression of TNF receptors ( TNF R ) on cells in the same compartments in patients with RA . ^^^ Sequential section and double immunofluorescence staining showed that the TNF R expressing cells were in the vicinity of TNF alpha containing cells , and some TNF alpha containing cells also expressed TNF R . ^^^ These results provide histologic evidence that both p 55 TNF R and p 75 TNF R are expressed by a variety of cell types in RA synovial tissue , reflecting the fact that a wide range of cells are potential targets for TNF alpha in this tissue . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Agonist antibodies ( Ab ) to the two TNF receptors , TNF R 1 ( 55 kDa ) and TNF R 2 ( 75 kDa ) , have been shown to signal many of the distinct functions induced by TNF alpha . ^^^ TNF R 1 but not TNF R 2 also signals killing of virus infected cells by TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MAbs TBP 1 and TBP 6 recognize two further , independent epitopes ; both bind sTNF R 1 in the presence of an excess of TNF alpha . ^^^ Both TBP 1 and TBP 6 markedly enhance the ability of sTNF R 1 to protect cells against the cytotoxic activities of TNF alpha and TNF beta , but have no activity in the absence of sTNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In certain cases in which TNF alpha , rather than TNF beta , induces AML growth through an autocrine mechanism , both TNF R ( p 55 ) and ( p 75 ) are involved . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
During the ongoing inflammation in RA , TNF alpha ( and other mediators ? ) induce the production of soluble TNF R which can act as natural inhibitors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Decreased levels of phosphorylation of TNF R alpha ( TNF receptor type alpha ) after staurosporin treatment correlated with increased induction of NF kappa B by TNF alpha . ^^^ PMA induced disappearance of TNF R alpha by shedding into the surrounding medium , with kinetics similar to those of its inhibition of NF kappa B activation by TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Human embryonic kidney cells transfected with a TNF R expression vector specifically bind both 125I labeled and biotinylated TNF alpha . ^^^ Unlabeled TNF alpha and TNF beta were equally effective at displacing the binding of labeled TNF alpha to TNF R expressing cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results suggest that in hairy cells , IFN alpha can interact in vivo with TNF alpha , through the modulation of TNF R . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Immunohistochemical analysis revealed that TNF alpha , TNF beta , TNF RI , and TNF RII antigens were associated predominately with tumor cells in the tissue . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The serum levels of soluble TNF receptors 1 ( sTNFR 1 ) and sTNFR 2 were measured frequently in 14 patients with sepsis to evaluate the pattern of these TNF antagonists in relation to TNF alpha , Soluble TNFR 1 and 2 could be detected in all samples with significantly higher levels ( p < 0 . 001 ) compared to healthy controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha is recognized by the receptors , CD120a ( p 55 ) and CD120b ( p 75 ) . ^^^ Ligation of CD120a ( p 55 ) by TNF alpha or by anti receptor agonistic antibodies initiates signal transduction leading to the activation of mitogen activated protein kinases ( MAPKs ) ( p42mapk / erk2 and p44mapk / erk1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using TNF alpha mutants with a selective capacity to bind to the TNF p 55 receptor ( TNFR 55 ) or to the p 75 receptor ( TNFR 75 ) we show here that these two major activities of TNF alpha can be dissociated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of tumour necrosis factor alpha ( TNF alpha ) and its two distinct receptors , TNF R p 55 and TNF R p 75 , was assessed by immunocytochemistry in 28 primary breast cancer and three reduction mammoplasty specimens ( ' normal ' breast tissue ) . ^^^ Expression of TNF alpha or TNF R p 75 was not detectable in normal breast tissue or in non malignant breast tissue adjacent to the tumours . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The relationships between epitope topography and agonistic / antagonistic effects of anti TNF receptor type 1 ( TNF R 1 ) antibodies on TNF alpha cytotoxic activity have been studied . ^^^ These results suggest that at least part of residues 143 148 of sTNF R 1 are surface exposed on the soluble as well as on the membrane forms of TNF R 1 and are accessible to TNF alpha antagonists . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The role of the two TNF receptor types , TNF R 55 and TNF R 75 , was studied on mouse fibroblasts , taking advantage of TNF R 55 deficient mice generated by gene targeting ( Tnfr 1 degree mice ) , and selectivity of human TNF alpha for mouse TNF R 55 . ^^^ Differential responses of fibroblasts from wild type and TNF R 55 deficient mice to mouse and human TNF alpha activation . ^^^ In general , mouse TNF alpha ( recognizing both mouse TNF receptors ) had a higher sp . act . than human TNF alpha ( recognizing only mouse TNF R 55 ) in wild type fibroblasts , whereas both mouse and human TNF alpha had similar cytotoxic activities in WEHI 164 cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The subsequent development of TNF alpha mutants with selective activity on either TNFR 55 or TNFR 75 suggest that such mutants might maintain the therapeutic ( anti tumor ) potential of wild type TNF alpha , but exhibit reduced toxicity ( proinflammatory effects ) . ^^^ Whereas TNFR 55 is involved in most observed responses to TNF alpha , signaling of TNFR 75 appears to be restricted to inhibitory effects on primitive progenitors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The phenotypic changes effected by TNF alpha can be recapitulated by crosslinking CD120b ( p 75 TNF receptor ) , but not CD120a ( p 55 TNF receptor ) , with mAbs presented on Fc gamma RII ( CD 32 ) expressing L cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have previously demonstrated that TNF alpha directly inhibits CSF induced proliferation of primitive murine lineage negative bone marrow progenitors ( Lin ) and stem cell antigen 1 hematopoietic progenitors through the 75 kDa TNF receptor ( TNF R 2 ) , whereas TNF alpha induced inhibition of more committed Lin progenitors is mediated through the 55 kDa TNF R ( TNF R 1 ) , indicating a differential role of the two TNF Rs in hematopoiesis . ^^^ While TNF alpha has been demonstrated to enhance SCF induced proliferation of myeloid leukemia blasts , the present report demonstrates that TNF alpha , by signaling through TNF R 2 , inhibits SCF induced proliferation of normal murine Lin and stem cell antigen 1 hematopoietic progenitors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFr 1 , TNFr 2 , Fas , BCL 2 and TNF alpha could be identified by Western blot analysis of proteins extracted from endometrium . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have now further assessed the modulatory role of TDRF on TNF alpha , TNF receptors ( TNF R ) and NOS mRNA synthesis . ^^^ These findings indicate that TDRF activity synergizes with either IL 2 or LPS triggering agents for enhanced activation of IFN gamma primed macrophages by promotion of TNF alpha and TNF R mRNA synthesis for autocrine induction of NOS with resultant increased NO mediated tumor cytotoxicity . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have investigated the role of the two distinct tumor necrosis factor ( TNF ) receptors ( TNFR 60 and TNFR 80 ) in endothelial cell activation employing an in vitro model of tumor necrosis factor alpha ( TNF alpha ) dependent tissue factor production of human umbilical vein endothelial cells ( HUVECs ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
DESIGN : Plasma TNF alpha , IL 6 and both forms of soluble TNF receptors ( p 55 and p 75 TNF R ) have been measured by ELISA in 31 pre eclamptic patients and 31 pregnant controls matched for age , parity and gestational age . ^^^ RESULTS : Levels of IL 6 , TNF alpha and soluble TNF R ( p 55 and p 75 ) were significantly higher in pre eclamptic patients , compared with age and gestation matched controls with a wide variation in levels between pre eclamptic individuals . ^^^ However , when the pre eclamptic patients were subdivided on the basis of the severity of their disease , the median values of plasma concentrations of IL 6 , TNF alpha and TNF R were all higher in the group with lower platelet counts . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine the role of TNF alpha in the generation and regulation of CHS , gene targeted mutant mice lacking TNF receptor ( p 55 ) gene ( TNF R 1 ( ) mice ) were treated with dinitrofluorobenzene ( DNFB ) to induce CHS . ^^^ To rule out possible signaling through p 75 TNF R , the mice were treated with anti TNF alpha Ab ( V1q ) , which can neutralize any TNF effects through either receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among those , TNF alpha receptors ( TNF R ) are modulated by various PMN activators , a mechanism which may be important to control cell responses to TNF in inflammatory reactions such as rheumatoid arthritis ( RA ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cross linking of the dichotomous cell surface receptors for TNF alpha ( CD120a ( p 55 ) and CD120b ( p 75 ) ) induces the activation of a variety of macrophage responses that mediate the role of this cell in inflammation and host defense . ^^^ To investigate the use of CD120a ( p 55 ) and CD120b ( p 75 ) in the activation of p42mapk / erk2 in mouse macrophages , we determined the effects of blocking Ab on the activation of p42mapk / erk2 in response to TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cellular effects of TNF alpha are mediated by two distinct cell surface receptors , TNF R 55 and TNF R 75 , both present on various types of cells , including fibroblasts . ^^^ In this study we wanted to elucidate the role of TNF R 55 as a mediator of the connective tissue effects of TNF alpha by using a mutant , TNF R 55 specific form of human TNF alpha . ^^^ In addition , TNF R 55 specific TNF alpha suppressed type 1 collagen mRNA levels as potently as wild type TNF alpha ( by 60 % ) . ^^^ The enhancement of collagenase gene expression by TNF R 55 specific TNF alpha was augmented by simultaneous treatment of normal and scleroderma skin fibroblasts with interferon gamma , indicating specific enhancement of TNF R 55 signaling pathway by interferon gamma . ^^^ These results show that stimulation of the TNF R 55 signaling pathway is sufficient for the inhibitory effects of TNF alpha on extracellular matrix formation by dermal fibroblasts . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha acts by binding to two specific receptors : TNFR 1 and TNFR 2 . ^^^ Moreover , immunohistochemical staining studies localized TNFR 1 and TNFR 2 to the cardiac myocyte , providing a potential signaling pathway for the deleterious effects of TNF alpha . ^^^ The functional significance of the expression of TNFR 1 and TNFR 2 was explored with the use of a simple cell motion assay in which we assessed the effect ( s ) of TNF alpha mutants known to bind selectively to human TNFR 1 and TNFR 2 . ^^^ We showed that the negative inotropic effect of wild type TNF alpha in isolated feline cardiac myocytes was mimicked by the TNF mutant that binds to TNFR 1 , whereas the TNF mutant that binds to TNFR 2 had no significant effect on cell motion . ^^^ CONCLUSIONS : Results of the present study show that the adult human heart expresses both mRNA and receptor proteins for TNFR 1 and TNFR 2 ; moreover , the negative inotropic effects of TNF alpha in adult cardiac myocytes appear to be initiated by activation of TNFR1 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In BMC , LPS elicited a down regulation of the TNF alpha receptors ( TNF R ) without direct binding to TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We report here that TNF alpha promotes dose and time dependent phosphorylation and activation of the c raf 1 kinase engaging the type 1 p 55 TNF receptor ( TNF R ) . c raf kinase activation was duplicated by an agonistic monoclonal antibody directed against the p 55 TNF R . ^^^ Moreover , ectopic expression of the human p 55 TNF R in murine pre B 70Z / 3 cells was sufficient to confer c raf 1 kinase activation by human TNF alpha . ^^^ By inhibiting intracellular activation of acidic sphingomyelinase ( SMase ) and by using deleted forms of the type 1 TNF R it was shown that the neutral , but not the acidic SMase , participated in TNF alpha mediated phosphorylation and activation of the c raf kinase . ^^^ TNF alpha induced transcriptional activation of a heterologous promoter construct harboring the AP 1 binding site was also mediated by the type 1 p 55 TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSIONS : In chronic active hepatitis B infection , there is an up regulation of the TNF receptor system , preferentially the TNF R p 75 signaling pathway , which suggests that the TNF alpha / TNF receptor system has an important role in the pathogenesis of liver damage and viral clearance . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF R ( 55 kDa ) , sIL 2R , and TNF alpha were measured by ELISA in sera and SF of patients with RA , ReA , and OA and correlated with serological and clinical disease activity variables . ^^^ In patients with RA , correlations were found between TNF R and TNF alpha in SF ( r = 0 . 32 , p < 0 . 01 ) , and between TNF R and early morning stiffness ( r = 0 . 4 , p < 0 . 003 in serum ; r = 0 . 29 , p < 0 . 05 in SF ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The elevation of respiratory burst activity by supernatants generated using combined treatments could be partially inhibited by prior treatment of the target macrophages with anti TNF alpha receptor 1 ( TNFR 1 ) monoclonal antibodies ( mAbs ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , we show that the mRNA for the 55 kDa TNF alpha receptor ( TNF R 1 ) is detected in embryonic rat hippocampal cultures , as well as in acutely dissected embryonic and adult rat hippocampi . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Functional in vitro studies have shown that anti TNF alpha , as well as anti 75 kDa TNF R antibodies , are able to inhibit the IL 2 induced TIL proliferation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) is bound by two cell surface receptors , CD120a ( p 55 ) and CD120b ( p 75 ) , that belong to the TNF / nerve growth factor receptor family and whose signaling is initiated by receptor multimerization in the plane of the plasma membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two recombinant soluble TNF R IgG fusion proteins , one containing p 55 TNR R , the other containing p 75 TNF R , and a recombinant monomeric soluble p 55 TNF R were all found to block the cytotoxicity generated by human TNF alpha and LT as well as also murine TNF . ^^^ The p 55 TNF R IgG fusion protein ( p 55 sf2 ) was the most effective of the antagonists tested , requiring an equimolar , ( based on a monomeric configuration of TNF alpha ) or a 3 fold higher ( based on a trimeric configuration of TNF alpha ) molar concentration to inhibit the cytotoxicity mediated TNF alpha by 50 % . p 55 sf2 was also as effective at inhibiting the cytotoxicity mediated by LT or murine TNF in the KYM 1D4 assay . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Most tumor cells produce both tumor necrosis factor ( TNF ) receptors , the M ( r ) 55 , 000 TNFRI and the M ( r ) 75 , 000 TNFRII , but they are mostly resistant to TNF alpha induced cytotoxicity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological activity of the pro inflammatory cytokine , tumor necrosis factor ( TNF ) alpha depends on the level of TNF alpha itself , the expression of the p 55 and p 75 cell surface receptors for TNF on target cells and the concentrations of the natural inhibitors of TNF alpha , the soluble p 55 and p 75 TNF receptors ( TNF R ) . ^^^ We , therefore , investigated the effects of IL 10 and IL 4 on the cell surface expression and release of TNF R by human monocytes to determine whether these cytokines also indirectly modulated the biological activity of TNF alpha . ^^^ Further , IL 1 alpha stimulated production of TNF alpha was diminished by IL 10 and only a small proportion of this TNF alpha was bioactive , consistent with increased production of inhibitory soluble TNF R . ^^^ However , the expression of soluble p 55 TNF R was much lower than soluble p 75 TNF R , indicating that it contributed less importantly to neutralization of TNF alpha under these conditions . ^^^ IL 10 , therefore , reduces the pro inflammatory potential of TNF in three ways : by down regulating surface TNF R expression whilst increasing production of soluble TNF R and inhibiting the release of TNF alpha itself . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To investigate the functional properties of IL 2 and TNF alpha on leukemic B cells , we evaluated ( 1 ) the regulation of expression of TNF receptors ( TNF R ) and IL 2 receptors on leukemic B cells after culture with TNF alpha and IL 2 ; ( 2 ) the effect of the combination of TNF alpha and IL 2 in a proliferative in vitro assay ; and ( 3 ) the expression and regulation by these cytokines of receptors for hematopoietic factors , including IL 3 , granulocyte colony stimulating factor ( G CSF ) , and granulocyte macrophage colony stimulating factor ( GM CSF ) . ^^^ Flow cytometry analysis showed that freshly isolated leukemic cells from B CLL patients bear the 75 kD TNF R and the 55 kD IL 2R ; TNF alpha was able to upregulate the 55 kD IL 2R but not the 75 kD TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF sR may play an important role in vivo as they can bind to TNF alpha and prevent ligand binding to the cellular TNF R , thus acting as naturally occurring inhibitors of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Evidence supporting the specificity of the TNF alpha effect included the following : ( 1 ) TNF alpha down regulation of protein S was completely blocked by TNF neutralizing antibody ; ( 2 ) the effect was transient , and protein S was restored to near normal levels after TNF was removed from cell cultures ; ( 3 ) an antibody directed to the TNF RI ( 55 kD receptor ) was shown to mimic the action of TNF alpha on HMEC 1 cells ; and ( 4 ) other proinflammatory cytokines , interleukin ( IL ) 1 , IL 6 , and TGF beta , had no effect on protein S secretion . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of this study was to determine whether TNF alpha inhibits mPL 2 secretion through TNF RI or TNF RII , and to investigate the gestational profile of TNF RI and TNF RII gene expression . ^^^ These results suggest that TNF RI is a main receptor for TNF alpha in mouse placenta and that TNF alpha may have an important role in regulating mPL 2 secretion after midpregnancy . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using Northern blotting , neither LPS nor TNF alpha altered the expression of 55 kDa TNF R mRNA , although the exposure of Kupffer cells to LPS decreased the binding of 125I labelled TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 4 treatment caused a small decrease in levels of bioactive TNF alpha in RA synovial culture supernatants , together with an increase in soluble p 75 TNF R levels although differences were not significant . ( ABSTRACT TRUNCATED AT 250 WORDS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The distribution of TNF alpha , p 55 TNF receptor ( TNF R ) and p 75 TNF R in normal skin and uninvolved and lesional skin from psoriasis patients has been investigated , using specific mono and polyclonal antibodies . ^^^ This suggests that the actions of TNF alpha on epidermal cells in vivo are mediated by binding to the p 55 TNF R . ^^^ Up regulation of TNF alpha , p 55 TNF R and p 75 TNF R on dermal blood vessels in psoriasis may play an important role in the pathogenesis of this condition by promoting cutaneous recruitment of inflammatory cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cell surface expression of TNF alpha receptors ( TNF R ) , as determined by binding assay using 125I labelled recombinant TNF alpha ( rTNF alpha ) , was also induced after SAC or TPA activation , but shed receptors ( TNF binding proteins ) were only observed after TPA activation . ^^^ The increased endogenous production and secretion of TNF alpha during induced growth stimulation , the induced expression of TNF R , and the mitogenic effect of TNF alpha on activated B CLL cells raise the question whether TNF alpha may function as an autocrine co stimulator of B CLL cell growth as recently suggested . anti TNF alpha and anti TNF R antibodies , however , failed to inhibit the IL 2 and IL 4 induced proliferation of activated 1 83 B CLL cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we show that cells treated with TNF alpha up regulate the TNF R 75 mRNA and protein levels . ^^^ Ligand binding assays using specific inhibitory antibodies showed a marked shift in active binding sites from p 55 to p 75 without significant changes in the total binding for TNF alpha after up regulation of p 75 TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) induced cell adhesion to human endothelial cells is under dominant control of one TNF receptor type , TNF R 55 . ^^^ HUVEC were activated by either TNF alpha , binding to both TNF R 55 and TNF R 75 , and by receptor type specific agonists , binding exclusively to TNF R 55 or to TNF R 75 . ^^^ The TNF alpha induced cell adhesion to HUVEC was found to be controlled almost exclusively by TNF R 55 . ^^^ This finding correlated with the exclusive activity of TNF R 55 in the TNF alpha dependent regulation of the expression of the intercellular adhesion molecule type 1 ( ICAM 1 ) , E selectin , and vascular cell adhesion molecule type 1 ( VCAM 1 ) . ^^^ The predominant role of TNF R 55 in TNF alpha induced adhesion in HUVEC may correlate with its specific control of NF kappa B activation , since kappa B elements are known to be present in ICAM 1 , E selectin , and VCAM 1 gene regulatory sequences . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) , jointly referring to TNF alpha and TNF beta , is a central mediator of immune and inflammatory responses ; its activities are mediated by two distinct receptors , TNFR 1 ( p 55 ) and TNFR 2 ( p 75 ) ( reviewed in refs 1 3 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Single cell RT PCR , [ 125I ] TNF alpha ligand binding and Western immunoblotting experiments demonstrated that rat cardiac cells predominantly express type 1 TNF alpha receptors ( TNFRI or p 60 ) . ^^^ Thus , it is possible that the negative inotropic effects of TNF alpha are the result of TNFRI mediated blockade of cardiac excitation contraction coupling . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Taken together , we show that CD40 / CD40 L and TNF R / TNF alpha interactions not only postpone or prevent B cell death , but are also involved in sensitizing B cells for Fas ligand ( Fas L ) dependent death . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The timing , cycloheximide sensitivity , and selectivity of stimulated release of TNF R 75 by monocytes are consistent with previous observations on other cell types of late ( 8 20 h ) increased synthesis and turnover of cell surface TNF R 75 , but not TNF R 55 , after stimulation with TNF alpha or IL 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The antiproliferative effect of TNF alpha was mediated by TNF receptor 1 ( TNF R 1 ) and correlated positively with both the number of TNF R 1 per cell and receptor affinity . ^^^ Whereas the TNF alpha response seems to depend on the expression of TNF R 1 , no simple correlation could be found between RA sensitivity and the expression pattern of RARs . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although TNF alpha is thought to exert its deleterious effects by binding to two cell surface receptors , TNFR 1 and TNFR 2 , the level of expression and regulation of TNF receptors in the heart in cardiac disease states is not known . ^^^ METHODS AND RESULTS : We examined mRNA and protein levels for TNFR 1 , TNFR 2 , and TNF alpha in explanted hearts from organ donors as well as in patients with end stage dilated cardiomyopathy ( DCM ) and ischemic heart disease ( IHD ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The role of endogenously synthesized complement subcomponent C1q on autocrine binding of tumor necrosis factors ( TNF alpha ) and on TNF alpha receptor ( TNF R ) mRNA synthesis by mouse macrophages was investigated . ^^^ Taken together , the data indicate that endogenously synthesized C1q is operative in promoting TNF R mRNA synthesis and resultant autocrine binding of TNF alpha for induction of NOS in the process of NO mediated tumor cytotoxicity by Lipid A activated macrophages . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Upon binding TNF alpha soluble TNF R ( sTNF R ) can inhibit its function . ^^^ The augmentation of surface TNF R expression was of biological relevance as TNF alpha mediated necrosis of human KYM . 1D4 rhabdosarcoma cells was enhanced approximately 15 fold in the presence of BB 2275 . ^^^ These results raise the interesting possibility that a close relationship exits between the enzyme ( s ) which process membrane bound TNF alpha , and those involved in surface TNF R cleavage . ^^^ Furthermore our observations suggest that hydroxamate inhibitors of MMP activity which block TNF alpha secretion and TNF R cleavage may not modulate down stream effects of TNA alpha , and as such suggest that the precise specificity of these compounds will be highly relevant to their clinical efficacy in inflammatory diseases . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
There are two distinct membrane receptors for TNF alpha , TNF receptor 1 ( TNF R 1 , p 55 ) and TNF receptor 2 ( TNF R 2 , p 75 ) , thought to be responsible for distinct TNF alpha activities . ^^^ The results revealed that anti TNF alpha antibody significantly inhibited LC accumulation in DLN in TNF R 1 deficient mice , thus suggesting that TNF R 2 signalling is involved in LC migration from skin to DLN and that murine LC express TNF R2 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
PbCl 2 decreased membrane associated TNF alpha ( mTNF alpha ) on LPS treated monocytes , whereas PbCl 2 increased TNF alpha receptor ( TNF R ) p 55 surface expression , and had no effect on TNF R p 75 surface expression by LPS treated monocytes . ^^^ Overall , the results suggest that PbCl 2 increases TNF alpha expression by posttranscriptional mechanisms in human PBMC , and enhances the reactivity and uptake of TNF alpha by increasing the surface expression of TNF R p55 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Induction of IL 6 mRNA as well as IL 1 alpha / beta and TNF alpha mRNAs upon L . monocytogenes infection of BMM phi occurs independently of autocrine TNF alpha signaling via TNF RI or TNF RII , as shown by infection of TNF RI and TNF RII deficient macrophages derived from mutant B 6 10 129 mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LPS had a lower TNF R 1 shedding activity while TNF alpha did not induce shedding . ^^^ No change in TNF R 1 mRNA levels was observed after IL 1 alpha or TNF alpha stimulation while TNF R 2 ( p 75 ) mRNA basal levels transiently increased three to fivefold , reaching a peak after four hours followed by an accumulation of sTNF R 2 in the supernatant . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The level of p 80 mRNA was unaffected by TNF alpha treatment , whereas p 60 mRNA was down regulated , and soluble TNF RI was shed from cells within 30 min . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Membrane bound TNF alpha , TNFR 1 and TNFR 2 surface expression were determined by flow cytometry . ^^^ TNF alpha mRNA was estimated by competitive polymerase chain reaction ( PCR ) , and TNF alpha , soluble TNFR 1 and soluble TNFR 2 supernatant content by enzyme linked immunosorbent assay . ^^^ More importantly , IL 10 is able to upregulate membrane bound TNF alpha and TNFR 1 , along with a consistent increase in the shedding of soluble TNFR 1 without inducing detectable TNF alpha secretion . ^^^ CONCLUSIONS : IL 10 activates HIV expression through the membrane bound TNF alpha / TNFR 1 pathway , suggesting an amplification mechanism of HIV expression that might occur during cell to cell interaction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) , a proinflammatory cytokine secreted predominantly by monocytemacrophages , interacts with two cell surface receptors : TNF R 55 and TNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha can down or up regulate fas and down regulates TNF R . ^^^ Moreover , an accelerated T cell apoptosis in HIV infected individuals is characterized by ( 1 ) HIV gp 120 CD4+ cross linking and subsequent aberrant signaling of T cells , ( 2 ) involvement of TNF alpha fas / Apo 1 ( TNF R ) binding , ( 3 ) involvement of accessory cells as an apoptosis inducer and as a result of defective antigen presentation , ( 4 ) possible superantigen activity induced by HIV products and cofactors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological activities of tumor necrosis factor alpha ( TNF alpha ) are mediated by two different receptors , TNFR 1 and TNFR 2 . ^^^ Both symmetric and asymmetric trimers of TNF alpha were used to model the complexes with TNFR 1 and R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results suggest that higher levels of serum sTNF RI , sTNF RII and IL 1Ra may reflect up regulation of TNF R expression and IL 1Ra production in allergic inflammation , and sTNF RI , sTNF RII and IL 1Ra may contribute to regulating TNF alpha and IL 1 mediated production and development of allergic inflammation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Higher numbers of p 75 TNF R epidermal dendritic cells were found in grafts following a course of TNF alpha , IL 6 or IL 1 treatment . ^^^ The p 55 form of the TNF R expressed by keratinocytes was significantly elevated after treatment with TNF alpha or IL 6 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two different receptors exist for tumor necrosis factor alpha ( TNF alpha ) , designated as p 55 ( TNF RI ) and p 75 ( TNF RII ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced ICAM 1 expression also was inhibited by pre and coincubation of TNF alpha with 3 micrograms / mL soluble TNF R 1 or by the PKC inhibitor , Calphostin C ( 0 . 1 and 0 . 5 microM ) . ^^^ Collectively , these results indicate that TNF alpha induced ICAM 1 surface expression is a specific receptor mediated response ( TNF R 1 ) , which is mediated by mechanisms dependent on PKC and intracellular reactive oxygen species . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Therefore the potential exists for the successful reintroduction of TNF alpha , in the form of TNFR 55 selective mutants , into the clinical arena with the promise of reduced side effects . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
After 24 h of treatment , IL 1 alpha and TNF alpha did not stimulate IL 6 production in osteoblasts from IL 1R1 / and TNFR 1 / mice , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha is recognized by two cell surface receptors , CD120a ( p 55 ) and CD120b ( p 75 ) that belong to the TNF / NGF receptor family . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cell killing effects of the cytokines TNF alpha and FasL are mediated by the distinct cell surface receptors TNFR 1 , TNFR 2 and Fas ( also known as CD95 / APO 1 ) , which are all members of a receptor superfamily that is important for regulating cell survival . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To obtain information about the involvement of this cytokine in the pathophysiology of SLE , serum levels of TNF alpha , the soluble forms of the 55 and 75 kDa tumour necrosis factor receptors ( TNF R 55 and TNF R 75 ) , and interleukin 6 ( IL 6 ) were measured by ELISA in nine female patients over a period of 2 yr . ^^^ Compared to healthy controls , levels of TNF alpha ( median 47 pg / ml , range < 15 222 pg / ml ) , TNF R 55 ( median 1 . 9 ng / ml , range 0 . 8 10 . 8 ng / ml ) , TNF R 75 ( median 4 . 7 ng / ml , range 1 . 5 15 ng / ml ) and IL 6 ( median 3 . 5 pg / ml , range < 3 . 5 52 pg / ml ) were significantly elevated in SLE patients ( P < 0 . 0001 vs controls in all cases ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In vitro comparison of inhibiting ability of soluble TNF receptor p 75 ( TBP 2 ) vs . soluble TNF receptor p 55 ( TBP 1 ) against TNF alpha and TNF beta . ^^^ In the present study , the murine A 9 cell line in vitro bioassay was used to test TBP 1 and TBP 2 for their neutralizing activity against recombinant human TNF alpha ( rHu TNF alpha ) , and TNF beta ( rHu TNF beta ) and recombinant murine TNF alpha ( rMu TNF alpha ) . ^^^ Moreover , TBP 1 and TBP 2 were tested for their ability to displace TBP 1 in the TNF TBP receptor binding assay ( RIBA ) against human and murine TNF alpha as well as TNF beta . ^^^ TBP 1 , from either recombinant ( from CHO and Escherichia coli ) or urinary origin , was the most effective inhibitor with respect to rHu TBP 2 ( from CHO ) against either human or murine TNF alpha both in the A 9 cells bioassay and in the RIBA assay . ^^^ Both TBP 1 and TBP 2 preparations were less effective in protecting the A 9 cells from the toxic effects of rMu TNF alpha than from those of rHu TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the presence of interferon gamma ( IFN gamma ) , human tumor necrosis factor alpha ( Hu TNF alpha ) , which binds to murine TNF alpha receptor type 1 ( TNF R 1 ) but not to murine TNF R 2 , was effective in inducing nitric oxide ( NO ) production in spleen derived macrophages ( M phi ) , albeit at concentrations 12 . 5 fold greater than those required by murine TNF alpha ( Mu TNF alpha ) , to achieve the same result . ^^^ Addition of anti TNF R 1 completely inhibited the Mu TNF alpha mediated induction of NO , demonstrating that TNF R 1 is critical to the IFN gamma dependent TNF alpha mediated induction of M phi effector function . ^^^ The dependence of spleen derived M phi on both TNF alpha receptors for signaling the induction of effector function supports an active signaling role for TNF R 2 in its synergy with TNF R 1 rather than a passive ligand passing role . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Laboratory assessment included a CBC , ESR , and whole blood cytokine ELISA for TNF alpha , TNF R 1 , and TNF R 2 at baseline , 1 day , 7 days and 3 months after the initiation of therapy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFr 75 blockade did not alter the dose response to agonistic TNFr 55 antibody induction ; verifying that the effect on the TNF alpha dose response was not due to negative signalling or cytolysis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha elicits its biological effects through two distinct TNF receptor ( TNFR ) subtypes : p 55 TNFR ( TNFR 1 ) and p 75 TNFR ( TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Tumor necrosis factor alpha ( TNF alpha ) is involved in the pathogenesis of myocarditis and can bind to either tumor necrosis factor receptor ( TNF R ) p 55 or TNF Rp 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In order to determine the pathways involved in inhibition of HIV 1 replication in primary TCDM pretreated with TNF alpha , we tested TNF alpha mutants T 55 and T 75 , which recognize either the 55 kDa ( TNF R 1 ) or the 75 kDa ( TNF R 2 ) TNF receptor , respectively . ^^^ These results suggest that the inhibition of HIV 1 replication in TCDM pretreated with TNF alpha might be mediated mainly through the 75 kDa TNF receptor ( TNF R 2 ) rather than through the 55 kDa receptor ( TNF R 1 ) . ^^^ The stimulation of HIV 1 replication by TNF alpha in a chronically infected promonocytic cell line , U 1 , which contains two copies of integrated provirus , was mediated through the 55 kDa TNF R 1 alone and not through the 75 kDa TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha elicits its complex biological responses through the individual or cooperative action of two TNF receptors of mol . wt 55 kDa ( TNF RI ) and mol . wt 75 kDa ( TNF RII ) . ^^^ Our findings show that : ( 1 ) TNF RII is able to activate two members of the MAP kinase family : extracellular regulated kinase ( ERK ) and c jun N terminal kinase ( JNK ) ; ( 2 ) TRAF 2 , a molecule that binds TNF RII and associates indirectly with TNF RI , is sufficient to activate JNK upon overexpression ; ( 3 ) dominant negative TRAF 2 blocks TNF alpha mediated JNK activation and ( 4 ) TRAF 2 signals the activation of JNK and NF kappaB through different pathways . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The present study was conducted to examine the expression of tumor necrosis factor alpha ( TNF alpha ) and its receptors ( types 1 and 2 , designated TNFR 1 and TNFR 2 , respectively ) in human oocytes and cumulus cells at the mRNA and protein levels . mRNA expression was investigated using a reverse transcriptase polymerase chain reaction ( PCR ) / Southern hybridization procedure . ^^^ These results indicate that human oocytes and cumulus cells express TNF alpha and its receptor type 2 ( TNFR 2 ) , and not type 1 ( TNFR 1 ) , both at the mRNA and protein levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) and lymphotoxin alpha ( LT alpha ) induce pleiotropic cellular effects through low affinity 55 kDa type 1 receptors ( TNFR 1 , CD120a ) and high affinity 75 kDa type 2 receptors ( TNFR 2 , CD120b ) . ^^^ In co cultures of microglia plated atop irradiated astrocytes , human TNF alpha ( which , on mouse cells , binds TNFR 1 exclusively ) induced microglial cell proliferation , whereas murine TNF alpha ( which binds both TNFRs ) did not . ^^^ Collectively , the data show that microglia , a primary source of TNF alpha at CNS inflammatory sites , express both TNFR 1 and TNFR 2 , whereas astrocytes and oligodendrocytes , whose embryological origin differs from that of microglia , predominantly express TNFR 1 . ^^^ TNF alpha increases expression of TNFR 1 by oligodendrocytes whereas it increases expression of TNFR 2 by microglia . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
An agonistic TNF R 1 specific antibody and recombinant human TNF alpha both exerted a cytotoxic effect when combined with IFN gamma , suggesting that the cytotoxicity was mediated through the TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In cultured BM cells , expression of TNFR 1 was not influenced by IFN gamma , TNF alpha or apoptosis inducing anti Fas monoclonal antibody ( mAb ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The binding of TNF alpha to tumor necrosis factor receptor type 1 ( TNFRI ) is considered the initial step responsible for some of the multiple biological functions mediated by TNF alpha . ^^^ The role of TNF alpha as an inflammatory mediator through human TNFRI makes TNFRI an attractive target for intervention in both acute and chronic inflammatory diseases . ^^^ In this study , we have identified partial phosphorothioate oligodeoxyribonucleotides ( ODNs ) containing C 5 propynyl or hexynyl derivatives of 2 ' deoxyuridine which specifically inhibited TNFRI and subsequently inhibited the functions of TNF alpha mediated through TNFRI . ^^^ The ODNs lowered TNFRI protein levels and TNF alpha mediated functions by specifically reducing levels of TNFRI mRNA . ^^^ These anti TNFRI ODNs offer a novel approach for controlling biological functions of TNF alpha and may be useful as human therapeutic agents for treating diseases in which TNF alpha has been implicated . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha and TNF beta interact with TNF receptor ( TNF R ) , of which two subtypes have been described : TNF R 1 and TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice deficient in either TNF alpha or TNFR 1 also fail to develop splenic FDC clusters and germinal centers , indicating that signaling by both LT alpha and TNF alpha is required for development of these specialized lymphoid tissue structures . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Whereas secretion of cytokines lacking a transmembrane domain precursor ( IL 1 alpha , IL 1 beta , IL 6 or IL 10 ) is either unaffected or augmented , shedding / secretion of transmembrane domain containing cytokines and cytokine receptors [ TNF alpha , macrophage colony stimulating factor ( M CSF ) , transforming growth factor ( TGF ) alpha , stem cell factor ( SCF ) , TNF R 55 , TNF R 75 , and IL 6R ] was dramatically decreased in the presence of the metalloproteinase inhibitor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These effects result from an early inhibition of both TNF alpha and TNF R shedding , as well as a later increase of the respective mRNA expression . ^^^ Thus , NAC exhibits a potent antitumoral activity by modulating TNF alpha and TNF R processing without showing any in vitro and in vivo toxicity . . ^^^ Our data show that NAC ( 1 ) induces an early and sustained increase of membrane tumor necrosis factor alpha ( TNF alpha ) expression on human stimulated peripheral blood ( PB ) T cells and ( 2 ) increases membrane TNF RI and TNF RII on tumoral cell lines and on T cells after stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Biological activities of TNF alpha are mediated by two distinct TNF receptors , p 55 type 1 receptor ( TNFR 1 ) and p 75 type 2 receptor ( TNFR 2 ) . ^^^ To determine the role of TNF alpha in the induction of inflammatory responses in the skin , gene targeted mutant mice lacking either TNFR 1 or TNFR 2 were painted with irritant chemicals . ^^^ Intradermal injection of TNF alpha ( 0 . 2 200 ng for 3 days ) into the ear induced less inflammation in TNFR 1 ( ) mice than in normal mice . ^^^ The levels of protein and mRNA for interleukin ( IL ) 6 were elevated in keratinocytes from normal as well as TNFR 2 ( ) mice after treatment with TNF alpha , while keratinocytes from TNFR 1 ( ) mice did not show any up regulation of IL 6 . ^^^ TNF alpha induced intercellular adhesion molecule ( ICAM ) 1 expression in the keratinocytes from normal and TNFR 2 ( ) mice , but not in those from TNFR 1 ( ) mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNFR 55 selective TNF alpha mutants ( E146K , R32W S86T ) induced neutrophil apoptosis but with a potency 14 fold lower than wild type TNF alpha . ^^^ Hence , TNF alpha has the unique ability to induce apoptosis in human neutrophils via a mechanism where TNFR 75 facilitates the dominant TNFR 55 death effect . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSION : Our data provide evidence for a central role of the TNF alpha / TNF R system in the early pathological events of scleroderma with prominent inflammation and endothelial cell damage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF alpha activity in TNF alpha / IL 1alpha stimulated astrocytes was exclusively mediated through TNFR 1 , most likely because TNFR 2 mediated signals in astrocytes did not connect to the p 38 ( MAPK ) pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 10 is known to inhibit TNF alpha production in lipopolysaccharide ( LPS ) stimulated monocytes ; however , the effects of IL 10 on TNF receptor ( TNF R ) expression are not well defined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The binding of TNF alpha to the p 55 tumor necrosis factor receptor type 1 ( TNFRI ) is considered one of the initial steps responsible for the multiple physiologic effects mediated by TNF alpha . ^^^ The role of TNF alpha as an inflammatory mediator through TNFRI makes both of these genes attractive targets for intervention in both acute and chronic inflammatory diseases . ^^^ In addition , events triggered by the binding of TNF alpha to TNFRI , such as the production of IL 6 and IL 8 , were significantly reduced by treatment of cells with the anti TNFRI ODN . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We conclude first , that the expansion of DC from BM progenitors could most effectively be enhanced in a two stage culture assay using SCF , GM CSF , TNF alpha and IL 4 ; second , that the effect of TNF alpha in DC generation involves signalling via the TNF R 1 receptor ; and third , that IFN gamma counteracts some of the effects of IL 4 in DC generation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Surprisingly , not only the TNFR 1 , but also the TNFR 2 , was able to mediate the antiviral effects of TNF alpha in vivo , whilst the antiviral activity observed following CD 40 CD40L interaction is a newly defined function which may involve apoptosis of infected cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Plasma TNF alpha level correlated with circulating CD120a ( r = 0 . 52 , N = 49 , P < 0 . 001 ) and weakly with CD120b ( r = 0 . 32 , N = 51 , P = 0 . 02 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Compared with wild type TNF alpha , it exhibits 11 and 71 fold lower binding affinities for the human TNF R 55 and TNF R 75 receptors , respectively , and in vitro cytotoxic effect and in vivo systemic toxicity of M3S are 20 and 10 times lower , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our results for TNF R agree with recent findings in PsA , since TNF alpha , an important stimulator for TNF R , is also significantly lower in PsA than in RA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Upon exposure to TNF alpha , the TNF R 2 mRNA level was greatly increased , while the TNF R 1 mRNA level remained unchanged even after 48 h . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Deletion of putative elastase cleavage sites at amino acids 151 to 153 , 162 to 163 , and 177 to 178 ( also a putative metalloprotease site similar to the cleavage site of TNF alpha ) or mutation of a serine threonine serine motif resembling a similar motif at the site of L selectin cleavage at amino acids 202 to 204 did not reduce shedding of p 75 TNF R after treatment of cells with PMA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha exerts its biologic activity through two distinct receptors , TNF receptor type 1 ( TNFR 1 , p 55 ) and TNF receptor type 2 ( TNFR 2 , p 75 ) . ^^^ Reverse transcribed PCR showed that in contrast to TNFR 2 ( 0 / 0 ) and wt mice , TNFR 1 ( 0 / 0 ) mice were unable to up regulate inducible nitric oxide synthase mRNA transcripts in the course of infection , whereas intracerebral levels of IFN gamma , TNF alpha , and IL 1beta mRNA transcripts , recruitment of immune cells to the brain , and the amount of apoptotic cells in inflammatory foci did not differ significantly among the various experimental groups . ^^^ These results illustrate that in Toxoplasma encephalitis , TNF alpha mediated immune responses are of crucial importance and that signaling through TNFR 1 , but not TNFR 2 , provides the stimulus required for the induction of protective nitric oxide . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The potential contribution made by the inflammatory cytokines , interleukin 6 ( IL 6 ) and tumour necrosis factor alpha ( TNF alpha ) to the adjuvant activity of aluminium hydroxide gels ( Alum ) or Freund ' s complete adjuvant ( FCA ) was studied by comparing the immunological responses of IL 6 or TNF receptor 1 ( p 55 ; TNFR 1 ) deficient mice with immunocompetent control mice . ^^^ As the majority of the effects of TNF alpha are mediated via TNFR 1 , we conclude that this cytokine inhibits the adjuvant activities of FCA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
DESIGN : Cartilage explants from specified sites in the knee joints of both OA patients and non arthritic ( NA ) subjects were cultured with and without TNF alpha for 14 days and cumulative glycosaminoglycan ( GAG ) release into the supernatant measured . p 55 and p 75 TNF R expression was measured by flow cytometry on chondrocytes isolated from the same sites . ^^^ Variations in p 55 and p 75 TNF R expression were found between chondrocytes from different sites . p 55 , but not p 75 TNF R , expression on chondrocytes was closely related to the susceptibility of explants from the same site to TNF alpha induced GAG loss . ^^^ CONCLUSION : It is considered that focal loss of cartilage will occur at sites where chondrocyte p 55 TNF R expression is high , if sufficient TNF alpha is present , and that these results identify a mechanism by which cytokine mediated focal loss of cartilage may occur . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
An agonistic TNFR 1 antibody completely mimicked the inhibitory action of TNF alpha on insulin signaling , whereas at 100 pmol / l TNF alpha , a nonagonistic p 80 TNFR antibody , was shown to ameliorate the inhibitory action of the cytokine . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our data show that both type 1 and type 2 TNF receptors ( TNF RI and TNF RII ) are expressed on all of these cells , and TNF alpha significantly stimulates the proliferation of growth factor dependent Mo7e cells but not of Meg 01 or Dami / HEL cells , which grow in a factor independent manner . ^^^ Flow cytometric studies demonstrated that TNF alpha binds to Mo7e cells that have been pretreated with either anti TNF RI or anti TNF RII neutralizing antibody , but TNF alpha does not bind to cells pre exposed to both receptor antibodies . ^^^ However , the incubation of Mo7e cells with either TNF RI or TNF RII neutralizing antibodies or with either soluble TNF RI or TNF RII inhibits TNF alpha induced cell proliferation , indicating the requirement of interactions with both TNF receptors for the mitogenic activity of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Immunohistochemical ( IHC ) staining was performed on formalin fixed , paraffin embedded tissues from 39 bronchogenic adenocarcinomas and 32 squamous cell carcinomas using polyclonal antibodies against TNF alpha , TNF beta , TNF R 1 , and TNF R 2 proteins . ^^^ RESULTS : Significant coexpression of TNF alpha , TNF beta , TNF R 1 , and TNF R 2 was observed in NSCLC ( significance range , P < 0 . 001 0 . 02 ) . ^^^ CONCLUSIONS : Although NSCLC exhibits strong coexpression of TNF alpha , TNF beta , TNF R 1 , and TNF R 2 , there is a loss / down regulation of TNF receptors in high stage tumors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The human lung adenocarcinoma cell line A 549 is known to be resistant to tumor necrosis factor alpha ( TNF alpha ) mediated tumor cell lysis in spite of the expression of 55 kDa TNF receptor ( TNF R 55 ) mRNA and its cell surface protein . ^^^ In this study , we investigated the mechanism of TNF alpha resistance and the role of two types of TNF receptors ( TNF R 55 and TNF R 75 ( 75 kDa TNF receptor ) ) . ^^^ On the other hand , the expression of TNF R 75 strongly induces TNF alpha mediated cytotoxicity through TNF R 55 in the absence of an intracellular signal via TNF R75 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In control in vitro experiments , macrophages from IFN gammaR or TNFR 55 deficient mice , while failing to respond to IFN gamma or TNF alpha , respectively , produced high levels of NO under appropriate stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Within the placenta tumour necrosis factor alpha ( TNF alpha ) and its surface receptors TNF RI and RII have been detected on villous cyto and syncytiotrophoblast and a role in trophoblast function / differentiation and turnover has been suggested . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The upregulation of TNF R 1 allowed TNF alpha to induce the binding of nuclear factor kappaB ( NF kappaB ) to the MHC CRE site . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cell surface expression of TNF alpha receptors on these canine cells was also determined with anti human TNF RI and RII polyclonal antibodies . ^^^ Our data shows that on CKCa 1 which has TNF RI receptors rh TNF alpha induced cytotoxicity . ^^^ Combined with ACT D , rh TNF alpha showed the cytotoxicity on MDCK which possessed both TNF RI and RII receptors . ^^^ The results indicate that the cytotoxicity of rh TNF alpha depends on the presence of TNF RI receptors on canine tumor cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The implantation of the Lewis lung carcinoma ( a fast growing mouse tumour that induces cachexia ) to both wild type and gene deficient mice for the TNF alpha receptor type 1 protein ( Tnfr 1 degree / Tnfr1 degree ) , resulted in a considerable loss of carcass weight in both groups . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of the p 55 TNF alpha receptor ( TNFR ) 1 expression revealed the greatest expression in MCF 7 N cells , whereas the MCF 7 L and M cells expressed 89 and 67 % of MCF 7 N cell TNFR 1 levels , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
UV irradiation stimulated the aggregation mediated activation of TNFR 1 which was coupled with activation of caspase 8 , the most proximal caspase in TNF alpha signaling pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Collectively , these findings support the involvement of p 46 JNK / SAPK and its upstream kinases in regulating the induction of iNOS following ligation of the TNF alpha receptor CD120a ( p 55 ) in the presence of IFN gamma . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It is generally believed that activation of TNF R 75 is responsible for the systemic toxicity of TNF alpha . ^^^ Hence , the development of TNF mutants , binding selectively to TNF R 55 , could lead to new option for an anticancer treatment that would be devoid of the deleterious effect of TNF alpha . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
