| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| It has been suggested that silencer of death domain ( SODD ) binds TNFR 1 monomers to prevent self aggregation . ^^^ We also determined that SODD binds through its BAG domain to TNFR 1 . ^^^ ATP , but not nonhydrolyzable ATP gamma S , regulates the SODD binding by Hsp 70 or TNFR 1 . ^^^ Furthermore , TNFR 1 was present in aggregates in ATP depleted cells and SODD disassembled aggregates in vitro only in the presence of ATP . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| Altered signaling of TNFalpha TNFR 1 and SODD / BAG4 is responsible for radioresistance in human HT R 15 cells . ^^^ This SODD protein is not involved in the regulation of cell survival after radiation or TNFalpha treatment but rather in altered TNFR 1 shedding . ^^^ Inhibition of TNFR 1 release by the metalloprotease inhibitor BB 2516 results in a significant increase of the 42 kDa SODD protein without affecting cell survival in sensitive or resistant HT cells . ^^^ These results suggest that defective TNFalpha signaling and / or altered silencing by SODD / BAG4 in HT R 15 cells are involved in the radiation resistance of HT R 15 cells and also affect the paracrine functions of TNFR 1 . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , WT and mutant full length TNFRSF1A formed cytoplasmic aggregates that co localized with ubiquitin and chaperones , and with the signal transducer TRADD , but not with the inhibitor , silencer of death domain ( SODD ) . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.84602178 |
| It was suggested that the silencer of death domains ( SODD ) protein constitutively associates intracellularly with TNFR 1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR 1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR 1 molecules that are juxtaposed in the absence of ligand stimulation . 0.84602178^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| The BAG 4 protein that we cloned also corresponds to the recently isolated suppressor of death domains ( SODD ) protein , a molecule that binds and inhibits signaling by tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| This apparent paradox may be explained by silencer of death domains ( SODD ) , a widely expressed approximately 60 kilodalton protein that was found to be associated with the death domain of TNF R 1 . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| Silencer of death domains ( SODD ) binds to TNF alpha receptor TNFR 1 , and prevents spontaneous self association of death domains and inappropriate receptor signaling . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| We have extended our studies to examine the expression of Silencer of Death Domains ( SODD ) , a protein that binds to the cytoplasmic portion of TNFR 1 to inhibit signaling in the absence of ligand . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| The silencer of death domains ( SODD ) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 ( TNFR 1 ) in the absence of ligand . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| The binding of SODD to DD of the TNFR 1 maintains DD in monomeric form and prevents their aggregation which is required for the apoptotic signal . ^^^ |
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| Interacting proteins: O95429 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
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