| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Human LT alpha and a fusion protein ( p 60 : Fc ) comprised of the extracellular domain of the 60 kDa TNF receptor ( TNFR 60 ) fused to the Fc portion of human IgG 1 were produced in insect cells infected with recombinant baculoviruses . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Spleen morphology and antibody response were investigated in wild type , TNFR 1 / , TNFR 2 / and TNF / LT alpha / mice immunized with SRBC . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Signals transduced by binding of tumour necrosis factor alpha ( TNF ) and lymphotoxin alpha ( LT alpha ) trimers to high affinity cell membrane receptors , TNF RI ( p55 / p60 ) and TNF RII ( p75 / p80 ) , affect many cell functions . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| A genetic linkage , as evidence for evolutionary relatedness , is also found by chromosomal cluster for CD 30 , CD120b , 4 1BB and OX 40 to 1p36 ; CD 27 , CD120a and TNFR RP to 12p13 ; TNF , LT alpha and LT beta to 6p21 ; CD27L and 4 1BBL to 19p13 ; CD95L and OX40L to 1q25 . ^^^ TNF , LT alpha and LT beta and their receptors ( CD120a , CD120b , TNFR RP ) interact in a complex fashion . ^^^ TNF and LT alpha / CD120a and CD120b , CD30 / CD30L , and CD40 / CD40L are clearly critical elements in the deregulated network of interactive signals between H RS cells and surrounding bystander cells with membrane associated and cytokine mediated events . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Its receptors , TNF R 55 and TNF R 75 , bind in clefts formed by adjacent identical LT alpha monomers . ^^^ As LT alpha 2 beta 1 expresses an LT alpha alpha cleft , it also binds TNF R . ^^^ In this report we have compared the effects of ligand engagement of TNF R and LT beta R by evaluating the ability of soluble LT alpha beta complexes to initiate activities of human umbilical vein endothelial cells which are characteristically signalled by TNF . ^^^ We also show that neither LT alpha beta heterotrimer signals via TNF R ; in fact LT alpha 2 beta 1 trimers fail to activate NF kappa B and rather inhibit ligand induced TNF R signalling supporting the role for aggregation in TNF R signalling . ^^^ Thus , the ability of LT alpha beta complexes to efficiently initiate tumoricidal but not inflammatory activities distinguishes the LT / LT beta R from the LT / TNF R pathways and suggest novel strategies for exploiting the LT ligands in tumor therapy and for inhibiting TNF R mediated inflammatory sequellae . . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Spleen morphology and antibody responses were investigated in wild type , TNFR 1 / , TNFR 2 / , and TNF / LT alpha / mice immunized with SRBC . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| LT alpha exists in its soluble form as a homotrimer , which like TNF only binds the TNF receptors , TNF R 55 or TNF R 75 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Antibody directed against Fas , TNFR 60 , TNFR 80 , LTBR , and LT alpha failed to inhibit receptor induced death . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor alpha ( TNF alpha ) and lymphotoxin alpha ( LT alpha ) induce pleiotropic cellular effects through low affinity 55 kDa type 1 receptors ( TNFR 1 , CD120a ) and high affinity 75 kDa type 2 receptors ( TNFR 2 , CD120b ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| To determine their role in vivo in lipopolysaccharide ( LPS ) and TNF induced skin inflammatory necrosis , TNFR 1 , TNFR 2 , and TNF lymphotoxin alpha ( LT alpha ) deficient mice were used . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| This action of LT alpha in lymph node organogenesis appears to be mediated by the membrane form of LT using a mechanism independent of TNF receptor 1 ( TNFR 1 ) or 2 ( TNFR 2 ) . ^^^ In contrast , normal Peyer ' s patch development appears to require both LT alpha and TNFR 1 , with TNFR 1 / mice showing hypoplastic Peyer ' s patch structures . ^^^ Mice deficient in either TNF alpha or TNFR 1 also fail to develop splenic FDC clusters and germinal centers , indicating that signaling by both LT alpha and TNF alpha is required for development of these specialized lymphoid tissue structures . ^^^ Finally , the splenic white pulp areas in LT alpha / mice lack the marginal zone of monoclonal antibody MOMA 1 staining metallophilic macrophages , whereas TNFR 1 deficient mice have preserved MOMA 1 staining . ^^^ Thus , certain actions of LT alpha to regulate spleen white pulp architecture are mediated by receptors other than TNFR 1 , most likely by the LT beta R or a closely related receptor . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Here we have used soluble receptor Ig forms of LT beta R and TNF R 55 and mAbs specific for murine LT alpha , LT beta , and LT beta R to characterize the appearance of surface LT alpha beta complexes and LT beta R on several common murine cell lines . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In mice deficient in either lymphotoxin alpha ( LT alpha ) or type 1 tumor necrosis factor receptor ( TNFR 1 ) , organized clusters of follicular dendritic cells ( FDC ) and germinal centers ( GC ) are absent from the spleen . ^^^ We investigated the role of LT alpha and TNFR 1 in the establishment of spleen FDC and GC structure by using reciprocal bone marrow ( BM ) transfer . ^^^ TNFR 1 deficient BM was able to restore FDC organization and GC formation in LT alpha deficient mice , indicating that formation of these structures does not require TNFR 1 expression on BM derived cells . ^^^ The data in this study demonstrate that FDC organization and GC formation are controlled by both LT alpha expressing BM derived cells and by TNFR 1 expressing non BM derived cells . . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the present study , the expression of TNF , LT alpha ( the soluble form of LT ) , LT beta ( the beta chain of LT alpha beta , the membrane bound form of LT ) , TNF RI , TNF RII , LT beta R , FasL , and Fas receptor in MS lesions has been examined by immunohistochemistry for protein and by RT PCR for mRNA . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The action of LT alpha in lymphoid organogenesis is mediated mostly by the membrane form of LT by a mechanism independent of TNF receptor 1 ( TNFR 1 ) or 2 ( TNFR 2 ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The effect of SEB to induce EAE in IL 6 ( / ) mice depends on TNF receptor type 1 ( TNFR 1 ) signaling because IL 6 / TNF / LT alpha ( / ) and IL 6 / TNFR1 ( / ) are refractory to SEB . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| LT consists of soluble LT alpha ( 3 ) , which binds to TNF R 1 and TNF R 2 , and membrane LT alpha ( 1 ) beta ( 2 ) , which binds to LT beta R . ^^^ This activity of LT depends on membrane LT alpha ( 1 ) beta ( 2 ) and not soluble LT alpha ( 3 ) , since DA virus persisted and induced inflammatory demyelination in LT beta R ( / ) , but not TNF R 1 ( / ) or TNF R 2 ( / ) , mice . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Subjects were genotyped for HLA DRB 1 alleles and polymorphisms in the following genes : TNF , LTA , TNFRSF1A , TNFRSF1B , FCGR2A , FCGR3A , and FCGR3B . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Lymphotoxins ( LT alpha and LT beta ) , LIGHT [ homologous to LT , inducible expression , competes with herpes simplex virus ( HSV ) glycoprotein D for HSV entry mediator ( HVEM ) , a receptor expressed on T lymphocytes ] , tumor necrosis factor ( TNF ) , and their specific receptors LT beta R , HVEM , and TNF receptor 1 ( TNFR 1 ) and TNFR 2 , form the immediate family of the larger TNF superfamily . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To determine the association between 17 single nucleotide polymorphisms ( SNPs ) of tumor necrosis factor alpha , lymphotoxin alpha , and the TNF receptors genes ( TNF , LTA , and TNFRSF1A and B ) and idiopathic acute anterior uveitis ( IAU ) and to investigate their association with HLA B 27 and / or the development of visually significant complications . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The Tlx 1 , Bapx 1 , Tcf 21 , Wt 1 and Dh genes are essential for development of the spleen , while mutations of Nkx 2 3 , Lta , Ltb , Ltbr , Map3k14 , Relb , Tnf , Tnfrsf1a , Cxcl 13 , Blr 1 ( Cxcr 5 ) , or cpdm genes result in disruption of normal splenic microarchitecture . ^^^ Here we review abnormalities of lymphoid organ development in immunodeficient mutant mice , including spontaneous and targeted mutations of Id 2 , Rorc , Tnf , Tnfrsf1a , Lta , Ltb , Ltbr , Tnfrsf11a , Tnfsf 11 , Relb , Map3k14 , IL7r , Blr 1 , and Cxcl 13 genes . . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In this review we summarize the essential findings about the function of tumour necrosis factor ( TNF ) and its cognate receptors TNFR 1 and TNFR 2 , and lymphotoxin alpha ( LT alpha ) ligands in immune mediated CNS inflammation and demyelination . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF alpha and LT alpha are both members of the TNF family of molecules and cause cell death by apoptosis following interaction with their counter receptors , the TNFR 1 and TNFR 2 , leading to a cascade of proteolytic events culminating in the blebbing of the cytoplasmic membrane , nuclear condensation and DNA fragmentation . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| We studied tumor necrosis factor ( TNF ) , lymphotoxin alpha ( LT alpha ) , and TNF receptors type 1 ( TNFR 1 ) and type 2 ( TNFR 2 ) gene polymorphisms as well as HLA class 2 DRB 1 alleles in Japanese patients with human T cell lymphotropic virus type 1 ( HTLV 1 ) associated myelopathy ( HAM ) ( n = 51 ) , patients with adult T cell leukemia / lymphoma ( ATL ) ( n = 48 ) , asymptomatic HTLV 1 carriers ( n = 50 ) , and HTLV 1 seronegative , normal controls ( n = 112 ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| To explore the latter possibility , the course of disease was examined in infected mice lacking TNFR 1 and / or TNFRII , TNF only , or both TNF and lymphotoxin alpha . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| MUC1 , while lymphotoxin alpha , but not TNFR 1 , was required for immunity against Panc02 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Immunity to Toxoplasma gondii critically depends on TNFR type 1 mediated immune reactions , but the precise role of the individual ligands of TNFR 1 , TNF and lymphotoxin alpha ( LTalpha ) , is still unknown . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In addition to lacking an adaptive immune system , these strains exhibit aberrant splenic architecture , and the defect in type 1 IFN production was also observed in mice lacking normal splenic marginal zone ( MZ ) organization due to genetic deficiencies in B cell development or in cytokine functions required for development of the MZ , i . e . , muMT , lymphotoxin alpha , and TNFR 1 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Competitive binding experiments showed that sTNF R 1 has a 50 60 fold higher affinity for TNF alpha than for TNF beta , in contrast to the equal affinities of TNF alpha and TNF beta for the full length TNF R 1 transiently expressed in mammalian cells . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Both TBP 1 and TBP 6 markedly enhance the ability of sTNF R 1 to protect cells against the cytotoxic activities of TNF alpha and TNF beta , but have no activity in the absence of sTNF R 1 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| We have previously demonstrated , using expressed deletion constructs , that the fourth membrane proximal cysteine rich repeat of the p 55 TNF receptor ( TNF R ) is not required for binding of tumour necrosis factor alpha ( TNF ) or lymphotoxin alpha ( LT ; tumour necrosis factor beta ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| To address the question of whether the cell death inducing cytokines TNF and lymphotoxin alpha are involved in this process , we generated nonobese diabetic ( NOD ) mice that are deficient for TNF receptor 1 ( TNFR 1 or TNFRp 55 ) . ^^^ Since this was probably due to the complex immunomodulatory effects of TNF and lymphotoxin alpha signaled via TNFR 1 on lymphohemopoietic cells , adoptive transfer experiments with spleen cells from diabetic NOD mice were conducted . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In certain cases in which TNF alpha , rather than TNF beta , induces AML growth through an autocrine mechanism , both TNF R ( p 55 ) and ( p 75 ) are involved . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Unlabeled TNF alpha and TNF beta were equally effective at displacing the binding of labeled TNF alpha to TNF R expressing cells . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Immunohistochemical analysis revealed that TNF alpha , TNF beta , TNF RI , and TNF RII antigens were associated predominately with tumor cells in the tissue . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using the RT / PCR method , we examined mRNA expression of several inflammatory factors in mouse embryos during mid late embryonal development . mRNAs of tumor necrosis factor ( TNF ) alpha , TNF beta , their receptors ( TNF RI , TNF RII ) , transforming growth factor ( TGF ) beta , were expressed constitutively in most of the embryonic tissues . 