On day 15 of pregnancy , when severe craniofacial anomalies increased , a significant increase in the intensity of TNF alpha , TNFR 1 mRNA transcripts , and TNF alpha protein expression were observed in cells of the malformed regions of the head and the brain . ^^^ In other nonmalformed organs of CP treated embryos such as the liver ( not macroscopically different from controls ) , neither TNF alpha nor TNFR 1 transcripts were detected . ^^^ To assess to what extent TNF alpha may be involved in the process of induced dysmorphogenesis , the expression of TNF alpha and TNF alpha receptor ( TNFRI ) mRNA as well as TNF alpha protein was evaluated in embryos responding to a cyclophosphamide ( CP ) induced teratogenic insult . ^^^ TNF alpha mRNA , TNFRI mRNA , and TNF alpha protein expression were evaluated by in situ hybridization and immunostaining techniques in control , teratogen treated , and immuno stimulated teratogen treated embryos . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) is important in resistance to various microorganisms and provides signals to the target cells through two different receptors , TNF alpha receptor 1 ( TNFRI ) ( p 55 receptor ) and TNFRII ( p 75 receptor ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus , we measured serum levels of apoptosis related markers , namely sFas , TNF alpha and two types of its receptor TNF RI and TNF RII in the patients with idiopathic cardiomyopathy . ^^^ There were significant correlation among TNF alpha , TNF RI and TNF RII in DCM group . ^^^ No transcardiac production of TNF alpha , TNF RI and TNF RII was found in cardiomyopathies in the present study . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , FIP 3 inhibited activation of NF kappaB induced by TNF alpha , the TNFR 1 receptor , RIP , NIK , and IKKbeta , as well as basal levels of endogenous NF kappaB in 293 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To identify which TNF alpha receptor is involved in TNF alpha induced MAPK activation , antibodies against the p 55 TNF alpha receptor 1 ( TNF R 1 ) and the p 75 TNF alpha receptor 2 ( TNF R 2 ) were used . ^^^ VSMC express both receptors , but TNF alpha induced MAPK activation was inhibited only by the TNF R 1 antibody . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Finally , expression of the TNF R 1 mRNA transcripts was upregulated at days 3 and 10 after ligation in the infarct and peri infarct zones , suggesting that the signal transduction pathways necessary for TNF alpha in the heart remain intact as TNF alpha biosynthesis increases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We studied the expression of TNF receptors ( TNF R ) on human articular chondrocytes and their regulation by IL 1beta , TNF alpha , and basic fibroblast growth factor ( bFGF ) . ^^^ On human chondrocytes the expression of TNF R 75 mRNA was markedly upregulated by IL ID , TNF alpha , and bFGF , whereas the expression of TNF R 55 mRNA remained largely unchanged . ^^^ A combination of IL 1beta and TNF alpha , but not of IL 1beta and bFGF , showed an additive effect on TNF R 75 mRNA expression . ^^^ CONCLUSION : The expression of TNF R 55 and TNF R 75 on human articular chondrocytes is modulated independently by IL 1beta , TNF alpha , and bFGF , suggesting a role of these regulatory mechanisms in the degradation processes of human articular cartilage in inflammatory joint diseases . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using neutralizing anti TNFR 1 and TNFR 2 mAbs , we have now obtained evidence that TNF alpha induced KS cell growth and ERK1 / 2 activation are mediated exclusively by TNFR 1 , not by TNFR 2 . ^^^ We therefore propose that the TNFR 1 ERK1 / 2 pathway plays a pivotal role in transmitting to KS cells the mitogenic signals of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The lethal outcome of T . gondii infected TNFR1 / 2 and TNFR 1 deficient mice , but not of TNFR 2 deficient and wild type animals , illustrated the important role of TNF alpha and TNFR 1 mediated signalling , respectively , in this infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Distribution of TNF alpha , TNF R 55 and TNF R 75 in the rheumatoid synovial membrane : TNF receptors are localized preferentially in the lining layer ; TNF alpha is distributed mainly in the vicinity of TNF receptors in the deeper layers . ^^^ Subsequently , the expression of membrane bound TNF alpha , TNF R 55 and TNF R 75 was tested by FACS analysis in isolated RA synoviocytes ( n = 7 patients ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Maturation and apoptosis of primary human acute myeloblastic leukemia cells are determined by TNF alpha exclusively through CD120A stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Inhibition of TNF alpha by TNF R in plasma supernatants of activated blood from PDR patients was demonstrated by increase of TNF alpha activity in the presence of anti TNF RI and anti TNF RII antibodies . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Parental NALM 6 expressed both TNF alpha receptors 1 ( TNFR 60 ) and 2 ( TNFR 80 ) , but these expressions were suppressed in tumor cells from mice with Matrigel . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In experiments testing the effects of recombinant mouse TNF alpha ( rmTNF alpha ) on viability and proliferation of the cell lines , rmTNF alpha modestly but dose dependently inhibited the growth of WT and TNF R 2 / cells while having no effect on TNF R 1 / cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Binding of tumour necrosis factor alpha ( TNF alpha ) to TNF RI induces caspase ( s ) dependent apoptosis in human cholangiocarcinoma cell lines . ^^^ Preincubation of both cell lines with MoAb to TNF RI or TNF RII before TNF alpha treatment showed that only the MoAb specific to TNF RI inhibited death . ^^^ These results indicate that the interaction between TNF alpha and TNF RI alone generated a sufficient signal to activate a caspase 2 subfamily dependent apoptosis in human cholangiocarcinoma cell lines . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Consistent with this hypothesis , cotreatment of EC with the metalloproteinase inhibitor Tapi ( TNF alpha proteinase inhibitor ) blocked the reduction in surface TNFR 1 by apoptogenic drugs and prevented inhibition of TNF induced IkappaBalpha degradation without blocking apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Suppressed alloantigen presentation , increased TNF alpha , IL 1 , IL 1Ra , IL 10 , and modulation of TNF R in UV irradiated human skin . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BALF from infected TNFR 1 ( / ) mice contained more neutrophils and TNF alpha and less interleukin 1beta and macrophage inflammatory protein 2 than that from control mice , but protein levels were similarly elevated in both groups . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Increased levels of soluble TNF receptors ( TNF R ) , which are known to inhibit TNF alpha activity , were recently described in the lungs of subjects with sarcoidosis . ^^^ We hypothesised that TNF alpha bioactivity may be inhibited in sarcoidosis by the presence of TNF R . ^^^ CONCLUSIONS : These results indicate that TNF alpha bioactivity may be inhibited by increased soluble TNF R in the lungs of subjects with sarcoidosis , and this inhibition may be greater in patients with stage 1 sarcoidosis than in those with stage II / III disease . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Endotoxin and ENC were determined by a special kinetic Limulus amoebocyte lysate ( LAL ) assay and TNF alpha , IL 6 , IL 10 , and TNF RI and 2 by commercial ELISA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A large majority of TNF alpha dependent activities can be mediated by TNFR 1 . ^^^ Recently , c Raf 1 kinase was identified as an intracellular target of a signal transduction cascade initiated by binding of TNF alpha to TNFR 1 . ^^^ The TNFR I / Grb2 interaction is essential for the TNF alpha dependent activation of c Raf 1 kinase ; activation of c Raf 1 kinase by TNF alpha can be blocked by coexpression of Grb 2 mutants harboring inactivating point mutations in the NH 2 or COOH terminal SH 3 domain , cell permeable peptides that disrupt the Grb2 / TNFR 1 interaction or transdominant negative Ras . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha acts via two different receptors of 55 ( TNF R 55 ) and 75 kD ( TNF R 75 ) . ^^^ Strong TNF R 55 expression on regenerating myonuclei is consistent with a role of TNF alpha and TNF R 55 in muscle regeneration . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutralizing anti TNF receptor type 1 ( TNFR 1 ; p 55 ) Ab almost completely reversed TNF alpha induced growth inhibition in both liquid and soft agar cultures , whereas anti TNFR 2 ( p 75 ) Ab had only a marginal effect . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this pilot study of PE cases , a statistically significant elevation in urinary levels of TNF alpha and soluble TNF R 1 was demonstrated in PE patients . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To obtain clear evidence for or against the hypothesis that TNF alpha is involved , we studied TNF receptor 1 ( TNF R 1 , p 55 ) or 2 ( TNF R 2 , p 75 ) knockout mice . ^^^ CONCLUSIONS : Long term ethanol feeding caused liver injury in wild type and TNF R 2 knockout mice but not in TNF R 1 knockout mice , providing solid evidence in support of the hypothesis that TNF alpha plays an important role in the development of early alcohol induced liver injury via the TNF R 1 pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The study presented here shows that autoregulation of TNF alpha gene transcription by selective signaling through tumor necrosis factor receptor 1 ( TNFR 1 ) requires p 38 mitogen activated protein ( MAP ) kinase activity and the binding of the transcription factors ATF 2 and Jun to the TNF alpha cAMP response element ( CRE ) promoter element . ^^^ Furthermore , overexpression of MADD ( MAP kinase activating death domain protein ) , an adapter protein that binds to the death domain of TNFR 1 and activates MAP kinase cascades , results in CRE dependent induction of TNF alpha gene expression . ^^^ Thus , the TNF alpha CRE site is the target of TNFR 1 stimulation and mediates the autoregulation of TNF alpha gene transcription . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the spleen , TNF alpha and TNF RII mRNA levels peaked on day 21 and then slowly decreased ; however , no increase in the level of TNF RI mRNA was observed throughout these experiments . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Animals with gene targeted deficiency in TNFR 1 ( p 55 / ) , TNFR 2 ( p 75 / ) , or combined TNFR I / TNFR 2 deficiency ( p 55 / p 75 / ) and their wild type controls were used as recipients of fully mismatched ( BALB / c ; n=88 ) or multiple minor alloantigen mismatched ( BALB . b ; n=62 ) orthotopic corneal transplants to determine the effect of selective deficiency in one or both TNF alpha receptors on corneal allograft survival . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Though there was also an upregulation of Fas ( Apo 1 / CD95 ) and tumor necrosis factor ( TNF ) receptor 1 ( TNF R 1 ) pathways , inhibition of Fas by soluble Fas and blocking of TNF alpha using a TNF binding protein did not prevent HSV induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , at present it is not clear whether human circulating platelets express TNF alpha or TNF receptors ( TNF R ) or whether impaired expression of these molecules and of the TNF reactive adhesion molecule ICAM 1 may be associated with platelet abnormalities in patients with IDDM . ^^^ There was a direct correlation between platelet expression of TNF alpha and that of TNF R in PDR patients , indicating that platelet staining for TNF alpha may be due to binding of this cytokine to its receptors . ^^^ The results suggest that increased platelet expression of TNF alpha , TNF R and ICAM 1 in IDDM patients may constitute important markers of thrombocyte abnormalities during the development of microvascular complications of diabetes mellitus . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice in which individual TNF alpha receptors TNFR 1 or TNFR 2 had been genetically knocked out were used , and results were compared with mice of C57Bl / 6 background after 5 days UUO . ^^^ TNFR 1 knockout displayed a significant reduction in amount of TNF alpha mRNA induced compared with wild type or TNFR 2 knockout mice . ^^^ Treatment of TNFR 1 knockout mice with an angiotensin converting enzyme inhibitor further decreased 10 ( int ) and TNF alpha mRNA induction , suggesting an interaction of ANG 2 and TNF alpha systems . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results suggest that TNF alpha can cause apoptosis in pancreatic beta cells through TNFR 1 linked apoptotic factors , TRADD , FADD , and FLICE , and TNF induced ceramide production may be involved in the pathways . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 1 mRNA expression in the liver was upregulated within 3 h after GalN administration , and anti TNFR 1 antibody protected GalN sensitized mice from hepatotoxic effects of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The objective of this study was to investigate tumor necrosis factor alpha ( TNF alpha ) expression , the presence of functional TNF alpha receptors , and expression of TNF receptor type 1 ( TNF RI ) mRNA in the bovine corpus luteum ( CL ) during different stages of the estrous cycle . ^^^ An RT PCR analysis showed higher levels of TNF RI mRNA in CL of Days 3 7 than of other stages ( P < 0 . 05 ) . ( 125 ) 1 TNF alpha binding to the membranes of bovine CL was maximal after incubation at 38 degrees C for 48 h . ^^^ These results indicate the local production of TNF alpha and the presence of functional TNF RI in bovine CL throughout the estrous cycle , and suggest that TNF alpha plays some roles in regulating bovine CL function throughout the estrous cycle . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using OA synovial fibroblasts , we investigated the effects of interleukin 8 ( IL 8 ) , leukaemia inhibitory factor ( LIF ) and IL 11 on the level of TNF alpha induced PGE ( 2 ) , and their impact on the TNF alpha induced cellular signalling cascades including the TNF receptor ( TNF R ) , soluble TNF R ( TNF sR ) , cytoplasmic phospholipase A 2 ( cPLA 2 ) , cyclooxygenase 2 ( COX 2 ) , and the transcription factors NF kappaB , C / EBP , CREB and AP 1 . ^^^ IL 8 ( 5 ng / ml ) and LIF ( 50 ng / ml ) alone upregulated ( 30 % ) the TNF R binding level , but significantly downregulated the TNF alpha induced levels ( P < 0 . 007 and P < 0 . 004 , respectively ) and the TNF sR 55 level . ^^^ In contrast , IL 11 reduced the basal level by 18 % ( P < 0 . 005 ) and the TNF alpha induced level of TNF R by 51 % ( P < 0 . 01 ) as well as decreasing both TNF sR 55 and TNF sR 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Osteoclast formation induced by TNF alpha was inhibited by the addition of respective antibodies against TNF receptor 1 ( TNFR 1 ) or TNFR 2 , but not by osteoclastogenesis inhibitory factor ( OCIF , also called OPG , a decoy receptor of ODF / RANKL ) , nor the Fab fragment of anti RANK ( ODF / RANKL receptor ) antibody . ^^^ Experiments using M BMM phi prepared from TNFR 1 or TNFR 2 deficient mice showed that both TNFR 1 and TNFR 2 induced signals were important for osteoclast formation induced by TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present study , we determined the forms of TNF alpha involved in the development of CCI neuropathy in rats , using Western blot analysis , and the temporal correlation of TNF alpha and TNFRI protein profiles with gelatinases activity at the site of peripheral nerve injury . ^^^ We conclude that severe nerve injury induces MMPs , TNF alpha and TNFRI , which interactively control the privileged endoneurial environment and the pathogenesis of the painful neuropathies associated with the macrophage dependent processes of Wallerian degeneration . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The present study evaluates in three lung cancer cell lines ( small cell carcinoma NCI H 69 , adenocarcinoma A 427 , squamous carcinoma SK MES 1 ) and one erythroleukaemia ( K 562 ) cell line the following evasion mechanisms : ( 1 ) inhibition of TNF alpha production , in indirect and direct co cultures with monocytes ; ( 2 ) the expression of type 1 and type 2 receptors for TNF alpha ( TNFRI and TNFRII ) by tumour cell lines , using indirect immunofluorescence and flow cytometry ; ( 3 ) the sensitivity of tumour cell lines to the toxic action of recombinant human TNF alpha ( rhTNF alpha ) . ^^^ Erythroleukaemia K 562 cells expressed both types of receptors for TNF alpha , whereas the NCI H 69 cells expressed only TNFRI , and the A 427 and SK MES 1 cells expressed no receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Results are presented demonstrating that signaling through TNFR 1 , but not TNFR 2 , is involved in TNF alpha mediated liver damage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The actions of TNF alpha are mediated by two transmembrane receptors of approximately 55 ( p 55 , CD120a ) and 75 kDa ( p 75 , CD120b ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Further , the expression of TNF alpha , IL 6 , and TNF receptors 1 and 2 ( TNFRI and TNFRII ) was examined by RT PCR . ^^^ Overexpression of TNF alpha as well as TNFRI may play a role in controlling T cell proliferation through an autocrine ( T cell T cell interaction ) and paracrine ( macrophage T cell interaction ) fashion . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) and tumor necrosis factor receptor 1 and 2 ( TNFRI and TNFRII ) were studied in 24 burn patients who had a total burn surface area ( TBSA ) of 50 . 2 + / 20 . 4 % . ^^^ The TNF alpha levels correlated significantly with both the TNFRI and the TNFRII levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effect of TNF alpha is mediated by two membrane receptors carried on the surface of target cells ( TNF RI p 55 and TNF RII p 75 ) which are released into the biological fluids ( synovial fluid and plasma ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The quantitative expression of genes for CD 14 , interferon gamma receptor ( IFN gamma R ) , tumor necrosis factor alpha ( TNF alpha ) , integrin alpha 4 beta 1 ( VLA 4 ) , tumor necrosis factor receptor p 55 ( TNFR 1 ) and CD 44 ( standard form ) was examined in 9 patients with primary or secondary leg lymphedema before and after phase 1 of CDP . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 1 was necessary for induction of cytokine interleukin ( IL ) 1beta , IL 1 receptor antagonist , chemokine macrophage inflammatory protein ( MIP ) 1beta , MIP 2 , interferon gamma induced protein 10 ( IP 10 ) , and monocyte chemoattractant protein ( MCP ) 1 mRNA in response to intratracheal administration of recombinant murine TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha , TNFRI , and TNFRII proteins were detected by immunocytochemistry in all three major corneal cell types in human corneal tissue . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Silencer of death domains ( SODD ) binds to TNF alpha receptor TNFR 1 , and prevents spontaneous self association of death domains and inappropriate receptor signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced ICAM 1 surface and gene expression were both blocked by the RNA polymerase 2 inhibitor actinomycin D ( 0 . 1 microg / ml ) , and surface expression was attenuated by a neutralizing monoclonal antibody directed against the TNF alpha receptor p 55 ( TNF RI ) . ^^^ The results support the following pathway , whereby TNF alpha enhances expression of ICAM 1 in NHBE cells : TNF alpha > TNF RI > PC PLC > DAG > PKC > ( NF kappaB ? ) > ICAM 1 mRNA > ICAM 1 surface expression . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological actions of tumor necrosis factor alpha ( TNF alpha ) are mediated by 2 distinct receptors , TNF RI ( p 55 ) and TNF RII ( p 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Activated tumor necrosis factor alpha ( TNF alpha ) receptor 1 ( TNFR 1 ) recruits TNFR 1 associated death domain protein ( TRADD ) , which in turn triggers two opposite signaling pathways leading to caspase activation for apoptosis induction and NF kappaB activation for antiapoptosis gene upregulation . ^^^ In HeLa cells , Stat 1 was associated with TNFR 1 and this association was increased with TNF alpha treatment . ^^^ TNFR 1 signaling factors TRADD and Fas associated death domain protein ( FADD ) were also found to interact with Stat 1 in a TNF alpha dependent process . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunohistochemical and semiquantitative study of TNF alpha , its receptors types 1 ( TNFR 1 ) and 2 ( TNFR 2 ) , cell proliferation ( Ki 67 nuclear antigen ) , and apoptosis ( Tunel method ) was carried out in human prostates , in normal healthy conditions , as well as in benign prostatic hyperplasia ( BPH ) and prostatic carcinoma ( PC ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha exerts many of its effects by binding , as a trimer , to either a 55 kDa cell membrane receptor termed TNFR 1 or a 75 kDa cell membrane receptor termed TNFR 2 . ^^^ The crystal structures of TNF alpha , TNF beta , the extracellular domain of TNFR 1 ( denoted sTNFR 1 ) , and the TNF beta sTNFR 1 complex have been defined by crystallography . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus , increased plasma levels of TNF alpha , IL 1 , IL 6 , IL 1 receptor antagonist ( IL Ira ) , TNF receptors ( TNF R ) , IL 10 , IL 8 and macrophage inflammatory protein ( MIP ) 1 are found after strenuous exercise . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , TNF alpha is an essential mediator of sHA induced DC maturation as shown by blocking studies with a soluble TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In livers of patients with FHF , infiltrating mononuclear cells express high amounts of TNF alpha and hepatocytes overexpress TNF receptor 1 ( TNF R 1 ) . ^^^ CONCLUSIONS : The results show that the TNF alpha / TNF R 1 system is involved in the pathogenesis of FHF in humans . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As soluble receptors for TNF alpha ( TNF R 55 and TNF R 75 ) regulate TNF alpha activity , we investigated their release by monocytes in Q fever . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This biphasic response may be related to the different expression of TNF alpha receptors ( TNFRs ) ; a significant increase in the density of TNFR 1 was in fact observed following RA induced differentiation . ^^^ Preincubation with an anti TNFR 1 antibody prevented the cytotoxic effect of TNF alpha in RA differentiated SK N BE cells , whereas the anti TNFR 2 antibody blocked the proliferative activity of the cytokine in undifferentiated cultures . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To gain insights into the putative role of the TNF alpha signalling pathway , we investigated expression of its receptors , TNFR 1 and 2 , in first trimester placentae and early trophoblasts , and studied the influence of the cytokine on cell proliferation and apoptosis . ^^^ TNF alpha / TNFRI in primary and immortalized first trimester cytotrophoblasts . ^^^ Interleukin ( IL ) 1 and phorbol 12 myristate 13 acetate ( PMA ) induced shedding of TNFRI from ED 27 and primary cells suggesting that under inflammatory conditions the soluble receptor protein may protect from cytotoxic effects of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological activities of TNF alpha are mediated by two structurally related , but functionally distinct receptors , TNF RI and TNF RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Normal tissue showed constitutive expression of TNF R 1 in the vasculature of the optic nerve heads but no positive labeling for TNF alpha . ^^^ In the glaucomatous optic nerve heads , the expression of both TNF alpha and TNF R 1 were apparently upregulated , primarily in glial fibrillary acidic protein ( GFAP ) positive astrocytes , and appeared to parallel the progression of optic nerve degeneration . ^^^ In eyes with severe glaucomatous damage , some HLA DR positive microglia also contained TNF alpha and TNF R 1 . ^^^ In the most severely damaged optic nerve heads , the axons of the retinal ganglion cells contained TNF R 1 and , therefore , are direct targets for neurodegeneration caused by TNF alpha . ^^^ In vitro astrocytes constitutively express TNF R 1 and TNF alpha stimulation induces expression of NOS 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) and its receptors ( TNFRI and TNFRII ) which exist in soluble form as a product of cleavage of the extracellular domain of membrane integrated receptors , still rise debate about their importance . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MEASUREMENTS : Body mass index ( BMI ) , waist to hip ratio ( WHR ) , percentage body fat , and fasting levels for serum TNF alpha , serum soluble TNF receptor p 55 ( TNF RI ) and TNF receptor p 75 ( TNF RII ) , serum lipids , HbA1c , and serum insulin before and after exercise . ^^^ RESULTS : In overweight to obese subjects , serum levels of TNF alpha , TNF RI and TNF RII were significantly higher than those in lean subjects . ^^^ In contrast , TNF alpha , TNF RI and TNF RII were negatively correlated with HDL cholesterol . ^^^ Regular exercise decreased BMI , percentage body fat , HbA1c , serum TNF alpha , TNF RI and TNF RII and increased HDL cholesterol levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Because TNF alpha and TNFR ( TNFRI and 2 ) expression are tightly regulated responses , we hypothesized that CpG containing oligodeoxynucleotide ( CpG ODN ) would also affect TNFRI and 2 shedding . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , the transducing molecule TRAF 2 co immunoprecipitates with IL 15Ralpha and may be deflected to TNFRI using anti IL 15 blocking mAbs and TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Such secretion could be inhibited by antibodies that block TNF alpha activity and binding to its receptors TNF RI ( p 55 ) and TNF RII ( p 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The role of tumor necrosis factor alpha ( TNF alpha ) and its type 1 receptor ( TNFRI ) in structural luteolysis was investigated . ^^^ In conclusion , this study suggests that TNF alpha induced PCD during structural luteolysis is mediated by TNFRI , primarily affects endothelial cells , and that the decline in progesterone , preceding structural luteolysis , is a prerequisite for the initiation of apoptosis in endothelial cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine if TNF alpha blockade with soluble TNF alpha receptors might alter immune system function , assays were assessed in rodents treated with a dimeric form of the p 55 TNF RI , Tumor Necrosis Factor binding protein ( TNFbp ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha and LT alpha are both members of the TNF family of molecules and cause cell death by apoptosis following interaction with their counter receptors , the TNFR 1 and TNFR 2 , leading to a cascade of proteolytic events culminating in the blebbing of the cytoplasmic membrane , nuclear condensation and DNA fragmentation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced expression of adhesion molecules in the liver is under the control of TNFR 1 relevance for concanavalin A induced hepatitis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) exerts its functions by binding two different receptors ( TNFR 55 and TNFR 75 ) . ^^^ Both TNF alpha and IL 1 beta upregulated the gene expression of TNFR 75 and did not affect that of TNFR 55 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) plays a pivotal role in the immune response and mediates inflammation by its receptors ( TNF RI and TNF RII ) , as observed during rejection episodes and impaired graft function after liver transplantation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , the levels of TNF alpha receptor R 1 ( TNF R 1 , p 55 ) , bcl 2 , soluble Fas ( sFas ) , and the activities of caspase 1 and caspase 3 were also elevated in the nigrostriatal DA regions in PD . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha acts by binding to two specific receptors : TNF R 1 and TNF R 2 . ^^^ Fas and its ligand have homologies respectively with TNF alpha and TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Osteoclast formation induced by TNF alpha was inhibited by antibodies against TNF type 1 receptor ( TNFR 1 ) or TNFR 2 , but not by OCIF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The plasma levels of TNF alpha , interferon gamma , interleukin ( IL ) 2 , IL 4 , IL 10 and soluble TNFR 1 and 2 ( sTNFR 1 and 2 ) were quantified by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Infiltrates of leukocytes expressing immunoreactive IL 1 : , IL 6 , and TNF alpha were found around blood vessels , cerebral ventricles , and meninges , and were accompanied by a profound microglial expression of IL1P , endothelial expression of IL 6 , and expression of TNF alpha and TNF R 1 in glia and neurons of cortex and hippocampus . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To examine whether tumor necrosis factor alpha ( TNF alpha ) contributes to the pathogenesis of bovine leukemia virus ( BLV ) infection , the mRNA expression patterns of TNF alpha and its receptors , type 1 ( TNF R 1 ) and type 2 ( TNF R 2 ) were investigated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We hypothesized that elevated expression of TNF alpha and its p 55 and p 75 receptors ( TNF R ) in gingival tissue might associate with periodontitis . ^^^ Immunohistochemistry was used for the study of the localization of TNF alpha and its p 55 and p 75 TNF R in adult periodontitis ( AP ) gingival tissue , in comparison with that in healthy control specimens . ^^^ TNF alpha and p 55 TNF R were detected in sulcular epithelial basal cells and in monocyte / macrophages , fibroblasts , and endothelial cells in the AP gingival tissue specimens , but mainly in fibroblasts and endothelial cells in control specimens . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated the effects of TNF receptor 1 ( TNFR 1 ) and 2 ( TNFR 2 ) modulation on the death of human aortic endothelial cells ( HAECs ) resistant to TNF alpha induced cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The frequency of the 308 TNFA , 383 TNFR 1 , 1087 IL 10 and codon 25 TGFB 1 alleles were analysed in two different ethnic groups : Chinese from Hong Kong and Caucasians from western Sweden . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using receptor specific blocking antibodies , we found that TNFR 1 primarily regulates TNF alpha induced IL 6 and RANTES secretion and activation of p 38 and p42 / 44 MAPK pathways . ^^^ Our data suggest that despite the presence of functional TNFR 2 , TNFR 1 associated with MAPK dependent and independent pathways is the primary signaling pathway involved in TNF alpha induced synthetic functions in ASM cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To evaluate the role played by each TNF alpha receptor in the pathogenesis of this syndrome , mice were generated that were deficient in TTP and either or both of the known TNF alpha receptors ( TNFRs ) , type 1 ( TNFR 1 ) and type 2 ( TNFR 2 ) . ^^^ Mice deficient in TTP and TNFR 1 , or in TTP and both receptors , were protected from developing the TNF alpha induced cachexia and inflammation . ^^^ Finally , the results showed that TNFR 1 plays an important role in mediating TNF alpha induced changes in TNF alpha and GM CSF mRNA stability . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We studied if the rate of apoptosis decreases after birth , by measuring the soluble ( s ) forms of Fas Fas ligand and Tumor necrosis factor receptor 1 ( TNFR 1 ) TNF alpha which attenuate apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Lung chemokine production and PMN accumulation were significantly lower in TNFRI KO , but not TNFRII KO , mice , despite no difference in TNF alpha production ( TNFRI KO , 925 + / 301 vs TNFRII KO , 837 + / 267 , P = 0 . 82 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
UVB but not TNF alpha induced the expression of TNF receptor type 1 ( TNFR 1 ) and type 2 ( TNFR 2 ) in a dose dependent manner . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Because all allografts in our protocol expressed TNF R 1 , direct antigraft effects of TNF alpha and LTalpha were not prevented . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , innovative immunobiologicals ( PEG TNFRI , PEG TNF alpha antibody fragments , soluble TNFRI , CTLA 4 Ig , CD 40 ligand antibody , antibodies against IFN gamma , IL 6 , IL 12 , IL 15 , IL 18 , complements ) , inhibitors of TNF alpha translation ( peptides , anti sense constructs ) or TNF alpha synthesis ( targeting NF kappa B , p 38 MAP kinase , phosphodiesterase 4 , TNF alpha converting enzyme ) are forthcoming . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) induces apoptosis predominantly via TNF receptor 1 ( TNF RI ) . ^^^ T cells from aged subjects show increased sensitivity to TNF alpha induced apoptosis that is associated with increased expression of TNF RI and decreased expression of TNF RII in both CD4+ and CD8+ T cells . ^^^ Agonistic TNF RI also induced greater apoptosis in T cells from aged subjects as compared to young subjects , suggesting that increased TNF alpha induced apoptosis in aging is predominantly mediated via TNF RI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Involvement of tumor necrosis factor ( TNF ) alpha and Fas signaling was evaluated using various knockout mice ( TNF receptor 1 [ TNF R 1 ] / , Fas [ lpr ] / , and Fas ligand [ gld ] / ) and wild type mice pretreated with pentoxifylline , an inhibitor of TNF alpha synthesis . ^^^ RESULTS : Expression of TNF alpha was increased after ischemia and reperfusion in wild type mice and TNF R 1 deficient mice when compared with sham operated animals . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MEASUREMENTS : Plasma concentrations of leptin , the inflammatory parameter soluble TNF alpha receptors ( TNFR 55 and TNFR 75 ) , the acute phase proteins lipopolysaccharide binding protein ( LBP ) , serum amyloid A ( SAA ) , alpha acid glycoprotein ( AGP ) , C reactive protein ( CRP ) , plasminogen activator inhibitor 1 ( PAI 1 ) and the anti inflammatory soluble Interleukin 1 decoy receptor ( sIL 1RII ) were measured . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
High prion titers were detected in lymph nodes , but not spleens , of TNFR 1 ( / ) and TNF alpha ( / ) mice despite absence of FDCs and germinal centers . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) activates Jak1 / Stat3 Stat5B signaling through TNFR 1 in human B cells . ^^^ The biological actions of tumor necrosis factor alpha ( TNF alpha ) are mediated by two cell surface receptors , TNFR 1 and TNFR 2 . ^^^ Furthermore , Jak 1 coprecipitated with TNFR 1 after TNF alpha treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The T cell blasts , which we activated in vitro , were sensitive to apoptosis induced by TNF alpha and by antibodies to TNFR 1 and / or TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this model of endotoxin shock , the major role has been attributed to TNF alpha acting through its receptor TNFRI ( p 55 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Virus activation was caused by a sensitization of TNF R 1 toward endogenously produced tumor necrosis factor alpha ( TNF alpha ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF alpha receptor 1 ( TNFR 1 ) density in peripheral blood monocytes was similar in DM 2 patients and in nondiabetic subjects . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effects of TNFa are mediated by TNF receptors ( TNF R ) , and these receptors are often found in soluble forms ( sTNF R ) , which can modulate TNFalpha actions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined two single nucleotide polymorphisms ( SNPs ) of the TNF alpha gene , TNF ( 308 G / A and 238 G / A ) , an SNP of the TNF receptor superfamily member 1A gene , TNFRSF1A ( also known as TNFR 1 ) , at codon 12 in exon 1 ( CCA / CCG ) , and two SNPs of the 1B gene , TNFRSF1B ( also known as TNFR 2 ) , ( 1466 A / G and 1493 C / T ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) is a proinflammatory mediator that exerts its biological functions by binding two TNF receptors ( TNF RI and TNF RII ) , which initiate biological responses by interacting with adaptor and signalling proteins . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Blocking experiments and evaluation of shedding of soluble TNF receptor type 1 ( TNF RI ) demonstrated that endogenous TNF alpha production is responsible for spontaneous apoptosis of biomaterial adherent cells and that IL 4 inhibits this apoptosis by increasing levels of shedding of soluble TNF RI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF alpha receptor , CD120a , has recently been shown to be localized to both plasma membrane lipid rafts and to the trans Golgi complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Forty patients with acute infection were randomly divided into 2 groups , 20 in the 912 group and 20 in the control group , and the levels of plasma endotoxin ( lipopolysaccharide , LPS ) , serum pro inflammatory cytokines , including tumor necrosis factor alpha ( TNF alpha ) and interleukin 6 ( IL 6 ) and anti inflammatory cytokines , including soluble TNF RI , IL 4 and IL 10 were measured before and after treatment by using limulus reagent stroma azo colored quantitative method and enzyme linked immunosorbent assay ( ELISA ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF alpha receptor 1 ( sTNFRI ) is an extracellular domain of TNFRI and antagonizes the activity of TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , since CYP3A2 protein expression appears to be important for the effects of phenobarbital and the alpha isomer of benzene hexachloride , mRNAs for IL 1 receptor type 1 ( IL 1R1 ) and TNF alpha receptor type 1 ( TNFR 1 ) whose ligands have roles not only in downregulating CYP3A2 expression but also in inducing antiproliferative effect or apoptosis in hepatocyte were examined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The most of TNF alpha effects are performed by two receptors termed as TNF RI and TNF RII identified on the surface of many cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) secretion by lymphocytes is important for maintaining FDC networks , and signaling is mediated through TNF receptor 1 ( TNFR 1 ) expressed on FDCs and / or their precursors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We therefore suggest that TNF R 1 mediated TNF alpha signals might support a systemic humoral immune response against H . pylori and that the gastric inflammatory response to H . pylori infection seems to be independent of TNF R 1 mediated signals . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Other polymorphisms ( TNF alpha promoter 238 , 308 , 376 , 857 , 1031 , TNF R 1 609 , +36 ( exon 1 ) , TNF R 2 1663 , 1690 ( 3 ' UTR ) ) were not associated with treatment response in both cohorts ( P > 0 . 5 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This TNF alpha induced proliferation of synoviocytes obtained from RA patients coincided with down regulation of TNFR 1 and up regulation of TNFR 2 and TRAF 1 6 , as well as NF kappaB activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Day 20 placentas from viable foetuses were examined for immunoexpression of ( a ) cytokines : tumour necrosis factor alpha ( TNF alpha ) , TNFR 1 receptor ( p 55 ) , leptin and leptin receptor , ( b ) apoptosis : TdT mediated dUTP nick end labelling ( TUNEL ) positive cells , bax and bcl 2 . ^^^ CONCLUSIONS : Maternal vitamin A deficiency is associated with abnormal placental apoptosis induced by neutrophil derived TNF alpha acting through the TNFR 1 ( p 55 ) and / or a change in the bcl 2 / bax ratio in the trophoblast giant cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , blocking antibodies to TNF RI or TNF RII protected HCs from IFN alpha induced apoptosis , demonstrating that such killing was mediated by TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This review describes the development of the soluble TNF alpha receptor ( p 75 TNF R : Fc ; etanercept ) and other agents inactivating or blocking TNF alpha in the management of patients with hematologic malignancies . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Results : 1 ) The presence of TNF alpha expression was observed in all examined samples , in contrast to TNF R 1 expression ; 2 ) The high level of TNF alpha expression was noted both for typical and sought TNF R2 / R7 isoforms and 3 ) A considerable number of samples displayed higher levels of TNF R 2 isoforms than TNF R2 / R7 mRNA expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) , a proinflammatory cytokine , exerts its biological activity by signaling via its two receptors , TNF RI and TNF RII , and by activating NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To test this hypothesis , the effects of dietary VT on feed intake , weight gain , serum IgA levels and kidney mesangial IgA deposition in mice homozygous for targeted disruption of the two known TNF alpha cell surface receptors , TNFR 1 ( p 55 ) or TNFR 2 ( p 75 ) , were compared to effects in corresponding C57BL / 6J wild type ( WT ) mice with normal receptor function . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological activities of TNF alpha are mediated by two structurally related but functionally distinct receptors , p 55 ( TNFR 1 ) and p 75 ( TNFR 2 ) , which are independently expressed on the cell surface . ^^^ These data indicate that , in the absence of TNFR 1 ( p 55 ) , where TNF alpha uses the p 75 pathway exclusively , the development of AHR is regulated by gammadelta T cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : The mRNA transcripts of TNF alpha and its receptors ( TNF RI and TNF RII ) were quantified in blood cells of pancreatic cancer patients , using competitive quantitative reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated the requirement for tumor necrosis factor alpha ( TNF alpha ) and interleukin ( IL ) 1 receptors in the pathogenesis of the pulmonary and hepatic responses to Escherichia coli lipopolysaccharide ( LPS ) by studying wild type mice and mice deficient in TNF type 1 receptor [ TNFR 1 knockout ( KO ) ] or both TNF type 1 and IL 1 receptors ( TNFR1 / IL 1R KO ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previously , we demonstrated that TNFa receptor ( TNFR 1 ) rapidly disappeared from the cell surface upon poliovirus infection , whereas FAS was much more stable [ 1 ] . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Similarly , anti TNF alpha and TNF R 2 MoAb inhibited anti snRNP antibody production in vitro , but anti CD 154 or TNF R 1 MoAb did not . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha acts via two different receptors , TNFR 1 and TNFR 2 , and is believed to have both a neuroprotective and a deleterious role for neurons . ^^^ In order to analyze the putative role of TNF alpha in parkinsonism , we compared the effect of the parkinsonian drug 1 methyl 4 phenyl 1 , 2 , 3 , 6 tetrahydropyridine ( MPTP ) in mice lacking TNFR 1 , TNFR 2 , or both receptors and in wild type littermates . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Shedding of TNFR 1 in regenerative liver can be induced with TNF alpha and PMA . ^^^ METHODS : The shedding of TNFR 1 in liver regeneration and changes of TNF alpha , PMA and plasma membrane purified from hepatocytes on this shedding process were measured with Western blot . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) binds to its receptor ( TNFR 1 ) and activates both death and inflammation / survival related signalling pathways . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The second objective of this study was to determine the relationship between soluble TNF alpha receptors ( TNFR 1 ; TNFR 2 ) and MMP plasma profiles . ^^^ METHODS AND RESULTS : Plasma levels of MMP 2 , MMP 9 , MMP 8 , TIMP 1 , TIMP 2 , TNF alpha , TNFR 1 , and TNFR 2 were measured by enzyme linked immunosorbent assay kits . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previous studies suggest that tumor necrosis factor alpha ( TNF alpha ) and the TNFRI ( p 55 ) and TNFRRII ( p 75 ) receptors mediate the pulmonary fibrotic response to silica . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptosis induced by rSV5deltaSH was inhibited by neutralizing antibodies against TNF alpha and TNF alpha receptor 1 ( TNF R 1 ) , suggesting that TNF alpha played an essential role in rSV5deltaSH induced apoptosis in a TNF R 1 dependent manner . ^^^ Examination of important proteins in the TNF alpha signaling pathway showed that p 65 , a major NF kappaB subunit whose activation can lead to transcription of TNF alpha , was first translocated to the nucleus and was capable of binding to DNA and then was targeted for degradation in rSV5deltaSH infected cells while expression levels of TNF R 1 remained relatively constant . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We evaluated by immunocytochemistry cellular localization and time dependent expression of tumor necrosis factor a ( TNF alpha ) and its receptors p 55 ( TNF RI ) and p 75 ( TNF R 2 ) in human ischemic brains . ^^^ In other cells , immunoreactions for both types of TNF alpha receptors were similar but the pattern of immunostaining was different : homogenous for TNF R 1 and granular for TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Hereditary , familial , and idiopathic chronic pancreatitis are not associated with polymorphisms in the tumor necrosis factor alpha ( TNF alpha ) promoter region or the TNF receptor 1 ( TNFR 1 ) gene . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our results show , that the exposure of three metastatic melanoma cell lines ( A 2058 , SK Mel 5 , and WM 266 4 ) to recombinant TIMP 3 , N terminal MMP inhibitory domain of TIMP 3 , as well as to adenovirally expressed TIMP 3 results in stabilization of tumor necrosis factor receptor 1 ( TNF RI ) , FAS , and TNF related apoptosis inducing ligand receptor 1 ( TRAIL RI ) on melanoma cell surface and sensitizes these cells to apoptosis induced by TNF alpha , anti Fas antibody and TRAIL . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
AIM : To investigate changes of tumor necrosis factor alpha ( TNF alpha ) and TNFR 1 expression in vital organs and their significance in the pathogenesis of multiple organ damage associated with endogenous endotoxin following major burns . ^^^ Tissue samples from liver , spleen , kidney , lung and intestine were collected to assay tissue endotoxin levels and measure TNF alpha and TNFR 1 expression . ^^^ The gene expression of TNF alpha in liver , lung and kidney was up regulated after thermal injury , while the TNFR 1 mRNA expression in liver , lung , kidney and intestine was shown decreased throughout the observation period . ^^^ Thus , the mRNA expression ratio of TNF alpha to TNFR 1 was significantly increased postburn , particularly in pulmonary tissue ( 67 fold ) . ^^^ In addition , the significant correlations between the expression of TNFR 1 or the expression ratio of TNF alpha / TNFR mRNA in liver tissue and serum aspartate aminotransferase levels were noted ( P < 0 . 05 0 . 01 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
There were statistically significant decreases ( p < 0 . 01 ) in serum tumor necrosis factor alpha ( TNF alpha ) , TNF RII and interleukin 2 ( IL 2 ) , and an increase in TNF RI levels between study entry and day 3 . ^^^ It may also influence TNF alpha , TNF RI and TNF RII serum complex levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we show that HCMV infection also prevents external signaling to the cell by disrupting the function of TNFRI , the 55 kDa receptor for tumor necrosis factor alpha ( TNF alpha ) , one of the receptors for a potent cytokine involved in eliciting a wide spectrum of cellular responses , including antiviral responses . ^^^ The reduction appeared to be due to relocalization of TNFRI from the cell surface and was reflected in the elimination of TNF alpha induced Jun kinase activity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Although non MMF based immunosuppression in ST patients did not result in compromised AC or lipopolysaccharide ( LPS ) stimulated monokine responses compared with healthy controls , we found MMF therapy to be associated with significantly reduced TNF R 1 expression on monocytes ( P < 0 . 001 ) , suppressed AC ( P < 0 . 02 , SED ) , and suppressed LPS stimulated IL 1 beta , IL 10 , and TNF alpha secretion ( P < 0 . 01 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Caspase 8 activation is an upstream event in the apoptotic pathway triggered by the activation of cytokines receptors such as TNF alpha receptor 1 ( TNFR 1 ) , and the presence of caspase 8 activation in fibroblast like cells in the aseptic interface membranes of THAs suggests a possible TNF alpha dependent apoptosis . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Antibody inhibition of caspase 3 activity as well as flow cytometry experiments implicated TNF related apoptosis inducing ligand ( TRAIL ) and TNF alpha receptor ( TNF R ) in apoptosis signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present studies , p 55 TNF receptor 1 ( TNFR 1 ) / mice were used to assess the role of TNF alpha in acetaminophen induced antioxidant defense . ^^^ These data indicate that TNF alpha signaling through TNFR 1 plays an important role in regulating the expression of antioxidants in this model . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We analyzed expression of TNF alpha , IL 6 , tumor necrosis factor ( TNF RI , TNF RII ) and interleukin 6 ( IL 6R ) receptors in the brain , kidney , spleen , liver , muscle , ascite tumors and serum , from Yoshida AH 130 hepatoma bearing rats . ^^^ This is the first demonstration of a selective up regulation of TNF RI in cancer cachexia and suggests that local production of TNF alpha and IL 6 is a corner stone in the induction / maintenance of this syndrome . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The upregulation of TNFR 2 but not TNFR 1 was blunted in TNF alpha deficient mice , indicating ligand dependent upregulation of TNFR 2 . ^^^ Moreover , renal TNF alpha expression , ICAM 1 expression , and serum TNF alpha levels were lower in TNFR 2 deficient mice compared with wild type or TNFR 1 deficient mice treated with cisplatin . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Correspondingly , both monocytes and VSMCs expressed TNF R 1 , and macrophages expressed cell surface TNF alpha . ^^^ Two NO donors upregulated VSMC surface TNF R 1 , and exogenous TNF alpha induced VSMC apoptosis synergistically with the NO donor diethylenetriamine / NO , indicating that NO sensitizes VSMCs to TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , multidrug resistance protein 5 ( MRP 5 ) and tumor necrosis factor receptor type 1 ( TNFR 1 ) mRNA expressions also appear to be possible markers for responsiveness to TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The SFB were then stimulated with TNF a ( 1 10 ng / ml ) or agonistic anti TNF R 55 ( HTR 9 ) and anti TNF R 75 ( UTR 1 ) monoclonal antibodies ( 1 25 micro g / ml each ) . ^^^ TNF a induced PGE ( 2 ) release by RA SFB ( 92 fold ) and OA SFB ( 56 fold ) was mediated by both TNF receptors ; however , predominantly by TNF R 55 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Adenovirus infected mice exhibited higher TNF alpha levels after LPS stimulation , no difference in TNFR 1 expression , and similar mortality from Fas induced fulminant hepatitis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This inhibition of TNF alpha signaling was explained by a decrease in TNF receptor 1 ( TNFR 1 ) and TNFR 2 that was due to decreased mRNA for the latter . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Myocardial biopsies from 17 patients at the time of LVAD implantation and after explantation , at the time of heart transplantation ( HTx ) , were examined by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) reaction and with antibodies against Fas ligand ( FasL ) , Fas , tumor necrosis factor ( TNF ) alpha receptor 1 ( TNF R 1 ) , TNF alpha receptor 2 ( TNF R 2 ) , TNF alpha , TNF alpha converting enzyme ( TACE ) , poly ( ADP ribose ) polymerase ( PARP ) , poly ( ADP ribose ) ( PAR ) , caspase 3 and FLICE inhibitory protein ( FLIP ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our results confirm that interaction of TNF alpha with TNF RII but not TNF RI is directly costimulatory to TCR mediated T cell activation , thereby augmenting T cell proliferation , expression of T cell activation markers ( CD 25 , human leukocyte antigen DR , TNF RII ) , and secretion of cytokines such as interferon gamma and TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RT PCR demonstrated TNF alpha mRNA expression from day 7 . 5 to 9 . 5 , TNF R 1 from day 6 . 5 to 9 . 5 and TNF R 2 from day 5 . 5 to 7 . 5 of pregnancy , and in situ hybridisation revealed the trophoblast giant cells ( TGCs ) of the early placenta as the site of TNF alpha expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Gene microarray analysis provided evidence for changes in gene expression , notably that TNF alpha and TNF R 1 , but not TNF R 2 , were significantly elevated in CFA treated TMJ tissues . ^^^ However , protein levels of TNF alpha , TNF R 1 , and TNF R 2 were all significantly increased in CFA treated TMJ tissues . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Transgenic mice with a targeted disruption of the tumor necrosis factor receptor 1 ( TNFR 1 ) gene were used to analyze the role of TNF alpha in pro and anti inflammatory mediator production and liver injury induced by acetaminophen . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effect of TNF alpha is mediated through its receptors TNFR 1 ( p 55 ) and TNFR 2 ( p 75 ) . ^^^ We suggest that the expression of TNFR 1 and TNFR 2 after SCI may contribute to posttraumatic inflammatory responses of TNF alpha . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Co immunoprecipitation experiments showed that TRUSS was constitutively associated with unligated TNF R 1 and that the complex was relatively insensitive to stimulation with TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cytokine tumor necrosis factor alpha ( TNF alpha ) stimulates the NF kappaB , SAPK / JNK , and p 38 mitogen activated protein ( MAP ) kinase pathways by recruiting RIP 1 and TRAF 2 proteins to the tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TMJ tissues were removed 2 days post injection to mimic conditions of acute inflammation and analysed for changes in expression of TNF alpha , the receptor TNF R 1 , caspase 3 and 8 , and apoptosis . ^^^ Concentrations of TNF alpha , TNF R 1 , caspase 3 and 8 , and apoptosis were significantly elevated in CFA injected animals compared to uninjected controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
STAT 1alpha associates with TNFR 1 in TNF alpha treated cells , and this association attenuates TNF alpha mediated NF kappaB activation . ^^^ We hypothesized that nuclear localization of STAT 1alpha due to IFN gamma signaling would preclude it from being recruited to the TNFR 1 and therefore enhance TNF alpha induced NF kappaB activation . ^^^ In the RAW264 . 7 macrophage cell line , TNF alpha treatment indeed recruits STAT 1alpha to the TNFR 1 , and this association is abrogated when cells are exposed to IFN gamma . ^^^ Our results suggest that a receptor proximal level of cross talk exists between these two cytokine pathways : IFN gamma limits STAT 1alpha availability to the TNFR 1 by depleting STAT 1alpha from the cytoplasm , thus allowing for optimal NF kappaB activation upon TNF alpha ligation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The serum TNF alpha and soluble TNF receptors ( TNF RI , TNF RII ) were measured in the serum samples of these patients before and after ivIg therapy by a sandwich ELISA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha has significant in vitro effects on steroidogenesis and folliculogenesis and reproductive alterations occur in TNF receptor type 1 ( TNFR 1 ) knockout mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Effect of low protein diet and protein supplementation on the expressions of TNF alpha , TNFR 1 , and TNFR 2 in organs and muscle of LPS injected rats . ^^^ Protein and mRNA expression of TNF alpha , TNFR 1 , and TNFR 2 in liver , spleen , and gastrocnemius were measured by Western blot and RT PCR , respectively . ^^^ In liver , the changes in TNF alpha , TNFR 1 , and TNFR 2 were translational , whereas in spleen the effects were due to a combination of transcription and translation . ^^^ In conclusion , protein deficiency in endotoxic rats increases the expression of TNFR 1 and TNFR 2 in all organs studied and TNF alpha in selected ones . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In these studies , TNF receptor 1 ( TNFR 1 ) knockout mice were used to analyze the role of TNF alpha in hepatocyte proliferation during acetaminophen induced hepatotoxicity . ^^^ These data suggest that TNF alpha signaling through TNFR 1 is important in regulating hepatocyte proliferation following acetaminophen induced tissue injury . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVES : To estimate the serum concentrations of Tumour Necrosis Factor alpha ( TNF alpha ) and soluble TNF receptors ( s TNF RI and TNF RII ) in patients with Guillain Barre syndrome ( GBS ) , before and after treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This enhancement was attenuated by preincubation of ESCs with the antibody against the type 2 TNF alpha receptor ( TNF RII ) , but not by the antibody against the type 1 TNF alpha receptor ( TNF RI ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha effects are primarily mediated through the major TNF alpha receptor , TNF R 1 , which is constitutively expressed in most cell types . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Protection against liver injury by PGE 1 or anti TNF alpha is associated with a reduction of TNF R 1 expression in hepatocytes . ^^^ The expression of TNF alpha receptor type 1 ( TNF R 1 ) and TNF alpha receptor type 2 ( TNF R 2 ) in hepatocytes was assessed by immunohistochemistry and immunoprecipitation + Western blot analysis . ^^^ Although PGE 1 enhanced and anti TNF alpha reduced TNF alpha concentration in serum , both protective treatments reduced the expression of TNF R 1 in hepatocytes . ^^^ CONCLUSIONS : Our study showed that reduction of liver injury by PGE 1 or anti TNF alpha antibodies was related to a reduction of TNF R 1 expression in hepatocytes . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cisplatin increased the renal expression of TNF alpha , monocyte chemoattractant protein 1 ( MCP 1 ) , intercellular adhesion molecule ( ICAM ) 1 , heme oxygenase 1 , TNF receptor 1 ( TNFR 1 ) , and TNF receptor 2 ( TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF alpha receptor 1 ( sTNFR 1 ) is an extracellular domain of TNFR 1 and an antagonist to TNF alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Up to 200 unrelated German RA and JRA patients each and 300 400 healthy controls have been genotyped for HLA DRB 1 , TNFa , TNFA 238a / g , TNFA 308a / g , TNFA 857c / t , TNFR 1 609g / t , TNFR 1 P12P , TNFR 2 del 15bp , IKBL 332a / g , IKBL 132t / a , IKBL C224R , CTLA 4 318c / t , CTLA 4 T17A , PTPRC P57P , MIF 173g / c , the MIF and IFNG microsatellites as well as for D17S795 , D17S807 , D17S1821 by polyacrylamide gel electrophoresis , single strand conformation polymorphism analysis , restriction fragment length polymorphism analysis or allele specific hybridization . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we show that TNFR 1 , a receptor for tumor necrosis factor alpha ( TNF alpha ) that is widely distributed on the airway epithelium , is a receptor for protein A . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Provided that TNF R 1 mediates the cytotoxic actions of TNFalpha , these results support the concept of dysregulated TNF alpha metabolism in AH . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Binding of TNF alpha to TNF alpha receptor 1 ( TNF R 1 ) activates death domain pathways , leading to necrosis and apoptosis in most tissues , and it also increases the expression of intercellular adhesion molecules ( i . e . , ICAM 1 ) , which promote inflammation . ^^^ These results indicate that exposure of different cell types to pharmacologic concentrations of ethanol increases TNF R 1 levels and may augment TNF alpha mediated cell injury in different tissues . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It is conceivable that the multiple TNF mediated chronic inflammatory disorders differ in terms of the ligand form ( soluble TNF alpha versus membrane bound TNF alpha ) , the receptor ( TNF R 1 versus TNF R 2 ) and the downstream signaling cascades utilized . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSION : The differential effects of TNF alpha and IL 1beta on proximal tubular MMP 9 and TIMP 1 expression are mediated through the TNF RI , the IL 1 RI and the different signaling pathways of PKC , ERK1 / 2 , and p 38 MAPK . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The presence TNFR 1 ir on dorsal horn afferents , suggests that TNF alpha may be a mechanism responsible for tactile hypersensitivity during illness . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BRE , brain and reproductive organ expressed protein , was found previously to bind the intracellular juxtamembrane domain of a ubiquitous death receptor , tumor necrosis factor receptor 1 ( TNF R 1 ) , and to down regulate TNF alpha induced activation of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this regard , we show that AFP inhibits TNF alpha induced cell death of murine hepatocellular carcinomas through association with TNF alpha and inhibition of TNFRI signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Body composition was assessed by dual energy 10 ray absorptiometry and bioelectrical impedance spectrometry ; functional capacity by hand grip strength , quadriceps strength , and 30 second sit to stand test ; systemic inflammation by tumor necrosis factor alpha ( TNF alpha ) and TNF receptor 1 ( TNFR 1 ) ; serum and muscle IGF 1 and IGFBP 3 by radioimmunoassay ; and fragmentation of serum IGFBP 3 by Western immunoblotting . ^^^ TNF alpha and TNFR 1 were elevated in patients ( P < . 001 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Serum levels of cytokines ( IL 4 , IL 5 , IFN gamma , TNF alpha ) , cytokine receptors ( TNFR 1 and 2 ) and one monokine ( neopterin ) were estimated in seven leprosy patients to establish disease associated markers for reversal reactions ( RR ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Upregulation of TNF alpha was induced by depsipeptide in HL 60 and K 562 cells , which expressed type 1 TNF receptors ( TNF RI ) . ^^^ Anti TNF alpha neutralizing antibody and short interfering RNA ( siRNA ) against TNF RI alleviated the activation of the caspase cascade and the induction of apoptosis , indicating the presence of an autocrine loop . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Inhibition of the p 38 MAP kinase pathway rescues by 80 % the initiation of pX mediated apoptosis , whereas subsequent apoptotic events involve both pathways . pX mediated activation of p 38 MAP kinase and JNK pathways is sustained , inducing the transcription of the death receptor family genes encoding Fas / FasL and tumor necrosis factor receptor 1 ( TNFR 1 ) / TNF alpha and the p 53 regulated Bax and Noxa genes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We analyzed the roles of expression of CD 30 , CD30L , TNF alpha , TNF R 1 , FAS , and FAS L in the tumors , and found that HSV induced apoptosis was suppressed by the respective antibodies . ^^^ These findings indicate that the CD30 / CD30L , TNF alpha / TNF R 1 , and FAS / FAS L interactions resulted in apoptosis and tumor regression in immunocompromised mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IFN gamma , IL 18 , TGF beta , IL 6 , IP 10 , MCP 1 , MIG , and IL 8 , but not of TNF alpha , IL 2 , IL 4 , IL 10 , IL 13 , or TNFRI , were highly elevated in the acute phase sera of Taiwan SARS patients . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The interaction of TNF alpha with TNF receptor 1 ( TNFR 1 ) activates several signal transduction pathways that lead to apoptosis or NF kappa B dependent inflammation and immunity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : In patients with RA under general anesthesia , the levels of IL 6 , TNF alpha , and TNF R 1 and TNF R 2 in the peripheral blood were significantly decreased compared with the levels before anesthesia ( p < 0 . 01 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In summary , these data show that IPC produces neuronal upregulation of TACE and TNFR 1 , and that the pathway TACE / TNF alpha / TNFR1 / NF kappaB is involved in IT . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : TNF alpha , TNF receptor 1 ( RI ) and TNF RII levels were significantly lower in controls ( P=0 . 02 ) than in subjects with LD , and there was a significant decrease in TNF RI and TNF RII levels ( P=0 . 01 and 0 . 03 , respectively ) on stopping PIs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , using primary Mphis from mice deficient in TNFR 1 , TNFR 2 , or both TNF alpha receptors ( TNFRs ) , we determined that AQARSAASKVKVSMKF induces MMP 9 expression by Mphis through a pathway triggered by TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effects of age and CR on muscle mass , myocyte area , fiber number , myocyte TNF alpha expression , plasma TNF alpha levels , and specific elements linked with the TNF alpha signaling cascade ( TNF R 1 , IKKgamma , IkappaBalpha , p 65 , NF kappaB binding activity , FADD , caspase 8 , and DNA fragmentation ) were investigated in soleus ( predominately Type 1 fiber ) , and superficial vastus lateralis ( SVL , predominately Type 2 fiber ) , of 6 month old ad libitum fed ( 6AL ) , 26 month old ad libitum fed ( 26AL ) , and 26 month old calorie restricted ( 26CR ) male Fischer 344 rats ( CR = 40 % restriction compared with ad libitum ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha induced hypernociception was abolished in TNF R 1 / mice , partially inhibited by pretreatment with IL 1 receptor antagonist ( IL 1ra ) or indomethacin and unaffected by Ab against KC ( AbKC ) or guanethidine . ^^^ In mice , the cytokine cascade begins with the release of TNF alpha ( acting on TNF R 1 receptor ) and KC , which stimulate the release of IL 1beta . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we extended the study and investigated TNF alpha receptor 1 ( / ) ( TNFR 1 ) and TNF alpha receptor 2 ( / ) ( TNFR 2 ) mice using a chronic MPTP dosing regimen ( 15 mg / kg MPTP on 8 consecutive days ) . ^^^ In contrast to TNF alpha deficiency neither TNFR 1 nor TNFR 2 gene ablation showed protection against MPTP neurotoxicity , which argues for a protective mechanism of TNF alpha not mediated by TNFR 1 and TNFR 2 signaling . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A human cell line ectopically expressing CIN 85 was 10 times more susceptible to TNF alpha induced apoptosis than control cells , which expressed identical levels of TNFR 1 on their surface . ^^^ TNF alpha treatment recruited CIN 85 to the TNFR 1 signaling complex . ^^^ Taken together , these results indicate that CIN 85 associates with TNFR 1 via Src and modulates TNF alpha induced apoptosis . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha , a pro inflammatory cytokine , exerts its biological activity by signaling via its two receptors , TNFR 1 and TNFR 2 and by activating NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of TNF alpha , TNF R 1 , TRAIL , NF ( kappa ) B and caspase 8 were studied in muscle biopsy specimens from 14 patients with a dystrophinopathy [ 10 Duchenne muscular dystrophies ( DMD ) , 2 Becker MD , and 2 DMD carriers ] by immunohistochemistry and Western blotting . ^^^ In all types of dystrophinopathies , necrotic muscle fibres undergoing myophagocytosis displayed strong expression of TNF alpha , TNF R 1 , and TRAIL , which , however , was attributed to phagocytosing cells and not to the muscle fibres themselves . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , TNF alpha administration to rodents results in increased expression and secretion of leptin from adipose tissue in a manner dependent on type 1 TNF alpha receptor ( TNF RI ) . ^^^ Epididymal TNF alpha and membranous TNF RI ( mTNF RI ) concentrations were both 2 . 3 times higher in DMN rats than in ad libitum controls but did not differ between ad libitum and pair fed groups . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 1 / and TNFR 2 / mice had increased serum concentrations of interleukin ( IL ) 1beta and total TNF alpha ( free plus receptor bound ) compared with wild type mice , but there were no differences in IL 6 or IL 10 concentrations . ^^^ These data suggest that in sepsis , TNFR 1 mediates much of the TNF alpha induced pathology , whereas TNFR 2 mediates protective effects . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Constitutive and LPS stimulated AM production of TNF alpha , TNF soluble receptors CD120a and CD120b , and IL 10 at the protein and mRNA level were measured by bioassay , ELISA and competitive PCR respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of tumour necrosis factor alpha ( TNF alpha ) and its receptors ( TNF R 1 , TNF R 2 ) , vascular endothelium growth factor ( VEGF ) and its receptors ( VEGF R 1 , VEGF R 2 ) were analysed by immunohistochemistry . ^^^ Transcranial vibration caused expression of TNF alpha , TNF R 1 and TNF R 2 in the cochlea and the expression of TNF R 2 was stronger than that of TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The engagement of TNFR 1 by TNF alpha led to a time dependent increase in acid sphingomyelinase ( SMase ; ASM ) activity , corresponding with a decrease in cellular sphingomyelin . ^^^ This potent ability of TNF alpha to rapidly modulate the TCR Ca ( 2+ ) signal via TNFR 1 induced ASM activation can explain its suppressive effect on T cell function . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As expected , the broad spectrum zinc metalloprotease inhibitor TNF alpha protease inhibitor 2 ( TAPI 2 ) attenuated clasto lactacystin beta lactone mediated TNFR 1 shedding , which is consistent with its ability to inhibit the zinc metalloprotease catalyzed cleavage of TNFR 1 ectodomains . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Hierarchical phosphorylation of the TNF alpha receptor , TNF R 1 , by p42Mapk / Erk at basic Pro directed kinase sites . ^^^ Phosphorylation of the TNF alpha receptor TNF R 1 has been shown to differentially regulate receptor signaling and function and promote changes in its subcellular localization . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The majority of biological responses classically attributed to tumor necrosis factor alpha ( TNF alpha ) is mediated by p 55 receptor ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 17A and IL 17F were potent inducers of growth related oncogene alpha and G CSF in HBE cells , and significant synergism was observed with TNF alpha largely due to signaling via TNFRI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , excessive production of proinflammatory cytokines , including TNF alpha , was observed in TNFR 1 deficient mice , compared with that observed in infected C57BL / 6 mice , which suggests that production was dysregulated in the absence of TNFR 1 signaling . ^^^ These data indicate that the antibacterial host response is dysregulated in mice lacking TNFR 1 or TNF alpha bioactivity . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The mRNA content of both TNF alpha and its receptors ( TNFR 1 and TNFR 2 ) in skeletal muscle and adipose tissue from cachectic rats has been assessed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These CSF samples were analyzed by ELISA for the presence of TNF alpha and soluble TNFR 1 and TNFR 2 ( sTNFR 1 and sTNFR 2 , respectively ) . ^^^ The spinal cord tissue was analyzed by immunohistochemistry for the expression of TNF alpha , TNFR 1 , and TNFR 2 , and by the TUNEL technique for the occurrence of neuronal death . ^^^ It is concluded that the shedding of TNFR 1 receptor may represent an important post traumatic physiological response aimed at reducing the proapoptotic effect of TNF alpha . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We evaluated the effect of an in vivo weekly iloprost treatment on TNF alpha and IL 6 monocyte production ( evaluated by ELISA ) , on monocyte apoptosis ( Annexin V / uptake of propidium iodide by flow cytometry ) and on peripheral blood mononuclear cell ( PBMC ) TNF alpha receptors ( TNF RI and TNF RII ) mRNA expression ( RT PCR ) in 14 atherosclerotic critical limb ischemia patients . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present study , the endometrial expressions of TNF alpha and its receptors ( TNFR 1 and TNFR 2 ) during early pregnancy , when the embryo lies free in the zona hatched state in the uterine lumen , were analyzed by immunohistochemistry . ^^^ The endometrial expressions of TNF alpha , TNFR 1 and TNFR 2 were found to be significantly up regulated ( p < 0 . 05 ) in the glandular epithelium on day 6 post ovulation in pregnant animals . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological effects of TNF alpha are mediated by binding to TNF receptors TNFR 1 ( also known as P 60 ) or TNFR 2 ( also known as P 80 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Production of soluble form of human TNF alpha ligand binding domain type 1 receptor by expression in Drosophila cells ] . 5His tagged human TNFalpha type 1 receptor ( TNFR 1 ) ligand binding domain was produced in Drosophila cells under control of metallothionein Cu inducible promoter and purified by Ni NTA affinity chromatography to homogeneity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , mice deficient in TNF alpha , tumor necrosis factor receptor 1 ( TNFRI ( / ) ) , and LTbetaR exhibited progressive impairment in malaria induced spleen closing . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In order to reveal the mechanisms underlying nurse cell formation during Trichinella spiralis infection , the expression of the factors of tumor necrosis factor alpha ( TNF alpha ) / TNF receptor 1 ( TNFR 1 ) signalling pathway mediating apoptosis was investigated . ^^^ The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^ Thus the present study suggests that the TNF alpha / TNFR 1 signalling pathway is involved in nurse cell formation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 1 was established as the main receptor involved in IL 12p40 regulation , because IL 12p40 levels were not affected by TNF alpha in TNFR 1 ( / ) derived macrophages . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha , TNFRI , and TNFRII mRNA expression was increased significantly in the colon of experimental animals compared to controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , we have found that TAK 1 is recruited to the TNF alpha receptor complex in a RIP dependent manner following the stimulation of TNF alpha receptor 1 ( TNF R 1 ) . ^^^ Moreover , a forced recruitment of TAK 1 to TNF R 1 in the absence of RIP is sufficient to mediate TNF alpha induced NF kappaB activation , indicating that the major function of RIP is to recruit its downstream kinases to the TNF R 1 complex . ^^^ Together , we conclude that TAK 1 is recruited to the TNF R 1 complex via RIP and likely cooperates with MEKK 3 to activate NF kappaB in TNF alpha signaling . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cryolesion produced a clear induction of the proinflammatory cytokines interleukin ( IL ) 1alpha , IL 1beta , IL 6 , and TNF alpha ; this induction was significantly lower in the TNFR 1 KO mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We show that exposing brain capillaries to the inflammatory cytokine tumor necrosis factor alpha ( TNF alpha ) , activated a TNF R 1 receptor , released ET 1 , activated ET ( B ) receptor signaling , and essentially abolished P glycoprotein mediated transport . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , only TNFRI was involved in TNF alpha induced chemokine production and apoptosis by NPCs , as anti TNFRI but not anti TNFRII antibodies blocked the stimulatory effect . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Activation of caspase 8 can occur via a death receptor dependent mechanism ( e . g . , TNF alpha binding to TNF alpha receptor 1 ( TNF R 1 ) ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The pluripotent cytokine tumor necrosis factor alpha ( TNF alpha ) binds to its cognate TNF receptor 1 ( TNF RI ) to stimulate inflammation via activation of the NF kappaB transcription factor . ^^^ To prevent the detrimental effects of TNF alpha in keratinocytes infected with the molluscum contagiosum virus ( MCV ) , this poxvirus is expected to produce proteins that block at least one step of the TNF RI signal transduction pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , astrocytes were found to constitutively and predominantly transcribe , translate and shed TNFR 1 rather than TNFR 2 , but TNFR 2 expression was increased by adding TNF alpha , IL 1 , and IFN gamma , but not by adding LPS . ^^^ To determine the functional roles of TNFR 1 and TNFR 2 on TNF induction , we investigated NF kappaB activation and TNF alpha induction after neutralizing TNFR 1 and TNFR 2 by an antibody treatment . ^^^ We found that NF kappaB activation and TNF alpha induction are blocked by TNFR 1 neutralizing antibody treatments . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cytokines such as tumor necrosis factor alpha ( TNF alpha ) , FasL , and TNF related apoptosis inducing ligand ( TRAIL ) induce apoptosis or inflammation through binding to their specific receptors , TNFR 1 , Fas , and DR 5 , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
But , in comparison to non cancer controls , HCC patients had higher values of IL 2R , IL 6R , TNF RI and TNF RII , but lower TNF alpha ( P < 0 . 001 ) . ^^^ But , in comparison to non cancer controls , CLD patients had higher values of IL 2R , TNF RI and TNF RII , but lower TNF alpha ( P < 0 . 001 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Intracerebral administration of either anti TNF alpha antibody or of a TNFR 1 antisense oligodeoxynucleotide also inhibited ischemic preconditioning induced EAAT 3 up regulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have examined the expression of TNF alpha and its receptors , TNFR 1 and TNFR 2 , during gastrulation in the chick embryo , and have investigated the possible role of this factor in the control of cell death at this early stage of development . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we show that constitutive MMP 9 secretion was abrogated in THP 1 monocytic leukemia cells by addition of neutralizing antibodies against tumor necrosis factor alpha ( TNF alpha ) or TNF receptor type 1 ( TNF R 1 ) , as well as by inhibition of TNF alpha converting enzyme ( TACE ) . ^^^ This indicates that MMP 9 production in these cells is maintained by autocrine stimulation , with TNF alpha acting via TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present work we have evaluated the expression of many pro inflammatory TNF system cytokines ( TNF alpha , TWEAK and their respective receptors , TNFR 1 , TNFR 2 and Fn 14 ) in human adipose tissue of 84 subjects some with different degree of obesity and type 2 diabetes , and its relation with inflammation by also measuring the expression of macrophage marker CD 68 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF alpha receptor 2 ( TNF RII ) was localized in the cytoplasm , whereas TNF receptor 1 ( TNF RI ) was found in both cytoplasm and plasma membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The proinflammatory cytokine tumor necrosis factor alpha ( TNF alpha ) and both its receptors ( TNFRI and TNFRII ) are expressed in biopsies of this malignancy . ^^^ Treatment with TNF alpha induced TNF alpha mRNA via TNFRI in both malignant and normal cells with evidence for enhanced TNF alpha mRNA stability in tumor cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Reverse transcriptase polymerase chain reaction , and flow cytometry demonstrated that Ramos cells expressed TNF R 1 but very little if any TNF R 2 , indicating that TNF alpha exerted its effects on Ramos cells through the former receptor . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The B 16 melanoma expresses TNFa mRNA , and induced SMW with no change in muscle levels of TNFa type 1 receptor ( TNFR 1 ) protein . ^^^ In contrast , the Lewis lung carcinoma expresses low levels of TNFa mRNA , induced SMW , and increased muscle levels of TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Partial 30 % liver transplantation was performed in C57BL / 6 wild type mice ( control group ) , and in three groups with down regulation of the TNF alpha pathway : ( 1 ) TNF receptor 1 knockout [ TNFR 1 ( / ) ] mice , and mice pretreated with ( 2 ) gadolinium chloride or ( 3 ) pentoxifylline ( PTX ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We report the serum concentrations of interleukin 6 ( IL 6 ) , tumour necrosis factor alpha ( TNF a ) , tumour necrosis factor receptors 1 and 2 ( TNFR 1 and 2 ) in a prospective , randomized , double blind trial involving the administration of AM 3 ( Inmunoferon ) , an oral booster immunomodulator , or placebo to 16 professional cyclists ( n = 8 in each group ) for 65 consecutive days . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The interaction of TNF alpha with TNF receptor 1 and receptor 2 ( TNFR 1 , TNFR 2 ) activates several signal transduction pathways , leading to the diverse functions of TNF alpha . ^^^ In this review , covering TNF alpha from the molecule to the clinic , we provide an overview of the use of TNF alpha in cancer starting with molecular insights into TNFR 1 signaling and cellular mechanisms of the antitumor activities of TNF alpha and ending with clinical response . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice treated with the TNF alpha blocking agent etanercept , as well as TNFRI knockout mice , are resistant to development of both coronary arteritis and coronary aneurysm formation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We found that immunoreactivity ( IR ) of TNF alpha and TNF receptor 1 ( TNFR 1 ) in ipsilateral ( but not in contralateral ) L 4 and L 5 dorsal root ganglion ( DRG ) was increased following L 5 VRT , started 1 day after the lesion and persisted for 2 weeks . ^^^ Double immunofluorescence staining revealed that the increased TNF alpha IR in DRG was in satellite glial cells , immune cells and neuronal cells , while TNFR 1 IR was almost restricted at DRG neuronal cells . ^^^ L 5 VRT increased TNF alpha IR and TNFR 1 IR in bilateral L 5 spinal dorsal horn , started 1 day after lesion and persisted for 2 weeks . ^^^ The increased TNF alpha IR in spinal dorsal horn was observed in astrocytes , microglias and neurons , but the upregulation of TNFR 1 was mainly in neurons . ^^^ These data suggest that the upregulation of TNF alpha and TNFR 1 in DRG and spinal dorsal horn is essential for the initiation but not for maintenance of the neuropathic pain induced by L 5 VRT . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of this study was to determine the kinetics and biologic role of TNF alpha and its receptors , TNF R 1 and TNF R 2 , in rat cardiac allografts . ^^^ RESULTS : During acute and chronic rejection , an increase in intragraft TNF alpha and TNF R 2 mRNA expression was recorded , but not TNF R 1 mRNA expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
SpA is also a potent activator of tumor necrosis factor alpha ( TNF alpha ) receptor 1 ( TNFR 1 ) signaling , inducing both chemokine expression and TNF converting enzyme dependent soluble TNFR 1 ( sTNFR 1 ) shedding , which has anti inflammatory consequences , particularly in the lung . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : We hypothesize that genetic variations ( single nucleotide polymorphisms SNPs ) in the tumor necrosis factor alpha ( TNF alpha ) , TNF receptors ( TNFRI and TNFRII ) , interleukin 6 ( IL 6 ) and IL 6 receptor ( IL 6R ) genes predict high risk status for spontaneous preterm birth ( sPTB ) in European American women . ^^^ STUDY DESIGN : Maternal DNA from cases of sPTB after preterm labor ( n = 101 ) and controls ( normal term labor and delivery ) ( n = 321 ) were genotyped for SNPs in the TNF alpha ( 6 ) , TNFRI ( 6 ) , TNFRII ( 7 ) , IL 6 ( 5 ) , and IL 6R ( 3 ) loci . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These effects are blocked by addition of soluble TNFR 1 ( sTNFbp ) , suggesting that a TNF alpha signaling pathway mediates these biological activities . sTNFbp also reduced the production of exosomes by RASF , suggesting the interruption of a positive amplification loop . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , we observed increased synthesis of tumor necrosis factor ( TNF ) alpha within infarcted hearts and TNF alpha receptor type 1 ( TNFR 1 ) within injured arteries . ^^^ CONCLUSIONS : Conditions after AMI could exacerbate postangioplasty restenosis , not by increasing mobilization of BM derived cells , but by stimulating signaling via TNF alpha , TNFR 1 and IL 6 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The number of testicular lymphocytes , mast cells and macrophages , and the expression of tumor necrosis factor alpha ( TNF alpha ) and its receptor ( TNFR 1 ) in testicular cells of the contralateral testis were quantified by histochemistry and immunohistochemistry . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We measured the serum levels of TNF alpha , its receptors ( tumor necrosis factor receptor 1 [ TNFR 1 ] and tumor necrosis factor receptor 2 [ TNFR 2 ] ) , and CHGA before and during the treatment . ^^^ The serum levels of TNFR 1 and TNFR 2 , which are a sensitive marker for the TNF alpha pathway , correlated with those of CHGA before treatment ( Pearson ' s coefficient , respectively , 0 . 59 and 0 . 53 ) . ^^^ Treatment with anti TNF alpha mAb provided a significant clinical response in all patients and the correlation between CHGA and TNFR 1 and TNFR 2 was no more evident during treatment ( respectively , 0 . 09 and 0 . 07 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Only IL 6 ( p=0 . 033 ) and TNFRI ( p < 0 . 001 ) increased statistically significantly after ablation , while the TNF alpha , IL 1 beta , and IL 10 levels remained unchanged . ^^^ MRI guided laser thermoablation induced an early systemic inflammatory reaction with statistically significantly elevated IL 6 , TNFRI , and CRP levels but not TNF alpha or IL 10 levels and without procedure related complications , favoring this procedure as a safe therapeutic alternative for well selected patients with liver tumors . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The generation of the anti apoptotic signal on binding of TNF alpha to the TNF receptor ( TNFR ) 1 has been shown to be associated with the recruitment of TRAF 2 to the TNFR 1 in a process that requires ubiquitination of TRAF 2 with lysine 63 linked polyubiquitin chains . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ PBMCs of RA patients showed a significant increase in TNF alpha and TNFR 1 expression as compared with that from control subjects along with significantly increased constitutive expression of TRADD , RIP , and TRAF 2 mRNA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunoexpression of TNF alpha and its receptors ( TNFRI and TNFRII ) were studied by western blotting and immunohistochemistry . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) is a proinflammatory cytokine , acting through the TNF R 1 and TNF R 2 receptors . ^^^ The two receptors have been proposed to mediate distinct TNF alpha effects in the CNS , TNF R 1 contributing to neuronal damage and TNF R 2 being neuroprotective . ^^^ Here we used mouse models with loss of TNF R 1 and TNF R 2 function to establish whether signaling through these receptors could influence hippocampal neurogenesis in vivo under basal conditions , as well as after status epilepticus ( SE ) , which is associated with inflammation and elevated TNF alpha levels . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Clones encoding the entire coding and 3 ' untranslated region of the human type 1 tumor necrosis factor receptor ( p 60 ) gene ( TNFR 1 ) were isolated by hybridization using probes derived from TNFR 1 cDNA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The largest group comprises the extracellular domains of cell surface cytokine receptors , and includes both tumor necrosis factor receptors ( TNF R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Site directed in vitro mutagenesis was employed to examine the processing of the p 55 tumor necrosis factor receptor chain ( TNF R 55 ) into soluble TNF binding protein ( TNF R 55 BP ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR 1 and TNFR 2 , the genes encoding the two forms of the human tumor necrosis factor receptor , were localized to normal human chromosomes by in situ hybridization and Southern blot analysis of a series of human 10 mouse hybrid cell lines . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To localize the protease ( s ) involved in shedding of tumor necrosis factor receptors ( TNF R ) from activated neutrophils ( PMN ) ( Porteu , F . , and C . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor genes , TNFR 1 and TNFR 2 , on human chromosomes 12 and 1 . ^^^ There are at least two types of receptors , tumor necrosis factor receptors 1 and 2 ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunological cross reactivity between tumor necrosis factor ( TNF ) binding proteins which are present in human urine ( designated TBPI and TBPII ) and two molecular species of the cell surface receptors for TNF is demonstrated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The individual roles of the murine type 1 and type 2 tumor necrosis factor ( TNF ) receptors ( TNF R 1 and TNF R 2 ) were investigated utilizing ( 1 ) the strong species specificity of TNF R 2 for murine TNF compared to human TNF and ( 2 ) agonistic rabbit polyclonal antibodies directed against the individual TNF receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Incubation of HeLa cell cultures with human interferon gamma ( IFN gamma ) increased the binding of radioiodinated human tumor necrosis factor ( TNF ) to specific cell surface receptors ( TNF R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Plasma levels of tumor necrosis factor ( TNF ) , interleukin 6 ( IL 6 ) , IL 8 , TNF receptors ( TNF R ) , and the TNF / TNF R ratios were significantly higher in severe malaria compared with uncomplicated malaria . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Monocyte expression and secretion of tumor necrosis factor ( TNF ) and TNF receptors ( TNF R ) p 55 and p 75 was studied in patients receiving granulocyte macrophage colony stimulating factor ( GM CSF ) after intensive chemotherapy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previously we demonstrated that two soluble ( s ) tumor necrosis factor receptors , TNF R 55 as well as sTNF R 75 , are constitutively released in vitro by monocytes , and that this release was markedly enhanced after activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble intercellular adhesion molecule 1 ( ICAM 1 ) , endothelial leukocyte adhesion molecule 1 ( ELAM 1 ) , and tumor necrosis factor receptor ( 55 kDa TNF R ) in patients with acute Plasmodium falciparum malaria . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Whereas there is ample evidence for involvement of the p 55 tumor necrosis factor ( TNF ) receptor ( p 55 R ) in the cytocidal effect of TNF , the role of the p 75 TNF receptor ( p 75 R ) in this effect is a matter of debate . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor ( TNF R ) and APO 1 / Fas ( CD 95 ) are members of the tumor necrosis factor / nerve growth factor receptor superfamily involved in various forms of physiological cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) is a potent activator of neutrophil granulocytes , which acts via two cell surface receptors : the p 55 TNF receptor ( TNF R 55 ) and the p 75 TNF receptor ( TNF R 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 is a member of the tumor necrosis factor receptor ( TNF R ) family that regulates B lymphocyte proliferation , immunoglobulin class switching , and apoptosis through poorly defined signal transduction mechanisms . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RIP also interacts weakly with the p 55 tumor necrosis factor receptor ( TNFR 1 ) intracellular domain , but not with a mutant version of Fas corresponding to the murine lprcg mutation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas and the type 1 tumor necrosis factor receptor ( TNF R ) are two cell surface receptors that , when stimulated with ligand or cross linking antibody , trigger apoptotic cell death by a mechanism that has yet to be elucidated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
By using monoclonal antibody specific for tumor necrosis factor receptor 80 ( TNFR 80 ) ( CD120b ) and TNFR 60 ( CD120a ) , we determined which receptor transduces the signals involved in activating natural killer ( NK ) cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice bearing a transgene coding for a soluble tumor necrosis factor receptor type 1 ( TNFR 1 ) FcIgG 3 fusion protein and placed under the control of the alpha 1 antitrypsin gene promoter were generated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In order to analyse the physiological relevance of the 55 kDa tumor necrosis factor receptor 1 ( TNFR 1 ) and its role in various TNF related pathological conditions , such as septic shock , we have generated mice by gene targeting deficient for TNFR 1 expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Induced shedding of the p 55 tumor necrosis factor receptor ( p 55 R ) was previously shown to be independent of the amino acid sequence properties of the intracellular domain of this receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cloning , sequencing and partial functional characterization of the 5 ' region of the human p 75 tumor necrosis factor receptor encoding gene ( TNF R ) . ^^^ A 1887 bp region at the 5 ' flank of the human p 75 tumor necrosis factor receptor ( p 75 TNF R ) encoding gene was found to be active in driving expression of the luc ( luciferase encoding ) reporter gene , suggesting that it contains the promoter for the receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) , through binding to the 55 kDa TNF receptor ( TNF R 55 ) , rapidly activates two distinct types of SMase , a membrane associated neutral ( N ) SMase , and an endosomal acidic ( A ) SMase . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The two tumor necrosis factor ( TNF ) receptors ( TNF R 55 and TNF R 75 ) can release soluble TNF binding proteins ( TNF R 55 BP and TNF R 75 BP ) by proteolytic cleavage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This review summarizes the mutant phenotypes of mice carrying a null mutation in the cytokine IL 6 gene or the tumor necrosis factor receptor 1 ( Tnfr 1 ) gene . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two types of tumor necrosis factor membrane receptors ( TNF R ) have been identified , namely 55 and 75 kDa TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Given the conflicting data pertaining to the role of tumor necrosis factor alpha ( TNF ) in Leishmania infection , we analyzed the expression of TNF , tumor necrosis factor beta ( lymphotoxin ) , and TNF receptor type 1 ( TNF RI ) and type 2 ( TNF RII ) genes in vivo and correlated TNF gene expression in vivo with the production of biologically active TNF by lymphoid cells in vitro . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using the RT / PCR method , we examined mRNA expression of several inflammatory factors in mouse embryos during mid late embryonal development . mRNAs of tumor necrosis factor ( TNF ) alpha , TNF beta , their receptors ( TNF RI , TNF RII ) , transforming growth factor ( TGF ) beta , were expressed constitutively in most of the embryonic tissues . 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two separate tumor necrosis factor ( TNF ) receptors of approximately 55 kDa ( TNF R 55 ) and 75 kDa ( TNF R 75 ) have been identified . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have demonstrated the presence of the 55 and 75 kDa receptor for tumor necrosis factor ( TNF ) and lymphotoxin ( LT ) ( TNF R ) in serum , and ascites from women with ovarian cancer . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
An 809 bp region at the 5 ' flank of the human p 55 tumor necrosis factor receptor ( TNF R ) encoding gene was found to be active in driving expression of the cat reporter gene , indicating that it contains a functional promoter . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To study mechanisms of antibiotic effects in typhoid fever , levels of interleukin 6 ( IL 6 ) , gamma interferon ( IFN gamma ) , and cytokine receptors ( tumor necrosis factor receptor [ TNF R ] p 55 and TNF R p 75 ) were measured in the plasma of 29 adult Nepalese with culture positive typhoid fever before therapy and on days 4 and 15 after start of therapy with either ceftriaxone at 2 g / day for 3 days or chloramphenicol at 50 mg / kg of body weight per day for 14 days . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effect of tumor necrosis factor alpha ( TNF ) on the expression of its specific receptors ( p 55 TNF R and p 75 TNF R ) on the surface of human neutrophils ( PMN ) and mononuclear cells ( MNC ) was investigated and compared to the effect of various agonists . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To understand the role of the 75 kDa tumor necrosis factor ( TNF ) receptor in non lymphoid cells , the cytotoxic signaling and ligand binding activities of the 55 kDa ( TNF R 1 ) and 75 kDa ( TNF R 2 ) TNF receptors were investigated using agonist and antagonist antibodies specific for the two receptor types . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The 60 kDa tumor necrosis factor receptor ( TNFR 60 ) is regarded as the major signal transducer of TNF induced cellular responses , whereas the signal capacity and role of the 80 kDa TNFR ( TNFR 80 ) remain largely undefined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) can induce apoptosis and activate NF kappa B through signaling cascades emanating from TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas antigen / Apo 1 ( Fas ) and the p 55 tumor necrosis factor receptor ( TNF R ) are two related cell surface molecules that induce apoptosis in susceptible cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recombinant human tumor necrosis factor ( TNF ) binding protein 1 ( r h TBP 1 ) and recombinant human soluble dimeric TNF receptor ( rhu TNFR : Fc ) were used to determine the relative contributions of TNF to phorbol myristate acetate ( PMA ) and cytokine induced human immunodeficiency virus type 1 ( HIV 1 ) replication in chronically infected cell lines . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The death domain of tumor necrosis factor ( TNF ) receptor 1 ( TNFR 1 ) triggers distinct signaling pathways leading to apoptosis and NF kappa B activation through its interaction with the death domain protein TRADD . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNF R 1 ) mediates most of the biological properties of TNF including activation of the transcription factor NF kappaB and programmed cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The role of the two types of tumor necrosis factor ( TNF ) receptors , TNF R 1 and TNF R 2 , in mediating the capacity of TNF to stimulate nerve growth factor ( NGF ) production in fibroblasts has been investigated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas / APO 1 and p 55 tumor necrosis factor ( TNF ) receptor ( p 55 R ) activate cellular mechanisms that result in cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor p 75 ( TNF R p 75 ) is a 75 kDa type 1 transmembrane protein expressed predominantly on cells of hematopoietic lineage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The development of arthritis in SCID animals can be prevented by infection ex vivo of DBA / 1 spleen cells with retroviruses expressing the monomeric soluble human p 75 tumor necrosis factor ( TNF ) receptor ( TNF R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The past year has witnessed remarkable advances in the understanding of signaling by the two TNF ( tumor necrosis factor ) receptors , TNFR 1 and TNFR 2 , and the related CD 40 receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signals triggered by tumor necrosis factor ( TNF ) are mediated by its two receptors : the 55 kDa TNF receptor one ( TNF R 1 ) and the 75 kDa TNF receptor two ( TNF R 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNFR 1 ) and CD 95 ( also called Fas or APO 1 ) are cytokine receptors that engage the apoptosis pathway through a region of intracellular homology , designated the `` death domain . ' ' Another death domain containing member of the TNFR family , death receptor 3 ( DR 3 ) , was identified and was shown to induce both apoptosis and activation of nuclear factor kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Activation of either the 55 kD tumor necrosis factor receptor ( TNF R 1 ) or CD 95 ( Fas / Apo 1 ) causes apoptosis of cells and liver failure in mice , and has been associated with human liver disorders . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To dissect tumor necrosis factor receptor ( Tnfr ) 1 ( CD120a ) and Tnfr 2 ( CD120b ) dependent signal transduction pathways , primary fibroblasts isolated from inguinal adipose tissue of wild type ( wt ) , tnfr 1 ( o ) , tnfr 2 ( o ) , and tnfr 1 ( o ) / tnfr2 ( o ) mice were studied . ^^^ Tumor necrosis factor receptors ( Tnfr ) in mouse fibroblasts deficient in Tnfr 1 or Tnfr 2 are signaling competent and activate the mitogen activated protein kinase pathway with differential kinetics . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The 55 kDa receptor for tumor necrosis factor ( TNF R 55 ) has become a paradigm for membrane receptors that are devoid of intrinsic enzymatic activity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , exogenous recombinant tumor necrosis factor ( TNF ) induced in vivo and in vitro enhanced CD 14 expression in Lpsn , Lpsd and also in TNF receptor 2 deficient ( TNFR 2 / ) mice , but failed to do so in TNFR 1 / mice , showing that TNFR 1 mediates the effect of TNF on CD 14 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The molecules which directly mediate adhesion between ATL cells and HUVEC were determined to be OX 40 and gp 34 , a member of the tumor necrosis factor receptor ( TNF R ) family and TNF family , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Interaction of the p 55 tumor necrosis factor receptor 1 ( TNF R 1 ) associated signal transducer TRADD with FADD signals apoptosis , whereas the TNF receptor associated factor 2 protein ( TRAF 2 ) is required for activation of the nuclear transcription factor nuclear factor kappa B . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Two receptors that contain the so called `` death domain ' have been described to date : tumor necrosis factor receptor 1 ( TNFR 1 ) and Fas / Apo 1 ( CD 95 ) ; both belong to the TNFR gene family . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Membrane tumor necrosis factor ( TNF ) induced cooperative signaling of TNFR 60 and TNFR 80 favors induction of cell death rather than virus production in HIV infected T cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Engagement of CD 95 or tumor necrosis factor 1 receptor ( TNFR 1 ) by ligand or agonist antibodies is capable of activating the cell death program , the effector arm of which is composed of mammalian interleukin 1beta converting enzyme ( ICE ) like cysteine proteases ( designated caspases ) that are related to the Caenorhabditis elegans death gene , CED 3 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine whether cytokines are involved in the initiation of liver growth , we studied the regeneration of the liver after partial hepatectomy ( PH ) in mice lacking type 1 tumor necrosis factor receptor ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FADD and FLICE participate in generating the death signal from both tumor necrosis factor receptor 1 ( TNFR 1 ) and the CD 95 receptor . ^^^ The flow of death signals from TNFR 1 occurs through the adaptor molecule tumor necrosis factor receptor associated death domain protein ( TRADD ) to FADD to FLICE , whereas for CD 95 the receptor directly communicates with FADD and then FLICE . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The death domain of the type 1 tumor necrosis factor receptor ( TNFR 1 ) mediates interactions with several proteins involved in signaling the downstream effects of TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the safety and efficacy of p 55 tumor necrosis factor receptor fusion protein , a recombinant chimeric protein of human p 55 ( type 1 ) tumor necrosis factor receptor ( CD120a ) extracellular domain and IgG 1 sequences ( referred to as p 55 IgG ) , in the treatment of patients with severe sepsis or septic shock . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The various biological activities of tumor necrosis factor ( TNF ) are mediated by two receptors , one of 55 kD ( TNF R 55 ) and one of 75 kD ( TNF R 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Baboons ( Papio anubis ) receiving a lethal intravenous infusion with live Escherichia coli were pretreated with either a 55 kDa tumor necrosis factor ( TNF ) receptor IgG fusion protein ( TNFR 55 : IgG ) ( n = 4 , 4 . 6 mg / kg ) or placebo ( n = 4 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) are membrane proteins that signal for apoptotic cell death by downstream activation of proteins of the interleukin 1 beta converting enzyme ( ICE ) family . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CASP 8 and CASP 10 , members of a cysteine protease family that participates in apoptosis , interact with MORT1 / FADD , an adapter protein in the CD120a ( p 55 tumor necrosis factor receptor ) , and CD 95 ( Fas / Apo 1 ) death inducing signaling pathways , through a shared N terminal sequence motif , the death effector domain . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine the nature of the so called inflammatory syndrome in schizophrenia , we investigated the circulating levels of various cytokines ( interleukin ( IL ) 1 beta , IL 6 , tumor necrosis factor ( TNF ) alpha ) , their natural antagonist ( IL 1 ra , TNF RI , TNF RII ) and leukocyte activation markers ( the soluble receptor of interleukin 2 , soluble CD 14 and soluble CD 23 ) in subjects with chronic schizophrenia ( n = 18 ) and in normal controls ( n = 21 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Like other members of the tumor necrosis factor ( TNF ) receptor family , p 55 TNF receptor 1 ( TNF R 1 ) lacks intrinsic signaling capacity and transduces signals by recruiting associating molecules . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) induced apoptosis is mediated by the interaction of FADD with caspase 8 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Upon activation , cell surface death receptors , Fas / APO 1 / CD95 and tumor necrosis factor receptor 1 ( TNFR 1 ) , are attached to cytosolic adaptor proteins , which in turn recruit caspase 8 ( MACH / FLICE / Mch5 ) to activate the interleukin 1 beta converting enzyme ( ICE ) / CED 3 family protease ( caspase ) cascade . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we show that one of the effects of CD 30 signal transduction is to render cells sensitive to apoptosis induced by the type 1 tumor necrosis factor receptor ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Sentrin is a ubiquitin like molecule that has been shown to interact with the death domains of Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) , PML , Rad 51 , Rad 52 , and RanGAP 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The applied model scFv was derived from a murine antibody ( H 398 ) against human tumor necrosis factor receptor 1 ( TNFR 60 ) , known to be a potent antagonist of TNF action in its monomeric form and a potential therapeutic agent for treatment of TNF mediated diseases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The Fas receptor is a member of a family of cell death receptors , including tumor necrosis factor receptor 1 ( TNFR 1 ) , death receptor 3 and 4 ( DR 3 and DR 4 ) , and cytopathic avian receptor 1 ( CAR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FDCs in the follicular apical light zone expressed transforming growth factor beta receptor 2 ( TGF betaR 2 ) , granulocyte macrophage colony stimulating factor receptor alpha ( GM CSFRalpha ; CDw 116 ) , tumor necrosis factor receptor 1 ( TNFR 1 ; CD120a ) , interleukin 1 receptor 2 ( IL 1R 2 ; CDw121b ) , IL 2 receptor beta ( IL 2Rbeta ; CD 122 ) , IL 4 receptor ( IL 4R ; CDw 124 ) , and IL 6 receptor ( IL 6R ; CD 126 ) , among the 10 receptors examined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The significance of tumor necrosis factor receptor 1 ( TNFR 1 ) for TNF function in vivo is well documented , whereas the role of TNFR 2 so far remains obscure . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In mice deficient in either lymphotoxin alpha ( LT alpha ) or type 1 tumor necrosis factor receptor ( TNFR 1 ) , organized clusters of follicular dendritic cells ( FDC ) and germinal centers ( GC ) are absent from the spleen . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We measured the plasma levels of anti inflammatory cytokines , including interleukin 1 receptor antagonist ( IL 1ra ) , IL 4 and IL 10 ; inflammatory cytokines , including IL 2 , IL 6 , IL 8 and tumor necrosis factor receptor 1 and 2 ( TNFR 1 and TNFR 2 ) ; and endotoxin in 11 patients with septic shock associated with gram negative bacteria and 12 patients with sepsis not associated with shock . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The secondary structure of human tumor necrosis factor receptor 1 ( TNFR 1 ) mRNA based on its lowest folding energy was predicted . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cell receptors belonging to the tumor necrosis factor receptor ( TNF R ) superfamily , such as TNF receptors and fas , are implicated in signaling the injury response of OLs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A 33 nucleotide ( nt ) region of the 55 kDa tumor necrosis factor receptor ( TNFR 55 ) mRNA , previously reported by us to engage in such interaction with proteins from U 937 cells , exhibits homology to a 38 nt regulatory region of the glucose transporter GLUT 1 mRNA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we report that in tumor necrosis factor receptor 1 deficient mice ( TNFR 1 ( / ) ) , the location of B cells was altered and that plasma cells were abnormally distributed in the splenic PALS . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Stimulation of the Fas or tumor necrosis factor receptor 1 ( TNFR 1 ) cell surface receptors leads to the activation of the death effector protease , caspase 8 , and subsequent apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