2 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Tumour necrosis factor ( TNF ) , jointly referring to TNF alpha and TNF beta , is a central mediator of immune and inflammatory responses ; its activities are mediated by two distinct receptors , TNFR 1 ( p 55 ) and TNFR 2 ( p 75 ) ( reviewed in refs 1 3 ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In vitro comparison of inhibiting ability of soluble TNF receptor p 75 ( TBP 2 ) vs . soluble TNF receptor p 55 ( TBP 1 ) against TNF alpha and TNF beta . ^^^ In the present study , the murine A 9 cell line in vitro bioassay was used to test TBP 1 and TBP 2 for their neutralizing activity against recombinant human TNF alpha ( rHu TNF alpha ) , and TNF beta ( rHu TNF beta ) and recombinant murine TNF alpha ( rMu TNF alpha ) . ^^^ Moreover , TBP 1 and TBP 2 were tested for their ability to displace TBP 1 in the TNF TBP receptor binding assay ( RIBA ) against human and murine TNF alpha as well as TNF beta . ^^^ The rHu TBP 2 preparation was the most effective in inhibiting the cytocidal effect of rHu TNF beta on A 9 cells and as active as TBP 1 in the RIBA assay . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF alpha and TNF beta interact with TNF receptor ( TNF R ) , of which two subtypes have been described : TNF R 1 and TNF R 2 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the case of the TNF R derived peptide scans , two of the identified regions interact with the structurally similar TNF beta in the TNF beta TNF R complex . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunohistochemical ( IHC ) staining was performed on formalin fixed , paraffin embedded tissues from 39 bronchogenic adenocarcinomas and 32 squamous cell carcinomas using polyclonal antibodies against TNF alpha , TNF beta , TNF R 1 , and TNF R 2 proteins . ^^^ RESULTS : Significant coexpression of TNF alpha , TNF beta , TNF R 1 , and TNF R 2 was observed in NSCLC ( significance range , P < 0 . 001 0 . 02 ) . ^^^ When all stages were considered together , immunoreactivity for TNF beta ( P < 0 . 001 ) , TNF R 1 , and TNF R 2 ( both P < 0 . 001 ) significantly correlated with favorable outcome in univariate analysis . ^^^ CONCLUSIONS : Although NSCLC exhibits strong coexpression of TNF alpha , TNF beta , TNF R 1 , and TNF R 2 , there is a loss / down regulation of TNF receptors in high stage tumors . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The crystal structures of TNF alpha , TNF beta , the extracellular domain of TNFR 1 ( denoted sTNFR 1 ) , and the TNF beta sTNFR 1 complex have been defined by crystallography . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| As the TNF beta : TNFR 1 co crystal structure was the first in the family to be solved , rational drug design based on the ligand : receptor interaction sites is more advanced . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Cells from mice defective in tumor necrosis factor ( TNF ) alpha , TNF beta , lymphotoxin beta , or TNFR 1 , TNFR 2 , Fas , or death receptor 6 were as susceptible to apoptosis signaling as wild type cells . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The gene encoding mouse LT beta R , Ltbr , contains 10 exons spanning 6 . 9 kb and maps to mouse chromosome 6 , which is closely linked to Tnfr 1 , consistent with the tight linkage of the human homologue of these genes on chromosome 12p13 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF R 1 but not TNF R 2 is responsible for TNF and LT ' s induction of MnSOD . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Analysis of soluble forms of TNF receptors ( TNF R 1 and TNF R 2 ) in sera of tumor bearing mice showed that soluble TNF R 1 was downregulated in both CHO TNF and CHO LT , in comparison with CHO neo cell injected mice and to normal SCID mice . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Anti TNF RI but not anti TNF RII antibody stimulated the superoxide release mimicking LT . ^^^ Anti TNF RI but not anti TNF RII antibody upregulated the adhesiveness and Mac 1 expression of PMN mimicking LT . ^^^ In summary , PMN predominantly express TNF RII , the signalling of LT ( and TNF ) in PMN is mediated mainly by TNF RI , and the adhesion function can be modulated also by TNF RII when TNF RI is stimulated . . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Homotypic aggregation of T LAK cells was induced by LT , TNF , and anti 75 but not by anti 55 kDa TNF R antibody . ^^^ Anti 75 but not 55 kDa TNF R antibody suppressed the proliferation , mimicking LT and TNF . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Two recombinant soluble TNF R IgG fusion proteins , one containing p 55 TNR R , the other containing p 75 TNF R , and a recombinant monomeric soluble p 55 TNF R were all found to block the cytotoxicity generated by human TNF alpha and LT as well as also murine TNF . ^^^ The p 55 TNF R IgG fusion protein ( p 55 sf2 ) was the most effective of the antagonists tested , requiring an equimolar , ( based on a monomeric configuration of TNF alpha ) or a 3 fold higher ( based on a trimeric configuration of TNF alpha ) molar concentration to inhibit the cytotoxicity mediated TNF alpha by 50 % . p 55 sf2 was also as effective at inhibiting the cytotoxicity mediated by LT or murine TNF in the KYM 1D4 assay . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Most human cells express two TNF and lymphotoxin ( LT ) membrane receptors ( TNF R ) , of 55 and 75 kDa . ^^^ Rabbit antihuman TNF R antisera specific for each receptor were employed as probes to selectively stimulate 55 and 75 kDa TNF / LT membrane receptor production . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| The serum concentrations of tumor necrosis factor beta ( TNF beta ) , TNF receptor 1 ( TNFR 1 ; 55 kDa ) and TNFR 2 ( 75 kDa ) , interleukin 4 ( IL 4 ) , interleukin 10 ( IL 10 ) and interferon gamma ( IFN gamma ) were measured by enzyme linked immunosorbent assay in all patients . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To determine serum levels of TNF beta and soluble TNF R in patients with primary highly malignant bone tumours . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| We investigated lymphotoxin ( LT ) and TNF function in lymph node genesis and cellular organization by manipulating LTbeta R and TNF R signaling . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : Human NK cell membrane bound LT signals across species via TNFRI , leading to NF kappaB nuclear translocation and transcription of E selectin and IL 8 , which results in EC activation . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| In vitro binding assays demonstrated that TRAF 4 interacts with the cytosolic domain of the lymphotoxin beta receptor ( LT beta R ) and weakly with the p 75 nerve growth factor receptor ( NGFR ) but not with TNFR 1 , TNFR 2 , Fas , or CD 40 . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Similarly , TNF alpha , lymphotoxin ( LT ) beta , TNFR 1 and TNFR 2 mRNA levels are also low in the spleens of IL 2 ( / ) animals , whereas IFN gamma and IL 4 mRNA levels remain unaffected in these animals . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| LTalpha is secreted as a homotrimer and signals through two TNF receptors of 55 60 kDa ( TNFR 60 ) or 75 80 kDa ( TNFR 80 ) . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| A complete lack of only PPs in mice heterozygous for both ltalpha and ltbeta , but not ltalpha or ltbeta alone , suggests a similar two ligand phenomenon in PP development and may explain the incomplete lack of PPs seen in tnfr 1 / mice . . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Here we report that BLC expression by follicular stromal cells is defective in TNF , TNF receptor 1 ( TNFR 1 ) , LTalpha and LTbeta deficient mice . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Because all allografts in our protocol expressed TNF R 1 , direct antigraft effects of TNF alpha and LTalpha were not prevented . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| We have demonstrated the presence of the 55 and 75 kDa receptor for tumor necrosis factor ( TNF ) and lymphotoxin ( LT ) ( TNF R ) in serum , and ascites from women with ovarian cancer . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| Cellular responses are initiated by a corresponding family of specific receptors that includes two distinct TNFR ( TNFR 60 and TNFR 80 ) , Fas ( CD 95 ) , CD 40 , p75NTF , and the recently identified lymphotoxin beta receptor ( LT beta R ) , among others . ^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.53849112 |
| In addition , the results suggest some overlap between the TNFR 1 binding sites for TNF alpha and TNF beta , despite low amino acid sequence homology between these cytokines . . 0.53849112^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.94550373 |
| Secreted LT alpha 3 can bind to two cell surface receptors , TNFR 1 and TNFR 2 , while the membrane bound heterotrimer LT alpha1beta2 has been shown to interact with a distinct receptor , LT betaR . 0.94550373^^^ |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P01374 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|