During inflammation , membrane expression of adhesion molecules and tumor necrosis factor ( TNF ) receptors ( TNF R ) are increased , and soluble forms of these molecules are released . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 95 , tumor necrosis factor receptor type 1 ( TNFR 1 ) , and death receptor 3 ( DR 3 ) did not induce apoptosis in FADD deficient embryonic fibroblasts , whereas DR 4 , oncogenes E1A and c myc , and chemotherapeutic agent adriamycin did . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A comparative examination of HVS transformed T cell clones and their native parental clones revealed that the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and members of the tumor necrosis factor receptor ( TNF R ) superfamily with a death domain , namely , TNF RI , CD 95 , and TRAMP , were not modulated by HVS . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MyD 88 has a modular organization , an N terminal death domain ( DD ) related to the cytoplasmic signaling domains found in many members of the tumor necrosis factor receptor ( TNF R ) superfamily , and a C terminal Toll domain similar to that found in the expanding family of Toll / interleukin 1 like receptors ( IL 1R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) is a multipotent cytokine produced by activated macrophages and lymphocytes and its activity is mediated by specific cell surface receptors , TNF RI and TNF RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The 55 kDa receptor for tumor necrosis factor ( TNF R 55 ) activates two types of SMases through distinct cytoplasmic domains . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signaling by tumor necrosis factor type 1 receptor ( TNFR 1 ) is required for the initiation of liver regeneration after partial hepatectomy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To determine whether the up regulation of chondrocyte tumor necrosis factor receptor ( TNF R ) expression in osteoarthritis ( OA ) is due to molecules released within the OA knee joint . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FADD is a death domain containing protein that binds to certain members of the tumor necrosis factor receptor family , namely TNFR 1 , Fas , and DR 3 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) elicits a diverse array of inflammatory responses through engagement of its type 1 receptor ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cooperative signaling by tumor necrosis factor receptors CD120a ( p 55 ) and CD120b ( p 75 ) in the expression of nitric oxide and inducible nitric oxide synthase by mouse macrophages . ^^^ Tumor necrosis factor alpha ( TNFalpha ) is recognized by the cell surface receptors CD120a ( p 55 ) and CD120b ( p 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The CHMS 1 sequence showed a 62 % homology with the tumor necrosis factor receptor ( TNF R 2 ) cDNA , and its amino acid deduced sequence shared a high level of homology with the `` death domain ' ' region found in various proteins , including two members of the TNF receptor superfamily , the TNF R 1 and Fas . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Fas ( APO 1 / CD95 ) is a member of the tumor necrosis factor receptor ( TNF R ) family and induces apoptosis when crosslinked with either Fas ligand or agonistic antibody ( Fas antibody ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Early events in the signalling of tumor necrosis factor receptor 1 ( TNF R 1 ) , which is the main TNF receptor on most cell types , have been clarified recently . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We show here that ligation of OX 40 Ag , a member of the tumor necrosis factor receptor ( TNF R ) family , on activated umbilical cord blood CD 4 ( + ) T cells upregulates IL 4 production at priming and thereby promotes their development into effector cells producing high levels of the type 2 cytokines IL 4 , IL 5 , and IL 13 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signaling through tumor necrosis factor receptor type 1 ( TNFR 1 ) using a pathway that involves nuclear factor kappaB ( NF kappaB ) , interleukin 6 ( IL 6 ) , and STAT 3 is required for the initiation of liver regeneration . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The interactions of CD 95 antigen ( Fas ) with its ligand ( CD95L ) and of tumor necrosis factor ( TNF ) alpha with its receptor ( TNF R 1 ) lead to apoptotic cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The molecules that comprise the tumor necrosis factor ligand and receptor ( TNF L and TNF R ) families play important roles in tissue homeostasis and in multiple sclerosis ( MS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Pfizenmaier , Membrane tumor necrosis factor ( TNF ) induced cooperative signaling of the TNFR 60 and TNFR 80 favors induction of cell death rather than virus production in HIV infected T cells , J . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , a dominant negative mutant tumor necrosis factor receptor 1 ( TNFRI ) expression vector was co transfected in inhibition studies . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : The responses of monocyte and neutrophil tumor necrosis factor receptor type 1 ( TNFR 1 ) and TNFR 2 during systemic inflammation have been described previously . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To analyze Fas and tumor necrosis factor receptor 1 ( TNFRI ) apoptosis pathways in salivary gland inflammatory disease induced by murine cytomegalovirus ( MCMV ) infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The roles of the known tumor necrosis factor ( TNF ) receptors ( TNFR 1 and TNFR 2 ) and their associated signaling pathways in mediating the diverse actions of TNF remain incompletely defined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor type 1 ( TNF R 1 ) contains a cytoplasmic death domain that is required for the signaling of TNF activities such as apoptosis and nuclear factor kappa B ( NF kappaB ) activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The generation of mice strains deficient for select members of the signaling complex of the 55 kDa tumor necrosis factor receptor ( TNF R 55 ) has allowed the assignment of specific cellular responses to distinct TNF R 55 associated proteins . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The individual role of tumor necrosis factor receptor 1 ( TNFR 1 ) and TNFR 2 signaling in experimental autoimmune encephalomeylitis ( EAE ) was investigated using mice lacking TNFR 1 ( TNFR 1 / ) , TNFR 2 ( TNFR 2 / ) as well as double receptor ( TNFR1 / 2 / ) and double ligand ( TNF / LT alpha / ) knockout mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine whether concentrations of the anti inflammatory peptide alpha melanocyte stimulating hormone ( alpha MSH ) are associated with accelerated or reduced disease progression in patients with HIV infection , plasma concentrations of alpha MSH and two other anticytokine molecules , interleukin 1 receptor antagonist ( IL 1 ra ) and soluble tumor necrosis factor receptor ( s TNF r ) , were taken repeatedly from HIV positive patients over a 1 year period . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In flow cytometric analysis , EoL 1 expressed two types of tumor necrosis factor receptors ( TNFR 1 and TNFR 2 ) , and the expression of TNFR 2 but not of TNFR 1 was up regulated significantly after the IFN gamma treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor , p 60 ( TNF R 1 ) , transduces death signals via the association of its cytoplasmic domain with several intracellular proteins . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In seven affected families , we found six different missense mutations of the 55 kDa tumor necrosis factor receptor ( TNFR 1 ) , five of which disrupt conserved extracellular disulfide bonds . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The death receptors Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) trigger apoptosis upon engagement by their cognate death ligands . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We scanned for all genetic variants in functionally important regions of the tumor necrosis factor receptor 1 gene ( TNF R 1 ) in 100 to 111 MS patients from Olmsted County , MN , and analyzed selected variants for an association with disease course and severity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Death receptors in the tumor necrosis factor ( TNF ) family such as TNFR 1 and Fas have been identified as regulators of apoptosis and may be responsible for the altered regulation of apoptosis seen in our coculture model . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor 1 ( TNFR 1 ) and the Fas receptor recruit complexes formed by the interactions between RIP kinase , TRADD , FADD and RAIDD adaptor proteins that contain death domains which in turn recruit other proteins to initiate signaling [ 1 ] [ 2 ] [ 3 ] [ 4 ] [ 5 ] . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor induced cytotoxicity is not related to rates of mitochondrial morphological abnormalities or autophagy changes that can be mediated by TNFR 1 or TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A site in the Epstein Barr virus ( EBV ) transforming protein LMP 1 that constitutively associates with the tumor necrosis factor receptor 1 ( TNFR 1 ) associated death domain protein TRADD to mediate NF kappaB and c Jun N terminal kinase activation is critical for long term lymphoblastoid cell proliferation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Sequence and quantitative analysis of the candidate gene , tumor necrosis factor receptor 1 ( Tnfr 1 , p 55 ) , indicates that it is unlikely to be Bphs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Osteoprotegerin ( OPG ) was recently identified as a soluble member of the tumor necrosis factor ( TNF ) receptor ( TNF R ) superfamily that is secreted by osteoblast lineage cells and acts by binding to and neutralizing its cognate ligand , OPG L , a required factor for osteoclastogenesis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated the expression of FasL , Fas and tumor necrosis factor ( TNF ) receptor 1 ( TNF R 1 , CD120a ) on cultured human lymphocytes and leukemic T and B cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among them are also molecules belonging to superfamily of tumor necrosis factor receptor ( TNFR ) which beside CD 30 include CD 27 , CD 40 , TNFR 1 and 2 , Fas ( CD 95 ) , OX 40 , 4 1BB ( CDw 137 ) , nerve growth factor receptor , lymphotoxin beta receptor , Apo3 / DR3 / Ws1 1 / lymphocyte associated receptor of death , DR 4 , DR5 / TNF related apoptosis inducing ligand , osteoprotegerin , and TNFR related 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Several models of tumor necrosis factor ( TNF ) / TNF receptor 1 ( TNF R 1 ) dependent liver injury in mice were investigated with respect to caspase 3 like protease activation representing a pivotal mechanism of apoptotic cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Phosphorylation of tumor necrosis factor receptor CD120a ( p 55 ) by p 42 ( mapk / erk2 ) induces changes in its subcellular localization . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
C57BL6 mice with targeted disruption of tumor necrosis factor ( TNF ) type 1 receptor ( TNFRI ) exhibited early vaginal opening when compared with wild type mice ( Day 24 + / 0 . 6 , n = 10 , vs . 28 + / 0 . 2 , n = 11 , P < 0 . 001 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The 15 kDa phosphoprotein enriched in astrocytes ( PEA 15 ) inhibits Fas mediated apoptosis and increases tumor necrosis factor receptor 1 ( TNF R 1 ) mediated apoptosis in the same cell type in a ligand dependent manner . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 , a member of the tumor necrosis factor receptor ( TNF R ) superfamily , is expressed on the surface of B cells , where its engagement results in IL 6 secretion . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) signaling through TNF receptor 1 ( TNFR 1 ) with downstream participation of nuclear factor kappaB ( NFkappaB ) , interleukin 6 ( IL 6 ) , and signal transducers and activators of transcription 3 ( STAT 3 ) is required for initiation of liver regeneration . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Phosphorylation of 130 and 95 kDa substrates associated with tumor necrosis factor alpha receptor CD120a ( p 55 ) . ^^^ Cross linking of CD120a ( p 55 ) , a receptor for tumor necrosis factor alpha ( TNFalpha ) , initiates downstream events , including the activation of protein Ser / Thr kinases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Phosphorylation of the membrane proximal region of tumor necrosis factor receptor CD120a ( p 55 ) at ERK consensus sites . ^^^ The interaction of tumor necrosis factor alpha with its receptor CD120a ( p 55 ) initiates downstream signaling cascades that include the activation of the mitogen activated protein kinase ( MAPK ) , p 42 ( mapk / erk2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We therefore hypothesized that , in the absence of RelA , embryos were sensitized to tumor necrosis factor ( TNF ) receptor 1 ( TNFR 1 ) mediated apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It may bind to the death domain of tumor necrosis factor receptor 1 ( TNFR 1 ) and to the cytoplasmic tail of lymphotoxin beta receptor , implying that it may be involved in the apoptosis and anti apoptosis signaling pathways . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : Sentrin , a novel antiapoptotic molecule , has been shown to interact with the signal competent form of Fas / APO 1 and tumor necrosis factor receptor 1 ( TNFRI ) , and thereby , to protect cells against anti Fas / APO 1 and TNF induced cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The death domain kinase , receptor interacting protein ( RIP ) , is one of the major components of the tumor necrosis factor receptor 1 ( TNFR 1 ) complex and plays an essential role in tumor necrosis factor ( TNF ) mediated nuclear factor kappaB ( NF kappaB ) activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) is a cytokine produced by macrophages and T lymphocytes that acts through two distinct receptors , TNFR 1 ( 60 kD , CD120a ) and TNFR 2 ( 80 kD , CD120b ) , to affect cellular proliferation , differentiation , survival , and cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas associated death domain protein ( FADD ) , caspase 8 related protein ( Casper ) , and caspase 8 are components of the tumor necrosis factor receptor type 1 ( TNF R 1 ) and Fas signaling complexes that are involved in TNF R 1 and Fas induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Correlation of the expression of nuclear factor kappa B , tumor necrosis factor receptor type 1 ( TNFR 1 ) and c Myc with the clinical course in the treatment of malignant astrocytomas with recombinant mutant human tumor necrosis factor alpha ( TNF SAM 2 ) . ^^^ We also investigated the expression of nuclear factor kappa B ( NF kappa B ) , tumor necrosis factor receptor type 1 ( TNFR 1 ) , and c Myc in human astrocytoma tissues in vivo in patients treated with TNF SAM 2 by RT PCR and immunohistochemical analysis to examine whether there is any correlation between the prognosis of these patients after TNF SAM 2 treatment and the expression of these factors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We hypothesized that the administration of monoclonal antibodies to intercellular adhesion molecule 1 ( CD 54 ) or E and L selectin ( CD62E / L ) would decrease serum levels of the proinflammatory cytokines interleukin 1beta ( IL 1 ) , IL 6 , and IL 8 and tumor necrosis factor receptor ( TNFR 1 ) in baboons during sepsis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor ( TNF ) receptor R 1 ( TNF R 1 , p 55 ) level was also elevated in the substantia nigra of the parkinsonian brain in comparison with that of controls ( p < 0 . 05 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) signalling via the TNF receptor 1 ( TNF R 1 ) is required for host resistance to mycobacterial infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas ( APO 1 / CD95 ) and tumor necrosis factor receptor 1 ( TNFR 1 ) trigger apoptosis by recruiting the apoptosis initiator caspase 8 through the adaptor FADD . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To characterize both phenotypic ( clinical features and magnetic resonance imaging [ MRI ] findings ) and genotypic aspects of autosomal dominant recurrent fever , also known as tumor necrosis factor receptor ( TNFR ) associated periodic syndrome ( TRAPS ) , in a French family and to investigate the role of the mutated 55 kd tumor necrosis factor alpha ( TNFalpha ) receptor ( TNFR 1 ) in the pathogenesis of the disease . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNFR 1 ) death domain ( DD ) is the intracellular functional domain responsible for the receptor signaling activities . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently , several tumor necrosis factor receptor 1 ( TNF R 1 ) and Fas related death receptors have been discovered and include DR 3 , DR 4 , DR 5 and DR 6 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FADD ( also known as MORT 1 ) is an essential adapter protein that couples the transmembrane receptors Fas ( CD 95 ) and tumor necrosis factor receptor 1 ( TNF R 1 ) to intracellular cysteine proteases known as caspases , which propagate and execute the programmed cell death inducing signal triggered by Fas ligand ( FasL , CD95L ) and TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) induces a typical apoptotic cell death program in various cell lines by interacting with the p 55 tumor necrosis factor receptor ( TNF R 55 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The two opposite signaling pathways that stimulate NF kappaB activation and apoptosis are both mediated by tumor necrosis factor receptor 1 ( TNFR 1 ) and its cytosolic associated proteins . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNFR 1 , CD120a ) has been implicated in the pathogenesis of several experimental models of T cell mediated autoimmune disorders , but its role in antibody mediated autoimmune diseases has not been addressed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These included the TNFRSF1A locus ( formerly known as TNFRI ) , which is involved in autosomal dominant tumor necrosis factor receptor associated periodic syndrome on chromosome 12p13 , the familial Mediterranean fever locus ( MEFV ) on chromosome 16p13 , the hyperimmunoglobulinemia D and periodic fever syndrome ( HIDS ) locus on chromosome 12q24 , and the Muckle Wells syndrome / familial cold urticaria ( MWS / FCU ) locus on distal chromosome 1q44 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we describe that HIPK 2 can also associate with TRADD , a protein that interacts with tumor necrosis factor receptor type 1 ( TNF R 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In order to investigate functionally important genes of the tumor necrosis factor alpha ( TNFalpha ) pathway we studied the frequency of DNA polymorphisms in the interleukin 6 ( IL 6 ) , the TNFalpha , and the TNFalpha receptor 1 ( TNFR 1 ) genes in 264 sporadic German PD patients and in 183 age and sex matched German healthy controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha is a mediator of septic shock and death , and it exerts its biologic effects by interacting with 2 receptors , TNF R 1 and TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , a parallel up regulation of tumor necrosis factor receptor ( TNFR ) 1 and 2 on Hep3B cells was detected after solamargine treatment , and the solamargine mediated cytotoxicity could be neutralized with either TNFR 1 or 2 specific antibody . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Treatment with the pure antiestrogen faslodex ( ICI 182780 ) induces tumor necrosis factor receptor 1 ( TNFR 1 ) expression in MCF 7 breast cancer cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor associated factor ( TRAF ) 2 is an intracellular adapter protein , which , upon TNF stimulation , is directly recruited to the intracellular region of TNF receptor 2 ( TNFR 2 ) or indirectly , via TRADD , to the intracellular region of TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) is an inflammatory disorder characterized by prolonged episodes of periodic fever and localized inflammation and dominantly inherited mutations in TNFRSF1A , the gene encoding the 55 kDa tumor necrosis factor receptor . ^^^ Patients were screened for mutations in TNFRSF1A , the gene coding for the p 55 tumor necrosis factor receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 2 induced tumor necrosis factor ( TNF ) beta expression : further analysis in the IL 2 knockout model , and comparison with TNF alpha , lymphotoxin beta , TNFR 1 and TNFR 2 modulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We studied tumor necrosis factor ( TNF ) , lymphotoxin alpha ( LT alpha ) , and TNF receptors type 1 ( TNFR 1 ) and type 2 ( TNFR 2 ) gene polymorphisms as well as HLA class 2 DRB 1 alleles in Japanese patients with human T cell lymphotropic virus type 1 ( HTLV 1 ) associated myelopathy ( HAM ) ( n = 51 ) , patients with adult T cell leukemia / lymphoma ( ATL ) ( n = 48 ) , asymptomatic HTLV 1 carriers ( n = 50 ) , and HTLV 1 seronegative , normal controls ( n = 112 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) in a Dutch family : evidence for a TNFRSF1A mutation with reduced penetrance . ^^^ Mutations of the tumor necrosis factor receptor 1 ( TNFRSF1A ) gene underly susceptibility to a subset of autosomal dominant recurrent fevers ( ADRFs ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previously , it has been demonstrated that the HCV core protein interacts with the cytoplasmic domain of tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Upon stimulation with tumor necrosis factor ( TNF ) , the TNF receptor ( TNFR 55 ) mediates a multitude of effects both in normal and in tumor cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas receptor and tumor necrosis factor receptor 1 ( TNFR 1 ) mediate the activation of acid sphingomyelinase ( ASMase ) , which catalyzes the hydrolysis of sphingomyelin to ceramide . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Phosphorylation of the tumor necrosis factor receptor CD120a ( p 55 ) recruits Bcl 2 and protects against apoptosis . ^^^ Ligation of the tumor necrosis factor alpha receptor CD120a initiates responses as diverse as apoptosis and the expression of NF kappaB dependent pro survival genes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined the apoptotic potential of known KILLER / DR5 lung tumor derived mutants ( n = 6 ) and DD mutants ( n = 18 ) generated based on conservation with DR 4 , Fas , Fas associated death domain ( FADD ) , and tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
PURPOSE : By using as an experimental model the male mouse gonad , which contains both radiosensitive ( germ ) and radioresistant ( somatic ) cells , we have studied the growth factor ( and / or receptor ) expression of transforming growth factor beta receptor ( TGFbeta RI ) , stem cell factor ( SCF ) , c kit , Fas L , Fas , tumor necrosis factor receptor ( TNF R 55 ) , and leukemia inhibiting factor receptor ( LIF R ) after local irradiation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A mutation search was performed in the MEFV ( Mediterranean fever ) and tumor necrosis factor receptor 1 ( TNFR 1 or TNFRSF1A ) genes causing familial Mediterranean fever ( FMF ) and tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Hepatitis C virus ( HCV ) core protein has been shown to interact with the death domain ( DD ) of tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor type 1 ( TNFR 1 ) and c Myc are important in signal transduction in tumor necrosis factor alpha ( TNF alpha ) induced cytotoxicity , whereas activation of nuclear factor kappa B ( NF kappa B ) protects against TNF alpha induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Maximal expression of NOS 2 after CFA immunization requires the presence of functional type 1 tumor necrosis factor alpha receptor ( TNFR 1 ) and interferon gamma . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
With regard to the mechanisms of the worsened effect in the Ad TIMP 1 treated mice , we observed 1 ) higher serum levels of anti type 2 collagen IgG2a , 2 ) a significant increase in endogenous soluble tumor necrosis factor receptor 1 ( TNFRI ) in sera , and 3 ) increased labeling of mouse tumor necrosis factor alpha and TNFRI within arthritic joints . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined the expression of tumor necrosis factor alpha ( TNF alpha ) and the Type 1 tumor necrosis factor receptor , ( TNFR 1 ) , in relation to c fos , a known regulator gene of immediate cellular responses , after an extended period of global ischemia . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor associated periodic syndrome : new mutations in TNFRSF1A , ancestral origins , genotype phenotype studies , and evidence for further genetic heterogeneity of periodic fevers . ^^^ Mutations in the extracellular domain of the 55 kD tumor necrosis factor ( TNF ) receptor ( TNFRSF1A ) , a key regulator of inflammation , define a periodic fever syndrome , TRAPS ( TNF receptor associated periodic syndrome [ MIM 142680 ] ) , which is characterized by attacks of fever , sterile peritonitis , arthralgia , myalgia , skin rash , and / or conjunctivitis ; some patients also develop systemic amyloidosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The bioactivity of tumor necrosis factor ( TNF ) is mediated by two TNF receptors ( TNF Rs ) , more particularly TNF RI and TNF RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 death domain ( TNFR 1 DD ) is the intracellular functional domain responsible for the receptor signaling activities . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Extravillous trophoblast hybrid cells were cocultured with activated macrophages exposed to exogenous tumor necrosis factor alpha ( TNFalpha ) , anti tumor necrosis factor receptor 1 ( TNF RI ) , and tryptophan depletion , and the rates of trophoblast apoptosis were measured . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined Muc 2 and Muc 3 expression in wild type mice and mice lacking gamma interferon receptor ( IFNgammaR / ) , tumor necrosis factor receptor 1 ( TNFR 1 / ) and interleukin 4 ( IL 4 / ) infected with Trichinella spiralis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas , together with its ligand , has been the most commonly studied death inducer in the mammalian ovary ; however , nothing is currently known regarding expression of either Fas or the related tumor necrosis factor receptor type 1 ( TNFR 1 ) , in avian species . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The OX 40 receptor ( OX 40R ) is a member of the tumor necrosis factor receptor ( TNF R ) superfamily that is expressed on activated CD4+ T cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The BAG 4 protein that we cloned also corresponds to the recently isolated suppressor of death domains ( SODD ) protein , a molecule that binds and inhibits signaling by tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have investigated the role of p 55 and p 75 tumor necrosis factor receptors 1 and 2 ( TNFR 1 and TNFR 2 , respectively ) in TNF induced alteration of endothelial permeability in vitro and in vivo . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of Fas , tumor necrosis factor receptor 1 ( TNF R 1 ) , and proliferation cell nuclear antigen ( PCNA ) was examined in 54 rats by immunohistochemistry . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 is a member of the growing tumor necrosis factor receptor ( TNF R ) family of molecules , and has been shown to play important roles in T cell mediated B lymphocyte activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recent experimental models suggested a role for the tumor necrosis factor receptor 1 ( TNFR 1 ) in the pathogenesis of the disease . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , pertussis toxin attenuates NF kappaB activation induced by acetaldehyde but not by HBX or HCV core protein , whereas HBX or HCV core protein mediated activation of NF kappaB is abolished completely in tumor necrosis factor a receptor 1 ( TNFR 1 ) ( / ) hepatocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , activation of TNFR 1 coupled to the tumor necrosis factor receptor associated factor ( TRAF ) 2 nuclear factor kappaB ( NF kappaB ) pathway alters calcium homeostasis in ASM , which appears to be a new potential mechanism underlying ASM hyper responsiveness . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently , pathology caused by alcohol was blocked nearly completely in tumor necrosis factor alpha receptor 1 ( TNF R 1 ) knockout mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the role of FADD ( Fas associated protein with death domain ) in Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) mediated hepatic injury and inflammatory response in vivo . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The CD 95 receptor , also known as Fas / Apo 1 , is a member of the Tumor Necrosis Factor receptor ( TNF R ) family of death receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The diagnosis of periodic fever was made when molecular analysis revealed novel mutations in the tumor necrosis factor ( TNF ) receptor gene ( TNFRSF1A ) , establishing the diagnosis of TNF receptor associated periodic syndrome . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MEASUREMENTS : Endogenous nitric oxide production was determined by measuring total plasma nitrite / nitrate ( Griess method ) , and levels of soluble tumor necrosis factor receptors type 1 and type 2 ( TNF R 1 and TNF R 2 , respectively ) were measured by commercially available enzyme linked immunosorbent assay . ^^^ MAIN RESULTS : In infants with left to right shunts , soluble tumor necrosis factor receptor levels were significantly elevated as compared with infants with cyanosis ( TNF R 1 : 1 . 7 + / 0 . 5 vs . 0 . 8 + / 0 . 3 ng / mL ; p = . 0003 ; TNF R 2 : 8 . 1 + / 4 . 0 vs . 5 . 1 + / 3 . 2 ng / mL ; p = . 049 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have previously reported the cloning and expression of a new tumor necrosis factor receptor ( TNF R ) related transcript , named CHMS 1 that encodes a potential death domain . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Gel shift assay and Western blot analysis supported microarray results , showing that 5 PYRRO / NO suppressed GlaN / LPS induced activation of nuclear factor kappaB and GlaN / LPS induced increases in caspase 1 , caspase 8 , tumor necrosis factor receptor 1 ( TNFR 1 ) associated death domain , and TNF related apoptosis inducing ligand . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this report , we studied down regulation of the virus specific CD 8 ( + ) T cell response during persistent infection of adult mice with LCMV , with emphasis on the role of perforin , Fas / FasL , or tumor necrosis factor receptor 1 ( TNFR 1 ) mediated cytolysis in regulating T cell homeostasis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Ligand binding to tumor necrosis factor receptor 1 ( TNFRI ) can promote cell survival or activate the apoptotic caspase cascade . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CADD interacts with death domains of tumor necrosis factor ( TNF ) family receptors TNFR 1 , Fas , DR 4 , and DR 5 but not with the respective downstream adaptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : DNA sequencing of exons 1 6 of the TNFRSF1A gene ( formerly TNFR 1 ) was performed in the patient and his parents to determine the presence of the autosomal dominant tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) ; informative markers spanning the TNFRSF1A locus were used to genotype all available members of the patient ' s family . ^^^ An Israeli Arab patient with a de novo TNFRSF1A mutation causing tumor necrosis factor receptor associated periodic syndrome . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappa B activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 ( TNFR 1 ) and TNFR 2 mediated apoptosis in HIV infection : relation to expression of Bcl 2 and active caspase 8 and caspase 3 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These cells express messenger RNA for the death receptors Fas , tumor necrosis factor receptor 1 ( TNF R 1 ) , death receptor 4 ( DR 4 ) , and DR 5 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Receptors belonging to the tumor necrosis factor receptor ( TNF R ) family utilize cytoplasmic adapter proteins called TNF R associated factors ( TRAFs ) as key elements in their signaling pathways . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Self aggregation of tumor necrosis factor receptor type 1 ( TNFR 1 ) induces spontaneous downstream signaling and results in cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the presence of TRAPS ( tumor necrosis factor receptor associated periodic syndrome ) , which is a recently defined , dominantly inherited autoinflammatory syndrome caused by mutations in the tumor necrosis factor receptor superfamily 1A gene ( TNFRSF1A , CD120a ) , in a Finnish family with recurrent fever . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : We assessed the presence of tumor necrosis factor receptor 1 ( TNF R 1 ) , apoptosis , and simultaneous expression of 92 kDa collagenase type 4 ( MMP 9 ) in samples of human chorioamnion from women with premature rupture of membranes ( PROM ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among induced genes , four ( TNFR 1 , TNFSF 7 , caspase 8 , and DAPK 1 ) were associated with the tumor necrosis factor ligand receptor death pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The adapter protein tumor necrosis factor receptor ( TNFR ) 1 associated death domain ( TRADD ) plays an essential role in recruiting signaling molecules to the TNFRI receptor complex at the cell membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Plasma levels of cytomegalovirus ( CMV ) specific immunoglobulin G ( IgG ) , soluble ( s ) CD 30 , sCD 26 ( dipeptidyl peptidase 4 [ DPP 4 ] ) enzyme activity , and tumor necrosis factor receptor 1 ( TNFR 1 ) were assessed in human immunodeficiency virus ( HIV ) infected patients who experienced CMV retinitis ( CMVR ) as an immune restoration disease ( IRD ) during their first 6 months of highly active antiretroviral therapy ( HAART ) and in CMV seropositive , HIV infected patients with similar baseline CD 4 ( + ) T cell counts who had uneventful immune reconstitution . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A key component of signaling by members of the tumor necrosis factor receptor ( TNF R ) family is interaction with the cytoplasmic adapter proteins known as TRAFs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The heat shock protein 90 ( Hsp 90 ) inhibitor , geldanamycin , and the proteasome inhibitor , MG 132 , both inhibited tumor necrosis factor receptor 1 ( TNF R 1 ) but not TRAIL induced apoptosis in Kym 1 cells , suggesting that TNF R 1 induced cell death is dependent on NF kappaB activation in this model . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : In a cross sectional study at baseline with a prospective 4 year follow up , intraplatelet cyclic 3 ' 5 ' adenosine monophosphate ( cAMP ) and cyclic 3 ' 5 ' guanosine monophosphate ( cGMP ) , plasma neutrophil gelatinase associated lipocalin ( NGAL ) , plasma soluble tumor necrosis factor receptor 1 ( TNFR 1 ) plasma neopterin and plasma endothelin 1 ( ET 1 ) were analysed together with IgG and IgA antibodies for C . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using a subtractive cDNA library hybridization approach , we found that receptor interacting protein 2 ( RIP 2 ) , a tumor necrosis factor receptor 1 ( TNFR 1 ) associated factor , is a novel early acting gene that decreases markedly in expression during myogenic differentiation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) triggers distinct pathways in liver cells through TNF receptor 1 ( TNF R 1 ) via adapter molecules , including the intracellular cascades leading to apoptosis , nuclear factor kappa B ( NF kappa B ) , and Jun kinase ( JNK ) activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNFR 1 ) can trigger distinct signaling pathways leading to either the activation of NF kappaB transcription factors or apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The RID complex prevents death of infected cells by blocking apoptosis initiated through death domain containing receptors of the tumor necrosis factor receptor ( TNFR ) superfamily , including TNFR 1 ( L . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) exists both as a membrane integrated type 2 precursor protein and a soluble cytokine that have different bioactivities on TNFR 2 ( CD120b ) but not on TNFR 1 ( CD120a ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) contributes to this syndrome , apparently by acting on its receptor 2 ( TNFR 2 ) because TNFR 1 / are susceptible , whereas TNFR 2 / mice are resistant . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study we cloned and analysed partial cDNA of tumor necrosis factor ( TNF ) and p 75 TNF R receptor of Syrian golden hamster ( Mesocricetus auratus ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Triggering tumor necrosis factor receptor 1 ( TNFR 1 ) induces apoptosis in various cell lines . ^^^ Geldanamycin pretreatment led to a proteasome dependent decrease in the levels of several TNFR 1 interacting proteins including the kinases receptor interacting protein , inhibitor of kappa B kinase alpha , inhibitor of kappa B kinase beta , and to a lesser extent the adaptors NF kappaB essential modulator and tumor necrosis factor receptor associated factor 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Tumor necrosis factor ( TNF ) receptor family members , such as Fas and TNF receptor 1 ( TNFR 1 ) , are thought to induce apoptosis in a variety of cells and organs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 , a member of the tumor necrosis factor receptor ( TNF R ) family , is a surface receptor best known for its capacity to initiate multifaceted activation signals in normal B cells and dendritic cells ( DCs ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It became clear that receptor mediated apoptosis is of specific interest in this context , and CD 95 and CD120a , both members of the tumor necrosis factor ( TNF ) receptor superfamily , are the most prominent cell death receptors involved . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Synergistic effect on the attenuation of collagen induced arthritis in tumor necrosis factor receptor 1 ( TNFRI ) and interleukin 6 double knockout mice . ^^^ OBJECTIVE : To evaluate any additive effect on attenuation of collagen induced arthritis ( CIA ) in tumor necrosis factor receptor 1 ( TNFRI ) and interleukin 6 ( IL 6 ) double knockout ( DKO ) mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A `` triple ' ' cytotoxic deficient model , involving transplantation of TNFR 1 ( / ) ( tumor necrosis factor receptor 1 ) progenitor grafts did not diminish the ability of B 6 cdd recipients to reject allografts . ^^^ Finally , injection of anti TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) monoclonal antibody ( mAb ) in B 6 cdd recipients also failed to inhibit rejection of TNFR 1 ( / ) marrow grafts . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Acid sphingomyelinase ( ASM ) has been shown to be activated by a variety of receptor molecules and stimuli including CD 95 , the tumor necrosis factor receptor ( TNF R ) , CD 40 , CD 28 , LFA 1 , CD 5 , during development , irradiation , heat shock , UV light or bacterial and viral infections . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Tumor necrosis factor alpha ( TNF ) and its cellular and soluble ( s ) receptors ( TNF R ) are important mediators in acute myeloid leukemia ( AML ) and infectious complications during cytoreductive therapy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cells treated with GA showed a reduced level of surface CD 14 detected by immunostaining , whereas the expression of other surface receptors , such as FC gamma receptor and tumor necrosis factor receptors ( TNF R 1 and TNF R 2 ) , was unaffected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) activates pro inflammatory functions of vascular endothelial cells ( EC ) through binding to receptor type 1 ( TNFR 1 ) molecules expressed on the cell surface . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : The expression pattern and prognostic impact of tumor necrosis factor receptor type 1 ( TNFR 1 ) in colorectal cancers are not known . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We first performed SBR or sham operations in mice , and the temporal expression of caspases 8 , 9 , and 3 , death receptors tumor necrosis factor receptor 1 ( TNFR 1 ) and Fas and corresponding ligands ( TNF and Fas ligand ) was determined in the remnant intestine at various postoperative time points . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Aminopeptidase regulator of TNFR 1 shedding ( ARTS 1 ) binds to the type 1 tumor necrosis factor receptor ( TNFR 1 ) and promotes receptor shedding . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signaling from tumor necrosis factor receptor type 1 ( TNFR 1 ) can elicit potent inflammatory and cytotoxic responses that need to be properly regulated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas and TNFRI , two members of the tumor necrosis factor receptor family with an intracellular death domain , each play critical roles in apoptotic death of lymphocytes and certain other cell types . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The common neurotrophin receptor p 75 ( NTR ) remains one of the most enigmatic of the tumor necrosis factor receptor ( TNFR ) superfamily : on the one hand , it displays a death domain and has been shown to be capable of mediating programmed cell death ( PCD ) upon ligand binding ; on the other hand , its death domain is of type 2 ( unlike that of Fas or TNFR 1 ) , and it has also been shown to be capable of mediating cell death in response to the withdrawal of ligand . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Nuclear factor kappaB inducing kinase ( NIK ) is a member of the MAP kinase kinase kinase family that was first identified as a component of the TNF R 1 induced NF kappaB activation pathway ( TNF , tumor necrosis factor ; nuclear factor kappaB , NF kappaB ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor 1 ( TNFR 1 ) , a prototypic member of the death receptor family signals both cell survival and apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNF R 1 ) signaling elicits a wide range of biological responses , including inflammation , proliferation , differentiation , and apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Binding of tumor necrosis factor alpha ( TNFalpha ) to its receptor , TNF R 1 , results in the activation of inhibitor of kappaB kinase ( IKK ) and c Jun N terminal kinase ( JNK ) pathways that are coordinately regulated and important in survival and death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The silencer of death domains ( SODD ) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 ( TNFR 1 ) in the absence of ligand . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Activation of Fas or tumor necrosis factor receptor 1 ( TNF R 1 ) on hepatocytes leads to apoptosis , which requires mitochondria activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Plasma concentrations of soluble tumor necrosis factor receptor superfamily 1A ( sTNFRSF1A ) were measured , and fluorescence activated cell sorter analysis was used to measure TNFRSF1A shedding from monocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We previously showed that the receptor for tumor necrosis factor alpha ( TNF R 1 ) was notably elevated at late presymptomatic as well as symptomatic phases of disease ( J . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Therefore , the effect of DHEA application on cytokine concentrations in tumor necrosis factor ( TNF ) receptor ( TNF RI ( / ) ) and interleukin 6 ( IL 6 ( / ) ) knockout mice was determined . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNF R 1 ) is a death receptor that transduces both the death and survival signals but the molecular mechanisms via which TNF R 1 mediates these signals remain poorly understood . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Ligation of ' death receptors ' such as tumor necrosis factor receptor 1 ( TNF R 1 ) triggers apoptosis , as well as NF kappaB , which counteracts this process by activating the transcription of anti apoptotic genes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We used wild type ( WT ) C57BL / 6 mice and knockouts for tumor necrosis factor receptors 1 and 2 ( TNFR 1 / , TNFR 2 / ) and recombination activating gene 1 / mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Receptor interacting protein ( RIP ) is a serine / threonine protein kinase that is critically involved in tumor necrosis factor receptor 1 ( TNF R 1 ) induced NF kappaB activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Overexpression of TRAF 1 , however , had no effect on the interaction of TRADD and TRAF 2 , known to be important for tumor necrosis factor receptor 1 ( TNF R 1 ) mediated NF kappaB activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
During studies to determine a role for tumor necrosis factor ( TNF ) in herpes simplex virus type 1 ( HSV 1 ) infection using TNF receptor null mutant mice , we discovered a genetic locus , closely linked to the TNF p 55 receptor ( Tnfrsf1a ) gene on mouse chromosome 6 ( c 6 ) , that determines resistance or susceptibility to HSV 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of this study was to investigate the detailed pattern of mRNA expression of the pro inflammatory cytokines tumor necrosis factor alpha ( TNFalpha ) , TNF receptor type 1 ( TNF R 1 ) , interleukin 1beta ( IL 1beta ) , and interferon gamma ( IFNgamma ) , and of the inducible nitric oxide synthase ( iNOS ) and the basic fibroblast growth factor ( FGF 2 ) during prostaglandin ( PG ) F ( 2alpha ) induced luteolysis in the bovine corpus luteum ( CL ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The main transcript , which is ubiquitously expressed , encodes a protein that binds tumor necrosis factor receptor 1 ( TNF R 1 ) and downregulates TNF induced activation of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND AND OBJECTIVES : We analyzed the correlations between pretreatment serum levels of 11 cytokines and soluble cytokine receptors ( interleukin 6 ( IL 6 ) ; interleukin 8 ( IL 8 ) ; interleukin 10 ( IL 10 ) ; vascular endothelial growth factor ( VEGF ) ; basic fibroblast growth factor ( bFGF ) ; macrophage colony stimulating factor ( M CSF ) ; granulocyte colony stimulating factor ( G CSF ) ; interleukin 1 receptor antagonist ( IL 1ra ) ; sIL 2Ralpha ; tumor necrosis factor receptor 1 ( TNF RI ) , and TNF RII ) with clinico pathological features and survival of patients with bone sarcomas . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To assess the specific role of tumor necrosis factor ( TNF ) death receptor signaling in the induction of retinal ganglion cell ( RGC ) death , optic nerves of mice deficient for TNF receptor 1 ( TNF R 1 / ) and control mice ( C57BL / 6J ) were unilaterally subjected to crush injury . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 1 ( TNFR 1 ) associated death domain protein ( TRADD ) is essential in recruiting signaling molecules to the TNFR 1 receptor complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : Results of genome scans in rheumatoid arthritis ( RA ) have suggested that the tumor necrosis factor receptor 1 ( TNFRI ) and TNFRII loci ( TNFR 1 and TNFR 2 ) are susceptibility loci . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To date six bona fide death receptors ( DRs ) have been discovered and include tumor necrosis factor receptor 1 ( TNF R 1 ) , Fas , DR 3 , DR 4 , DR 5 and DR 6 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor type 1 receptor ( TNFRI ) , a death receptor , mediates apoptosis and plays a crucial role in the interaction between the nervous and immune systems . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) alpha induced neutral sphingomyelinase mediated generation of ceramide , a bioactive lipid molecule , is transduced by the adaptor protein FAN , which binds to the intracellular region of the CD120a TNFalpha receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptosis inducing agents have been reported to cause rapid shedding of tumor necrosis factor receptor 1 ( TNFR 1 ) in endothelial cells ( EC ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We now show that by crossing K 5 IkappaBalpha mice onto a tumor necrosis factor receptor 1 ( Tnfr 1 ) null background , both the inflammatory and the tumorigenic responses are blocked . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The typing results were evaluated for four different SNPs on tumor necrosis factor receptor 1 and 2 genes ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BRE has previously been shown to interact with type 1 tumor necrosis factor receptor ( TNFR 1 ) and modulate the action of TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
When overexpressed , PIAS 3 inhibits NF kappaB dependent transcription induced by treatment with tumor necrosis factor alpha ( TNF alpha ) or interleukin 1beta or by overexpression of TNF family receptors such as RANK , TNFR 1 , and CD 30 or signal transducers of TNF receptor associated factors ( TRAFs ) , including TRAF 2 , TRAF 5 , and TRAF 6 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We show that tumor necrosis factor receptor 1 ( TNFR 1 ) signaling is required for VCAM 1 expression by astrocytes , not the vascular endothelium . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have previously shown that two tumor necrosis factor ( TNF ) receptors ( TNFR ) exhibit antagonistic functions during neurodegenerative processes in vivo with TNFR 1 aggravating and TNFR 2 reducing neuronal cell loss , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast , specific activators of cAMP dependent protein kinase type 1 ( cA PKI ) could protect against death receptor [ tumor necrosis factor receptor 1 ( TNFR 1 ) , Fas ] mediated apoptosis as well as cycloheximide accelerated `` spontaneous ' ' apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of the present study was to investigate the importance of tumor necrosis factor ( TNF ) alpha receptor 1 ( TNFR 1 ) mediated pathways in a murine model of myocardial infarction and remodeling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Divergent life or death responses of a cell can be controlled by a single cytokine ( tumor necrosis factor alpha , TNF ) via the signaling pathways that respond to activation of its two receptors ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Significant differences between patients and controls in the allelic and genotypic frequencies of polymorphisms in the other cytokine and cytokine receptor genes studied ( tumor necrosis factor alpha [ TNFalpha ] , TNF receptor 1 [ TNFRI ] , TNFRII , interleukin 1beta [ IL 1beta ] , IL 6 ) were not found . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of mutations in tumor necrosis factor receptor superfamily 1A ( TNFRSF1A ) on the ability of the receptors to be cleaved from the cell surface upon stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice expressing SOD 1 mutants demonstrate a robust neuroinflammatory reaction characterized , in part , by up regulation of tumor necrosis factor alpha ( TNFalpha ) and its primary receptor TNF RI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signaling complexes formed on tumor necrosis factor receptor 2 ( TNF R 2 ) contain adaptor proteins TNF R associated factors ( TRAFs ) 1 and 2 , and cellular inhibitors of apoptosis ( cIAPs ) 1 and 2 which function as regulators of programmed cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor associated periodic syndrome and with systemic lupus erythematosus in Japanese . ^^^ Molecular defects of TNFRSF1A was investigated in members of a family presenting with typical phenotypes of tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) and in patients with the autoimmune disorders , systemic lupus erythematosus ( SLE ) and rheumatoid arthritis ( RA ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The second concerned two systems for which much less information is available : ( a ) the TNFRSF1A gene , implicated in tumor necrosis factor receptor associated periodic syndrome , and ( b ) the MEFV gene , which is believed to be involved in familial Mediterranean fever . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two familial cases with tumor necrosis factor receptor associated periodic syndrome caused by a non cysteine mutation ( T50M ) in the TNFRSF1A gene associated with severe multiorganic amyloidosis . ^^^ DNA sequence analysis revealed a heterozygous mutation in the TNFRSF1A ( TNFa receptor 1 ) gene ( T50M ) in both father and son causing tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVES : To compare tumor necrosis factor receptor 1 ( TNFR 1 ) protein expression in women with unexplained early spontaneous abortion ( UESA ) and normal pregnancy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present studies , recombinant adenoviruses encoding secreted ( human apolipoprotein A 1 ) or intracellular ( beta galactosidase ) gene products were infused into mice with genetic deficiencies affecting the granule exocytosis , Fas , or tumor necrosis factor receptor 1 ( TNFR 1 ) mediated pathways of CTL and natural killer cell effector function ; the rates of clearance of adenovirus encoded gene products were assessed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) contributes to insulin resistance by binding to the 55kDa TNF receptor ( TNF R 55 ) , resulting in serine phosphorylation of proteins such as insulin receptor ( IR ) substrate ( IRS ) 1 , followed by reduced tyrosine phosphorylation of IRS 1 through the IR and , thereby , diminished IR signal transduction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To identify the molecular mechanisms underlying this , we have examined the expression and potency of three major death receptors : tumor necrosis factor receptor ( TNF R ) , TNF related apoptosis inducing ligand receptor ( TRAIL R ) , and Fas in mediating cytotoxicity in four invasive pancreatic cancer cell lines . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The murine colon 38 adenocarcinoma was grown in C57Bl wild type mice and mice lacking expression of either tumor necrosis factor receptor 1 ( TNFR 1 ( / ) ) or TNF ( TNF / ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CRT on RK ( 13 ) cell surface ( srCRT ) forms complex ( es ) with tumor necrosis factor receptor 1 ( TNFR 1 ) and TNFR associated death domain ( TRADD ) protein of the cell membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Similarly , CD4C / HIV Tg mice homozygous for mutations of two other genes implicated in cell death ( interleukin 1beta converting enzyme [ ICE ] , tumor necrosis factor receptor 1 [ TNFR 1 ] ) developed similar AIDS like disease as their respective heterozygous controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) signaling is mediated via two distinct receptors , TNFR 2 and TNFR 1 , which shows partially overlapping signaling mechanisms and biological roles . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of tumor necrosis factor receptor 1 ( TNFR 1 ) in intestinal tissue was tested by immunohistochemistry Envision Two Steps . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cells from mice defective in tumor necrosis factor ( TNF ) alpha , TNF beta , lymphotoxin beta , or TNFR 1 , TNFR 2 , Fas , or death receptor 6 were as susceptible to apoptosis signaling as wild type cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : Tumor necrosis factor receptor associated periodic syndrome ( TRAPS ) is an autoinflammatory syndrome associated with mutations in the gene that encodes tumor necrosis factor receptor superfamily 1A ( TNFRSF1A ) . ^^^ The purpose of this study was to describe a novel TNFRSF1A mutation ( C43S ) in a patient with TRAPS and to examine the effects of this TNFRSF1A mutation on tumor necrosis factor alpha ( TNFalpha ) induced signaling in a patient derived primary dermal fibroblast line . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the molecular consequences of expressing mutated forms of tumor necrosis factor receptor 1 ( TNFRI ) as found in patients with TNFR associated periodic syndrome ( TRAPS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate whether polymorphisms in the tumor necrosis factor receptor 1 ( TNFRSF1A ) and receptor 2 ( TNFRSF1B ) genes are associated with the anemia observed in rheumatoid arthritis ( RA ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We present here the exhaustive genotyping of a candidate gene , tumor necrosis factor receptor 1 ( TNFR 1 ) , in the genetic of resistance to immunodeficiency virus ( GRIV ) AIDS cohort . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have recently shown that the E 3 10 . 4K / 14 . 5K ( RIDalpha / beta ) complex downregulates tumor necrosis factor receptor 1 ( TNFR 1 ) expression at the plasma membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptors ( TNF R ) mediated cell survival or apoptosis has been demonstrated in many cells , but little is known about survival or apoptotic signals via TNF R 1 in tendinocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas associated death domain protein ( FADD ) , the component of the tumor necrosis factor receptor type 1 ( TNFR 1 ) and Fas signaling complexes , is involved in TNFR 1 and Fas induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among these were members of the tumor necrosis factor receptor super family 1A and 5 ( TNFR 1 and 5 ) and peptidoglycan recognition proteins ( associated with the extrinsic apoptotic pathway ) , and granzymes A and B , growth arrest and DNA damage inducible 45 gamma , sphingosine phosphate lyase 1 , and caspase 9 ( associated with the intrinsic apoptotic pathway ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of this research is to study on PBMCs and in the serum of stable and active MS subjects ( 1 ) the behavior of the CD40 / CD40L system and the consequent balance of Th 1 and Th 2 cytokines and ( 2 ) the apoptosis marker system CD95 / CD95L and tumor necrosis factor ( TNF ) binding receptors , TNFRI and TNFRII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Peak oxygen uptake ( peak VO 2 ) and the plasma concentrations of noradrenaline ( NA ) , brain natriuretic peptide ( BNP ) , and soluble tumor necrosis factor receptors 1 and 2 ( TNFR 1 and 2 ) were all measured during the CPX . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , genetic ablation of tumor necrosis factor receptor 1 ( TNFRI ) rescued the skin phenotype demonstrating that TNF signaling is essential for skin lesion pathogenesis in IP . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently , mutations in the TNFRSF1A gene on chromosome 12p13 encoding tumor necrosis factor receptor type 1 have been linked to this autoinflammatory syndrome . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We report here that death receptor 5 ( DR 5 ) , tumor necrosis factor receptor 1 ( TNF R 1 ) , and Fas receptor ( FasR ) are all located in the caveolin 1 enriched membrane fractions , and TRAIL caused the translocation of DR 5 , FasR , and TNF R 1 to the caveolar fractions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor induced apoptosis : pathogenetic and clinical implications . ^^^ OBJECTIVE : To explore tumor necrosis factor ( TNF ) induced apoptosis in neutrophils from patients with TNF receptor associated periodic syndrome ( TRAPS ) and to correlate the results with the different kinds of TNFRSF1A mutations . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We examined the role of tumor necrosis factor receptor 1 ( TNFR 1 ) in inflammation initiated by the adoptive transfer of central nervous system ( CNS ) specific Th 1 cells in experimental autoimmune encephalomyelitis , a murine model of multiple sclerosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Stimulation of tumor necrosis factor receptor 1 ( TNFR 1 ) can initiate several cellular responses , including apoptosis , which relies on caspases , necrotic cell death , which depends on receptor interacting protein kinase 1 ( RIP 1 ) , and NF kappaB activation , which induces survival and inflammatory responses . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A near significant higher fatty mass ( skinfold thicknesses , at the end , 121 mm , at the beginning , 100 mm , p = 0 . 100 ) , combined with a significant increase of concentration of leptin ( 1 . 5 vs . 4 . 7 ng / ml , p = 0 , 044 ) , as well as a decrease in serum concentrations of soluble receptors of tumor necrosis factor ( TNFRI , 104 vs . 73 pg / ml , p = 0 . 022 ; TNFRII 253 vs . 195 pg / ml , p = 0 . 098 ) were detected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The suppression of NF kappaB activation correlated with sequential inhibition of the tumor necrosis factor ( TNF ) induced activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , p 65 phosphorylation , p 65 nuclear translocation , and the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRAF 2 , NIK , IKK beta , and the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The cytoplasmic tail of the tumor necrosis factor receptor 1 ( TNF RI ) contains several functionally distinct domains involved in apoptotic signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As radiation can generate apoptotic signals , we wished to examine the potential to protect the liver by inhibiting apoptosis through two key mediators , FAS and tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor associated periodic syndrome ( TRAPS ) is an autosomal dominant systemic autoinflammatory disease associated with heterozygous mutations in TNF receptor 1 ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Secreted tumor necrosis factor ( TNF ) alpha and the expression level of TNF receptor 1 ( TNFR 1 ) and TNFR 2 were compared in EBV positive and negative B cell lines . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we report that the receptor for tumor necrosis factor alpha ( TNF R 1 ) rapidly disappears from both the cell surface and total cell lysates in cells infected with wild type virus or a variety of mutants but not in cells infected with the mutant DeltaU ( L ) 41 , which lacks the U ( L ) 41 gene , the virion host shutoff gene . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CpG ODN induced the release of tumor necrosis factor ( TNF ) alpha and the expression of TNF receptor ( TNFR ) 2 , but not of TNFR 1 , in a time dependent manner and stimulated significant , though delayed , MMP 9 expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the effect of mutations in the tumor necrosis factor receptor superfamily 1A ( TNFRSF1A ) gene on the conformation and behavior of the TNFRSF1A protein . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas and tumor necrosis factor receptor 1 ( TNFR 1 ) are death receptors involved in various diseases such as hepatitis , sepsis , or graft rejection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We also focus on new B7 / CD28 and tumor necrosis factor ( TNF ) / TNF R family costimulatory molecules that can deliver positive or negative costimulation signals regulating the alloimmune response . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Poxvirus tumor necrosis factor receptor ( TNFR ) like T 2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR 1 induced cell death . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The mechanistic relationship between the signalling for the TNF effects by the human p 55 TNF receptor ( hu p 55 TNF R ) and the formation of a soluble form of the receptor , which is inhibitory to these effects , was explored by examining the function of C terminally truncated mutants of the receptor , expressed in rodent cells . ^^^ These findings suggest that signalling and shedding of the p 55 TNF R are mechanistically distinct . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The increase was apparently due to enhanced expression of the 75 kDa TNF R , whereas the amounts of the 55 kDa TNF R did not change significantly . ^^^ In contrast , in HL 60 cells induced to differentiate into macrophage like cells , expression of the 55 kDa TNF R species was completely abolished . ^^^ The pattern of TNF R expression in the differentiated HL 60 cells was similar to that observed in leukocytes isolated from peripheral blood : on granulocytes , there were about equal amounts of both receptor species , whereas on monocytes the 75 kDa receptor was predominant . ^^^ The loss of 55 kDa receptors during differentiation of HL 60 cells into macrophage like cells was accompanied by a pronounced decrease in the level of the mRNA for that receptor , suggesting that at least part of the change in TNF R expression is due to mechanisms that control the amounts of receptor mRNA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In resting PMNs , the p 55 receptor was associated with both gamma and beta fractions , enriched in plasma membranes and specific granules , respectively , whereas the p 75 TNF R was located only in the gamma fraction . ^^^ Intracellular p 55 TNF R bound 125I labeled TNF in a ligand blot assay and migrated as a diffuse band of 46 60 kd , similar to the plasma membrane receptor . ^^^ Activation of PMNs with the chemoattractant N formyl methionyl leucyl phenylalanine ( fMLP ) , in conditions that induced the selective release of the tertiary granule marker gelatinase , caused the shedding of most of membrane p 55 TNF R as a 28 kd soluble form but had little effect on the distribution of the receptors in beta fractions . ^^^ By contrast , when specific granule secretion was induced in the presence of cytochalasin B , a marked decrease in reactivity of beta fractions with anti p 55 TNF R antibody was observed . ^^^ Thus , the intracellular pool of p 55 TNF R is associated with functional secretory granules and is redistributed in response to PMN activation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These data provide direct evidence for a functional role of TNF R 75 , without ligand dependent TNF R 55 involvement , in the induction of cytokine secretion in T cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have synthesized a series of peptides , which cover almost the whole range of the N terminal extracellular domain of human 55kDa TNF receptor ( 55kDa TNF R ) . ^^^ These results indicate that the specific binding site of 55kDa TNF R to TNF might reside within the peptide segment of amino acid numbers 159 to 178 in the N terminal extracellular domain . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Characterization of the TNF R by flow cytometric analysis revealed increased membrane expression of the 75 kDa , but not the 55 kDa , TNF binding protein as a result of IL 1 costimulation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The results are discussed with respect to recent findings showing that , in the mouse , rhTNF can only bind to the TNF R 55 receptor type , while rmTNF can bind both to the TNF R 55 and TNF R 75 receptor types . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have previously shown that to obtain lethality in mice after TNF administration both TNF receptor ( TNF R ) types have to be triggered . ^^^ This is illustrated by the fact that recombinant human ( rh ) TNF , which is a selective murine ( m ) TNF R 55 agonist , is not lethal , whereas mTNF , which binds both mTNF R 55 and mTNF R 75 , is lethal in mice . ^^^ Triggering of TNF R 75 is , however , no longer needed when sensitizers such as galactosamine or low doses of LPS or interleukin ( IL ) 1 are also present . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The regulation of the 55 kDa TNF receptor ( TNF R ) mRNA synthesis , membrane expression , and TNF binding factor ( BF ) release was examined in resting and activated human monocytic THP 1 and human promyelocytic leukemia HL 60 cells in vitro . ^^^ Fifty five kilodalton TNF R mRNA expression during this time period did not correlate with the level of membrane TNF binding site expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast , differentiated effector T cells triggered through the TCR or protein kinase C initiated a rapid down regulation ( transmodulation ) of the TNFR 1 that preceded TNF or lymphotoxin secretion . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
On the other hand , amino acid sequences in the soluble form of the type 2 TNF R ( TBPII ) , while indicating a marked homology of structure , did not suggest any identity between this protein and the extracellular domain of the type 1 TNF R . ^^^ The cDNA for the type 1 TNF R , cloned using amino acid sequence data of its soluble form , encodes both the cell surface and a soluble form of the receptor . ^^^ The two proteins cross react immunologically with two species of cell surface TNF receptors ( TNF R ) . ^^^ Oligonucleotide probes designed on the basis of the NH 2 terminal amino acid sequence of TBPI were used to clone the cDNA for the structurally related cell surface type 1 TNF R . ^^^ The amino acid composition and size of the extracellular domain of the type 1 TNF R closely resemble those of TBPI . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF BP contains 24 cysteine residues and three potential N glycosylation sites and shows sequence homology to the extracellular portions of TNF R p 80 chain and nerve growth factor receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 27 belongs to a newly defined family of transmembrane R , including the nerve growth factor R , two distinct TNF R and CD 40 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
By using mAb against the p 55 and p 75 TNF R , NK cells were found to express both p 55 and p 75 upon activation , and both receptors were involved in the generation of lymphokine activated killer cells activity . ^^^ Furthermore , addition of rTNF alpha increased the IL 2 induced proliferation of NK cells . mAb to p 55 and p 75 inhibited the IL 2 induced proliferation indicating that both TNF R are involved in mediating this effect . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Both physiological ( poly ) peptides ( FMLP , C5a , CSF GM ) and pharmacologic agonists ( PMN , calcium ionophore A 23187 ) induced the loss of TNF receptors ( TNF R ) from the cell surface . ^^^ Half maximal loss in TNF R ensued after only approximately 2 min with 10 ( 7 ) M FMLP at 37 degrees C , and required only 10 ( 9 ) M FMLP during a 30 min exposure . ^^^ The binding of anti TNF R mAbs to PMN decreased in parallel , providing independent evidence for the loss of TNF R from the cell surface . ^^^ At the same time , soluble TNF R appeared in the medium of stimulated PMN . ^^^ This inference was based on the PMN and FMLP dependent generation of a nonsedimentable activity that could inhibit the binding of TNF to fresh human PMN or to mouse macrophages , and the ability of mAbs specific for human TNF R to abolish inhibition by PMN conditioned medium of binding of TNF to mouse macrophages . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Protein sequencing has verified that it is distinct from a previously described TNF inhibitor that is a soluble fragment of a TNF receptor molecule ( TNFrI ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These studies indicate that unlike IL 1 , membrane associated TNF is not an integral membrane protein and that TNF may be associated with the monocyte membrane by occupying the TNF R . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The Fas Ag and the p 55 TNF receptor ( TNF R 1 ) are related molecules that can signal apoptosis . ^^^ Some tumor cell lines are selectively killed by Fas activation and others by TNF R 1 activation even though both receptors are often co expressed . ^^^ TNF R 1 mediated cytotoxicity can be selectively inhibited under conditions in which Fas mediated cell death is not affected . ^^^ These results indicate that different biochemical pathways are activated by Fas and TNF R 1 . ^^^ Combination treatment with agonists of Fas and TNF R 1 may have therapeutic potential . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This cytotoxic effect does not involve the Fas death pathway and differs from the TNF triggered death of tumor cells in several respects : 1 ) It is a slower process , requiring 2 to 3 days ; 2 ) it is blocked , rather than enhanced , by cycloheximide ; and 3 ) based on the agonistic effect of anti TNF receptor Abs , it involves a synergistic effect of both the 55 kDa TNFR 1 and the 75 kDa TNFR 2 , as opposed to the dominance of TNFR 1 for tumor cytotoxicity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These anti TNF R 75 antibodies bound effectively to HUVEC , as evidenced in binding studies using 125I TNF , but they did not induce or enhance E selectin or ICAM 1 expression as did agonistic anti TNF R 55 antibodies . ^^^ These results support the hypothesis , that in cells responding to TNF via the signalling pathway of the TNF R 55 , the extracellular part of TNF R 75 captures TNF and delivers it to TNF R 55 , resulting in an enhanced response to TNF . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Presumably , the latter efficiently traps the ligand and transfers it to TNF R 55 , and / or by binding it , protects the endogenously made TNF from inactivation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Anti p 75 TNF R 2 receptor and to a lesser extent anti p 55 TNF R 1 MAbs inhibited TNF mediated up regulation of DR mRNA and TNF mRNA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 1 but not TNF R 2 is responsible for TNF and LT ' s induction of MnSOD . ^^^ Paradoxically , the TNF R 1 is also the receptor that mediates the production of oxygen free radicals and apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It exerts its effects by binding two cell surface receptors , designated TNF R 1 and 2 , also referred to as the p 55 and p 75 receptors , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Both human microglia and oligodendrocytes express the two TNF receptors , TNF R 1 , which has been implicated in cytotoxicity , and TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It has been proposed that the modulation of TNF R expression , particularly by IFNs , is an important factor in TNF ' s biological effects . ^^^ This finding stimulated interest in examining IFN gamma modulation of TNF R as a factor in the antiviral activity of TNF . ^^^ HSV 1 infection of L 929 cells resulted in a significant upregulation of TNF R expression which was reversed if the cells had been preexposed to IFN gamma . ^^^ The inclusion of TNF with IFN gamma before infection restored TNF R expression but did not show any further synergistic or additive effects on TNF R expression . ^^^ Some minor increases in TNF R expression were seen if Mab 32 was included with these two cytokines . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF , a potent activator of neutrophil granulocytes , acts via two cell surface receptors : the p 55 TNF receptor ( TNF R 55 ) and the p 75 TNF receptor ( TNF R 75 ) , which can be cleaved from the cell surface and thus form soluble TNF binding proteins ( TNF BP ) . ^^^ Two mAbs reacting with TNF R 55 ( H 398 and TBP 2 ) induced O 2 release in a similar manner but to a lesser extent than TNF . ^^^ This inhibitory effect could not be explained by cross down regulation of TNF R 55 because the TNF R 75 mAb had no effect on TNF binding to TNF R 55 as determined by binding of 125I labeled TNF or release of TNF R 55 BP as measured by ELISA . ^^^ Furthermore , the TNF R 75 mAb did not decrease superoxide anion generation induced by the TNF R 55 mAb H 398 , thus ruling out that the inhibitory effect of the TNF R 75 mAb is due to inhibition of the signaling pathway downstream of TNF R 55 . ^^^ In contrast to the TNF R 75 mAb , TNF R 55 mAbs induced down regulation of TNF R 75 and shedding of both TNF R 55 BP and TNF R 75 BP . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The present study shows that , surprisingly , rTNF added after an antigen ( PPD ) pulse inhibited , while anti TNF monoclonal antibody ( mAb ) enhanced , antigen presentation . mAbs htr 9 against p 55 TNF receptor type 1 ( TNF RI ) abrogated rTNF enhancing effect on PPD presentation and decreased presenting activity of untreated monocytes while utr 1 mAb , against p 75 TNF receptor type 2 ( TNF RII ) , reversed the inhibitory effect of rTNF given after antigen pulse . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of soluble forms of TNF receptors ( TNF R 1 and TNF R 2 ) in sera of tumor bearing mice showed that soluble TNF R 1 was downregulated in both CHO TNF and CHO LT , in comparison with CHO neo cell injected mice and to normal SCID mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression and biological role of 55 and 75 kDa tumour necrosis factor receptors ( TNF RI and TNF RII ) in human polymorphonuclear cells ( PMN ) in vitro were studied using agonistic rabbit polyclonal anti TNF R antibodies . ^^^ Anti TNF RI but not anti TNF RII antibody stimulated the superoxide release mimicking LT . ^^^ Anti TNF RI but not anti TNF RII antibody augmented the elastase release . ^^^ Anti TNF RI but not anti TNF RII antibody enhanced the lactoferrin release . ^^^ Anti TNF RI but not anti TNF RII antibody upregulated the adhesiveness and Mac 1 expression of PMN mimicking LT . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , it has not been clear whether the 55 kDa or 75 kDa TNF R is responsible for initiation of cytolysis . ^^^ Thus , the Epo R group was used to drive dimerization of the TNF R cytoplasmic domain . ^^^ Both the 55 kDa and the 75 kDa Epo / TNF R chimeras exerted a constitutive cytotoxic effect detected by cotransfection or clonogenic assay . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Intracellular adhesion molecule ( ICAM ) , IL 8 , and TNF R levels were also increased after ILP with TNF / IFN / M . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
None of the above events occurred in hepatocytes lacking the gene for the 55 kDa TNF receptor ( TNF R 1 ) , even after stimulation with > 1 micrograms / ml TNF . ^^^ However , selective stimulation of the TNF R 1 in wild type hepatocytes with huTNF alpha elicited a pattern of responses essentially similar to that seen with muTNF alpha . ^^^ We obtained analogous results when we examined the hepatotoxicity of TNF in D galactosamine sensitized mice , i . e . , DNA fragmentation and liver failure was noted in wild type mice , whereas TNF R 1 deficient mice were completely resistant . ^^^ We conclude that the TNF R 1 is not only necessary , but also sufficient for TNF signaling in murine hepatocytes . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus , the domain 4 of TNFR 2 , but not that of TNFR 1 , appears to be involved directly in binding TNF , although it is also possible that the domain 4 of TNFR 2 is involved in the correct folding of other domains . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Molecules of the TNF R family have been shown to be essential in the regulation of lymphocyte growth and differentiation . ^^^ The TNF R family member CD 27 binds to a type 2 transmembrane molecule belonging to the TNF gene family ( CD27L ) that is identical to the lymphocyte activation Ag CD 70 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In healthy mice , murine ( m ) TNF is fairly lethal , whereas human ( h ) TNF ( a selective murine TNF R 55 agonist ) is rather harmless . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A rat / mouse T cell hybridoma ( PC 60 ) was transfected either with human ( h ) TNF R p 55 ( TNF R 55 ) , p 75 ( TNF R 75 ) or both cDNAs . hTNF R 55 expression was below 50 molecules / cell , whereas the number of hTNF R 75 reached about 4000 molecules / cell . ^^^ Only cells co expressing the two types of receptor showed TNF dependent apoptosis , in contrast to cells expressing similar levels of only one receptor type , indicating that both TNF R 55 and TNF R 75 are required . ^^^ Both receptors are signal transducing because simultaneous triggering of hTNF R 55 and hTNF R 75 by agonistic mAbs or by TNF R specific TNF muteins induced similar levels of apoptosis as wild type hTNF . ^^^ Apoptotic killing of only those lymphocytes expressing a high , induced level of TNF R 75 , in addition to TNF R 55 , may play a physiologically important role . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We found that CD 8 cells express the 75 kDa ( CD120a ) but not the 55 kDa ( CD120a ) TNF Rs , whereas AMs were devoid of TNF R expression . ^^^ TNF R expression was determined by flow cytometry on BAL CD 8 lymphocytes and AMs ( i . e . , the cells that account for the alveolitis in HIV 1 infection ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The role of 55 and 75 kDa TNF receptor ( TNF R ) in the aggregation and proliferation of T LAK cells was investigated using agonistic anti TNF R rabbit polyclonal antibodies . ^^^ Human peripheral blood T cells and T LAK cells predominantly express 75 kDa TNF R . ^^^ In this phase , the proliferation was upregulated by anti 75 but not 55 kDa TNF R antibody . ^^^ Homotypic aggregation of T LAK cells was induced by LT , TNF , and anti 75 but not by anti 55 kDa TNF R antibody . ^^^ The increase of homotypic aggregation was accompanied by up regulation of intercellular adhesion molecule 1 but not lymphocyte function associated antigen 1 expression on cells and by an elevation of membrane fluidity , both of which were up regulated by anti 75 but not 55 kDa TNF R antibody . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using panels of T cell lines and clones expressing high levels of p 75 TNF R , we found that p 75 sTNF R production upon stimulation is a feature common to all subsets of T cells , including cells of the CD 4 CD8 double negative phenotype expressing either alpha beta or gamma delta T cell receptors ( TCR ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition to pro inflammatory cytokine production , at sites of inflammation such as the RA synovial joint , there is also evidence for homeostatic immunoregulatory mechanisms which include the production of cytokine inhibitors , such as soluble TNF R and the IL 1 receptor antagonist , and cytokines with immunoregulatory properties like IL 10 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The use of TNF mutants that are selective agonists of the TNF R 55 is one strategy that is being explored to broaden the therapeutic margin of TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF is a potent activator of neutrophil granulocytes which acts via two cell surface receptors : the p 55 TNF receptor ( TNF R 55 ) and the p 75 TNF receptor ( TNF R 75 ) . ^^^ The extracellular region of the receptors can be released by proteolytic cleavage and form soluble TNF binding proteins , TNF R 55 BP and TNF R 75 BP , respectively . ^^^ The phorbol ester PMA , the chemotactic peptide FMLP , and TNF were all found to induce release of TNF R 55 BP and TNF R 75 BP from neutrophils in suspension in a time and dose dependent manner as measured by ELISA . ^^^ Exposure of neutrophils to 10 ng / ml of PMA for 60 min resulted in release of 900 pg of TNF R 55 BP and 350 pg of TNF R 75 BP per 5 million cells , corresponding to approximately 4800 receptors per cell . ^^^ In addition , adherence by itself of neutrophils to fibrinogen coated culture plates and other surfaces resulted in a release of TNF R 55 BP of the same magnitude as seen in response of neutrophils in suspension to 1 nM TNF , whereas the release of TNF R 75 BP was less pronounced . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 12 also upregulated the expression of the 75 kDa TNF receptor ( TNF R p 75 ) and the upregulation was inhibited by anti IFN gamma antibody . ^^^ The 55 kDa TNF receptor ( TNF R p 55 ) , however , was not affected by IL 12 , but in the presence of anti IFN gamma antibody , its expression was enhanced . ^^^ Thus , these results suggest that IFN gamma selectively upregulates the expression of TNF R p 75 by IL 12 but inhibits the expression of TNF R p 55 by IL 12 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , little is still known about preexisting serum TNF R levels in patients with chronic renal failure , with or without hemodialysis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Activation of TNF R 1 receptor in the presence of copper kills TNF resistant CEM leukemic T cells . ^^^ The copper cytotoxic effect was shown to be mediated through the TNF R 1 receptor and independent of phospholipase A 2 signaling . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF R also proved to be useful for the differentiation of cyclosporin nephrotoxicity . ^^^ Therefore we believe that the soluble TNF R and its concentration course may be of diagnostic and prognostic value in kidney graft rejection , as it supports the diagnosis of transplant rejection , indicates the rejection event very early , and reflects the response to anti rejection therapy . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) elicits multiple biological effects through two distinct cell surface receptors , TNF R 1 ( p 55 ) and TNF R 2 ( p 75 ) . ^^^ Most TNF mediated biological responses , such as cell death , gene induction , antiviral activity and cytokine production , have been attributed to TNF R 1 ( refs 1 5 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently two distinct types of IL 1 receptors ( IL 1 Rs ) , IL 1R ( p 80 ) and IL 1 R ( p 65 ) , as well as two distinct types of TNF receptors ( TNF Rs ) , TNF R ( p 55 ) and TNF R ( p 75 ) have been identified . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Transformation of peripheral blood B cells to generate LCL also resulted in an increase in surface p 75 ( p < 0 . 02 ) and to a lesser extent p 55 ( not significant , ns ) TNF receptor ( TNF R ) expression . ^^^ Similar increases in surface TNF R ( p 75 p < 0 . 02 , p 55 ns ) were observed on the ' group 3 ' BL cell lines compared with the ' group 1 ' BL cell lines . ^^^ This proliferation could also be blocked in the presence of the antagonistic anti p 55 TNF R antibody , H 398 , but not the antagonistic antibody anti p 75 TNF R antibody UTR 1 . ^^^ In contrast to these observations with p 55 TNF R antibodies , two out of six of the ' group 3 ' BL lines ( Jijoye and Oba ) only expressed the p 75 TNF R and proliferation of these cells could only be blocked by the antagonistic anti p 75 TNF R antibody UTR 1 . ^^^ Furthermore , although both TNF R are increased on the surface of these cells , this autocrine growth signal is mediated principally through binding to the p 55 TNF R . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 27 is a lymphocyte specific member of the tumour necrosis factor receptor ( TNF R ) family , expression of which is tightly regulated during T cell ontogeny . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF is a pluripotent cytokine that mediates activities through two distinct receptors of 55 to 60 kDa ( CD120a , known as TNFR 60 ) and 75 to 80 kDa ( CD120b , known as TNFR 80 ) . ^^^ In the U 937 monocytic cell line , prelabeled with 32PO4 , TNF induces the association of several phosphoproteins with TNFR 60 , but not TNFR 80 . ^^^ The TNFR 60 immune complexes also contain a TNF dependent serine protein kinase activity , which was detected by an in vitro kinase assay , that phosphorylates proteins of 125 , 97 , 85 , and 60 kDa , which are of apparent molecular masses that are similar to those of TNF induced phosphoproteins that coprecipitate with TNFR 60 . ^^^ Association of serine protein kinase activity with TNFR 60 is rapid and dependent on the concentration of TNF . ^^^ Proteins of molecular mass similar to the 125 and 97 kDa protein kinase substrates seem to be associated with TNFR 60 immune complexes only after exposure of U 937 cells to TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Most human cells express two TNF and lymphotoxin ( LT ) membrane receptors ( TNF R ) , of 55 and 75 kDa . ^^^ Rabbit antihuman TNF R antisera specific for each receptor were employed as probes to selectively stimulate 55 and 75 kDa TNF / LT membrane receptor production . ^^^ In the present study , we demonstrated biologic activity for anti 55 kDa TNF R antiserum . ^^^ For example , antibodies that bind to the 55 kDa TNF R caused cytolysis of HeLa and ME 180 human cervical cancer cells and induced proliferation of MRC 5 human fibroblasts . ^^^ In contrast , however , anti 75 kDa TNF R antiserum demonstrated no bioactivity in these assays . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Because hTNF exhibits negligible binding to the type 2 murine TNF receptor ( TNF R ) , we questioned whether murine TNF ( mTNF ) would have therapeutic benefits , scheduling requirements , and toxic effects similar to those of the hIL 2 hTNF combination . ^^^ To evaluate the biological effects of TNF R types 1 and 2 interaction , we directly compared the effects of mTNF and hTNF in combination with hIL 2 on in vivo tumor regression and in vitro activation of murine splenocytes . ^^^ Our results demonstrate for the first time that ( a ) the cytokine combination hTNF hIL 2 is consistently more efficacious than mTNF hIL 2 in in vivo murine immunotherapy models ; ( b ) the in vivo antitumor effects of hTNF hIL 2 and not mTNF hIL 2 are critically dependent upon cytokine scheduling ; and ( c ) in vitro culture of splenocytes with mTNF hIL 2 enhances cellular proliferation , Lyt 2 , and TNF RI expression compared with hTNF hIL 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated the effects of a single bacterial lipopolysaccharide ( LPS ) injection in vivo on the gene expression of tumor necrosis factor alpha ( TNF ) and its receptors : TNF receptor type 1 ( TNF R 55 kDa or TNF R 1 ) and TNF receptor type 2 ( TNF R 75 kDa or TNF R 2 ) in various tissues and white blood cells . ^^^ While TNF mRNA rapidly accumulated in most tissues , TNF R 1 and TNF R 2 mRNA levels were found to be differentially regulated in lung , spleen , lymph nodes and white blood cells . ^^^ In most cases , TNF R mRNA levels did not parallel TNF mRNA levels . ^^^ These observations indicate that TNF R of both types of capable of modulating the host response to LPS , not only by shedding of their extracellular domains , but also by strict regulation of their gene expression . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Specific agonist and blocking antibodies to either 55 kDa ( TNF R 1 ) or 75 kDa ( TNF R 2 ) TNF receptors combined with two dimensional gel analysis were employed to determine which receptor type is responsible for mediating the induction of individual melanoma proteins . ^^^ Our results indicate that the enhanced synthesis of proteins 21 / > 7 ( M ( r ) / pI ) , 28 / 5 . 6 , and 41 / 5 . 7 is selectively induced through TNF R 1 . ^^^ TNF induces these proteins ; antagonist antibody to TNF R 1 prevents their induction by TNF , and TNF R 1 agonist induces them in the absence of TNF . ^^^ Furthermore , TNF cytotoxicity for A 375 cells is also mediated by TNF R 1 . ^^^ These studies indicate that TNF R 1 is a critical signaling receptor for TNF action on A 375 cells and demonstrate the potential use of TNF R 1 antibodies to selectively block or enhance specific effects of TNF on melanoma cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , we investigated the release of soluble ( s ) TNF R by PBMC in vitro . ^^^ In contrast to shedding of TNF R by neutrophils upon activation , release of sTNF R by PBMC proved to be a relatively slow process , reaching a plateau after 2 days of culture . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To identify potential targets for this cytokine , the cells in early and late gestation placentas and extraplacental membranes that express the two TNF receptor ( TNF R ) genes , p 60 and p 80 , were identified by using in situ hybridization and immunocytochemistry . ^^^ Gestation related , cell lineage specific differences in steady state levels of p 60 and p 80 TNF R messenger RNA were observed . p 60 TNF R messenger RNA predominated at both early and late stages of gestation , being high in both mesenchymal and trophoblastic cell lineages . ^^^ By contrast , p 80 TNF R messenger RNA was abundant only in intermittent stretches of first trimester syncytiotrophoblast and term placental mesenchymal cells . ^^^ Overall , intensities of the TNF R hybridization signals were stronger in term than in first trimester tissues . ^^^ Transcription of the two TNF R genes was confirmed by Northern blot hybridization . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Levels of immunoreactive TNF correlated closely with levels of soluble TNF R 1 and R 2 ( r = . 75 and . 59 , respectively ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In muscle from these diabetic animals , RNA transcripts encoding both TNF R 1 ( p 55 ) and R 2 were significantly elevated , although R 2 transcript abundance was less elevated than in fat . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Human LT alpha and a fusion protein ( p 60 : Fc ) comprised of the extracellular domain of the 60 kDa TNF receptor ( TNFR 60 ) fused to the Fc portion of human IgG 1 were produced in insect cells infected with recombinant baculoviruses . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This dual action of TNF may be explained by the existence of two types of receptor for TNF : the smaller , TNF R 55 , is present on most cells and particularly on those susceptible to the cytotoxic action of TNF ; the larger , TNF R 75 , is also present on many cell types , especially those of myeloid origin , and is strongly expressed on stimulated T and B lymphocytes . ^^^ In mice , human TNF binds only to murine TNF R 55 ( ref . 15 ) , which can then mediate cytotoxic activity on malignant cells . ^^^ Here we describe human TNF mutants that sill interact with the human TNF R 55 receptor but which have largely lost their ability to bind to human TNF R 75 . ^^^ Activation of TNF R 55 is sufficient to trigger cytotoxic activity towards transformed cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In cells treated with TNF or IL 1 , the 55 kDa TNF R , although increasing after initial down modulation , remained lower than before treatment . ^^^ Expression of the 75 kDa TNF R species upon treatment with either cytokine was markedly increased . ^^^ The effects of TNF on cell surface expression of the TNF R could not be blocked with antibodies to IL 1 , nor could the effects of IL 1 be blocked with antibodies to TNF , indicating that each cytokine affects the cell surface expression of the receptors independently of the other . ^^^ Applying both cytokines together resulted in much stronger increase in expression of the 75 kDa TNF R than applying each alone . ^^^ Similar changes in cell surface expression and mRNA levels of the two TNF R as observed in SV 80 cells were also found in TNF and IL 1 treated human foreskin fibroblasts . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Both p 60 and p 80 TNF R mRNA were present in the choriocarcinoma cell lines , and DNA synthesis was inhibited by antibody to the p 60 TNF R . ^^^ Collectively , the results indicate that : 1 ) the TNF gene is expressed in both normal and malignant cytotrophoblast ; 2 ) certain molecular , immunologic , and biochemical characteristics of trophoblast derived TNF are similar to macrophage TNF ; and 3 ) the p 60 TNF R facilitates utilization of TNF as an autocrine growth factor by choriocarcinoma cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 55 and TNF R 75 . ^^^ Since human TNF has retained antitumor activity , esp . in combination with IFN gamma , TNF mutants that are selective agonists for the TNF R 55 might have a broader therapeutic margin . ^^^ However , several sensitizing agents may mimic TNF R 75 triggering and so make TNF R 55 triggering a lethal challenge . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Deletion mutagenesis of the intracellular region of the 55 kd TNF receptor ( TNF R 1 ) identified an approximately 80 amino acid domain near the C terminus responsible for signaling cytotoxicity . ^^^ Alanine scanning mutagenesis of TNF R 1 confirmed that many of the amino acids conserved with Fas antigen are critical for the cytotoxic signal . ^^^ This region of TNF R 1 Fas homology is therefore likely to define a novel domain ( death domain ) that signals programmed cell death . ^^^ Mutations within the death domain of TNF R 1 also disrupted its ability to signal anti viral activity and nitric oxide ( NO ) synthase induction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , we noted an increase in the cytokine and growth factor receptors TNF R , IL 1R type 2 , IL 2R , IFN gamma R and PDGF beta R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast to previously examined TNF activities in human cells , thymocyte proliferation was stimulated in response to rabbit polyclonal antibodies directed against the 75 kDa TNF receptor ( TNF R 2 ) , but not those directed against the 55 kDa TNF receptor ( TNF R 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently , we have shown that these differences can be the result of the detection of free TNF vs TNF complexed with soluble TNF R . ^^^ Enhanced levels of soluble TNF R have been reported in patients with kidney malfunction . ^^^ Because the kidney is thought to play an important role in TNF and TNF R metabolism , we investigated the influence of bilateral nephrectomy on TNF clearance and TNF R regulation in a murine model . ^^^ To investigate the roles of TNF R 1 ( P 55 ) and TNF R 2 ( P 75 ) in this process , clearance of TNF was studied by injection of murine and human TNF . ^^^ Based on the fact that murine TNF R 1 ( 55 kDa ) has a similar affinity for murine and human TNF , whereas murine TNF R 2 ( 75 kDa ) shows affinity only for murine TNF , the data obtained suggest an important role for TNF R 2 in inactivation and clearance of TNF by the kidney . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine if this complexity results from changes in the expression of the two TNF receptors during thymocyte differentiation , we examined the expression of the 55 kDa TNF receptor ( TNF R 1 ) and the 75 kDa TNF receptor ( TNF R 2 ) on postnatal human thymocytes . ^^^ Both TNF R 1 and TNF R 2 mRNA were found in resting human thymocytes by reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ Using mAb which specifically react with the respective TNF receptors and a highly sensitive , three step method of immunofluorescence , cell surface TNF R 1 was detected on the vast majority of thymocytes . ^^^ TNF conjugated to phycoerythrin ( TNF PE ) also reacted with a small population of thymocytes and was found to specifically block binding of the TNF R 2 mAb and not the TNF R 1 mAb , implicating preferential binding of TNF PE to TNF R 2 . ^^^ Thus , immature ( TCRneg / low ) thymocytes express TNF R 1 while mature ( TCRhigh ) thymocytes can also express TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Up regulation of IFN gamma receptors and TNF R p 60 receptors was found , while the TNF R p 80 receptor was absent . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We developed a transfection based assay for evaluating human ( h ) Tumour Necrosis Factor receptor ( TNF R ) activities in a rat / mouse T cell hybridoma , viz . ^^^ Here we report on the role of TNF R 75 cross linking in induction of GM CSF secretion and apoptosis . ^^^ The effect of TNF R 75 dimerization , in contrast to trimerization , was analysed by replacing the extracellular domain of this receptor with the equivalent domain of the murine erythropoietin receptor ( EPO R ) , which dimerizes upon ligand interaction . ^^^ To determine the role of the transmembrane region in signal transduction , chimeric EPO R / TNF R 75 were constructed in which the respective transmembrane domains were interchanged . ^^^ By this approach we demonstrated that dimerized chimeric EPO R / TNF R 75 receptors act synergistically with hTNF R 55 induced cytokine production and apoptosis as does trimerized wild type hTNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of ELAM 1 and TNF receptor p 55 ( TNF R 1 ) was not significant on the surface of either ARDS derived or control pulmonary MVEC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fas and TNF receptor 1 ( TNF RI ) share homology at their cytoplasmic death domain and belong to the same gene family , but utilize different pathways to signal activation induced cell death . ^^^ To determine the combined effects of defective TNF RI and Fas signaling on lymphadenopathy and autoimmune disease , we backcrossed TNF RI knockout mice ( Tnfr 1 ( 0 / 0 ) ) with Fas deficient C57BL / 6 lpr / lpr mice . ^^^ These results indicate that the Fas mediated apoptosis defect in lpr mice is accelerated in the absence of TNF RI and that normal expression of TNF RI might partially compensate for the Fas mediated apoptosis defect of mononuclear cells in lpr mice . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To investigate the role of these receptor structures in the pulmonary environment , we evaluated the expression of some members of the TNF receptor ( CD 27 , CD 30 , CD 40 , CD95 / Fas , CD120a , and CD120b ) and TNF ligand ( CD40L , CD70 / CD27L , CD30L , and mTNFalpha ) superfamilies by bronchoalveolar lavage ( BAL ) T cells recovered from healthy subjects and patients with interstitial lung disease ( ILD ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
One , MORT 1 ( also called FADD ) , binds to Fas / APO1 but not to p 55 R ; another , TRADD , binds to the p 55 TNF receptor but not to Fas / APO1 ; and the third , RIP , binds weakly to both receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Spleen morphology and antibody response were investigated in wild type , TNFR 1 / , TNFR 2 / and TNF / LT alpha / mice immunized with SRBC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Human TNF , a specific agonist of murine ( m ) TNF R 55 , is fairly harmless in healthy mice , but readily induces lethality in animals sensitized by a malignant tumor or a bacterial infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , TNFR 2 is the principal mediator of the effects of TNF on cellular immunity , and it may cooperate with TNFR 1 in the killing of nonlymphoid cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The extracellular domains of the human 55 and 75 kD TNF receptors ( p 55 and p 75 TNF R ) are proteolytically cleaved to produce 30 and 40 kD soluble fragments , respectively . ^^^ In this study , the enzymatic activity involved in the cleavage of human p 75 TNF R , named TNF R releasing enzyme ( TRRE ) , was identified in the culture supernatant of PMA stimulated THP 1 cells using an activity assay system established by our group . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Release of sTNF RI was a result of shedding because Northern blot analysis showed that SKv 1 cells expressed a full length TNF RI mRNA , and radioimmunoprecipitation of TNF RI from [ 32S ] cysteine labelled cell extracts demonstrated the presence of normal 55 kDa molecule . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Protection against lethal Escherichia coli bacteremia in baboons ( Papio anubis ) by pretreatment with a 55 kDa TNF receptor ( CD120a ) Ig fusion protein , Ro 45 2081 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signals transduced by binding of tumour necrosis factor alpha ( TNF ) and lymphotoxin alpha ( LT alpha ) trimers to high affinity cell membrane receptors , TNF RI ( p55 / p60 ) and TNF RII ( p75 / p80 ) , affect many cell functions . ^^^ In this study , expression of the gene encoding TNF RI in uteri of cyclic mice was mapped using in situ hybridization . ^^^ TNF RI hybridization signals fluctuated during the cycle . ^^^ Signal intensity was highest during dioestrus 2 , when mRNA encoding TNF RI was present in endometrial epithelial and stroma cells , as well as in myometrial smooth muscle and connective tissue cells . ^^^ The ability of oestradiol and progesterone to modulate steady state concentrations of mRNA encoding TNF RI in uterine cells was assessed by using in situ and northern blot hybridization procedures . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Firstly , stimulation of the 60 kDa TNF receptor ( TNFR 60 ) by a mutant of TNF specific for TNFR 60 induced responses comparable to wild type TNF . ^^^ In contrast , stimulation of TNFR 80 by a TNFR 80 specific TNF mutein did not result in enhancement of tissue factor expression even in the presence of a suboptimal TNFR 60 triggering . ^^^ A TNFR 60 specific antibody inhibited tissue factor production over a broad range of TNF concentrations , indicating an essential role of TNFR 60 in the TNF / VEGF synergy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This is compensated to some degree by the increased production of anti inflammatory cytokines such as IL 10 and TGF beta and cytokine inhibitors such as IL 1ra and soluble TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results suggested that TNF B might still interact with the human TNF R 55 receptor , but it might largely lose its ability to bind to human TNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results suggested that TNF B might still interact with the human TNF R 55 receptor , but it might largely lose its ability to bind to human TNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunocytochemistry of cells grown on slides showed that the TNF receptor type 1 ( TNFR 1 , p 55 ) was the predominant receptor in NN fibroblasts and was localized to the nucleus of cytoplasma . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We also studied the expression of the TNF receptor type 1 ( TNF R 1 ) , known to neutralize TNF activity in its soluble form , and found that expression of the mRNA was increased after endotoxin stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Ectopic expression of a dominant negative mutant of FADD , a cytoplasmic protein that mediates death signalling by Fas / Apo 1 and by TNF receptor type 1 ( TNFR 1 ) [ 6 9 ] , inhibited the induction of apoptosis by anti Fas / Apo 1 antibody , but had little effect on Apo 2L function . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To block rhTNF from binding to receptors , the cells were incubated with monoclonal antibodies against TNF receptors ( anti CD120a and anti CD120b ) . ^^^ MEASUREMENTS AND MAIN RESULTS : Blocking of either CD120a or CD120b receptors individually resulted in inhibition of TNF induced E selectin expression on human umbilical vein endothelial cells . ^^^ CONCLUSIONS : Both CD120a and CD120b receptors are involved in TNF induced E selectin expression on human umbilical vein endothelial cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunohistochemical studies conducted with monoclonal antibodies ( mAbs ) directed against two TNF receptor associated proteins of 55 kDa ( TNF R 1 ) and 75 kDa ( TNF R 2 ) showed that TNF binding sites were expressed in approximately 100 % gastric chief cells . ^^^ Western blot analysis of whole chief cell lysates probed with the TNF R 1 and TNF R 2 mAbs gave two distinct bands of 55 and 75 kDa in the immunoprecipitate . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The initiation of intracellular signaling events through the 55 kDa tumor necrosis factor receptor ( TNF R 55 ) appears to depend on protein intermediates that interact with specific cytoplasmic domains of TNF R 55 . ^^^ By combined use of the yeast interaction trap system and a peptide scanning library , the novel WD repeat protein FAN has been identified , which specifically binds to a cytoplasmic nine amino acid binding motif of TNF R 55 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Attenuation of collagen induced arthritis in 55 kDa TNF receptor type 1 ( TNFR 1 ) IgG 1 treated and TNFR 1 deficient mice . ^^^ The role of TNF and its type 1 receptor ( TNFR 1 ) in the pathogenesis of collagen induced arthritis ( CIA ) was investigated in mice using two approaches . ^^^ First , DBA / 1 mice were treated after immunization with type 2 collagen by injecting TNFR 1 IgG1 fusion protein to neutralize systemic TNF . ^^^ These data suggest that TNFR 1 is the main transducer of TNF proinflammatory effects establishing CIA , but the progression of arthritis to tissue destruction and ankylosis is independent of TNFR1 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF binding to TNFR 60 activates a serine protein kinase activity and phosphoproteins are recruited to the receptor forming a multicomponent signaling complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ TNF , LT alpha and LT beta and their receptors ( CD120a , CD120b , TNFR RP ) interact in a complex fashion . ^^^ Furthermore , H RS cells express several TNF receptors , such as CD 30 , CD 40 , CD 95 , CD120a , CD120b and 4 1BB . ^^^ TNF and LT alpha / CD120a and CD120b , CD30 / CD30L , and CD40 / CD40L are clearly critical elements in the deregulated network of interactive signals between H RS cells and surrounding bystander cells with membrane associated and cytokine mediated events . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , dexamethasone increased while PMA decreased total cellular 55 kDa TNF RI protein as detected by immunoblotting . ^^^ These changes in total cellular 55kDa TNF RI protein did not appear to be mediated at the mRNA level , as assessed by ribonuclease protection assays . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We transiently expressed the intracellular domains of p 55 TNF receptor ( TNFR 1 ) as either a cytosolic or a membrane associated form and examined their effects on the endogenous receptor mediated gene expression as well as on cell viability . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Its receptors , TNF R 55 and TNF R 75 , bind in clefts formed by adjacent identical LT alpha monomers . ^^^ As LT alpha 2 beta 1 expresses an LT alpha alpha cleft , it also binds TNF R . ^^^ In this report we have compared the effects of ligand engagement of TNF R and LT beta R by evaluating the ability of soluble LT alpha beta complexes to initiate activities of human umbilical vein endothelial cells which are characteristically signalled by TNF . ^^^ We also show that neither LT alpha beta heterotrimer signals via TNF R ; in fact LT alpha 2 beta 1 trimers fail to activate NF kappa B and rather inhibit ligand induced TNF R signalling supporting the role for aggregation in TNF R signalling . ^^^ Thus , the ability of LT alpha beta complexes to efficiently initiate tumoricidal but not inflammatory activities distinguishes the LT / LT beta R from the LT / TNF R pathways and suggest novel strategies for exploiting the LT ligands in tumor therapy and for inhibiting TNF R mediated inflammatory sequellae . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Occupancy of the TNF R 55 and engagement of beta 2 integrins cosignaled for an early , marked , and prolonged Cl efflux that was accompanied by a fall in intracellular chloride levels ( Cl 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Through its type 1 receptor ( TNFR 1 ) , the cytokine TNF elicits an unusually wide range of biological responses , including inflammation , tumor necrosis , cell proliferation , differentiation , and apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : The contribution of TNF receptor ( TNF R ) expression was investigated with respect to TNF sensitivity or insensitivity for androgen dependent and androgen independent human prostate cancer ( PCA ) cell lines , respectively . ^^^ METHODS : Flow cytometric analyses using monoclonal antibodies against the 55 kDa receptor ( TNF R 1 ) and the 75 kDa receptor ( TNF R 2 ) indicated that both receptors were expressed on all three cell lines . ^^^ RESULTS : Moreover , expression of TNF R 1 was greater than expression of TNF R 2 in these PCA cells . ^^^ CONCLUSIONS : These data suggest that the lack of an antiproliferative effect of rTNF on the androgen independent PCA cell lines PC 3 and JCA 1 is not due to the failure of these cells to express TNF R , but may be related to the differences in TNF mediated IL 6 expression by these PCA cell lines . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MEASUREMENTS AND RESULTS : Cytokine levels [ tumor necrosis factor alpha ( TNF ) ] , soluble TNF receptor [ TNF R ] , and interleukin 6 [ IL 6 ] and inflammatory proteins [ C reactive protein , alpha 1 antitrypsin ( AAT ) , fibronectin , and haptoglobin ] , as well as hemodynamic parameters and the APACHE 3 score were evaluated before initiation of therapy and 24 h later . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
DESIGN : Transgenic ( knockout [ KO ] ) mice deficient in either the p 55 TNF receptor ( TNF RI ) or the p 80 IL 1 receptor ( IL 1 RI ) were challenged with intravenous lipopolysaccharide ( endotoxin ) or intraperitoneal live Escherichia coli 0111 : B 4 . ^^^ Infection led to 100 % mortality in TNF RI KO mice . ^^^ The IL 1 RI KO mice exhibited less bacteremia and diminished endotoxemia compared with control and TNF RI KO mice 18 and 24 hours after infection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF receptors ( TNF R 1 and TNF R 2 ) are the sole mediators of TNF signaling . ^^^ We have now determined the structure of the soluble extracellular domain of TNF R 1 in two crystal forms at pH 3 . 7 in addition to our earlier report of one form at pH 7 . 5 . ^^^ In all crystal forms , the uncomplexed soluble extracellular domain of the type 1 TNF R ( sTNF R 1 ) exists as a dimer . ^^^ This modular approach will allow us to build accurate models for all members of the TNF R superfamily . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF induced apoptosis , e . g . in murine PC 60 cells , requires the TNF receptor p 55 ( TNF R 55 ) and the TNF receptor p 75 ( TNF R 75 ) ; the latter even does not have to be triggered . ^^^ The intracellular domain of TNF R 55 can be activated in the cytosol by linking it to the trimeric CAT protein ; induction of this fusion protein leads to a full TNF response . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Spleen morphology and antibody responses were investigated in wild type , TNFR 1 / , TNFR 2 / , and TNF / LT alpha / mice immunized with SRBC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LT alpha exists in its soluble form as a homotrimer , which like TNF only binds the TNF receptors , TNF R 55 or TNF R 75 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two TNF receptors that belong to the cysteine rich low affinity nerve growth factor receptor family ( TNF R 1 and TNF R 2 ) are the sole mediators of TNF signalling . ^^^ Three of the four cysteine rich domains of TNF R 1 are constructed from two distinct structural modules , termed A 1 and B 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The association of TRADD , a 34 kDa cytoplasmic protein containing a C terminal death domain , with aggregated TNF receptor 1 ( TNF R 1 ) through their respective death domains leads to NF kappa B activation and programmed cell death . ^^^ Here we show that the TNF R 2 signal transducers TRAF 2 and c IAP 1 are a part of the TNF R 1 signaling complex . ^^^ The recruitment of TRAF 2 and c IAP 1 to TNF R 1 is TNF dependent , is mediated by TRADD , and is independent of TNF R 2 . ^^^ These data establish the physiological involvement of TRAF 2 and c IAP 1 in TNF R 1 signaling and help provide a molecular explanation for both the overlapping and distinct signals generated by the two TNF receptors . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Corynebacterium parvum and Mycobacterium bovis bacillus Calmette Guerin induced granuloma formation is inhibited in TNF receptor 1 ( TNF RI ) knockout mice and by treatment with soluble TNF RI . ^^^ The aim of this study was to examine the role of TNF receptor 1 ( TNF RI ) in the pathogenesis of heat killed Corynebacterium parvum and live bacillus Calmette Guerin ( BCG ) induced granulomas . ^^^ Granuloma formation was analyzed in TNF RI knockout mice and after treatment with soluble TNF RI ( sTNF RI ) . ^^^ TNF RI knockout mice injected with C . parvum or BCG developed fewer and smaller granulomas than wild type control mice . ^^^ In conclusion , TNF signaling via TNF RI contributes to the pathogenesis of C . parvum and BCG induced granulomas . sTNF RI inhibits the development of granulomas and can cause the regression of established granulomas . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The two major signaling molecules for AICD are the Fas and TNF R pathways of apoptosis . ^^^ Defective Fas apoptosis in lpr / lpr mice results in a compensatory increase in TNF R / TNF mediated apoptosis . ^^^ TNF / TNF R has been shown to be a compensatory pathway of apoptosis in T cells and macrophages of lpr / lpr mice . ^^^ Therefore , early production of TNF / TNF R limit an immune response by inducing AICD in the absence of an intact Fas / Fas ligand apoptosis pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The MyD 88 protein has a modular structure composed of an N terminal ' death domain ' ( DD ) similar to the intracellular segments of TNF receptor 1 ( TNFR 1 ) and FAS and a C terminal region related to the signaling domains of vertebrate interleukin 1 receptors ( IL 1R ) and the Drosophila morphogen Toll . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This review summarizes the regulation of TNF R shedding and its kinetics , the complex interaction between the soluble receptors and their ligand in vitro and in vivo , and the potential diagnostic , prognostic and therapeutic value of the soluble receptors in malignant , inflammatory , infectious and autoimmune disorders . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To evaluate potential roles for macrophages , IFN gamma , and TNF receptor 1 ( TNFR 1 ) in the regulation of LPS induced inducible nitric oxide synthase ( iNOS ) mRNA expression , we used a model of macrophage depletion as well as IFN gamma ( GKO ) and TNFR 1 ( TNFR 1 / ) knockout mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A soluble TNF binding protein 1 ( TNF BP 1 ) and a synthetic fragment of TNF BP 1 , TNF R ( 159 178 ) , that contains the biologically active region of TNF BP 1 , were used . ^^^ Four doses of TNF R ( 159 178 ) ( 0 . 25 micrograms , 2 . 5 micrograms , 25 micrograms and 50 micrograms ) were used . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , we examined the adipose expression of both TNF receptors ( TNFR 1 and TNFR 2 ) in human obesity and demonstrated that obese female subjects express approximately twofold more TNFR 2 mRNA in fat tissue and approximately sixfold more soluble TNFR 2 in circulation relative to lean control subjects . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFR p 60 ( TNFR 60 ) is the main mediator of TNF induced apoptosis , although in some cells TNFR 80 is also involved . ^^^ The ability of TNFR 80 to cooperate with TNFR 60 could be mapped to the binding site for the TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
During CM , a significant upregulation of TNF receptor 2 ( TNFR 2 ) , but not of TNFR 1 , was found in brain microvessels of susceptible , but not resistant mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The death signaling pathways induced by TNF R 1 and CD 95 involve a group of death domain containing proteins , including caspase 8 , a member of the interleukin 1beta converting enzyme family . ^^^ TNF R 1 and TNF R 2 also interact with the members of both the TNF R associated factor family and the inhibitor of apoptosis protein family ; these interactions lead to cell survival . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The two apoptosis receptors of mammalian cells , i . e . the 55 kDa TNF receptor ( TNF R 1 ) and CD 95 ( Fas / APO1 ) are activated independently of each other , however , their signaling involves a variety of ICE related proteases [ 1 ] . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This increased expression leads to a reduced sensitivity toward TNFR 1 mediated phenomena , such as the sensitized TNF cytolytic activity on lung MVEC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine their role in vivo in lipopolysaccharide ( LPS ) and TNF induced skin inflammatory necrosis , TNFR 1 , TNFR 2 , and TNF lymphotoxin alpha ( LT alpha ) deficient mice were used . ^^^ The present data strongly suggest that TNFR 1 , rather than TNFR 2 , is engaged in LPS and TNF induced skin necrosis and highlight the predominant role played by TNF in LPS induced inflammatory diseases . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , T cell responses of HNT TCR transgenic mice also expressing the human TNF globin transgene were markedly reduced compared to HNT TCR single transgenic littermates , indicating that sustained p 55 TNF R signaling is sufficient to suppress T cell function in vivo . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Therefore , we investigated the expression of tumour necrosis factor alpha receptor ( TNF R ) 1 and 2 in lesional skin of 15 patients suffering from acute eruptive LP by means of immunohistochemistry . ^^^ These enhanced serum titres were correlated with a prominent expression of TNF RI on lesional keratinocytes ( basal > suprabasal ) and of both receptors on skin infiltrating lymphocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Caspase 8 is recruited to Fas and TNF receptor 1 ( TNF R 1 ) through interaction of its prodomain with the death effector domain ( DED ) of the receptor associating FADD . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , the effects of TNF binding protein 1 ( TBP 1 ) on TNF induced changes of human brain microvascular endothelial cells ( MVEC ) were investigated . ^^^ TBP 1 completely abolished TNF induced IL 6 production and E selectin induction , while it partially inhibited TNF induced IL 8 production and up regulation of ICAM 1 and VCAM 1 . ^^^ Moreover , TBP 1 significantly inhibited TNF induced cytotoxicity and leukocyte adherence on human brain MVEC . ^^^ The inhibitory activity of TBP 1 for TNF was dose dependent and related to the time of administration after TNF stimulation . ^^^ In addition , TBP 1 inhibited membrane bound TNF induced activation of human brain MVEC , but the concentration required was about 10 fold higher than that for soluble TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LTalpha is secreted as a homotrimer and signals through two TNF receptors of 55 60 kDa ( TNFR 60 ) or 75 80 kDa ( TNFR 80 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A significant increase in the expression of TNF receptor 2 ( TNFR 2 , p 75 ) , but not of TNFR 1 ( p 55 ) , was found on brain microvessels at the time of CM in susceptible animals . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two types of TNF receptor ( TNF RI and TNF RII ) are expressed in virtually every cell and have different biologic roles . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Sterile , cytokine free ascites or saline ( control ) was subsequently administered intravenously ( 20 ml / kg ) to healthy rats and to IL 1 R 1 or TNF R 1 knockout mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF exerts its biological activities through two distinct receptors of TNF R 55 and TNF R 75 . ^^^ Various TNF mutants with higher affinity to TNF R 55 and lower affinity to TNF R 75 are being clarified biogenetically . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we have used soluble receptor Ig forms of LT beta R and TNF R 55 and mAbs specific for murine LT alpha , LT beta , and LT beta R to characterize the appearance of surface LT alpha beta complexes and LT beta R on several common murine cell lines . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The weak activity observed was inhibited by a soluble murine TNF R 55 Ig fusion protein ( mTNF R 55 Ig ) , but not by mLT beta R Ig . ^^^ Combined , these observations suggest that secreted mLT alpha may not play a role in the mouse via interactions with TNF R 55 , and the ramifications of this hypothesis are discussed . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The implantation of the Lewis lung carcinoma ( a fast growing mouse tumour that induces cachexia ) to both wild type and gene deficient mice for the tumour necrosis factor ( TNF ) receptor type 1 protein ( Tnfr 1 ( 0 ) / Tnfr1 ( 0 ) ) , resulted in a considerable loss of carcass ( 26 % ) and white ( 77 % ) and brown adipose ( 37 % ) tissue weights in the wild type mice , while it induced much less marked effects in the gene deficient mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The L929sA CAT R55i cell line , in which cell death can be induced by controlled cytoplasmic expression of a trimeric fusion protein between chloramphenicol acetyltransferase and the intracellular domain of TNF R 55 ( CAT R55i ) , was supertransfected with the murine TNF gene . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TRAF 2 is an intracellular signal transducing protein recruited to the TNFR 1 and TNFR 2 receptors following TNF stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
High sensitivity of transgenic mice expressing soluble TNFR 1 fusion protein to mycobacterial infections : synergistic action of TNF and IFN gamma in the differentiation of protective granulomas . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The type 1 receptor ( TNF R 1 ) has been shown to be essential and sufficient for most cellular responses to soluble TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cellular responses to TNF are initiated by either of two cell surface receptors , the type 1 TNF receptor ( TNFR 1 ) and the type 2 TNF receptor ( TNFR 2 ) . ^^^ Phosphorylation of Jak proteins was also induced by human TNF , which selectively binds to TNFR 1 on murine cells . 35S labeled Jak kinases were precipitated from a cell free system and from lysates of 3T3 L 1 adipocytes by a glutathione S transferase fusion protein containing the cytoplasmic domain of TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF receptors , TNF R 55 and TNF R 75 , may undergo proteolytic cleavage and form soluble receptor forms , TNF R 55 BP and TNF R 75 BP . ^^^ Neutrophils are abundant with both forms of TNF receptors , while endothelial cells ( ECV 304 ) only express TNF R 55 . ^^^ In addition , TNF R 55 BP decreased the production of TNF from IL 1 beta stimulated endothelial cells , suggesting that soluble TNF receptor forms are able to inhibit TNF production . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cloning of the respective cDNAs and obtaining the receptor specific molecular tools such a agonistic and blocking monoclonal antibodies , TNF muteins with exclusive ability to bind to only one receptor type , as well as generation of TNF R mutants by site directed mutagenesis enabled researchers to answer key questions of the biology of initial steps in the cascade of TNF signal transduction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using immuno fluorescence and confocal microscopy , it was shown that TNFalpha and TNF receptor ( TNFR 1 , and TNFR 2 ) immunoreactivity was present in sections of chick embryo lenses . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mitochondrial translocation correlated with sensitivity to the cell death inducing activity of TNF and was mediated by the 55 kDa TNF receptor ( TNF R 55 ) , but not by Fas , indicating that the signaling pathway requires a TNF R 55 specific but death domain independent signal . ^^^ Indeed , using L 929 cells that express mutant TNF R 55 , we showed that the membrane proximal region of TNF R 55 was essential for signaling to mitochondrial translocation . ^^^ Based on this functional mimicry , we propose that a TNF R 55 membrane proximal region dependent signal impedes mitochondria associated kinesin , resulting in cooperation with the TNF R 55 death domain induced cytotoxic response and causing the observed clustering of mitochondria . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These include Fas , TNF R 1 , lymphocyte associated receptor of death ( LARD ) , DR 4 , and TNF related apoptosis inducing ligand receptor inducer of cell killing 2 ( TRICK 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The presence of the core protein did not alter the level of TNFR 1 mRNA in the cells or expression of TNFR 1 on the cell surface , suggesting that the sensitization of cells to TNF by the viral core protein was not due to up regulation of TNFR 1 . ^^^ These results together suggest that the core protein can promote cell death during HCV infection via TNF signaling pathways possibly as a result of its interaction with the cytoplasmic tail of TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus , gene therapy combining transfection of the TNF R 55 gene with administration of mutein TNF 471 may provide a new modality for the treatment of pancreatic cancer . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutralizing antibodies to TNF , to the TNF receptor 1 ( TNFR 1 ) , and to the TNF receptor 2 ( TNFR 2 ) were administered by epineurial injection once daily to mice with CCI . ^^^ Testing of the animals ' hind paws with thermal and innocuous mechanical stimuli revealed a reduction in thermal hyperalgesia and mechanical allodynia in mice treated with neutralizing antibodies to TNF and to TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Deletion analysis of the cytoplasmic domain of CD 27 revealed that the C terminal PIQEDYR motif was indispensable for both NF kappaB and SAPK / JNK activation and was also required for the interaction with TNF receptor associated factor ( TRAF ) 2 and TRAF 5 , both of which have been implicated in NF kappaB activation by members of the TNF R superfamily . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The binding affinity of the mutant to TNF R 55 and TNF R 75 receptors was over 10 fold higher than that of the wild type . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Role of TNFR 1 and TNFR 2 in TNF induced platelet consumption in mice . ^^^ To explore the site of action of TNF , labeled platelets from TNFR 1 / or + / + donors were transferred to TNFR 1 / or + / + recipients . ^^^ TNF induced the consumption of platelets from TNFR 1 / donors when injected into + / + recipients , while platelets from + / + donors were not consumed when present in TNFR 1 / recipients ; this finding indicates that TNF acts on the TNFR 1 of host cells but does not act on platelets . ^^^ These results indicate that TNF induces platelet consumption by acting not on platelets directly but on the TNFR 1 of other cells , presumably increasing the release of factors with agonist activity for platelets . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 55 is the main receptor mediating TNF induced cytotoxicity . ^^^ However , in some cells TNF R 75 also signals cell death . ^^^ In PC 60 cells , the presence of both receptor types is required to induce apoptosis following either specific TNF R 55 or TNF R 75 triggering , pointing to a mechanism of receptor cooperation . ^^^ In this study , we extend previous observations and show that TNF R 55 and TNF R 75 cooperation in the case of apoptosis in PC 60 cells is bidirectional . ^^^ We also demonstrate ligand independent TNF R 55 mediated cooperation in TNF R 75 induced granulocyte / macrophage CSF secretion , but not vice versa . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FACS analyses showed that NB 4 cells express both TNF receptor 1 ( TNF R 1 ) and TNF R 2 to a similar extent . ^^^ Blocking MoABs against TNF R 1 ( anti TNF R 1 ) decreased the constitutive expression of MMP 9 , whereas anti TNF R 2 had almost no effect . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Depending on the DNA virus and the viral proteins , the following mechanisms to prevent TNF receptor and Fas induced apoptosis are used : ( 1 ) absorption of extracellular TNF by secreted homologs of the TNF receptor ; ( 2 ) degradation of Fas ; ( 3 ) inhibition of the assembly of FADD and Caspase 8 with TNFR 1 and Fas ; ( 4 ) direct inhibition of proapoptotic caspase enzymatic activity ; and ( 5 ) inhibition of the proapoptotic members of the Bcl 2 family . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated lymphotoxin ( LT ) and TNF function in lymph node genesis and cellular organization by manipulating LTbeta R and TNF R signaling . ^^^ Normal mice treated in utero with LTbeta R Ig and TNF R 55 Ig or anti TNF lacked all lymph nodes , indicating that TNF signaling contributes to lymph node genesis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recent studies in mice harboring a targeted disruption of genes encoding TNF receptor 1 ( TNFR 1 ) or Interleukin 6 ( IL 6 ) suggested a critical role for TNF and IL 6 in initiation of liver regeneration after 2 / 3 partial hepatectomy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We used KO mice lacking either TNF receptor 1 ( TNFR 1 ) or receptor 2 ( TNFR 2 ) to determine whether signaling at the start of liver regeneration after partial hepatectomy ( PH ) involves only one or both TNF receptors and to analyze in more detail the abnormalities caused by lack of TNFR 1 receptor , which is required for the initiation of liver regeneration . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This recombinant protein will be useful for developing TNFR 1 antibodies and studying the roles of TNF and TNFR 1 in the pathogenesis of infectious diseases in swine . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although death mediated by TNF RII is not as widely studied as that mediated by TNF RI , we show here that it is also dependent on proteolytic cleavage by caspases and triggered by a brief initial encounter with antigen . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As soluble TNF receptors ( TNF R ) act as naturally occurring competitive inhibitors of this cytokine , we investigated plasma levels of the soluble sTNF R 55 and sTNF R 75 in comparison with plasma cortisol and body temperature in nine healthy male volunteers during a defined 16 h light / 8 h dark cycle . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have previously demonstrated , using expressed deletion constructs , that the fourth membrane proximal cysteine rich repeat of the p 55 TNF receptor ( TNF R ) is not required for binding of tumour necrosis factor alpha ( TNF ) or lymphotoxin alpha ( LT ; tumour necrosis factor beta ) . ^^^ We and others have also shown that the soluble p 55 TNF R , rendered dimeric by fusion to an IgG backbone is extremely effective at neutralizing the harmful effects of TNF overproduction , such as in toxic shock . ^^^ Here we address the question of how the TNF binding properties of the truncated TNF R comprising the three distal cysteine rich repeats ( delta 4 TNF R ) , when fused with an IgG backbone , compare with those of the full length soluble receptor . ^^^ We constructed several versions of the soluble delta 4 TNF R , on a complete IgG heavy chain backbone and on an IgG lacking the CH 1 ( first constant region ) domain . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF injection induced a cell loss of similar magnitude in wild type ( + / + ) or in mice lacking the TNF receptor ( TNFR ) 2 ( p 75 , TNFR 2 / ) , while mice lacking the TNFR 1 ( p 55 , TNFR 1 / ) were completely resistant to this effect . ^^^ TNF increased the expression of p 53 in both TNFR 2 / and TNFR 1 / mice . ^^^ The results indicate that TNF , acting on its receptor 1 , induces an apoptotic detachment of the enterocytes from the tip of the villi ( i . e . the old enterocytes ) , while in the enterocytes from the crypts ( the young enterocytes ) TNF increases , via either TNFR 1 or TNFR 2 , the expression of p 53 , without inducing apoptosis . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To assess the role of either TNF receptor ( TNFR ) type in apoptosis , MVEC isolated from mice genetically deficient in TNFR 1 ( Tnfr1o mice ) or TNFR 2 ( Tnfr2o mice ) were incubated with TNF in the presence or absence of Act . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In conclusion , SV induced cell injury is mediated by CD 95 and TNF R 1 independent activation of caspases , leading to the death of host cells without impairment of the viral life cycle . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although the surface expression of TNF R assessed by 125I TNF specific binding was decreased in the presence of hydrogen peroxide or PMA , TNF RI mRNA transcript levels remained unchanged . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we demonstrate that TNF R 55 is sufficient to activate p42 / p44 MAPK and p 38 MAPK . ^^^ Moreover , by expressing different membrane bound or purely cytoplasmic truncations of TNF R 55 , we show that the intracellular death domain of TNF R 55 is the crucial domain involved . ^^^ The cytoplasmic membrane proximal region of TNF R 55 , known to induce neutral sphingomyelinase activation , is not required for activation of p 38 MAPK or p421p44 MAPK . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The exclusive role of the 55 kDa TNF receptor ( TNF R 55 ) as the signaling receptor in TNF induced activation of respiratory burst by human polymorphonuclear leukocytes residing on biologic surfaces has been inferred from results obtained with receptor specific monoclonal and polyclonal Abs . ^^^ This conclusion stems from three sets of data : 1 ) none of the TNF R 55 specific agonists used , i . e . , mAbs or p55TNF , induced a respiratory burst comparable with that induced by TNF ; 2 ) selective down modulation of TNF R 75 resulted in a diminished response to TNF but not to TNF R 55 specific agonists or to the chemotactic peptide FMLP ; and 3 ) mAbs that either block or stabilize binding of TNF to TNF R 75 inhibited the response to the cytokine , suggesting that cooperation requires not only TNF binding to the receptor but also an appropriate dissociability from it . ^^^ Such a cooperation does not seem to rely on the activation of a TNF R 75 linked signaling pathway independent of TNF R 55 , since the response to p55TNF and p75TNF given in combination was not higher than the response to p55TNF alone . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we report that BLC expression by follicular stromal cells is defective in TNF , TNF receptor 1 ( TNFR 1 ) , LTalpha and LTbeta deficient mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we report that stimulation of the 55 kDa TNF receptor ( TNFR 1 ) induced an overall decrease in filamentous actin ( F actin ) , inhibited CSF 1 and Cdc 42 dependent filopodium formation , and stimulated macropinocytosis . ^^^ We conclude that different domains of TNFR 1 mediate distinct changes in the Mphi cytoskeleton , and that the ability of TNF to inhibit Mphi chemotaxis may be due to decreased filopodium formation downstream of Cdc42 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF recruits TRADD to the plasma membrane but not the trans Golgi network , the principal subcellular location of TNF R 1 . ^^^ The subcellular localization of TNF R 1 to the Golgi apparatus , initially observed in endothelial cells , has been confirmed using transfection of bovine aortic endothelial cells with a human TNF R 1 expression plasmid . ^^^ The subcellular interactions of TNF R 1 and the TRADD ( TNFR associated death domain protein ) adaptor protein have been analyzed in the human monocyte cell line U 937 and the human endothelial cell line ECV 304 by confocal immunofluorescence microscopy and by Western blot analysis of fractionated cell extracts . ^^^ In untreated cells , in which TNF R 1 is found on the cell surface but principally localizes to the trans Golgi network , TRADD is concentrated in the cis or medial Golgi region , but separates from the Golgi during cell fractionation . ^^^ Coimmunoprecipitation studies have shown that TRADD binds to TNF R 1 within 1 min of TNF treatment in a cell fraction containing plasma membrane . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The constitutive expression of TNF receptors ( TNFRI and TNFRII ) and the adapter molecules , including TNFR associated death domain protein ( TRADD ) , TNFR associated factor 2 ( TRAF 2 ) , and receptor interacting protein ( RIP ) , were analyzed both at the protein level by flow cytometry or Western blotting , and at the mRNA level using quantitative PCR or Northern blotting in lymphocytes from aged and young subjects . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
High TNF R production could thus suggest that HCV related liver disease involves immunological mechanisms , including activation of the TNF system . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MEASUREMENTS AND MAIN RESULTS : Using monoclonal antibodies , fluorescence labeling , and high sensitivity flow cytometry , we measured the expression of membrane TNF receptor subtypes TNF R 55 and TNF R 75 on peripheral blood leukocytes . ^^^ In controls , TNF R 55 was only weakly expressed ( monocytes : 2 . 5+ / 1 . 8 ; neutrophils : 0 . 7+ / 0 . 8 ) , whereas expression of TNF R 75 was higher ( monocytes : 28 . 6+ / 9 . 0 ; neutrophils : 4 . 8+ / 1 . 0 ) and was also found on lymphocytes ( on CD8+ lymphocytes : 5 . 7+ / 1 . 8 ; CD16+ : 5 . 5+ / 1 . 2 ; CD4+ : 9 . 7+ / 3 . 7 ) . ^^^ In SIRS , we observed increased expression of TNF R 55 on monocytes ( 6 . 9+ / 3 . 4 , p < . 001 ) and neutrophils ( 2 . 2+ / 1 . 9 , p < . 01 ) , as well as decreased expression of TNF R 75 on monocytes ( 17 . 3+ / 13 . 2 ; p < . 001 ) . ^^^ The extent of TNF R 55 up regulation did not correlate with that of TNF R 75 down regulation . ^^^ TNF R 55 on monocytes and neutrophils strongly correlated with body temperature but not with survival , whereas monocyte TNF R 75 was considerably lower in nonsurvivors , albeit not significantly ( 12 . 3+ / 7 . 1 vs . 23 . 9+ / 16 . 7 ; p = . 07 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To address the question of whether the cell death inducing cytokines TNF and lymphotoxin alpha are involved in this process , we generated nonobese diabetic ( NOD ) mice that are deficient for TNF receptor 1 ( TNFR 1 or TNFRp 55 ) . ^^^ Since this was probably due to the complex immunomodulatory effects of TNF and lymphotoxin alpha signaled via TNFR 1 on lymphohemopoietic cells , adoptive transfer experiments with spleen cells from diabetic NOD mice were conducted . ^^^ Together with the described expression patterns of perforin and TNF in the mononuclear islet infiltrates of NOD mice , these results indicate that two diabetogenic effector mechanisms are delivered by distinct cell populations : CD8+ T cells lyse beta cells via perforin dependent cytotoxicity , whereas CD4+ T cells , macrophages , and dendritic cells contribute to diabetes development via TNFR 1 dependent beta cell toxicity . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our data suggest that in addition to its role in IL 1 signaling , mPLK / IRAK is a component of a novel signal transduction pathway through which TNF R 1 activates NF kappaB dependent gene expression . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We observed an upregulation of TNF R 1 and R 2 mRNA in high endothelial venules ( HEVs ) in the lymph node and CNS before the onset of EAE ( preclinical phase ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Induction of cell death by tumour necrosis factor ( TNF ) receptor 2 , CD 40 and CD 30 : a role for TNF R 1 activation by endogenous membrane anchored TNF . ^^^ Several members of the tumour necrosis factor receptor ( TNF R ) superfamily can induce cell death . ^^^ For TNF R 1 , Fas / APO 1 , DR 3 , DR 6 , TRAIL R 1 and TRAIL R 2 , a conserved ' death domain ' in the intracellular region couples these receptors to activation of caspases . ^^^ However , it is not yet known how TNF receptor family members lacking a death domain , such as TNF R 2 , CD 40 , LT betaR , CD 27 or CD 30 , execute their death inducing capability . ^^^ Here we demonstrate in different cellular systems that cytotoxic effects induced by TNF R 2 , CD 40 and CD 30 are mediated by endogenous production of TNF and autotropic or paratropic activation of TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The promoter region of the murine p 75 TNF receptor ( TNF R ) was isolated from a mouse genomic DNA cosmid library . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This effect was more than 100 fold stronger if both of the TNF R were stimulated , compared to stimulation of the p 55 TNF R alone , indicating an important apoptosis enhancing effect of the p 75 TNF R . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TWEAK induced apoptosis is indirect and is mediated by the interaction of endogenous TNF and TNF receptor ( TNFR ) 1 , as each TNFR 1 Fc , neutralizing TNF specific antibodies and TNFR 1 specific Fab fragments efficiently antagonize cell death induction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Moreover , triggering of TNF R 1 , CD 40 , and the interleukin 1 receptor resulted in transcription of the TRAF 1 gene , whereas receptors that are not activators or only poor activators of NF kappaB in HeLa cells failed to show a significant TRAF 1 induction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Primary beta cells express low levels of the type 1 TNF receptor ( TNFR 1 ) but do not express the type 2 receptor ( TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To explore the latter possibility , the course of disease was examined in infected mice lacking TNFR 1 and / or TNFRII , TNF only , or both TNF and lymphotoxin alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Among these modulators are soluble TNF receptors ( TNF R ) that are cleaved from the extracellular domain of the TNF Rs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The Fas receptor ( FasR ) and the tumour necrosis factor ( TNF ) receptor 55 / 60 kDa ( TNFR 1 ) are recognized as apoptosis signalling receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , the biological signal of TNF may be influenced by the expression of the two TNF receptors : the p 60 TNF receptor , TNFR 60 , and the p 80 TNF receptor , TNFR 80 . ^^^ Although TNFR 60 mRNA did not vary within each obese group , there was a wide variation in the levels of TNFR 80 mRNA and of TNF mRNA . ^^^ The TNFR 60 expression level was positively correlated with BMI and fat cell size , whereas TNFR 80 and TNF mRNA levels showed positive associations with serum insulin and triglyceride concentrations . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
One prominent path toward apoptosis is the ligand induced association of TNF receptor 1 ( TNFR 1 ) with death domain adaptor proteins . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Kinetics of serum soluble tumour necrosis factor receptor ( TNF R ) type 1 and type 2 after a single interferon alpha ( IFN alpha ) injection in chronic hepatitis C . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF receptor responsible for this function was determined by expressing mTNFDelta 1 9K11E in preadipocyte cell lines lacking either TNF receptor 1 ( TNFR 1 ) , 2 ( TNFR 2 ) , or both . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of TNF receptor type 1 ( TNF RI ) mRNA was determined in both cell types . ^^^ These results indicate the presence of two types of TNF receptors and the expression of TNF RI mRNA in the endothelial cells derived from bovine CL , and suggest that TNFalpha plays two or more roles in regulating the secretory function of the endothelial cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have examined whether TNF plays a role in lung phase immunity to schistosomes using mice with a disrupted gene for TNFRI ( TNFRI / ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate the relationship between plasma leptin and the tumor necrosis factor alpha ( TNFalpha ) , TNF receptor p 60 ( TNF R 1 ) and TNF receptor p 80 ( TNF R 2 ) concentrations in obese subjects . ^^^ MEASUREMENTS : Body mass index ( BMI ) , waist circumference , hip circumference , waist to hip ratio ( WHR ) , fasting plasma glucose , fasting plasma insulin , homeostasis model assessment of insulin resistance ( HOMA IR ) , plasma leptin , TNFalpha , TNF R 1 and TNF R 2 concentrations were evaluated in obese subjects ( n = 42 ) and in age and gender matched , lean healthy controls ( n = 16 ) . ^^^ RESULTS : In obese subjects , fasting plasma glucose and insulin , HOMA IR , plasma leptin , TNFalpha , TNF R 1 and TNF R 2 concentrations were significantly higher than in controls . ^^^ Furthermore , females showed higher leptin , TNF R 1 and TNF R 2 plasma concentrations compared to males , in both control and obese subjects . ^^^ In control subjects , plasma leptin concentrations showed a direct correlation with BMI ( r=0 . 74 , P < 0 . 001 ) , hip circumference ( r=0 . 94 , P < 0 . 001 ) , TNF R 1 ( r=0 . 79 , P < 0 . 001 ) and TNF R 2 ( r=0 . 64 , P < 0 . 01 ) , and a negative correlation with WHR ( r= 0 . 58 , P < 0 . 05 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we determine the role of TNF receptor 1 ( TNFR 1 ) , TNF receptor 2 ( TNFR 2 ) , and nuclear factor kappa beta ( NFkappaB ) in the response of mouse hepatocytes to the PP , nafenopin . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The development of pharmaceuticals that selectively interfere with the detrimental pathways induced by TNF during intoxication with bacteria , viruses , drugs , or other chemicals requires detailed knowledge of the signaling pathways originating from the two TNF receptors ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This clue was validated using anti TNFalpha treatment of an animal model of RA , murine collagen induced arthritis , and by immunohistochemical demonstration of upregulated TNF and TNF R expression in the synovium . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A more complete understanding of the temporal and spatial context of TNF / TNF receptor ( TNF R ) function and of the molecular and cellular pathways leading to the development of TNF / TNF R mediated pathologies is necessary to fully comprehend relevant mechanisms of disease induction and progression in humans . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In TNF receptor p 55 deficient ( TNF R 55 deficient ) mice ( hr ( + / + ) ) , cutaneous barrier repair was delayed compared with wild type ( hr ( + / + ) ) or TNF R 75 deficient ( hr ( + / + ) ) animals . ^^^ After barrier disruption in hairless ( hr ( / ) ) and wild type ( hr ( + / + ) ) , but not in TNF R 55 deficient ( hr ( + / + ) ) mice , the enzymatic activities of both A SMase and N SMase were significantly enhanced . ^^^ Together , these results suggest that TNF R 55 signaling pathways contribute to cutaneous permeability barrier repair through SMase mediated generation of ceramide . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus we performed similar association studies using markers for the TNF R genes . ^^^ Gene association studies were carried out on 199 216 normal controls , 174 RR / SPMS patients and 102 PPMS patients using polymorphic dinucleotide repeat TNF markers ( a , b and d ) , and separate markers for TNF RI and TNF RII . ^^^ No association occurred with the TNFd marker , and there were also no significant differences in allele frequencies between MS groups and controls regarding the marker for TNF RI or TNF RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 40 is a cell surface receptor that belongs to the tumor necrosis factor R ( TNF R ) family , and that was first identified and functionally characterized on B lymphocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we examined the role of these molecules in the murine model of lymphocytic choriomeningitis virus ( LCMV ) infection using LCMV TCR transgenic ( tg ) mice lacking TNF , TNF receptor 1 ( TNFR 1 ) , CD 95 or both TNFR 1 and CD 95 . ^^^ Furthermore , peripheral deletion of LCMV specific CD 8 T cells induced by LCMV peptide injection or by adoptive transfer of tg spleen cells expressing the corresponding LCMV epitope was not impaired in mice lacking TNF , TNFR 1 and / or CD 95 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF receptor 1 ( TNFR 1 ) and CD 95 are not required for T cell deletion after virus infection but contribute to peptide induced deletion under limited conditions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The action of LT alpha in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor 1 ( TNFR 1 ) or 2 ( TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
They bind to specific receptors , CD 95 and TNF R , which are induced either by other cytokines , such as interferon gamma , or by Helicobacter pylori itself . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The present report will focus on the role of the prototypic ligand TNF and its two receptors , TNFR 1 and TNFR 2 , in viral pathogenesis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cardiomyocyte expression of iNOS and TNF type 1 receptor ( TNFR 1 ) mRNA was determined by reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present studies , knockout mice lacking either a functional IL 1 type 1 receptor ( IL 1RI ( / ) ) , a TNF type 1 receptor ( TNFR 1 ( / ) ) , or both IL 1 type 1 and TNF type 1 receptors ( IL 1RI ( / ) / TNFR 1 ( / ) ) received a turpentine abscess . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It was possible to define cut off levels for some cytokines ( sCD 30 > 33 . 15 U / mL , TNFalpha > 29 . 71 pg / mL , IL 6 > 12 . 43 pg / mL , TNF RI > 3 . 23 ng / mL , IL 6 R > 57 ng / mL ) that significantly correlate with systemic symptoms , higher disease stages , ESR , serum copper , WBC counts and PS . ^^^ Our study shows that high sCD 30 , TNFalpha , IL 6 and TNF RI levels are associated with advanced disease or a worse prognostic score . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Left ventricular infarct size was assessed at 24 h after acute coronary occlusion by triphenyltetrazolium chloride ( TTC ) staining in wild type ( both TNF receptors present ) and mice lacking either the type 1 ( TNFR 1 ) , type 2 ( TNFR 2 ) , or both TNF receptors ( TNFR1 / TNFR2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Interestingly , IgA 1 protease specifically cleaved the TNF receptor 2 ( TNF RII ) on the surface of intact cells whereas TNF RI was not affected by the enzyme . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The distinct roles of TRAF 2 and RIP in IKK activation by TNF R 1 : TRAF 2 recruits IKK to TNF R 1 while RIP mediates IKK activation . ^^^ To understand the mechanism by which RIP and TRAF 2 regulate TNF induced activation of the transcription factor NF kappaB , we investigated their respective roles in TNF R 1 mediated IKK activation using both RIP / and TRAF 2 / fibroblasts . ^^^ We found that TNF R 1 mediated IKK activation requires both RIP and TRAF 2 proteins . ^^^ Although TRAF 2 or RIP can be independently recruited to the TNF R 1 complex , neither one of them alone is capable of transducing the TNF signal that leads to IKK activation . ^^^ Moreover , we demonstrated that IKK is recruited to the TNF R 1 complex through TRAF 2 upon TNF treatment and that IKK activation requires the presence of RIP in the same complex . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS AND RESULTS : An adenovirus encoding the 55 kDa TNF receptor IgG fusion protein ( AdTNFRI ) was injected intravenously into 6 week old transgenic mice , which resulted in high levels of TNFRI in both plasma and myocardium . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Peripheral blood MO , MO derived macrophages ( MPhi ) , or the monocytic cell line Mono Mac 6 were preincubated with human microvascular EC that constitutively express TNF receptor type 1 ( TNF R 1 ) and subsequently stimulated with LPS . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological effects of tumour necrosis factor ( TNF ) alpha are mediated through either the TNFR 1 or the TNFR 2 receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The activation of the death receptors , tumor necrosis factor receptor 1 ( TNF R 1 ) or CD 95 , is a hallmark of inflammatory or viral liver disease . ^^^ Under GSH depletion , also caspase independent , TNF R 1 mediated injury ( high dose actinomycin D or alpha amanitin ) , as well as necrotic hepatotoxicity ( high dose lipopolysaccharide ) were entirely blocked . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These data suggest that TNFR 1 , through a TNF receptor associated factor 2 NF kappaB signaling pathway , mediates TNFalpha induced expression of ICAM 1 on ASM cells by involving a thapsigargin sensitive signaling pathway . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In human umbilical vein endothelial cells ( HUVEC ) , TNF R 1 mRNA is increased four fold following incubation with recombinant EMAP 2 . ^^^ Conditioned media from cell lines known to produce high levels of EMAP 2 upregulated TNF R 1 but not TNF R 2 by up to twenty fold compared to media controls and low expressing cell lines ; this effect was blocked by anti EMAP 2 antibody . ^^^ Recombinant EMAP 2 upregulated TNF R 1 expression by approximately six fold . ^^^ Analysis of HUVEC lysates by ELISA showed increased expression of TNF R 1 within 2 h ; TNF R 2 expression was unaffected by recombinant EMAP 2 . ^^^ Finally , immunohistochemistry of human melanomas in vivo showed that TNF R 1 staining is increased on the vessels of tumours known to express high levels of EMAP 2 compared to low EMAP 2 expressing tumours . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A rapid decrease in the binding of radiolabelled anti p 75 TNF R Mab which gradually increased after 16 h was seen in normal controls , while NHL patients showed a rapid increase in the binding of the Mab after activation of cells and a decrease in binding was observed only after 24 h . ^^^ Western blot analysis for normal controls showed a weak presence of the 42 kDa fragment only , while the cytosolic extracts from fresh PBMNCs of NHL patients showed presence of both intact p 75 TNF R , as well as a 42 kDa fragment corresponding to a soluble form of p 75 TNF R . ^^^ Our results suggest that increased cytosolic pools of TNF R in NHL patients might contribute to a rapid increase in its surface expression following activation of cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The soluble TNF receptor TNF R 55 ( sTNF R 55 ) inhibits TNFalpha functioning . ^^^ Serum values of TNFalpha and TNF R 55 have been observed in patients with different cancers . ^^^ At least four different monoclonal antibodies against human TNFalpha and human TNF R 55 , respectively , were prepared to obtain sensitive and reliable sandwich enzyme linked immunosorbent assays . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The ability of CD 40 to mediate apoptosis in carcinoma cells is intriguing given the fact that the CD 40 cytoplasmic C terminus lacks a death domain homology with the cytotoxic members of the TNFR superfamily , such as Fas , TNFR 1 , and TNF related apoptosis inducing ligand ( TRAIL ) receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , recent studies in animal models suggest that not only polymorphisms within the TNF cluster are important in the regulation of TNF production but also the receptors as well ( TNF R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TRAPS is caused by dominantly inherited mutations in TNFRSF1A ( formerly termed TNFR 1 ) , the gene encoding the 55 kDa TNF receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunohistology for several other TNF ( R ) family members revealed in proliferative lupus nephritis a similar distribution for TNFR 1 as was observed for CD134L . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Earlier results had suggested that a pathway involving the p 55 TNF receptor ( TNF R 55 ) , neutral sphingomyelinase ( N SMase ) , and c Raf 1 activates ERK and cPLA ( 2 ) . ^^^ We have previously shown that a cytoplasmic region of TNF R 55 distinct from the death domain regulates the activation of N SMase through binding of the adapter protein FAN . ^^^ Furthermore , we provide evidence that the TNF dependent activation of ERK and cPLA ( 2 ) requires the intact death domain of TNF R 55 . ^^^ Finally , we demonstrate that in murine fibroblasts cPLA ( 2 ) is phosphorylated in response to TNF solely by ERK , but not by p 38 mitogen activated protein kinase , suggesting a signaling pathway from TNF R 55 via the death domain to ERK and cPLA ( 2 ) . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A down modulation of both the 55 kDa ( TNF R 55 ) and the 75 kDa ( TNF R 75 ) TNF receptors is observed in neutrophils exposed to a variety of stimuli . ^^^ Proteolytic cleavage of the extracellular region of both receptors ( shedding ) and , with TNF , internalization of TNF R 55 and shedding of TNF R 75 are the proposed mechanisms . ^^^ A release of TNF receptors comparable to that observed with TNF was induced with TNF R 55 specific reagents ( mAbs and a mutant of TNF ) but not with the corresponding TNF R 75 specific reagents . ^^^ A hydroxamic acid compound ( KB 8301 ) almost completely inhibited shedding of TNF R 55 and to a lesser degree shedding of TNF R 75 . ^^^ These results suggest that TNF induces release of its receptors , that such a release is mediated via TNF R 55 , and that a membrane bound and non matrix metalloproteinase is involved in the process . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF signals are mediated through two different receptors , TNFR 1 and TNFR 2 . ^^^ Overexpressed TNFR 1 ( DD ) did not activate NF kappaB but acted as a ligand specific dominant negative inhibitor of TNF actions . ^^^ Unexpectedly , TNF responses were also inhibited by overexpressed TNFR 1 and TNFR 2 ( +DD ) , but not TNFR 2 . ^^^ We conclude that the death domain of TNFR 1 is required for retention of TNFR 1 in the Golgi apparatus but is not sufficient to direct Golgi retention of a TNFR 2 ( +DD ) chimera , and that overexpressed receptors that contain the death domain ( TNFR 1 and TNFR 2 ( +DD ) ) spontaneously activate NF kappaB while inhibiting TNF responses . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Synergism of Pseudomonas aeruginosa exotoxin A with endotoxin , superantigen , or TNF results in TNFR 1 and TNFR 2 dependent liver toxicity in mice . ^^^ In view of the fact that TNFR 1 , but not TNFR 2 , signaling is unequivocally required for host defense , our results suggest that anti TNFR 2 strategies might be beneficial to protect the liver from inflammatory damage caused by synergistic interactions of PEA with other TNF inducing bacterial toxins . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this review we summarize the essential findings about the function of tumour necrosis factor ( TNF ) and its cognate receptors TNFR 1 and TNFR 2 , and lymphotoxin alpha ( LT alpha ) ligands in immune mediated CNS inflammation and demyelination . ^^^ Studies with knockout mice in which genes of the TNF ligand / receptor superfamily are not expressed and studies with transgenic mice overexpressing TNF and TNFR reveal the critical role of the TNFR 1 signalling pathway in the control of CNS demyelination and inflammation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFalpha levels are elevated in twitcher mice compared to control animals , and studies on another demyelinating disease , experimental allergic encephalomyelitis , indicate that TNF promotes pathogenesis via TNF receptor 1 ( TNF R 1 ) . ^^^ In the present study , twitcher / TNF R 1 deficient mice were generated , and the clinical and pathological course was compared between these mice and regular twitcher mice . ^^^ If mice were administered an intraperitoneal injection of LPS , then twitcher / TNF R 1 deficient mice had a longer [ corrected ] life span and a decreased [ corrected ] disruption to the blood brain barrier compared to regular twitcher mice . ^^^ These results showed that TNF R 1 is not sufficiently activated to affect the pathological and / or clinical signs during the natural course of this disease . ^^^ However , when there is a secondary insult , TNF R 1 activation does lead to a significant acceleration of the development of clinical and pathological signs . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We found TNF , via TNF type 1 receptor ( TNFr 1 ) , prompts robust osteoclastogenesis by osteoclast precursors pretreated with RANKL , and deletion of TNFr 1 abrogates this response . ^^^ Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^ Finally , we found that TNF and RANKL synergistically up regulate RANK expression in wild type precursors , whereas basal and stimulated levels of RANK are significantly lower in TNFr 1 knockout cells . ^^^ Our data suggest that exuberant TNF induced osteoclastogensis is the result of coupling between RANK and TNFr 1 and is dependent upon signals transmitted by the latter receptor . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Further , n monomethyl L arginine ( n MMA ) and a soluble TNF receptor 1 ( TNFRI IgG ) blocked bacterial growth and NO synthesis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TNF receptor associated factor 2 , and NF kappaB inducing kinase was also abrogated by IFN alpha pretreatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of the study was , to examine the relationship between serum levels of soluble tumour necrosis factor receptors ( sTNF R ) and the gene expression of two types of receptor for TNF ( TNF R ) , a 55 a receptor ( TNF R 1 ) and a 75 kDa receptor ( TNF R 2 ) , bloodin peripheral mononuclear cells ( PBMC ) from patients with polymyositis and dermatomyositis ( PM / DM ) . ^^^ Expression of TNF R 1 and TNF R 2 mRNAs in PBMC was analysed by Northern blotting . ^^^ TNF R 1 gene expression was enhanced in freshly isolated PBMC from patients with active stage PM / DM . ^^^ In contrast , TNF R 2 mRNA was expressed constitutively in patients with active stage PM / DM and in normal controls . ^^^ The expression of TNF R 1 and TNF R 2 mRNAs in PBMC and elevation of their soluble forms in the sera of patients with active stage PM / DM suggest increased proteolytic cleavage of cell surface TNF R from PBMC in patients with active stage PM / DM , and that sTNF R may regulate TNF alpha mediated muscle fibre damage in PM / DM . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We evaluated mice deficient in TNF receptor 1 ( TNFR 1 ) and TNFR 2 [ TNFR ( / ) mice ] in a murine model of allergic inflammation and found that TNFR ( / ) mice had comparable or accentuated responses compared with wild type [ TNFR ( + / + ) ] mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Significant enhancement of TNF receptor 1 ( CD120a ) and , to a lesser extent , Fas ( CD 95 ) mediated apoptosis was observed when overexpressing the C terminal TRAF 1 fragment in HEK293T and HT 1080 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Leptin levels correlate with TNF RI in cachectic heart failure patients ( r=0 . 58 , P=0 . 018 ) . ^^^ The TNF RI levels were also correlated with Fas , both in all the patients taken together ( r=0 . 5 , P=0 . 006 ) and in those with cachexia ( r=0 . 52 , P=0 . 036 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have investigated the roles of the p 55 and p 75 TNF receptors ( TNFR 1 and TNFR 2 ) in the induction of mouse L M cell death in the presence of a caspase inhibitor ( zVAD fmk ) and a transcription inhibitor ( actinomycin D ) , i . e . under conditions in which protective pathways requiring caspase activation and protein synthesis were blocked . ^^^ Stimulation of TNFR 1 was sufficient to induce either cell necrosis or apoptosis , even when we blocked endogenous TNF with an anti murine TNF antibody . ^^^ Simultaneous stimulation of TNFR 2 and TNFR 1 with specific agonists indicated that TNFR 2 functionally cooperates with TNFR 1 to potentiate the response indirectly , by inducing endogenous TNF cytotoxicity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : IL 6 knockout ( IL 6 ( / ) ) , TNF receptor 1 knockout ( TNFR 1 ( / ) ) and wild type mice were treated with the peroxisome proliferator nafenopin and the anti androgen cyproterone acetate ( CPA ) in one single injection or for 6 days with daily injections , and examined at 24 or 48 h after treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A cDNA encoding the extracellular domain of bovine TNF RI was placed under the control of the powerful and tightly regulated alcohol oxidase 1 ( AOX 1 ) gene promoter of the pPICZa A vector and the resulting construct integrated into the 5 ' region of the alcohol oxidase genes of GS 115 and KM 71 strains of Pichia . ^^^ Soluble bovine TNF RI was secreted into the medium following induction of the AOX 1 gene promoter with methanol , and purified to greater than 95 % purity by ion exchange chromatography . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
B 6 [ wild type ( wt ) ] mice and B 6 mice with targeted disruption ( knockout ) of the genes for the p 55 TNF receptor [ TNFR 1 ( / ) ] , the p 75 TNF receptor [ TNFR 2 ( / ) ] , or both receptors [ TNFR1 / TNFR2 ( / ) ] were exposed to 0 . 3 parts / million O ( 3 ) for 48 h ( subacute ) , and lung responses were determined by bronchoalveolar lavage . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A polymorphic microsatellite marker in the human p 55 TNF receptor , CD120a . ^^^ We provide characterization of a highly polymorphic dinucleotide repeat in the human TNF receptor 1 gene ( TNFR 1 , TNFRp 55 , CD120a ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine whether signaling from these early response cytokines is essential to orchestrating innate immune responses to intrapulmonary bacteria , the early inflammatory events induced by instillation of Escherichia coli into the lungs were compared in wild type ( WT ) mice and mice deficient in both TNF receptor 1 ( TNFR 1 ) and the type 1 IL 1 receptor ( IL1R1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF receptors TNFRI and TNFRII co localized with biotinylated TNF alpha tracer along the nerve trunk , suggesting that TNF alpha transport may be receptor mediated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF receptors ( TNF R p 55 and p 75 ) , also known as CD120a and b , have also been shown to be present in the lung , but their functional importance is only just emerging . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast , TNF stimulation of the TNFR 1 , but not the TNFR 2 , elicited nuclear factor kappaB transcription factor function , a species known to be important in mediation of certain inflammatory cellular responses . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Both TNFR 1 and TNFR 2 appear to be involved in regulating ephrin A 1 expression in endothelial cells , because neutralizing antibodies to either TNFR 1 or TNFR 2 inhibited TNF alpha induced ephrin A 1 expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF TNFR 1 system . ^^^ Here , we examined the role of one of its member , TNF receptor type 1 ( TNFR 1 ) , in an in vivo model of p 53 dependent radiation induced IEC apoptosis . ^^^ We demonstrate that mice genetically engineered to be deficient in TNF receptor type 1 ( TNFR 1 ( / ) ) and mice injected with TNFR 1 fusion chimeric protein ( TNFR 1 Fc ; a competitive inhibitor of TNFR 1 ) were partially protected ( 30 40 % ) from p 53 dependent radiation induced IEC apoptosis . ^^^ However , we found no evidence to support the possibility p 53 transcriptionally regulates the expression of TNFR 1 nor increases the susceptibility of IEC to TNF mediated apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have investigated the roles of TNF receptor 1 ( TNFR 1 ) and TNF receptor 2 ( TNFR 2 ) in collagen induced arthritis ( CIA ) by inducing CIA in mice genetically deficient in TNFR 1 . ^^^ Neutralization of TNF with soluble TNF binding protein suppressed the development of arthritis in TNFR1+ / mice but not in TNFR 1 / mice , indicating that TNFR 2 can not substitute for TNFR 1 for the proinflammatory function . ^^^ To further investigate the functions of TNFR 2 , TNFR 1 / mice were injected with murine TNF alpha at different stages during the course of CIA . ^^^ These results show that the engagement of TNFR 2 by TNF is involved in the development of CIA in the absence of TNFR 1 and that opposing signals can be transduced by TNFR2 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Changes in the activation of caspase 8 that parallel changes in regulatory light chain phosphorylation levels reveal that myosin 2 motor activities regulate TNF receptor 1 ( TNFR 1 ) signaling at an early step in the TNF death signaling pathway . ^^^ Treatment of cells with either ionomycin or endotoxin ( lipopolysaccharide ) leads to activation of myosin 2 and increased translocation of TNFR 1 to the plasma membrane independent of TNF signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effect was associated with significant increases in TNF alpha and alanine transaminase ( ALT ) levels in serum , the number of apoptotic hepatocytes , CPP32 / caspase 3 activity , and TNF receptor 1 ( TNFR 1 ) mRNA expression in the liver . ^^^ Etoposide treatment reduced CPP32 / caspase 3 activity in the liver , although it did not alter the serum TNF alpha levels or hepatic TNFR 1 mRNA expressions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As the TNF beta : TNFR 1 co crystal structure was the first in the family to be solved , rational drug design based on the ligand : receptor interaction sites is more advanced . ^^^ Small peptide sequences from TNFR 1 which interact with the ligand have shown some activity in blocking the biological actions of TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The effect of SEB to induce EAE in IL 6 ( / ) mice depends on TNF receptor type 1 ( TNFR 1 ) signaling because IL 6 / TNF / LT alpha ( / ) and IL 6 / TNFR1 ( / ) are refractory to SEB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We therefore evaluated ICAM 1 and VCAM 1 regulation in knockout ( KO ) mice deficient in both IL 1 receptor 1 ( R 1 ) and TNF R 1 during renal ischemia reperfusion injury . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
There has been a gradual realisation of the value of TNF / TNFR ratios as predictors of disease outcome , and the discovery of functional regulatory polymorphisms of the TNF gene and mutations of TNFRSF1A ( TNFR 1 receptor ) have led to conceptual breakthroughs in our understanding of the genetic control of inflammation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Preincubation with antibody against TNF receptor type 1 ( TNFR 1 ) or TNF receptor type 2 reduced the specific binding by 95 and 15 % , respectively , suggesting a dominating role of TNFR 1 in 125I labeled TNFalpha ( 125I TNFalpha ) binding . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This review will focus on the crosstalk that exists between proteins of the TNF receptor ( TNF R ) signalosome , and which are involved in the initiation of nuclear factor kappa B ( NF kappaB ) activation or apoptosis . ^^^ At least four different mechanisms of regulation can be distinguished : ( 1 ) NF kappaB mediated induction of proteins of the TNF R complex ; ( 2 ) NF kappaB independent protection against apoptosis by the TNF R associating factor 2 ( TRAF 2 ) mediated recruitment of antiapoptotic proteins ; ( 3 ) dual activation of apoptosis and NF kappaB by a single molecule ; and ( 4 ) amplification of the death signal by proteolytic inactivation of signaling proteins that are involved in NF kappaB activation or cell survival . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Thus , increased plasma levels of tumour necrosis factor ( TNF ) alpha , interleukin ( IL 1 ) beta , IL 1 receptor antagonist ( IL 1ra ) , TNF receptors ( TNF R ) , IL 10 , IL 8 , and macrophage inflammatory protein ( MIP ) 1 are found after strenuous exercise . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
By contrast , HHV 7 infection caused a marked decrease of surface TRAIL R 1 , but not of TRAIL R 2 , CD 95 , TNF R 1 , or TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previous studies in TNF receptor ( TNFR ) deficient preadipocytes have demonstrated that the anti adipogenic effect of both secreted and transmembrane TNFalpha is mediated solely by TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of mice lacking TNF receptor 1 ( TNFR 1 ) or TNFR 2 indicated that TNFR 2 , not TNFR 1 , is critical to oligodendrocyte regeneration . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The pleitropic actions of tumour necrosis factor alpha ( TNF ) are transmitted by the type 1 55 kDa TNF receptor ( TNFR 1 ) and type 2 75 kDa TNF receptor ( TNFR 2 ) , but the signalling mechanisms elicited by these two receptors are not fully understood . ^^^ KYM 1 human rhabdomyosarcoma cells and HeLa human cervical epithelial cells , engineered to overexpress TNFR 2 , displayed c Jun N terminal kinase ( JNK ) activation by wild type TNF , a TNFR 1 specific TNF mutant and a TNFR 2 specific mutant TNF in combination with an agonistic TNFR 2 specific monoclonal antiserum . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Leptin and TNF receptor 1 ( TNFr 1 ) were measured by enzyme linked immunosorbent assay . ^^^ TNFr 1 was found in all serum samples and levels were statistically higher in patients with active CD ( p = 0 . 0003 ) , suggesting that the TNF system is activated in this disease . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We have now identified human TNF receptor type 1 ( TNFR 1 ) associated death domain protein ( TRADD ) to be the K 18 interacting protein . ^^^ These results indicate that K 18 may sequester TRADD to attenuate interactions between TRADD and activated TNFR 1 and moderate TNF induced apoptosis in simple epithelial cells . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Function blocking antibodies against either TNFalpha or TNF receptor 1 ( TNFR 1 ) rescued many sympathetic and sensory neurons following NGF deprivation in vitro . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumor macrophages express cell surface associated TNF , TNF type 1 ( CD120a ) and 2 ( CD120b ) receptors , and , upon contact with T cells which induces release of IFN gamma from T cells , secrete nitric oxide . ^^^ Killing of T cells in vitro is blocked by Abs to IFN gamma , TNF , CD120a , or CD120b , or N methyl L arginine . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Activation of the TNF signal transduction cascade is initiated by the interaction of TNF with either of two cell surface receptors , TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Expression of TNF receptor subtypes ( TNFR 1 and TNFR 2 ) on sensory neurones was identified using immunohistochemistry , fluorescence activated cell sorting analysis and RT PCR . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF RI , TNF RII ) ELISA method . ^^^ The most frequent alterations were : neutrophilia ( 28 . 3 % of cases ) , leukocytosis ( 27 . 6 % ) , decreased HGB ( 25 . 5 % ) , monocytosis ( 19 . 3 % ) and thrombocytosis ( 14 . 5 % ) ; they correlated strongly with elevated serum levels of several cytokines and soluble cytokine receptors ( particularly : sIL 2R , IL 6 , IL 8 , M CSF , VEGF , TNF RI , TNF RII ) ( P < 0 . 001 ) . ^^^ Lymphocytopenia ( LY < 1 . 0 ) found in 10 . 3 % of patients correlated strongly with increased serum levels of IL 6 , sIL 2R , TNF RI . ^^^ In parallel , we found a significant difference in serum levels of 11 of 13 cytokines ( IL 1ra . sIL 2R , IL 6 , IL 8 , IL 10 , TNF RI , TNF RII , TNFalpha , M CSF , bFGF , VEGF ) ( P < 0 . 001 ) in soft tissue sarcoma patients compared to healthy controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LPS stimulation greatly increased the occurrence of neutrophil surface 55 kDa TNF receptor [ TNF R ( p 55 ) ] , when observation was made under laser microscopy . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Significantly , the TVB receptor represents the fourth death domain containing receptor ( also including Fas , TNF R 1 , and DR 6 ) found to be expressed within hen granulosa cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
GA treatment reduces the size of the IKK complex and abolishes TNF dependent recruitment of the IKK complex to TNF receptor 1 ( TNF R 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our data supports this hypothesis as evidenced by increased proliferating cell nuclear antigen ( PCNA ) expression in the livers of mice expressing A 20 compared with a dominant negative mutant of the TNF receptor ( TNF R ) , 6 hours following D gal / LPS administration . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This review addresses the structural basis of TNF signalling , the pathways employed with their cellular consequences , and focuses on the specific role played by each of the two TNF receptor isotypes , TNFR 1 and TNFR2 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In retinal ischemia , we show early , transient upregulation of TNF , TNF receptor 1 ( TNF R 1 ) , and TNF R 2 6 hr after reperfusion preceding neuronal cell loss . ^^^ To assess the specific role of TNF and its receptors , we compared ischemia reperfusion induced retinal damage in mice deficient for TNF R 1 , TNF R 2 , or TNF by quantifying neuronal cell loss 8 d after the insult . ^^^ Surprisingly , TNF deficiency did not affect overall cell loss , yet absence of TNF R 1 led to a strong reduction of neurodegeneration and lack of TNF R 2 led to an enhancement of neurodegeneration , indicative of TNF independent and TNF dependent processes in the retina , with TNF R 1 augmenting neuronal death and TNF R 2 promoting neuroprotection . ^^^ Inhibition of the phosphatidylinositol 3 kinase signaling pathway reverted neuroprotection in TNF R 1 deficient mice , indicating an instrumental role of Akt / PKB in neuroprotection and TNF R 2 dependence of this pathway . ^^^ Selective inhibition of TNF R 1 function may represent a new approach to reduce ischemia induced neuronal damage , being potentially superior to strategies aimed at suppression of TNF activity in general . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In fact , E 6 binds directly to TNF R 1 , as shown both by co immunoprecipitation and mammalian two hybrid approaches . ^^^ E 6 requires the same C terminal portion of TNF R 1 for binding as does TNF R 1 associated death domain , and TNF R1 / TNF R 1 associated death domain interactions are decreased in the presence of E 6 . ^^^ HA E 6 also blocked cell death triggered by transfection of the death domain of TNF R 1 . ^^^ Together , these results provide strong support for a model in which HPV E 6 binding to TNF R 1 interferes with formation of the death inducing signaling complex and thus with transduction of proapoptotic signals . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The serum concentrations of tumor necrosis factor beta ( TNF beta ) , TNF receptor 1 ( TNFR 1 ; 55 kDa ) and TNFR 2 ( 75 kDa ) , interleukin 4 ( IL 4 ) , interleukin 10 ( IL 10 ) and interferon gamma ( IFN gamma ) were measured by enzyme linked immunosorbent assay in all patients . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
SLE lymphocytes had a similar surface expression of TNF RI as healthy lymphocytes , their expression of TNF RII was slightly increased . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The encouraging outcome of anti tumour necrosis factor ( TNF ) treatment , as well as serological studies , has implicated TNF and its receptors ( TNFRI and TNFRII , or TNFRSF1B ) in the pathogenesis of JIA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
HT R 15 cells are characterized by elevated protein levels of TNFR 1 and TNF and by increased sensitivity to exogenous TNFalpha compared to their parental HT 29 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF R 1 signaling : a beautiful pathway . ^^^ The interaction of TNF with TNF receptor 1 ( TNF R 1 ) activates several signal transduction pathways . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF receptor 1 ( TNFR 1 ) expression was determined by immunofluorescent staining . ^^^ RESULTS : TNF pretreatment did not affect TNFR 1 expression in the liver and resulted in time dependent up regulation of iNOS , IL 1beta and HO 1 . ^^^ CONCLUSIONS : TNF tolerance towards GalN / TNF treatment is mediated by TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine whether TNF contributed to the bile duct damage seen in chronically infected animals , we bred B 6 mice with disrupted genes for Tnfrsf1a , Tnfrsf1b and Tnfsf 5 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptotic crosstalk of TNF receptors : TNF R 2 induces depletion of TRAF 2 and IAP proteins and accelerates TNF R 1 dependent activation of caspase 8 . ^^^ We have recently shown that stimulation of TNF R 2 selectively enhances apoptosis induction by the death receptor TNF R 1 . ^^^ Here , we demonstrate that stimulation of CD 30 or CD 40 also leads to selective enhancement of TNF R 1 induced cell death . ^^^ When both TNF receptors were stimulated simultaneously , TNF R 1 induced NF kappaB activation remained unaffected but TNF R 1 induced apoptosis was still significantly enhanced . ^^^ Compared with FasL induced cell death TNF R 1 induced activation of caspase 8 was significantly weaker and delayed . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Membrane targeting dependent immobilization of the TNF Selectokine induced cell death in TNFR 1 and TNFR 2 dependent manner , thus cell bound TNF Selectokine mimicks membrane TNF . ^^^ To restrict TNF activity to the tumor , a prototype of a TNF Selectokine prodrug was constructed by insertion of a TNFR 1 fragment , separated from TNF by a protease sensitive linker . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we studied the influence of TNF and TNF receptors ( TNFR ) on intercellular adhesion molecule 1 ( ICAM 1 ) and macrophage influx following chronic constrictive injury ( CCI ) in mice by three different paradigms : ( 1 ) C57BL / Wld mice with delayed TNF up regulation , ( 2 ) in vivo inhibition of TNFR 1 and TNFR 2 by neutralizing antibodies , and ( 3 ) three different types of mice with a genetic deficiency for TNFR . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In 40 . 4 % of patients 6 or more cytokines and cytokine receptors ( most frequently : TNF RI , IL 6 , IL 8 ) were elevated in parallel . ^^^ Serum levels of IL 6 , sIL 2R , VEGF , M CSF and TNF RI correlated significantly with tumor size and serum levels of IL 8 and IL 6 were significantly higher in patients with Grade 2 / 3 vs . ^^^ G2 / 3 ) , presence of metastases , pretreatment serum levels of 8 cytokines ( IL 6 , IL 8 , IL 10 , sIL 2R , TNF RI , TNF RII , M CSF , VEGF ) and the number of cytokines increased ( 0 1 vs . 2 5 vs . < or = 6 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These observations indicate that TNF activates platelet caspases via the TNFR 1 , which results in platelet fragmentation and thrombocytopenia . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Recently , it was shown that TNF receptor 1 ( TNFR 1 ) knockout mice ( R1KO ) sleep less during the light period than controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Proteolytic cleavage of TNF receptor 1 ( TNFR 1 ) generates soluble receptors that regulate TNF bioactivity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These range from pro inflammatory effects of soluble TNF signalling through one of its receptors TNF RI , to protective / regenerative effects of membrane associated TNF signalling through the other receptor , TNF RII . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Flow cytometry and ELISA showed FasL up regulation and increased IFN gamma synthesis in IL 12 treated T cells , while Fas and TNF R 1 showed little change . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The action of TNF at the cellular level is mediated by two cell surface receptors , TNF R 1 ( p 60 ) and TNF R 2 ( p 80 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
A total of 20 mutations have been identified since our initial discovery of 6 missense mutations in TNF receptor super family 1A ( TNFRSF1A ) in 1999 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
While most TNF actions have been attributed to TNFR 1 , our studies demonstrate that Etk is a TNFR 2 specific kinase involved in TNF induced angiogenic events . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two TNF specific cell surface receptors , TNF R 1 ( p 60 ) and TNF R 2 ( p 80 ) , have been identified and the function of these receptors and the downstream intracellular signal transduction pathways have been extensively studied in vitro . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Factor associated with neutral sphingomyelinase activation ( FAN ) represents a p 55 TNFR ( TNF R 55 ) associated protein essential for the activation of neutral sphingomyelinase . ^^^ Colocalization studies in transfected cells suggest that TNF R 55 forms a complex with FAN and that this complex recruits RACK 1 to the plasma membrane . ^^^ Furthermore , activation of N SMase by TNF was strongly enhanced when RACK 1 , FAN , and a noncytotoxic TNF R 55 mutant were expressed concurrently , suggesting RACK 1 as a modulator of N SMase activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although con A induced liver injury depends on both TNFR 1 and TNFR 2 , TNF dependent iNOS expression is mediated exclusively by TNFR 1 and requires NF kappaB activation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Localization of IL 1alpha , IL 1 RI , TNF , TNF RI and TNF RII during physiological drift of rat molar teeth an immunohistochemical and in situ hybridization study . ^^^ To this end we studied the expression of IL 1alpha and TNF both at the transcription and protein level by means of in situ hybridization and immunohistochemistry and investigated the distribution of IL 1RI , TNF RI and TNF RII immunohistochemically in 10 jaw specimens taken from male Wistar rats . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Hyper IgD syndrome ( HIDS ) associated with in vitro evidence of defective monocyte TNFRSF1A shedding and partial response to TNF receptor blockade with etanercept . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Fluid accumulation was significantly reduced in TNF receptor 1 ( TNFR 1 ( / ) ) , but not IFN gamma knockout mice . ^^^ Anti CD 3 mAb decreased mucosal Na ( + ) / K ( + ) ATPase activity , which was blocked by anti TNF mAb and occurred to a lesser degree in TNFR 1 ( / ) mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
With mouse TNFR 1 or TNFR 2 knockout intestinal epithelial cells , gene transfection , and pharmacological inhibitors , we show a concentration dependent receptor mediated regulation of intestinal cell migration by TNF . ^^^ A physiological TNF level ( 1 ng / ml ) enhances migration through TNFR 2 , whereas a pathological level ( 100 ng / ml ) inhibits wound closure through TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF ) is capable of activating many downstream signaling molecules via its two receptors TNFR 1 and TNFR 2 . ^^^ NF kappaB becomes activated mainly through TNFR 1 while JNK can be stimulated by either TNF receptor subtype . ^^^ TNF can also induce apoptosis within cells due to its ability to recruit procaspase 8 to TNFR 1 , which in turn induces the caspase proteolytic cascade . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In contrast , FT expression of IL 6 and of the cytokine receptors IL 6R , TNF receptor 1 ( TNF RI ) , and TNF RII was constitutive and was not increased by gonococcal challenge . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cytotoxic potential of proinflammatory cytokines : combined deletion of TNF receptors TNFR 1 and TNFR 2 prevents motoneuron cell death after facial axotomy in adult mouse . ^^^ Homozygous deletion of IL 1 receptor 1 ( IL1R1 ) , TNF receptor 1 or 2 ( TNFR 1 or TNFR 2 ) , or IFNgamma receptor 1 ( IFNgammaR 1 ) alone had no effect but combined deletion of TNFR 1 and TNFR 2 caused a striking absence of alphaX beta 2 integrin / IBA1 double labeled , phagocytic microglial nodules in the axotomized facial motor nucleus 14 days after nerve cut . ^^^ However , there was still the same 22 % difference in the total number of motoneurons between the wild type and TNFR 1 & 2 deficient mice , underlining the role of TNF ligands and both TNF receptors in mediating the early phase of neuronal cell loss after traumatic injury . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Bryostatin 1 reduced TNF receptor ( TNF R 1 ) surface availability , as demonstrated by radiolabeled TNF binding and cell surface biotinylation assays , and increased TNF R 1 receptor shedding . ^^^ In addition , after bryostatin 1 treatment , PKC delta and TNF R 1 became associated , as determined by mutual coimmunoprecipitation assay , which has been shown to lead to receptor desensitization in neutrophils . ^^^ TNF induced barrier dysfunction occurs independently of PKC , but selective modulation of novel PKC isozymes may regulate TNF R 1 signaling . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , little is known about the role of TNF receptors ( TNF R ) in this disease . ^^^ Here , we found that TNF R 2 ( in contrast to TNF R 1 ) was significantly up regulated on lamina propria and peripheral blood T cells in CD compared to control patients . ^^^ To directly test the functional role of TNF R 2 in Th 1 mediated experimental colitis in vivo , we took advantage of transgenic animals overexpressing TNF R 2 in T cells . ^^^ Reconstitution of SCID mice with CD4+ CD62L+ T cells from TNF R 2 transgenic mice led to an earlier wasting syndrome , a more severe colitis and augmented Th 1 cytokine production than reconstitution with cells from wild type littermates . ^^^ In addition , TUNEL staining revealed a significantly decreased apoptosis rate of lamina propria mononuclear cells in mice reconstituted with TNF R 2 transgenic T cells compared to mice reconstituted with wild type T cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We also analyzed TNF receptors type 1 ( TNFR 1 ) and type 2 ( TNFR 2 ) gene polymorphisms , located on chromosome 12p13 and 1p36 , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To assess the effects prospectively of tumour necrosis factor ( TNF ) receptor superfamily ( TNFRSF ) fusion proteins TNFRSF1B ( etanercept ) and TNFRSF1A ( p55TNFr Ig ) in patients with TNF receptor associated periodic syndrome ( TRAPS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The number of apoptotic TNF receptor 1 ( TNFR 1 ) positive germ cells was identified by combining in situ end labeling of apoptotic DNA and immunohistochemical techniques . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although human ASM cells expressed both receptor subtypes , TNF R 1 and TNF R 2 , the activation of RhoA was predominantly via stimulation of the TNF R 1 , although RhoA did not immunoprecipitate with the TNF R 1 . ^^^ In conclusion , the TNF induced increase in the Ca ( 2+ ) sensitivity of MLC ( 20 ) phosphorylation is through stimulation of the TNF R 1 receptor and via a RhoA / Rho kinase pathway leading to inhibition of the myosin light chain phosphatase . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Adenosine also suppressed NF kappaB dependent reporter gene expression activated by TNF or by overexpression of TNFR 1 , TRAF 2 , NIK , and p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
AD cases had increased levels of proapoptotic markers including tumor necrosis factor alpha ( TNFalpha ) , TNF receptor type 1 ( TNF R 1 ) , TNF receptor associated death domain ( TRADD ) , and caspase 3 , 2 to 10 fold higher ( P < . 01 ) than age matched controls and 1 to 3 times higher than transitional cases . ^^^ Overall , there was an elevation in proapoptotic elements , including a 5 fold increase in TNF R 1 and a 12 fold decrease in FLIP in AD brains . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The best studied death inducing ligand receptor pairs are TNF / TNF receptor 1 ( TNFR 1 ) and CD95L / CD95 ( Fas , Apo 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
It has been shown that two distinct TNF receptors ( TNFRs ) , TNFR type 1 ( TNFR 1 ) and TNFR type 2 ( TNFR 2 ) , have different functions in signal transduction , which is possibly associated with the development of a variety of diseases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CD 95 , TNF related apoptosis inducing ligand ( TRAIL R 1 ) , and TRAIL R 2 bind FADD directly , whereas recruitment to TNF R 1 is indirect through another adaptor TNF receptor associated death domain protein ( TRADD ) . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To assess the role of polymorphisms of the tumour necrosis factor ( TNF ) receptors , TNF RI ( p 55 ) and TNF RII ( p 75 ) in the susceptibility to and severity of rheumatoid arthritis ( RA ) in Dutch patients . ^^^ METHODS : A total of 319 consecutive RA patients , and a cohort of 90 female RA patients with detailed 12 yr follow up were genotyped for the TNF RI exon 1 ( +36 A to G ) and TNF RII 3 ' UTR ( +1690 T to C ) polymorphisms . ^^^ RESULTS : The frequencies of the TNF RI and TNF RII polymorphisms were determined in both patient groups and healthy controls , but no significant differences were found . ^^^ CONCLUSION : These TNF RI and TNF RII polymorphisms were not found to be associated with susceptibility to or severity of RA in the Dutch population . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
IL 6 increased the mRNA level of TNF R 1 1 . 35 fold and augmented cell surface binding of [ 125I ] TNFalpha 3 fold . ^^^ CONCLUSIONS : IL 6 in contrast to its anti apoptotic modulation of the Fas induced pathway exerted a pro apoptotic effect on the TNFalpha / actinomycin D induced apoptosis by increasing the number of TNF R on hepatocytes . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We explored the possible involvement of these cytokines during the main phase of lymphocyte recruitment into the axotomised facial motor nucleus 7 21 days after nerve cut using mice homozygously deficient for IL 1 receptor type 1 ( IL1R1 / ) , TNF receptor type 1 ( TNFR 1 / ) , type 2 ( TNFR 2 / ) and type 1 and 2 ( TNFR 1 & 2 / ) , IFNgamma receptor type 1 ( IFNgammaR 1 / ) , and the appropriate controls for the genetic background . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunity to Toxoplasma gondii critically depends on TNFR type 1 mediated immune reactions , but the precise role of the individual ligands of TNFR 1 , TNF and lymphotoxin alpha ( LTalpha ) , is still unknown . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As TNF exerts its effects via two receptors , TNF receptor 1 ( TNF R 1 ) and TNF receptor 2 ( TNF R 2 ) , we also investigated , which of the receptors is relevant to the causation of pain in this model . ^^^ It turned out that antibodies to TNF R 1 , but not to TNF R 2 reduced hyperalgesia , indicating that TNF R 1 is the receptor concerned . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LMP 1 associates simultaneously with lipid rafts and with its signaling molecules , tumor necrosis factor receptor ( TNF R ) associated factors ( TRAFs ) and TNF R 1 associated death domain protein ( TRADD ) intracellularly , although it can be detected at low levels at the plasma membrane , indicating that most of LMP 1 ' s signaling complex resides in intracellular compartments . ^^^ The fusion of the transmembrane domain of LMP 1 to signaling domains of CD 40 , TNF R 1 and Fas activates their signaling ; we demonstrate that a fusion of LMP 1 with CD 40 recruits TRAF 2 intracellularly . ^^^ Our results imply that members of the TNF R family can signal from intracellular compartments containing lipid rafts and may do so when they act in autocrine loops . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The genes involved in these syndromes are respectively TNFRSF1A ( TNF receptor 1 ) and CIAS 1 ( a gene containing both pyrin and NBS domains ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Since TNF induced apoptosis is mediated by the type 1 TNF receptor ( TNFRI ) , we investigated up regulation of this receptor in IL 18 treated LEC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OPG did not influence levels of hTNF , TNF receptor 1 ( TNFRI ) , interleukin 1beta ( IL 1beta ) , and IL 6 . ^^^ Anti TNF , however , did not affect levels of TNF and TNFRI at the concentrations tested . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In situ localization of TNFalpha / beta , TACE and TNF receptors TNF R 1 and TNF R 2 in control and LPS treated lung tissue . ^^^ Two closely related variants , TNFalpha and TNFbeta , elicit various cellular responses via two distinct TNF receptors , the 55 kDa TNF R 1 and the 75 kDa TNF R 2 . ^^^ Both TNF receptors were detected , with TNF R 1 being prominent on bronchial epithelial cells and endothelial cells , and TNF R 2 being expressed by nearly all cell types . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We investigated whether this particular SNP , and also one at position +36 in exon 1 of the TNF receptor 1 ( TNFRSF1A ) gene , are associated with disease severity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Arthritic DBA / 1 mice received single periarticular injections of retroviral constructs encoding human TNF receptor ( TNF R ) into the affected arthritic paw , at the onset of arthritis . ^^^ Severity of arthritis , antibodies to collagen type 2 ( CII ) , and extent of pathological joint damage of arthritic paws were compared between TNF R and media treated ( control ) animals 3 , 7 , 14 , 21 , and 49 days after disease onset . ^^^ RESULTS : Severity of CIA was significantly decreased in TNF R treated animals compared with controls , 14 34 days after disease onset . ^^^ Joint destruction was reduced in TNF R injected joints and in the uninjected contralateral and ipsilateral paws of TNF R treated animals . ^^^ Seven days after disease onset , TNF R treated mice had lower levels of inflammatory Th 1 driven IgG2a antibodies to CII ( p < 0 . 05 ) than controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
LT consists of soluble LT alpha ( 3 ) , which binds to TNF R 1 and TNF R 2 , and membrane LT alpha ( 1 ) beta ( 2 ) , which binds to LT beta R . ^^^ This activity of LT depends on membrane LT alpha ( 1 ) beta ( 2 ) and not soluble LT alpha ( 3 ) , since DA virus persisted and induced inflammatory demyelination in LT beta R ( / ) , but not TNF R 1 ( / ) or TNF R 2 ( / ) , mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptosis induced by TNF receptor 1 ( TNFR 1 ) is thought to proceed via recruitment of the adaptor FADD and caspase 8 to the receptor complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This link involves the transcriptional upregulation of gadd45beta / myd118 ( ref . 4 ) , which downregulates JNK signalling induced by the TNF receptor ( TNF R ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Significantly , this effect was not confined to TRAIL , because isolation of the native TNF receptor signaling complex revealed that PKC activation also inhibited TNF receptor associated death domain protein recruitment to TNF R 1 and TNF induced phosphorylation of IkappaB alpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Utilizing animals lacking individual TNF receptors , we document that TNFr 1 is required for transmitting the cytokine ' s inhibitory effect . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To explore mechanisms responsible for this observation , the present studies examined the effects of TNF versus TNF receptor 1 ( TNFR 1 ) or TNFR 2 deficiency on the course of antiviral immune responses to a replication deficient , beta galactosidase encoding recombinant adenovirus ( AdCMV lacZ ) . ^^^ Numbers of interferon gamma expressing intrahepatic lymphocytes ( IHL ) were similar in AdCMV lacZ infected , TNF deficient , TNFR 1 deficient , TNFR 2 deficient , and control mice . ^^^ Similar defects in allo specific killing of Fas sensitive hepatocyte targets by TNF deficient or TNFR 2 deficient but not TNFR 1 deficient CTL were also noted . ^^^ No defects in generation of allo specific cytotoxicity directed against perforin sensitive target cells were noted in TNF , TNFR 1 , or TNFR 2 deficient lymphocytes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neither patient had mutations in TNFRSF1A or MEFV , the genes for the TNF receptor associated periodic syndrome and familial Mediterranean fever , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFalpha receptors are upregulated in CM , with TNF receptor 2 ( TNFR 2 ) showing a higher upregulation than TNFR 1 in vivo ; ( 4 ) . in murine CM , low doses of TNFalpha seem to protect from CM , whereas excess TNFalpha induces CM and anti TNFalpha therapies ( antibodies , pentoxifylline ) did not show any efficiency in protection from CM . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Death receptors [ Fas / Apo 1 / CD95 , TNF R 1 [ tumour necrosis factor ( TNF ) receptor 1 ] , DR 3 [ death receptor 3 ] , TRAIL R 1 [ TNF related apoptosis inducing ligand receptor 1 ] , TRAIL R 2 , DR 6 , p 75 NGFR [ p 75 nerve growth factor receptor ] , EDAR [ ectodermal dysplasia receptor ] ] form a subgroup of the TNF R superfamily that can induce apoptosis ( programmed cell death ) via a conserved cytoplasmic signalling module termed the death domain . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Local venom effects ( edema , hemorrhage and necrosis ) were induced experimentally in knockout mice deficient in the TNF receptors TNFR 1 or TNFR 2 , IL 1betaR , IL 6 and iNOS . ^^^ Jararhagin induced dermal necrosis was abolished in mice deficient in the TNF receptors TNFR 1 and TNFR 2 , and the same activity was significantly reduced in IL 6 ( / ) mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptosis pathways activated by death receptors of the tumour necrosis factor ( TNF ) family such as Fas , TNFR 1 , or the TRAIL receptors DR 4 and DR 5 are implicated in diverse diseases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This study provides in vivo evidence that TNF signalling via the TNFR 1 is important for the activation of GM1b type ganglioside biosynthetic pathway in CD 8 T lymphocytes , suggesting its possible role in the effector T lymphocyte function . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present study , using immunohistochemical analysis , we performed a time course in mnd mice ( 1 , 4 and 9 months of age ) evaluating the expression and the distribution of astroglial and microglial cells and the expression of both TNF receptors , TNFR 1 and TNFR 2 . ^^^ The role of TNF and TNFR 1 on motor neurons is still to be demonstrated . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Direct fluorescence conjugated antibodies directed against intracellular cytokines ( interferon gamma , tumour necrosis factor [ TNF ] alpha , interleukin 1 ) and their receptors ( CD 119 , CD120a , CD121a ) were used . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Two receptors ( TNF R ) mediate these effects , but their precise role in different cell types is far from solved . ^^^ Recent research suggests that several TNF R associated proteins , including kinases , may initiate cytoplasmic signal transduction . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF did not induce SAA 3 mRNA in granulosa cells from TNF receptor type 1 ( TNFR 1 ) knockout mice , although SAA 3 mRNA was induced within 3 h after TNF treatment in wild type cells . ^^^ In granulosa cells from TNFR 1 knockout mice , the SAA 3 promoter ( 198 / +73 ) was responsive to transfection with the p 65 component of NF kappaB , but neither TNF treatment nor overexpression of the p 50 component of NF kappaB increased promoter activity . ^^^ Thus , TNF likely increased SAA 3 promoter activity and protein by activating NF kappaB signaling via TNFR 1 in mouse granulosa cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , a combined deletion of TNF receptors 1 and 2 ( TNFR 1 & 2 KO ) led to a decrease in microglial MHC 1 IR and to a striking absence of the phagocytic microglial nodules . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In vivo , TNFalpha is detected within somite macrophages , and TNF receptor 1 ( TNFR 1 ) is detected within motoneurons precisely between E 12 and E 13 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This example of a product activation was CD 30 selective since other TACE substrates such as TNFR 1 or TNF alpha were not affected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Although both TNF receptor 1 ( TNFR 1 ) and 2 ( TNFR 2 ) are present in the heart , comparatively little is known about the role of TNFR 2 . ^^^ METHODS AND RESULTS : We bred TNFR 1 knockout ( KO ) or TNFR2KO mice to transgenic ( TG ) mice with cardiac specific overexpression of TNF alpha and analyzed resultant progeny . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine the role of TNF , similar experiments were performed using mice defective in the TNF gene ( TNF ( / ) ) or the TNF receptor 1 gene ( TNFR 1 ( / ) ) . ^^^ Coadministration of cyclophosphamide had similar effects on thalidomide t ( 1 / 2 ) in C57Bl / 6 , TNF ( / ) and TNFR 1 ( / ) mice , while coadministration of DMXAA did not alter the t ( 1 / 2 ) or AUC in TNF ( / ) and TNFR 1 ( / ) mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
SCH 66336 also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Antiapoptotic signaling is mediated principally through the TNF receptor 1 ( TNFR 1 ) . ^^^ In adherent neutrophils , when beta integrin signaling is activated , TNF phosphorylates TNFR 1 and activates prosurvival and antiapoptotic signaling . ^^^ Both kinases associate with TNFR 1 in response to TNF and are required for TNFR 1 serine phosphorylation , NF kappaB activation , and inhibition of apoptosis . ^^^ Coimmunoprecipitation studies established that PI 3 kinase , delta PKC , and TNFR 1 formed a signal complex in response to TNF . delta PKC recruitment required both delta PKC and PI 3 kinase activity , whereas PI 3 kinase recruitment was delta PKC independent , suggesting that PI 3 kinase acts upstream of delta PKC . ^^^ Inhibition of either delta PKC or PI 3 kinase decreased TNF mediated recruitment of RIP and TRAF 2 to TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The pro apoptotic effect is uniquely TNFR 1 ( TNF receptor 1 ) and TNFR 2 dependent and the latter survival process is mediated via phosphoinositide 3 kinase and NF kappaB ( nuclear factor kappaB ) activation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Autocrine or paracrine induction of IL 6 , and up regulation of membrane TNF and phosphorylation of TNFR 1 may partially explain the contradictory biological effects of CD 40 cross linking on XG 2 by anti CD 40 mAb . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The other death receptor derived peptides , which are the corresponding regions of TNFR 1 and Fas , also showed specific binding to TNF alpha and FasL and inhibited the ligand induced cell death , respectively . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of TNF receptor 1 ( TNFR 1 ) by flow cytometry and Western blotting indicated that Sca 2 expression downregulated cell surface but not de novo synthesis of TNFR 1 in the hepatoma cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Antibody blocking test and RT PCR were used to evaluate the role of ICAM 1 and VCAM 1 in the cytotoxicity of TM TNF alpha mediated by TNFR 1 or TNFR 2 . ^^^ RESULTS : After the ICAM 1 expressed on the membrane of MCF 7 cells ( expressing TNFRI ) was blocked , the cytotoxicity of TM TNF alpha to this cell lines decreased significantly , while blocking VCAM 1 had no effect . ^^^ CONCLUSION : ICAM 1 participates in the cytotoxicity of TM TNF mediated by TNFRI . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To report a novel mutation of the TNF receptor type 1 gene ( TNFRSF1A ) in a Finnish patient and her mother , both suffering from periodic fever . ^^^ Sequencing revealed a missense mutation in exon 3 in the second extracellular domain of TNFRSF1A , resulting in a substitution of cysteine with arginine at residue 73 ( C73R ) , confirming the diagnosis of TNF receptor associated periodic syndrome ( TRAPS ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The amino terminal domain of A 20 , which is a de ubiquitinating ( DUB ) enzyme of the OTU ( ovarian tumour ) family , removes lysine 63 ( K 63 ) linked ubiquitin chains from receptor interacting protein ( RIP ) , an essential mediator of the proximal TNF receptor 1 ( TNFR 1 ) signalling complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF is a major proinflammatory cytokine , which exerts its effects through two different receptors known as TNF R 1 and TNF R 2 . ^^^ Whereas TNF R 1 induced signaling pathways have been very well characterized during the past years , TNF R 2 has been much less well studied . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Enzyme amplified sensitivity immunoassay ( EASIA ) analysis was used to assess serum levels of TNF , the 55 kDa TNF receptor ( TNFRSF1A ) and the 75 kDa TNF receptor ( TNFRSF1B ) . ^^^ Although high titres of serum TNF and soluble TNFRSF1B protein were observed in this patient , low titres of soluble TNFRSF1A protein were detected . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNFRSF1A is usually low between the attacks and may be normal during the attacks , when TNF levels are high . ^^^ TRAPS is the first condition for which naturally occurring mutations in a TNF receptor were found ; the mutations affect the soluble TNFRSF1A gene in the 12p13 region . ^^^ The pathogenic hypothesis involving defective TNFRSF1A shedding suggests that medications targeting TNF may be effective in TRAPS . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Selective inhibition of methyltransferases with 5 aza 2 ' deoxycytidine increases the expression of TNFR 1 in human ( WM 35 ) and murine ( B16F10 ) melanoma cells and sensitizes them to TNF induced apoptosis both in vitro and in vivo . ^^^ Demethylating agent 5 aza 2 ' deoxycytidine enhances expression of TNFRI and promotes TNF mediated apoptosis in vitro and in vivo . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF action is mediated by its two receptors ( TNFRs ) , TNFR 1 , which mediates inhibition of adipocyte differentiation , and TNFR 2 , which was linked to the proliferation of thymocytes . ^^^ We conclude that high levels of estrogen found in breast tumors promote the antiadipogenic action of TNF on breast adipose fibroblasts by selectively up regulating TNFR 1 , which may be a critical mechanism for desmoplastic reaction . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF binding induces release of AIP 1 from TNFR 1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP 1 , TRAF 2 , and AIPl . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Rats were sacrificed at 0 , 1 , 2 , 4 , 6 , and 24 h following LPS and serum TNF and TNFRI were measured by ELISAs . ^^^ LPS pretreatment ( preconditioning ) resulted in a significant increase in TNFRI and a significant decrease in TNF . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NF kappaB dependent reporter gene transcription induced by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK was also blocked by guggulsterone but without affecting p 65 mediated gene transcription . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We conducted in vivo experiments by subcutaneous inoculation of LPS in wild type , TNFR 1 / R 2 / , TNFR 1 / , and TNFR 2 / mice to identify which TNF receptors are involved and the specific caspase pathway activated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The molecular regulation of the recruitment of initial signaling complexes at the TNF R 1 is poorly defined . ^^^ We demonstrate here that within minutes internalized TNF R 1 ( TNF receptosomes ) recruits TRADD , FADD , and caspase 8 to establish the `` death inducing signaling complex ' ' ( DISC ) . ^^^ In addition , we identified the TNF R 1 internalization domain ( TRID ) required for receptor endocytosis and provide evidence that TNF R 1 internalization , DISC formation , and apoptosis are inseparable events . ^^^ Analyzing cell lines expressing an internalization deficient receptor ( TNF R 1 DeltaTRID ) revealed that recruitment of RIP 1 and TRAF 2 to TNF R 1 occurred at the level of the plasma membrane . ^^^ In contrast , aggregation of TRADD , FADD , and caspase 8 to establish the TNF R 1 associated DISC is critically dependent on receptor endocytosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Higher levels of the TNF R 1 receptor subtype were detected in membrane preparations from Ep SMCs than in membranes from Sp SMCs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BLM exposure had no marked effect on AM expression of TNF R 1 or caspase 8 activation , but significantly increased the expression of TNF R 2 that was accompanied by a rise in c IAP 1 and a decrease in TRAF 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Subjects were genotyped for HLA DRB 1 alleles and polymorphisms in the following genes : TNF , LTA , TNFRSF1A , TNFRSF1B , FCGR2A , FCGR3A , and FCGR3B . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF , a key pro inflammatory cytokine when binding to TNF receptor 1 ( TNFR 1 ) , may cause survival or apoptosis , dependent on biochemical modifications that determine the type of complex formed ; one complex causes NFkappaB activation and gives a cell survival signal ( pro oncogenic ) , while the other ( modified ) complex recruits caspases and causes apoptosis ( anti oncogenic ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
We show that Fas and TNF are two pathways in BCG induced apoptosis of diabetogenic T cells , since in vitro blocking FasL or TNFR 1 with antibody reduced T cell apoptosis and increased T cell proliferative response . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This study provides in vivo evidence that TNF signaling via the TNFR 1 is involved in the acquisition of a divergent GSL assembly in the brain , an immunologically privileged organ , and the spleen , typical secondary lymphoid organ . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Are alterations of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment mediated by the tumour necrosis factor ( TNF ) alpha receptor ( TNF RI ) . ^^^ A study in TNF RI ( TNF RI ( / ) ) knock out rodents . ^^^ CLP was performed in genetically modified TNF RI knock out ( TNF RI ( / ) ) and genetically unmodified ( wild type , WT ) mice . ^^^ A mortality rate of 91 . 7 % was observed in TNF RI ( / ) mice after CLP . ^^^ In sham operated TNF RI ( / ) animals , a significantly higher proportion of NK cells within the lymphocyte population was measured compared with the corresponding WT group . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This study investigated whether common polymorphisms of the TNF locus and the two receptor genes , TNFRSF1A and TNFRSF1B , influence circulating levels of encoded proteins , and whether individual polymorphisms or extended haplotypes of these genes are associated with susceptibility , severity of illness or outcome in adult patients with severe sepsis or septic shock . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Human atrial myofibroblasts expressed the TNF RI and TNF RII receptor subtypes . ^^^ Using TNF R specific neutralizing antibodies , we determined that these cellular effects of TNFalpha were predominantly TNF RI mediated . ^^^ CONCLUSIONS : TNFalpha , acting predominantly via the TNF R 1 receptor , increased human atrial myofibroblast proliferation , invasion and MMP 9 secretion , all of which were inhibited by simvastatin . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To determine the mechanism of inhibition of these pathways by the adenovirus E 3 10 . 4K / 14 . 5K proteins , we have examined the effects of this viral complex on the inhibition of AP 1 and NF kappaB activation by TNF and found a reduction in assembly of the TNF receptor 1 ( TNFR 1 ) signaling complex at the plasma membrane accompanied by downregulation of surface levels of TNFR1 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Cleavage and degradation of TNF pathway components TNFR 1 , RIP , and Hsp 90 were observed in l mimosine and H ( 2 ) O ( 2 ) treated cells indicating a putative mechanism for selective inhibition of TNF but not IL 1beta induced IKK activation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tolerance induction has been shown to be dependent on TNFR 1 ( TNF receptor 1 ) signalling , but mechanisms and mediators of TNF induced hepatic tolerance are unknown . ^^^ We found that , out of 793 investigated genes involved in inflammation , cell cycle and signal transduction , 282 were expressed in the mouse liver in response to TNF via TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The levels of secreted MCP 1 , RANTES , IL 6 , PAI 1 , soluble ICAM 1 , and soluble TNF receptor type 1 ( TNFR 1 ; CD120a ) antigens , MMP 9 activity and of cell surface ICAM 1 were not significantly different between the two types of MAEC . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , TNF receptor 1 ( TNFR 1 ) signaling complexes in lipid rafts were investigated in the cerebral cortex of adult male Sprague Dawley rats subjected to moderate ( 1 . 8 2 . 2 atmospheres ) fluid percussion TBI and naive controls . ^^^ In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Mice deficient for TNFalpha ( TNFalpha / ) or the TNF receptor 1 ( TNFRI / ) gene and their wild types were subjected to 60 minutes of hyperoxia or sham treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , growth of the colon 26 adenocarcinoma in mice was associated with diminished gastrocnemius muscle mass and increased muscle levels of actin , ubiquitin conjugated proteins , free ubiquitin , E 3 ubiquitin ligases , and the type 1 TNF receptor ( TNFR 1 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To reveal signaling events mediated by TNF receptors ( TNF Rs ) in tendinocytes , we focused on four signaling factors , TNF R 1 , TNF R 2 , TNF R associated factor 2 ( TRAF 2 ) and nuclear factor kappa B ( NF kappaB ) , and investigated the distribution and production of these factors . ^^^ Although TNF R 1 and TNF R 2 co localized on the same tendinocyte , in untreated control cells ( normal condition ) , immunoreactivity against TNF R 1 was very weak but TNF R 2 showed a strong reaction . ^^^ However , TNF R 1 showed the same high level of reaction as TNF R 2 in TNFalpha treated cells ( inflamed condition ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Interestingly , IL 3 and GM CSF down regulated both mRNA and surface expression of TNF receptor 1 ( TNFR 1 ) and TNFR 2 . ^^^ In summary , we provide the first evidence that IL 3 and GM CSF block TNF alpha induced osteoclast differentiation by down regulation of mRNA and surface expression of TNFR 1 and TNFR2 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) alpha , a major proinflammatory cytokine , exerts its role on bone cells through two receptors ( TNFR 1 and TNFR 2 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Previously we reported that both human TNFR 1 and TNFR 2 mediate TNF induced apoptosis in the transfected rat / mouse T cell hybridoma PC 60 . ^^^ TNFR 2 induced apoptosis is independent of endogenous TNF or other death inducing ligand production and subsequent activation of TNFR 1 or other death receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results indicate a distinction between TNF Receptor family members CD 40 and TNFR 1 in their utilization of MAP3Ks , and demonstrate TRAF dependence of Tpl 2 association with the CD 40 receptor complex . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : In 63 women with various stages of endometriosis preoperative levels of cytokines , including IL 6 , IL 8 , BVEGF , b FGF , of TNF RI and TNF RII were analysed employing ELISA tests ( R & D kits ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we investigated local protein levels of the two known TNF receptors , TNF receptor 1 and 2 ( TNFR 1 , TNFR 2 ) , on days 0 , 1 , 3 , 7 , 14 , and 28 after unilateral crush or chronic constriction injury ( CCI ) of mouse sciatic nerves using enzyme linked immunoassay . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Evodiamine also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In parallel , TNFalpha is released , leading to activation of signaling pathways mediated by TNF receptor 1 ( TNF R 1 ) . ^^^ In concert with the down regulation of IAPs and FLIP , TNF R 1 activation as an additional proapoptotic stimulus now results in significant enhancement of UVB induced apoptosis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Liver fibrosis caused by chronic CCl 4 exposure was TNF dependent ; histological fibrosis was seen in wild type ( WT ) and TNFR 2 knockout ( KO ) mice , but not in TNFR 1 KO mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The aim of the study was to answer the following questions : 1 ) Is it possible to apply elements of non linear dynamics to assess the level of expression of TNF , TNFRI , TNFRII genes in tumor cells , pathologically unchanged tissue and metastatically changed lymph nodes . 2 ) Is theoretically anticipated variability of cytokine and its receptors in colorectal carcinoma cells and the immediate vicinity justified in the developed mathematical model . ^^^ Its activity depends on the type of target cells and different regulating factors , but the effect of biological activity is conditioned by specific receptors such as p 55 ( type 1 , TNF R 55 ) and p 75 ( type 2 , TNF R 75 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present study , we found that TNFalpha as well as its receptors , TNFR 1 ( TNF Receptor 1 ) and TNFR 2 , were clearly expressed in ameloblastoma tissues and AM 1 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Methyl beta cyclodextrin did not alter total cell surface expression of TNFR 1 or TNF induced degradation of IkappaBalpha , a measure of nuclear factor kappaB activation , but it did inhibit TNF induced phosphorylation of Akt , a measure of phosphatidylinositol 3 kinase activation . ^^^ Treatment with TNF induced disappearance of TNFR 1 from caveolae and dissociation from caveolin 1 within 5 minutes . ^^^ By 60 minutes of treatment with TNF , TNFR 1 appeared in endosomes . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Examination of structural models of TNF bound to soluble TNF receptor 1 ( TNFR 1 ) indicates that simple mutations in the tip region most probably can not interact with receptor binding sites , and therefore do not directly modulate cytotoxicity . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Tissue specimens of 10 tooth germs , 40 benign ameloblastomas , and five malignant ameloblastomas were examined by reverse transcriptase polymerase chain reaction ( RT PCR ) and immunohistochemistry to determine the expression of TNFalpha , TNF receptor 1 ( TNFRI ) , TRAIL , TRAIL receptor 1 ( TRAIL R 1 ) , TRAIL R 2 , caspase 8 , and nuclear factor kappaB ( NF kappaB ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
INTRODUCTION : TNF receptor associated factor 2 ( TRAF 2 ) is a signal transducer for RANK and for two TNF receptor isotypes , TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , TNF has proinflammatory and immunosuppressive properties that may segregate at the level of the 2 TNF receptors ( TNFRs ) , TNFR 1 and TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
PURPOSE : To determine the association between 17 single nucleotide polymorphisms ( SNPs ) of tumor necrosis factor alpha , lymphotoxin alpha , and the TNF receptors genes ( TNF , LTA , and TNFRSF1A and B ) and idiopathic acute anterior uveitis ( IAU ) and to investigate their association with HLA B 27 and / or the development of visually significant complications . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF R family members summarized in this review includes : TNF RI + 2 , OX 40 , and 4 1BB and they are expressed on a variety of leukocytes within the body . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : To evaluate whether local TNF receptor ( TNF R ) gene therapy in DBA / 1 mice exerts an influence beyond anti inflammatory effects . ^^^ METHODS : DBA / 1 mice received single periarticular injections of media or retroviral vectors containing LacZ or human TNF R into affected arthritic paws at disease onset . ^^^ Disease severity was monitored , immune responses towards the immunodominant bovine CII 245 270 and subdominant CII 334 360 peptide epitopes were assessed by ELISA , and T cell Vbeta usage was analysed by real time polymerase chain reaction for the LacZ transduced , TNF R , and viral free media treated control animals . ^^^ The therapeutic influence of TNF R gene transduction was compared with other groups at different times after treatment . ^^^ RESULTS : Reduced disease severity was seen 15 35 days after treatment , with a concomitant increase in immunity towards the subdominant CII 334 360 peptide epitope rather than the immunodominant CII 245 270 peptide in TNF R treated animals . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , the TNF receptor 1 ( TNFR 1 ) expression was lower on CB granulocytes than that on AB granulocytes ( 69 . 98 + / 7 . 32 versus 89 . 04 + / 3 . 73 % , p = 0 . 029 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Reverse transcription PCR indicated that HPC and microglial cells express both TNF receptors , TNF R 1 and TNF R 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
ACA also inhibited NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TNFR associated death domain protein , TNFR associated factor 2 , and IkappaBalpha kinase , but not that activated by p 65 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The anti TNF receptor 1 ( TNFR 1 ) antibody , but not the TNF receptor 2 ( TNFR 2 ) antibody , repressed this upregulation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Using quantitative assays to monitor levels of IDO mRNA , protein expression , and enzyme activity , we report that PGE 2 induces mRNA expression of IDO ; however , a second signal through TNF receptor ( TNF R ) or a Toll like receptor ( TLR ) is necessary to activate the enzyme . ^^^ A better understanding of these regulatory mechanisms and the crosstalk between TNF R / TLR and EP 2 signaling pathways will provide insight into the regulation of T cell activation by DCs and may help to improve existing immunotherapy protocols . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The developed tolerance to either LPS or TNF can be reciprocally cross reacted between LPS and TNF challenges , whereas the signaling of induction of tolerance and promotion of apoptosis was through TNFR 1 , rather than TNFR2 . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF has greater affinity for TNF R 1 than for TNF R 2 . ^^^ Since TNF R 2 signaling tends to be more anti apoptotic and activating of nuclear factor kappa B , NFkB , than is TNF R 1 , and TNF R 1 tends to be more pro apoptotic than is TNF R 2 , by inactivating soluble TNF while leaving transmembrane TNF signaling relatively unchanged , etanercept changed the balance in TNF signaling from TNF R 1 towards TNF R 2 weighting . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These results highlight the potential for TNF to play a vital role in inflammatory hyperalgesia , both by a direct action on neurons via TNFR 1 and by facilitating the accumulation of macrophages in the DRG via a TNFR 2 mediated pathway . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The biological effects of TNF are mediated via two cell surface TNF receptors : p55TNFR ( TNFR 1 ; CD120a ) and p75TNFR ( TNFR 2 ; CD120b ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Zerumbone also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The expression of TNF R 1 , IL 1beta , and IL 12 genes decreased only in glandular cystic hyperplasia ( p < 0 . 05 for all genes ) , expression of insulin like growth factor 1 gene decreased only in adenomatous hyperplasia ( p < 0 . 05 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONTEXT : TNF receptor associated periodic syndrome ( TRAPS ) is a hereditary fever syndrome that results from mutations in the TNF receptor superfamily 1A gene ( TNFRSF1A ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The TNF alpha induced RANTES gene expression and secretion was attenuated with a neutralizing monoclonal antibody directed against the TNF receptor type 1 ( TNFR 1 ) . ^^^ Conversely , a neutralizing monoclonal antibody directed against TNF receptor type 2 had no effect , suggesting that these events were regulated through the TNFR 1 receptor . ^^^ In these studies , the enzymatically inactive form of AP had no effect on TNF alpha induced RANTES secretion , shedding of sTNFR 1 , or membrane associated TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Introduction of matrix metalloproteinase ( MMP ) 2 recognition motifs between TNF and the TNFR 1 fragment allowed activation by recombinant MMP 2 and MMP expressing HT 1080 cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Gene expression of Tnfrsf1a and Tnfrsf1b was downregulated in colon and small intestine of experimental animals , possibly as a mechanism of protection against TNF cytotoxicity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our data indicate that the TNF / TNFR 1 signaling system mediates mucosal damage through the enhancement of NF kappa B activity and that continuous infiltration of TNF producing cells , probably a key pathogeneses of colitis , may be closely associated with defective apoptosis of LPMC , which is possibly independent of the TNF / TNFR signaling system in TNBS induced colitis . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Immunolabeling was applied for detection of TNF , TNFR 1 , TNFR 2 and phosphorylation of CREB . ^^^ After 1 1 . 5 h incubation , mRNA expression of TNF was ( PKA independently ) attenuated by 8 bromo cAMP ( p < 0 . 05 ) , whereas that of TNFR 1 was PKA dependently stimulated ( p < 0 . 05 ) . ^^^ CONCLUSION : Expression of TNF and its receptors in alveolar epithelial cells may contribute to the response to organic dust . 8 bromo cAMP , which increased the number of cells exhibiting phosphorylation of CREB exerted opposite effects on TNF and TNFR 1 mRNA expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Neutralization of TNF prevented melphalan induced apoptosis and liver cells derived from mice genetically deficient in either TNFR 1 or 2 , but not from lpr mice lacking a functional CD 95 receptor , were completely resistant . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor receptor associated periodic syndrome ( TRAPS ) results from point mutations in the extracellular domain of TNF receptor 1 ( TNFRSF1A ) , but the effects of the mutations are controversial . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
METHODS : Male mice deficient in both TNF receptors 1 ( TNFR 1 ) and 2 ( TNFR 2 ) ( TNFRDKO mice ) and wild type mice were fed a methionine and choline deficient ( MCD ) diet or a control diet for eight weeks , maintaining isoenergetic intake . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Wild type TNF induces TNFR 2 and Etk and activates both ASK 1 and Etk but does not down regulate TNFR 1 . ^^^ Wild type TNF and TNFR 1 specific mutein trigger tubular cell apoptosis whereas wild type TNF and TNFR 2 specific mutein induce tubular cells to express proliferating cell nuclear antigen . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Levels of soluble TNF R 1 and TNF R 2 in normal pregnancy were elevated when compared with non pregnant normal women and pregnant RSA women . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Human TNFalpha induced rat TNFalpha gene expression , indicating that type 1 TNF receptor ( TNF R ) is involved in the autoinduction . ^^^ TNFalpha did not increase either type 1 or type 2 TNF R mRNA levels , suggesting that upregulation of TNF receptors is not involved in the autoinduction of TNFalpha . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
INTRODUCTION : TNF receptor 1 or 2 ( TNF RI or TNF RII ) is thought to induce its own trimerization by ligand binding ; however , recently TNF RI or TNF RII was shown to form a trimer through its extracellular domain without ligand binding . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Members of the tumour necrosis factor ( TNF ) / TNF receptor ( TNF R ) superfamily coordinate the immune response at multiple levels . ^^^ Most notable are the development of spontaneous inflammatory polyarthritis in human TNF globin transgenic mice , the auto inflammatory syndromes resulting from mutations in the 55 kDa TNF R , and , in particular , the obligatory role for the RANKL / RANK axis in osteoclastogenesis and bone remodelling . ^^^ A growing appreciation of the molecular basis of signalling pathways transduced by TNF R has provided a framework for better understanding the biology of this expanding family . ^^^ For while the rapid and robust activation of NF kappaB and MAPK pathways is typical of acute TNF R engagement , the molecular basis of sustained receptor signalling remains a mystery , in spite of its relevance to chronic inflammatory and immune responses . ^^^ Focusing on T cells , this report describes some of the molecular footprints of sustained TNF R engagement and illustrates how these may influence immune function . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RESULTS : Irrespective of genotype , MCD diet fed mice developed hepatic lipid peroxidation and serum ALT elevation ; at day 10 , livers from wt , TNF / , and TNFR 1 / mice showed equivalent steatohepatitis . ^^^ Likewise , NF kappaB activation and ICAM 1 expression were enhanced by MCD dietary feeding in TNF / and TNFR 1 / mice compared with respective controls . ^^^ CONCLUSIONS : In the MCD dietary model of steatohepatitis , NF kappaB is activated early and is an important proinflammatory mediator of lesion development , but steatohepatitis occurs independently of TNF synthesis and TNFR 1 activation . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Systemic cytokine levels and the effects of etanercept in TNF receptor associated periodic syndrome ( TRAPS ) involving a C33Y mutation in TNFRSF1A . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF receptors TNF R 1 and TNF R 2 were found in macrophage and fibroblast like cells , vascular endothelial cells in post capillary venules , and basal epithelial cells in pericoronitis , but were only weakly expressed in controls . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BACKGROUND : Tumour necrosis factor ( TNF ) receptor associated periodic syndrome ( TRAPS ) is caused by dominant mutations in the TNFRSF1A gene . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The suppression of LTP by Abeta was absent in mutant mice null for TNF receptor type 1 ( TNF R 1 ) and was prevented by the inhibitors of TNFalpha , infliximab and TNF peptide antagonist , and by the inhibitor of TNFalpha production , thalidomide . ^^^ In addition , exogenous TNFalpha inhibited LTP induction , an action mediated via TNF R 1 as such inhibition was absent in mutant mice null for TNF R 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Differential regulation of interleukin 8 gene transcription by death receptor 3 ( DR 3 ) and type 1 TNF receptor ( TNFRI ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The presentation of TNFR 1 at the surface of these cells was reduced , which affected the sensitivity of the cells to the TNF treatment . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
AIMS / HYPOTHESIS : We studied the impact of genetic versus pre and postnatal environmental factors on the plasma levels of IL 6 , TNF and the soluble TNF receptor superfamily , member 1A ( TNFRSF1A , previously known as TNF receptor type 1 [ TNFR 1 ] ) . ^^^ Fasting plasma IL 6 , TNF and soluble TNFRSF1A levels were measured using ELISA in 55 young and 43 elderly twin pairs . ^^^ RESULTS : Plasma IL 6 and TNF were influenced by genetic factors in young and elderly twins respectively , while no significant impact of genetics was found for soluble TNFRSF1A . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Furthermore , SAHA inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NF kappaB inducing kinase , IkappaBalpha kinase , and the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Ablation of the TNF receptor gene p 55 ( Tnfrsf1a ) or treatment with a synthetic metalloproteinase inhibitor rescues timp 3 / mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This potentiation of TTX resistant currents by TNFalpha is dramatically reduced in DRG neurons from TNF receptor 1 ( TNFR 1 ) knock out mice and is blocked by the p 38 mitogen activated protein kinase inhibitor SB 202190 [ 4 ( 4 fluorophenyl ) 2 ( 4 hydroxyphenyl ) 5 ( 4 pyridyl ) 1H imidazole ] . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In human vascular endothelial cells ( HUVEC ) , extracellular TNFR 1 ( type 1 TNF receptor , TNFRSF1A ) is generated by two mechanisms , proteolytic cleavage of soluble TNFR 1 ectodomains and the release of full length 55 kDa TNFR 1 in the membranes of exosome like vesicles . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Tumour necrosis factor ( TNF ) receptor associated periodic syndrome ( TRAPS ) is an autoinflammatory disorder characterized by periodic attacks of fever and inflammation , due to mutations in the gene coding for the TNF type 1 receptor ( TNFRSF1A ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
As a first step in addressing the signal transduction cascades involved in the UCB induced astroglial immunological response , we tested whether tumour necrosis factor ( TNF ) alpha receptor 1 ( TNFR 1 ) , mitogen activated protein kinase ( MAPK ) and nuclear factor kappaB ( NF kappaB ) would be activated in astrocytes exposed to UCB , and examined the profile of cytokine production . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
BLyS binds to 3 TNF R receptors , TACI , BCMA , BAFF R , to regulate B cell survival , differentiation , and proliferation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The first pattern was seen in SCID mice and in mice with deleted alpha / beta T receptor , TNF R 1 , IL 12 , IFN gamma , or iNOS genes , and showed a massive INPG with a high granulomatous infiltration of the lung , a large and homogeneous eosinophilic necrosis full of acid fast bacilli , with marked karyorrhexis , coarse basophilic necrosis , and surrounded by patches delimited by partially conserved alveolar septum full of PMNs . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , we have observed that LPS activated BV 2 supernatant induces NSC 34 cell death in association with an upregulation of the TNF receptor 1 ( TNFR 1 ) expression on NSC 34 cells , both at the transcription level and at the cell surface protein level . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here , we show that NEMO binds to Lys 63 but not Lys 48 linked polyubiquitin , and that single point mutations in NEMO that prevent binding to Lys 63 linked polyubiquitin also abrogates the binding of NEMO to RIP in tumour necrosis factor ( TNF ) alpha stimulated cells , the recruitment of IKK to TNF receptor ( TNF R ) 1 , and the activation of IKK and NF kappaB . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
OBJECTIVE : Tumour necrosis factor receptor associated periodic syndrome ( TRAPS ) has been associated with several mutations in the TNF receptor super family 1A ( TNFRSF1A ) , including most cysteine substitutions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Lastly , these studies provide mechanistic insights by demonstrating that CCR 5 is required for optimal IL 13 stimulation of select chemokines ( MIP 1alpha / CCL3 , MIP 1beta / CCL4 , MCP 1 / CCL 2 ) , matrix metalloproteinase 9 and cell death regulators ( Fas , TNF , TNFR 1 , TNFR 2 , Bid ) , optimal IL 13 inhibition of alpha 1 antitrypsin , and IL 13 induction of and activation of caspases 3 , 8 , and 9 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In vivo protein protein interaction studies displayed an association between TNF receptor 1 ( TNFR 1 ) and TNFR 1 associated death domain protein ( TRADD ) , suggesting that the core protein does not perturb this interaction . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Intratumoural expression of TNF R 1 and EMAP 2 in relation to response of patients treated with TNF based isolated limb perfusion . ^^^ However , intra tumoural expression of TNF receptor 1 ( TNF R 1 ) and TNF R 1 upregulating factors are unknown . ^^^ We determined the expression of TNF R 1 , proEMAP and endothelial monocyte activating polypeptide 2 ( EMAP 2 ) before and after ILP and evaluated this against clinical response . ^^^ Biopsies were randomly analysed by western blotting for proEMAP / EMAP 2 and TNF R 1 expression . ^^^ Appropriate melanoma biopsies were stained for EMAP 2 , TNF R 1 , CD 31 and CD 68 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In urothelial cultures , only siRNAs targeting TNFR 1 , but not TNFR 2 , blocked TNF induced apoptosis , indicating a primary role for TNFR 1 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
K 17 interacts with TNF receptor 1 ( TNFR 1 ) associated death domain protein ( TRADD ) , a death adaptor essential for TNFR 1 dependent signal relay , suggesting a functional link between this keratin and TNFalpha signaling . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In conclusion , these results suggest that death signaling cascades triggered by TNF receptor 1 ( TNFR 1 ) and Fas are present in both normal and tumoral pituitary cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Signals through the type 1 TNF receptor ( TNFR 1 ) are required for severe EAE to develop , whereas deficiency in IFN gamma or its receptor result in more severe EAE . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In an effort to understand this association better we ( 1 ) profiled gene expression patterns of TNF , TNFR 1 and TNFR 2 and ( 2 ) investigated the effects of TNF on glucose uptake in isolated adipocytes and adipose tissue explants from omental and subcutaneous depots from lean , overweight and obese individuals . ^^^ TNF expression correlated with expression of TNFR 2 , but not TNFR 1 , and TNF and TNFR 2 expression increased in obesity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NF kappaB reporter activity induced by TNFR 1 , TNF receptor associated death domain , TRAF 2 , TAK 1 , NF kappaB inducing kinase , and IKKbeta was inhibited by indirubin but not that induced by p 65 transfection . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of the upstream signaling events affected by PMA revealed that it markedly inhibited the TNF induced recruitment of TNFR 1 associated death domain protein ( TRADD ) and receptor interacting protein ( RIP ) to TNFR 1 , subsequently inhibiting TNF induced activation of nuclear factor kappaB and c Jun NH 2 terminal kinase ( JNK ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNF contributes to postischemic myocardial dysfunction and induces proinflammatory signaling , which may be mediated by the 55 kDa TNF receptor ( TNFR 1 ) . ^^^ Female WT mice had less myocardial depression after TNF infusion despite equivalent TNFR 1 expression . ^^^ CONCLUSIONS : This study demonstrates that sex differences exist in myocardial TNF signaling by TNFR 1 after I / R . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The Tlx 1 , Bapx 1 , Tcf 21 , Wt 1 and Dh genes are essential for development of the spleen , while mutations of Nkx 2 3 , Lta , Ltb , Ltbr , Map3k14 , Relb , Tnf , Tnfrsf1a , Cxcl 13 , Blr 1 ( Cxcr 5 ) , or cpdm genes result in disruption of normal splenic microarchitecture . ^^^ Here we review abnormalities of lymphoid organ development in immunodeficient mutant mice , including spontaneous and targeted mutations of Id 2 , Rorc , Tnf , Tnfrsf1a , Lta , Ltb , Ltbr , Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , IL7r , Blr 1 , and Cxcl 13 genes . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Analysis of complex formation of wild type TNF and of both fusion proteins with TNFR type 1 ( TNF R 1 ) using surface plasmon resonance correlated well with in vitro and in vivo toxicity data . ^^^ Reduction of unspecific peripheral complexation of TNF R 1 resulted in higher anticancer potency by immunotargeting of fibroblast activating protein expressing xenografts . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Peripheral blood mononuclear cells were stained for CD 3 , CD 4 , CD 8 , CD 28 , TNF receptor 1 ( TNFRI ) , and TNFRII , and analyzed by quantitative flow cytometry . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FasL is likely to be particularly important but tumour necrosis factor ( TNF ) may well contribute , via the TNF receptor 1 ( TNF R 1 ) death pathway . ^^^ Alternatively , we suggest the possibility of upregulation of an antiapoptotic TNF R 1 nuclear factor kappaB pathway , which would proscribe treatments which downregulate this pathway . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNF R p 75 levels were consistently elevated in the narcoleptic patients compared with their sex and age matched ( P = . 001 ) as well as sex , BMI , and age matched counterparts ( P = . 003 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFalpha receptor 1 ( p 55 , TNFRI ) and 2 ( p 75 , TNFRII ) shedding was also inhibited by GI 129471 ( IC 50 = 1 . 5 and 3 . 1 microM , respectively ) and BB 2516 ( IC 50 = 14 and 15 microM , respectively ) . ^^^ In contrast to pro TNFalpha surface expression , TNFRI surface expression was not augmented by these MMP inhibitors in THP 1 cells after LPS stimulation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSIONS : These results suggest that the activation of Kupffer cells , TNFalpha and caspases downstream of TNFR 1 were involved in hepatocyte apoptosis induced by LPS . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NGF also binds to the common neurotrophin receptor ( p 75 ( NTR ) ) , a member of the TNFalpha receptor ( TNFR 1 ) superfamily , whose function may be to modulate apoptosis via the release of ceramide and the activation of the transcription factor nuclear factor kappa B ( NFkappaB ) . ^^^ The similarity between p 75 ( NTR ) and TNFR 1 signal transduction pathways suggests that one of the mechanisms by which TNFalpha affects neuronal survival is by impacting upon these pathways that normally promote NGF support of neurons . ^^^ Our results also suggest that AA , an inflammatory signal lipid induced by TNFalpha via binding to TNFR 1 , may reduce neuronal survival by inhibiting elements of the signal cascade induced by NGF . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To investigate the mechanism of the long lasting efficacy of chimeric monoclonal anti TNFalpha antibody ( cA 2 ) therapy for rheumatoid arthritis ( RA ) , eight patients with refractory RA were treated with a single infusion of cA 2 and the changes in circulating cytokines ( IL 1 , IL 6 , TNFalpha , and IL 10 ) , soluble cytokine receptors ( TNF RI , RII , and sIL 6R ) and peripheral white blood cell ( WBC ) subset counts were followed up long term ( 12 weeks ) after cA 2 therapy in them . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In wild type ( TNFR 1 ( + / + ) R 2 ( + / + ) ) and TNFR 2 ( / ) adipocytes , TNFalpha stimulated lipolysis and inhibited insulin stimulated glucose transport as well as insulin receptor autophosphorylation . ^^^ Taken together , these studies demonstrate that TNFalpha induced lipolysis , as well as inhibition of insulin stimulated glucose transport are predominantly mediated by TNFR 1 and that the presence of TNFR 2 is not necessary for these functions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Transcriptional expression of TNFR 1 ( p 55 ) , as well as that of FLICE , Fas , FADD , DR 3 , FAF , TRADD , and RIP was similar in these cell lines , indicating that the susceptibility to TNFalpha induced apoptosis may not be determined by the constitutive expression level of these factors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Concentrations of TNFalpha , p 55 and p 75 soluble ( s ) TNF R in supernatants from cultured OA and non arthritic ( NA ) synovium were measured by ELISA . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Following oligomerization by TNFalpha , the receptors TNF RI and TNF RII associate with adapter molecules via specific protein protein interactions . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In TNFalpha receptor ( TNFR ) intact ( wild type , WT ) mice following 4 and 7 DMN exposures , hepatic transcripts for TNFalpha and TNFR 1 were elevated as compared to vehicle controls . ^^^ Taken together , these data show DMN induced hepatic TNFalpha expression and suggest that TNFR 1 signaling may be up regulated following 4 and 7 daily DMN exposures . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To further investigate the relative contribution of the two TNFalpha receptors ( TNFR 1 and TNFR 2 or P 55 and P 75 receptors ) we evaluated the hepatotoxicity of FB 1 in male C57BL / 6J mice ( WT ) and a corresponding TNFR 1 knockout ( TNFRKO ) strain , genetically modified by a targeted deletion of this receptor . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Soluble TNFRI reduced serum levels of TNFalpha and led to a 2 fold increase in the lifespan of me / me mice , compared with the control treatment group . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Binding of TNFalpha to its two receptors , TNFR 1 and TNFR 2 , results in recruitment of signal transducers that activate at least three distinct effectors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
To define the role of TNFalpha signaling in hepatocellular growth induced by peroxisome proliferators we administered three daily gavage doses of the potent peroxisome proliferator , Wy 14 643 , to mice nullizygous for TNF receptor 1 ( TNFR 1 ) , TNFR 2 , or both receptors . ^^^ Expression of Il1alpha , Tnfalpha , Tnfr 1 , Tnfr 2 , Pparalpha , or C / ebpalpha was not altered by acute Wy 14 643 exposure or in adenomas induced by Wy 14643 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In addition , the ratio of ( 3 ) H TDR incorporation and the expression of ET R mRNA and TNF R 1 mRNA ( 545 bp and 347 bp ) were markedly increased than that of the control group ( P < 0 . 05 ) when ET 1 or TNFalpha was added in the culture media . ^^^ ET 1 and TNFalpha are also effective in promoting the proliferation of renal interstitial fibroblasts through ET R and TNF R . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The studies with neutralizing antibodies against soluble TNFRI suggest that endogenous cartilage derived TNFalpha antagonists modulate NO production in osteoarthritic cartilage . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Apoptosis in BxPC 3 cells mediated by TNF related apoptosis inducing ligand ( TRAIL ) and CD95L was likewise increased 2 . 3 + / 0 . 5 fold and 7 . 4 + / 2 . 5 fold , respectively . sst 2 dependent activation and cell sensitization to death ligand induced apoptosis involved activation of the executioner caspases , key factors in both death ligand or mitochondria mediated apoptosis . sst 2 affected both pathways : first , by up regulating expression of TRAIL and TNFalpha receptors , DR 4 and TNFRI , respectively , and sensitizing the cells to death ligand induced initiator capase 8 activation , and , second , by down regulating expression of the antiapoptotic mitochondrial Bcl 2 protein . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we show that upon TNFalpha binding , TNFR 1 translocates to cholesterol and sphingolipid enriched membrane microdomains , termed lipid rafts , where it associates with the Ser / Thr kinase RIP and the adaptor proteins TRADD and TRAF 2 , forming a signaling complex . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These data demonstrate that TNFalpha transiently inhibits the hsp 70 stress response via TNF R 1 and activation of protein phosphatases . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
E increased estrogen receptor alpha ( ERalpha ) and Bcl xL expression and all but abolished TNFalpha receptor 1 ( TNFR 1 ) expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
These recombinant peptides effectively competed for [ 125I ] TNFalpha binding to TNFR 1 in a dose dependent manner , with IC ( 50 ) from 10 to 160 microM . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The induction of TP by TNFalpha was mimicked by an antibody to the TNFalpha receptor R 2 ( TNF R 2 ; p 75 ) , but not by an antibody to TNF R 1 ( p 55 ) , suggesting that the TNF R 2 plays a role in the regulation of TP expression . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Our observations that neutralisation of TNFalpha and absence of TNFR 1 has no discernible effect on development of EAG suggest that TNFalpha is not required for mucosal cell damage or development of autoimmune gastritis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Compared to wild type murine embryonic fibroblasts , antisense treatment of NFkappaB and TNFR 1 KO cells resulted in markedly more pronounced cell death , whereas antisense treated TNFalpha and TNFR 2 knockouts exhibited less prominent apoptosis . ^^^ Antisense abrogation of DENN expression culminated in upregulated expression of TNFR 2 , TRAIL and Fas , but downregulation of TNFalpha , TNFR 1 and cyclin D 3 . ^^^ The participation of TNFalpha , TNFR 1 , TNFR 2 and Fas in the inhibition of DENN expression was also demonstrated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
FLIP and Fas gene and protein expression were not significantly altered in hypoxic cells compared to normoxic controls . mRNA and protein levels of TNFalpha and TNFR 1 were significantly decreased , while FasL mRNA and proteins levels were significantly increased in hypoxic HCEC . ^^^ Caspase 8 activity may be suppressed because the loss of TNFalpha and TNFR 1 gene and protein expression inhibits the initial formation of a death signaling complex . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
However , in mice deficient in the receptor type 1 for TNFalpha ( TNFR 1 ( / ) ) , ethanol induced liver injury and the increase in Ras activity were significantly blunted compared with wild type mice . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In aged coronary arteries there was an increased expression of TNFalpha , TNFbeta , and caspase 9 ( microarray , real time PCR ) , as well as increased caspase 9 and caspase 3 activity , whereas expression of TNFR 1 , TNFalpha converting enzyme ( TACE ) , Bcl 2 , Bcl 10 ( L ) , Bid , Bax , caspase 8 , and caspase 3 were unchanged . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study we analyze the mRNA expression levels of TNFalpha and its receptors ( TNFR 1 and TNFR 2 ) , in peripheral blood mononuclear cells ( PBMC ) from eleven , non morbid , obese and 14 , obese , type 2 DM women , by real time quantitative PCR . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In this study , we investigated the expression of TNFalpha and both its receptors ( TNFRI and TNFRII ) in both viral and nonviral myocarditis . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Interestingly , TNFalpha is expressed in the prenatal and postnatal liver but not in adult liver , whereas TNFR 1 , a TNFalpha receptor , is expressed in both fetal and adult livers . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NAK is recruited to the TNFR 1 complex in a TNFalpha dependent manner and mediates the production of RANTES : identification of endogenous TNFR interacting proteins by a proteomic approach . ^^^ TNFalpha signaling is triggered by the engagement of soluble TNFalpha to two types of cell surface receptors , TNFR 1 and TNFR 2 . ^^^ We further showed that NAK is recruited to TNFR 1 in a temporally regulated and TNFalpha dependent manner and that it mediates the TNFalpha induced production of the chemokine RANTES ( regulated on activation normal T cell expressed and secreted ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Therefore , we differentiated the neuronal and non neuronal sites of TNFalpha , TNFR 1 , and TNFR 2 mRNA synthesis in dorsal root ganglion ( DRG ) of control rats and evaluated how their expression is altered under systemic challenge with LPS . ^^^ Taken together , we provide evidence that non neuronally synthesized TNFalpha may directly act on primary afferent neurons via TNFR 1 but not TNFR 2 . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSION : In the initiation phase of pulmonary oxygen toxicity , an increase of TNFalpha and its receptor TNFR 1 leads to the activation of caspase 8 and 3 in TIIcells . ^^^ Intratracheal application of anti TNFalpha antibodies prevented the increase of TNFRI and of caspase 3 activity . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Ischemia reperfusion induced endometrial apoptosis was markedly decreased in TNF R p 55 deficient mice , confirming the essential role of TNFalpha in the induction of apoptosis by ischemia reperfusion ( n = 4 ) . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
The up regulatory effect of TNFalpha on 52 kd Ro / SSA mRNA and protein expression was inhibited by anti TNFRI antibodies but enhanced by anti TNFRII antibodies . ^^^ CONCLUSION : The finding that TNFalpha up regulates 52 kd Ro / SSA expression in keratinocytes via TNFRI suggests that it may play a role in the pathogenesis of anti Ro / SSA associated cutaneous lupus erythematosus . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
At baseline , patients had a lower peak Vo ( 2 ) ( p=0 . 009 ) and a trend for higher levels of e selectin ( p=0 . 08 ) and sCD 14 ( p=0 . 06 ) , in addition to significantly elevated levels of sICAM ( p=0 . 02 ) , TNFalpha ( p=0 . 02 ) and TNF R 2 ( p=0 . 002 ) ; TNF R 1 and IL 6 were not elevated . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we demonstrate that TNFalpha acts on neuronal TNFR 1 receptors to preferentially exocytose glutamate receptor 2 lacking AMPA receptors through a phosphatidylinositol 3 kinase dependent process . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
CONCLUSIONS : TNFalpha signaling through TNFR 1 is protective in the trinitrobenzene sulfonic acid mouse model of inflammatory bowel disease . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Perturbations in the TNFalpha / TNF R pathway may play a role in these abnormalities . ^^^ CONCLUSIONS : Although our data do not support a causative role of TNFalpha / TNF R alterations in FCHL , they confirm that variation in TNF R shedding may influence lipid phenotypic expression in FCHL families . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Intestinal myofibroblasts from wild type ( WT ) mice or mice homozygous for disruption of genes encoding TNFR 1 ( TNFR 1 / ) , TNFR 2 ( TNFR 2 / ) , or both ( TNFR1 / 2 / ) , were treated with TNFalpha , IGF 1 , or both . ^^^ These responses to TNFalpha were absent in TNFR 2 / and TNFR1 / 2 / myofibroblasts , whereas TNFR 1 / cells showed similar responses to WT . ^^^ Inhibition of ERK1 / 2 diminished TNFalpha induced DNA synthesis in WT and TNFR 1 / cells . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Plasma concentrations of tumour necrosis factor alpha ( TNFalpha ) , TNFalpha receptors TNFRI and TNFRII , interferon gamma ( IFNgamma ) , interleukin 2 ( IL 2 ) , IL 12 , IL 4 , and IL 10 were determined by enzyme linked immunosorbent assays . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
This effect is associated with a selective increase of phosphorylated MKK 3 6 , MKK 4 and ASK 1 and a concomitant upregulation of the TNFalpha receptors ( TNFR 1 and TNFR 2 ) , but not IL1beta and Fas receptors . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
RT PCR analyses demonstrated an increased level of HO 1 , Mn SOD , Cox 2 , iNOS , TNFalpha , TNFR 1 , IL 1beta , IL 6 , Bax , Bak , and Bad gene expression , while Bcl 2 mRNA expression level decreased . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
In the present study , we show that caspase 8 activation in these cells is mediated through ER stress associated elevation of death receptor DR 5 and the C / EBP homologous protein ( GADD153 / CHOP ) , an ER stress initiated transcription factor , rather than through TNFalpha and TNF R 1 interactions on the cell surface . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Inhibition of cell surface APN appears to interfere with the shedding of TNFRI , and as a consequence results in augmented TNFalpha induced apoptosis , cell polarization , and TNFalpha primed , formyl methionyl leucyl phenylalanine stimulated respiratory burst . ^^^ These data suggest significant variation in the activity of APN / CD13 on the cell surface of neutrophils in normal individuals and reveal a novel mechanism whereby APN / CD13 regulates TNFalpha induced apoptosis via inhibition of TNFRI shedding . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
TNFalpha and both of its receptors ( TNFR 1 and TNFR 2 ) can be co expressed on the same cell , allowing for local signaling . ^^^ Macrophage and dendritic differentiation of human peripheral blood monocytes decreased their TNFalpha and TNFR 2 expression while increasing the TNFR 1 mRNA . ^^^ In colon epithelial cell lines ( HT 29 and Caco 2 ) TNFalpha , TNFR 1 , and TNFR 2 expression was decreased upon differentiation . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
Here we attempt to review the existing knowledge on the involvement of ROS in death receptor signaling using TNFalpha TNFR 1 as the model system , specifically addressing the involvement of intracellular ROS in TNFalpha induced cell death and in TNFalpha induced activation of NF kappaB and JNK and their crosstalk . . ^^^
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and P19438	Pubmed	SVM Score :0.0
NA