| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| This outcome is consistent with the existence of another related ligand that binds TNFRI / II to mediate liver damage during infection with this mutant . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Osteoprotegerin ( OPG ) was recently identified as a soluble member of the tumor necrosis factor ( TNF ) receptor ( TNF R ) superfamily that is secreted by osteoblast lineage cells and acts by binding to and neutralizing its cognate ligand , OPG L , a required factor for osteoclastogenesis . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Among them are also molecules belonging to superfamily of tumor necrosis factor receptor ( TNFR ) which beside CD 30 include CD 27 , CD 40 , TNFR 1 and 2 , Fas ( CD 95 ) , OX 40 , 4 1BB ( CDw 137 ) , nerve growth factor receptor , lymphotoxin beta receptor , Apo3 / DR3 / Ws1 1 / lymphocyte associated receptor of death , DR 4 , DR5 / TNF related apoptosis inducing ligand , osteoprotegerin , and TNFR related 2 . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The same can be said about the tumor necrosis factor receptor 1 ( TNFR 1 ) and its ligand , TNF alpha . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The present report will focus on the role of the prototypic ligand TNF and its two receptors , TNFR 1 and TNFR 2 , in viral pathogenesis . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The ability of CD 40 to mediate apoptosis in carcinoma cells is intriguing given the fact that the CD 40 cytoplasmic C terminus lacks a death domain homology with the cytotoxic members of the TNFR superfamily , such as Fas , TNFR 1 , and TNF related apoptosis inducing ligand ( TRAIL ) receptors . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| TRADD is a multifunctional signaling adaptor protein that is recruited to TNFR 1 upon ligand binding . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| However , TGF beta treatment of BL 41 cells was found not to affect the cell surface expression of Fas , TNF R 1 , DR 3 , DR 4 , or DR 5 , or the steady state expression levels of Fas ligand , TNF R 1 , DR 3 , DR 4 , and DR 5 . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| FADD ( also known as MORT 1 ) is an essential adapter protein that couples the transmembrane receptors Fas ( CD 95 ) and tumor necrosis factor receptor 1 ( TNF R 1 ) to intracellular cysteine proteases known as caspases , which propagate and execute the programmed cell death inducing signal triggered by Fas ligand ( FasL , CD95L ) and TNF . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.66324116 |
| The TNF R 55 was found to be the major receptor species responsible for ligand binding activity , such as COX 2 induction and PGE 2 synthesis , since a specific antireceptor TNF R 55 blocking antibody inhibited about 76 % of TNF alpha binding and TNF alpha stimulated COX 2 induction and PGE 2 production . 0.66324116^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Intracellular p 55 TNF R bound 125I labeled TNF in a ligand blot assay and migrated as a diffuse band of 46 60 kd , similar to the plasma membrane receptor . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Analyses by ligand cross linking and competitive binding assays with mAb to the 80 kDa receptor ( TNFR 1 ) , demonstrated that the TNFR 1 was the predominant receptor expressed on activated CD4+ and CD8+ T cell subsets . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Soluble TNF R activity was associated with a protein of Mr approximately 28 , 000 by ligand blot analysis of cell free supernatants of FMLP treated PMN . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas and the type 1 tumor necrosis factor receptor ( TNF R ) are two cell surface receptors that , when stimulated with ligand or cross linking antibody , trigger apoptotic cell death by a mechanism that has yet to be elucidated . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Presumably , the latter efficiently traps the ligand and transfers it to TNF R 55 , and / or by binding it , protects the endogenously made TNF from inactivation . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We show that the TNFR 1 virtually monopolises TNF mediated signaling in all these situations and that the 75 kDa TNFR 2 seems to be largely restricted to an accessory role , which is compatible with the previously established `` ligand passing ' ' hypothesis . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| These data demonstrate that TILs are equipped with a fully functional TNF R system and suggest a putative role for this receptor and its ligand in the activation and expression of TILs following immunotherapy with IL 2 . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The results showed that deletion of the fourth cysteine rich domain of the p 55 receptor ( TNFR 1 ) did not alter ligand binding affinity significantly . ^^^ Deletion of domains 3 and 4 of TNFR 1 resulted in no ligand binding , suggesting that domain 3 , but not 4 , of TNFR 1 binds directly to ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The initial signaling events activated by receptor crosslinking are unknown , although activation of the mitogen activated protein kinase ( MAPK ) cascade occurs shortly after ligand binding to CD120a . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNF sR may play an important role in vivo as they can bind to TNF alpha and prevent ligand binding to the cellular TNF R , thus acting as naturally occurring inhibitors of TNF alpha . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Ligand dependent stimulation of a serine protein kinase activity associated with ( CD120a ) TNFR 60 . ^^^ These results suggest a serine protein kinase ( s ) , and , possibly , other TNF dependent TNFR 60 associated proteins may be involved in mediating signals through TNFR 60 in response to ligand binding . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Ligand binding assays using specific inhibitory antibodies showed a marked shift in active binding sites from p 55 to p 75 without significant changes in the total binding for TNF alpha after up regulation of p 75 TNF R . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| To understand the role of the 75 kDa tumor necrosis factor ( TNF ) receptor in non lymphoid cells , the cytotoxic signaling and ligand binding activities of the 55 kDa ( TNF R 1 ) and 75 kDa ( TNF R 2 ) TNF receptors were investigated using agonist and antagonist antibodies specific for the two receptor types . ^^^ Instead , TNF R 2 regulates the rate of TNF association with TNF R 1 , possibly by increasing the local concentration of TNF at the cell surface through rapid ligand association and dissociation . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Single cell RT PCR , [ 125I ] TNF alpha ligand binding and Western immunoblotting experiments demonstrated that rat cardiac cells predominantly express type 1 TNF alpha receptors ( TNFRI or p 60 ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Motifs in ligand binding domains of the neurotrophin ( NTR ) and lymphotoxin ( TNFR 1 ) receptors define a family of receptors that mediates programmed cell death . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The effect of TNF R 75 dimerization , in contrast to trimerization , was analysed by replacing the extracellular domain of this receptor with the equivalent domain of the murine erythropoietin receptor ( EPO R ) , which dimerizes upon ligand interaction . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| To investigate the role of these receptor structures in the pulmonary environment , we evaluated the expression of some members of the TNF receptor ( CD 27 , CD 30 , CD 40 , CD95 / Fas , CD120a , and CD120b ) and TNF ligand ( CD40L , CD70 / CD27L , CD30L , and mTNFalpha ) superfamilies by bronchoalveolar lavage ( BAL ) T cells recovered from healthy subjects and patients with interstitial lung disease ( ILD ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| In this report we have compared the effects of ligand engagement of TNF R and LT beta R by evaluating the ability of soluble LT alpha beta complexes to initiate activities of human umbilical vein endothelial cells which are characteristically signalled by TNF . ^^^ We also show that neither LT alpha beta heterotrimer signals via TNF R ; in fact LT alpha 2 beta 1 trimers fail to activate NF kappa B and rather inhibit ligand induced TNF R signalling supporting the role for aggregation in TNF R signalling . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The initial signalling events activated by receptor cross linking are unknown although activation of the mitogen activated protein kinase ( MAPK ) cascade occurs shortly after ligand binding to CD120a ( p 55 ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Therefore , early production of TNF / TNF R limit an immune response by inducing AICD in the absence of an intact Fas / Fas ligand apoptosis pathway . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| This review summarizes the regulation of TNF R shedding and its kinetics , the complex interaction between the soluble receptors and their ligand in vitro and in vivo , and the potential diagnostic , prognostic and therapeutic value of the soluble receptors in malignant , inflammatory , infectious and autoimmune disorders . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The dependence of spleen derived M phi on both TNF alpha receptors for signaling the induction of effector function supports an active signaling role for TNF R 2 in its synergy with TNF R 1 rather than a passive ligand passing role . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Engagement of CD 95 or tumor necrosis factor 1 receptor ( TNFR 1 ) by ligand or agonist antibodies is capable of activating the cell death program , the effector arm of which is composed of mammalian interleukin 1beta converting enzyme ( ICE ) like cysteine proteases ( designated caspases ) that are related to the Caenorhabditis elegans death gene , CED 3 . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Ligand passing is not critically involved , because a similar potentiation of TNFR 60 mediated cytotoxicity was observed when agonistic Abs were used for stimulation of both receptors . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using a series of chimeric Fc receptor fusion proteins between the human Fas receptor and TNFR 1 , each cysteine rich domain of Fas was found to be required for interaction with the Fas ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Transient expression of a dominant negative mutant of FADD impairs TNFR 60 mediated and Fas / Apo1 mediated apoptosis [ 13 ] [ 20 ] , but has no effect on TNF related apoptosis inducing ligand ( TRAIL / Apo2L ) induced cell death [ 7 ] [ 8 ] [ 9 ] [ 10 ] [ 21 ] . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| These include Fas , TNF R 1 , lymphocyte associated receptor of death ( LARD ) , DR 4 , and TNF related apoptosis inducing ligand receptor inducer of cell killing 2 ( TRICK 2 ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that while cross linking of CD120a ( p 55 ) is necessary and sufficient for iNOS mRNA and NO 2 expression , CD120b ( p 75 ) participates by ( 1 ) increasing the sensitivity of the cells to TNFalpha , probably by `` passing ' ' ligand to CD120a ( p 55 ) , and ( 2 ) initiating a signaling event that results in a more sustained induction of iNOS mRNA and protein and thereby augments the production of nitric oxide . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Fas ( APO 1 / CD95 ) is a member of the tumor necrosis factor receptor ( TNF R ) family and induces apoptosis when crosslinked with either Fas ligand or agonistic antibody ( Fas antibody ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| In this study , we show that this enhancement is TNFR 60 selective , as neither TNF related apoptosis inducing ligand / Apo2 ligand , Apo1 / Fas , ceramide , nor daunorubicin mediated cell death was affected by costimulation of TNFR 80 . ^^^ We propose that the apoptotic TNFR cross talk is based on TNFR 80 mediated abrogation of antiapoptotic TRAF 2 dependent signaling pathways initiated by TNFR 60 , but not Apo1 / Fas or the apoptotic TNF related apoptosis inducing ligand receptors . . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Both responses are initiated by ligand binding to TNFR 1 ( the p 55 receptor ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The interactions of CD 95 antigen ( Fas ) with its ligand ( CD95L ) and of tumor necrosis factor ( TNF ) alpha with its receptor ( TNF R 1 ) lead to apoptotic cell death . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The molecules that comprise the tumor necrosis factor ligand and receptor ( TNF L and TNF R ) families play important roles in tissue homeostasis and in multiple sclerosis ( MS ) . ^^^ Members of the TNF R family are typical signal sensors which upon binding with ligand aggregate and recruit signal transducers . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Using p 53 null cells , we demonstrate that UV stimulated ligand independent activation of TNFR 1 plays a major role in mediating the apoptotic effects of UV irradiation . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| However , TNF R 1 self associates and signals independently of ligand when overexpressed . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The individual role of tumor necrosis factor receptor 1 ( TNFR 1 ) and TNFR 2 signaling in experimental autoimmune encephalomeylitis ( EAE ) was investigated using mice lacking TNFR 1 ( TNFR 1 / ) , TNFR 2 ( TNFR 2 / ) as well as double receptor ( TNFR1 / 2 / ) and double ligand ( TNF / LT alpha / ) knockout mice . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : The expression of TNF R 55 and TNF R 75 on human nonarthritic articular chondrocytes was analyzed on protein and mRNA levels by ligand binding studies and reverse transcription polymerase chain reaction ( RT PCR ) technique . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Recently , researchers have discovered several novel homologues of Fas and TNFR 1 : DR 3 , 4 , 5 , and 6 function as death receptors that signal apoptosis , whereas DcR 1 , 2 , and 3 act as decoys that compete with specific death receptors for ligand binding . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Shortly after activation , naive T cells express surface OX 40 , a TNF R family member whose ligand ( OX40L ) is constitutively expressed on a subset of dendritic cells . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Four members of the tumor necrosis factor ( TNF ) ligand family , TNF alpha , LT alpha , LT beta , and LIGHT , interact with four receptors of the TNF / nerve growth factor family , the p 55 TNF receptor ( CD120a ) , the p 75 TNF receptor ( CD120b ) , the lymphotoxin beta receptor ( LT beta R ) , and herpes virus entry mediator ( HVEM ) to control a wide range of innate and adaptive immune response functions . ^^^ Fas / Apo1 ( CD 95 ) , a receptor of the TNF receptor family activated by a distinct ligand , induces death in cells through mechanisms shared with CD120a . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| These families may include receptor / ligand molecules such as Fas , Fas ligand , tumor necrosis factor receptor 1 ( TNFR 1 ) , and TNF related apoptosis inducing ligand ( TRAIL ) ; signal transduction adapter molecules such as Fas associated death domain ( FADD ) , TNFR 1 associated death domain ( TRADD ) , receptor interacting protein ( RIP ) , Fas associated factor ( FAF ) , and Fas associated phosphatase ( FAP ) ; or effector molecules such as caspases . ^^^ To detect the expression of apoptosis related molecules , ribonuclease protection assay was used with specific antisense RNA probes for Fas , Fas ligand , TNFR 1 , TRAIL , FADD , TRADD , RIP , FAF , FAP , and caspase 8 . ^^^ Compared with control and contralateral kidneys , the ligated kidneys displayed a dynamic expression of mRNAs for many apoptosis related molecules , which included an up to threefold increase for Fas , Fas ligand , TNF R 1 , TRAIL , TRADD , RIP , and caspase 8 , and an up to twofold increase for FADD and FAP , but there was little change for FAF . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| This ligand induced trimerisation model of TNFR signalling is mainly supported by crystallographic data of the p 60 TNFR 1 and TNFbeta complex in which the trimeric ligand interdigitates between the individual receptor chains and prevents the receptor subunits from interacting with each other . ^^^ Recently , a domain NH ( 2 ) terminal to the ligand binding domain in the extracellular region of p 60 TNFR 1 , p 80 TNFR 2 and Fas was identified that mediates receptor self association before ligand binding . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas and its ligand have homologies respectively with TNF alpha and TNF R . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| As the TNF beta : TNFR 1 co crystal structure was the first in the family to be solved , rational drug design based on the ligand : receptor interaction sites is more advanced . ^^^ Small peptide sequences from TNFR 1 which interact with the ligand have shown some activity in blocking the biological actions of TNF . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The accumulation of membrane Fas , the Fas ligand , and TNFR 1 were not apparent due to exposure to SI 27 , and antagonistic anti Fas or anti Fas ligand antibodies did not block SI 27 induced apoptosis . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Fas , together with its ligand , has been the most commonly studied death inducer in the mammalian ovary ; however , nothing is currently known regarding expression of either Fas or the related tumor necrosis factor receptor type 1 ( TNFR 1 ) , in avian species . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| SUMMARY BACKGROUND DATA : Fas and TNFR 1 are cell surface molecules that trigger apoptosis or inflammation on engagement by a specific ligand or antibody . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We studied if the rate of apoptosis decreases after birth , by measuring the soluble ( s ) forms of Fas Fas ligand and Tumor necrosis factor receptor 1 ( TNFR 1 ) TNF alpha which attenuate apoptosis . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Gel shift assay and Western blot analysis supported microarray results , showing that 5 PYRRO / NO suppressed GlaN / LPS induced activation of nuclear factor kappaB and GlaN / LPS induced increases in caspase 1 , caspase 8 , tumor necrosis factor receptor 1 ( TNFR 1 ) associated death domain , and TNF related apoptosis inducing ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Ligand binding to tumor necrosis factor receptor 1 ( TNFRI ) can promote cell survival or activate the apoptotic caspase cascade . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Moreover , innovative immunobiologicals ( PEG TNFRI , PEG TNF alpha antibody fragments , soluble TNFRI , CTLA 4 Ig , CD 40 ligand antibody , antibodies against IFN gamma , IL 6 , IL 12 , IL 15 , IL 18 , complements ) , inhibitors of TNF alpha translation ( peptides , anti sense constructs ) or TNF alpha synthesis ( targeting NF kappa B , p 38 MAP kinase , phosphodiesterase 4 , TNF alpha converting enzyme ) are forthcoming . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Involvement of tumor necrosis factor ( TNF ) alpha and Fas signaling was evaluated using various knockout mice ( TNF receptor 1 [ TNF R 1 ] / , Fas [ lpr ] / , and Fas ligand [ gld ] / ) and wild type mice pretreated with pentoxifylline , an inhibitor of TNF alpha synthesis . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We conclude that RIP proteins can act independently of TNFR 1 stimulation by ligand to modulate downstream signaling pathways , such as activation of NF kappa B . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Apoptosis in BxPC 3 cells mediated by TNF related apoptosis inducing ligand ( TRAIL ) and CD95L was likewise increased 2 . 3 + / 0 . 5 fold and 7 . 4 + / 2 . 5 fold , respectively . sst 2 dependent activation and cell sensitization to death ligand induced apoptosis involved activation of the executioner caspases , key factors in both death ligand or mitochondria mediated apoptosis . sst 2 affected both pathways : first , by up regulating expression of TRAIL and TNFalpha receptors , DR 4 and TNFRI , respectively , and sensitizing the cells to death ligand induced initiator capase 8 activation , and , second , by down regulating expression of the antiapoptotic mitochondrial Bcl 2 protein . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Finally , injection of anti TRAIL ( tumor necrosis factor related apoptosis inducing ligand ) monoclonal antibody ( mAb ) in B 6 cdd recipients also failed to inhibit rejection of TNFR 1 ( / ) marrow grafts . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The best studied death inducing ligand receptor pairs are TNF / TNF receptor 1 ( TNFR 1 ) and CD95L / CD95 ( Fas , Apo 1 ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Our results show , that the exposure of three metastatic melanoma cell lines ( A 2058 , SK Mel 5 , and WM 266 4 ) to recombinant TIMP 3 , N terminal MMP inhibitory domain of TIMP 3 , as well as to adenovirally expressed TIMP 3 results in stabilization of tumor necrosis factor receptor 1 ( TNF RI ) , FAS , and TNF related apoptosis inducing ligand receptor 1 ( TRAIL RI ) on melanoma cell surface and sensitizes these cells to apoptosis induced by TNF alpha , anti Fas antibody and TRAIL . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| CD 95 , TNF related apoptosis inducing ligand ( TRAIL R 1 ) , and TRAIL R 2 bind FADD directly , whereas recruitment to TNF R 1 is indirect through another adaptor TNF receptor associated death domain protein ( TRADD ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We first performed SBR or sham operations in mice , and the temporal expression of caspases 8 , 9 , and 3 , death receptors tumor necrosis factor receptor 1 ( TNFR 1 ) and Fas and corresponding ligands ( TNF and Fas ligand ) was determined in the remnant intestine at various postoperative time points . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| It was suggested that the silencer of death domains ( SODD ) protein constitutively associates intracellularly with TNFR 1 and inhibits the recruitment of cytoplasmic signaling proteins to TNFR 1 to prevent spontaneous aggregation of the cytoplasmic death domains of TNFR 1 molecules that are juxtaposed in the absence of ligand stimulation . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The common neurotrophin receptor p 75 ( NTR ) remains one of the most enigmatic of the tumor necrosis factor receptor ( TNFR ) superfamily : on the one hand , it displays a death domain and has been shown to be capable of mediating programmed cell death ( PCD ) upon ligand binding ; on the other hand , its death domain is of type 2 ( unlike that of Fas or TNFR 1 ) , and it has also been shown to be capable of mediating cell death in response to the withdrawal of ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Antibody inhibition of caspase 3 activity as well as flow cytometry experiments implicated TNF related apoptosis inducing ligand ( TRAIL ) and TNF alpha receptor ( TNF R ) in apoptosis signaling . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Because cellular FLICE / caspase 8 inhibitory protein ( cFLIP ) is a recently identified intracellular inhibitor of caspase 8 activation that potently inhibits death signaling mediated by all known death receptors , including Fas , TNF receptor ( TNF R ) , and TNF related apoptosis inducing ligand receptors ( TRAIL Rs ) , we investigated the expression and function of cFLIP in human HCCs . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We have extended our studies to examine the expression of Silencer of Death Domains ( SODD ) , a protein that binds to the cytoplasmic portion of TNFR 1 to inhibit signaling in the absence of ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The silencer of death domains ( SODD ) has been proposed to prevent constitutive signaling of tumor necrosis factor receptor 1 ( TNFR 1 ) in the absence of ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| In the past decade , it was concluded from a number of investigations that death domain containing members of the tumor necrosis factor receptor ( TNF R ) family and their ligands such as Fas / FasL and TNF related apoptosis inducing ligand ( TRAIL ) R / TRAIL are essential for maintaining an intact immune system for surveillance against infection and cancer development and that nondeath domain containing members such as CD 30 or CD 40 are involved in the fine tuning of this system during the selection process of the lymphatic system . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| METHODS : Myocardial biopsies from 17 patients at the time of LVAD implantation and after explantation , at the time of heart transplantation ( HTx ) , were examined by terminal deoxynucleotidyltransferase mediated dUTP nick end labeling ( TUNEL ) reaction and with antibodies against Fas ligand ( FasL ) , Fas , tumor necrosis factor ( TNF ) alpha receptor 1 ( TNF R 1 ) , TNF alpha receptor 2 ( TNF R 2 ) , TNF alpha , TNF alpha converting enzyme ( TACE ) , poly ( ADP ribose ) polymerase ( PARP ) , poly ( ADP ribose ) ( PAR ) , caspase 3 and FLICE inhibitory protein ( FLIP ) . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Death receptors [ Fas / Apo 1 / CD95 , TNF R 1 [ tumour necrosis factor ( TNF ) receptor 1 ] , DR 3 [ death receptor 3 ] , TRAIL R 1 [ TNF related apoptosis inducing ligand receptor 1 ] , TRAIL R 2 , DR 6 , p 75 NGFR [ p 75 nerve growth factor receptor ] , EDAR [ ectodermal dysplasia receptor ] ] form a subgroup of the TNF R superfamily that can induce apoptosis ( programmed cell death ) via a conserved cytoplasmic signalling module termed the death domain . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Protection against murine leukemia virus induced spongiform myeloencephalopathy in mice overexpressing Bcl 2 but not in mice deficient for interleukin 6 , inducible nitric oxide synthetase , ICE , Fas , Fas ligand , or TNF R 1 genes . ^^^ We show here that interleukin 6 ( IL 6 ) , inducible nitric oxide synthetase ( iNOS ) , ICE , Fas , Fas ligand ( FasL ) , and TNF R 1 KO mice still develop signs of disease . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| LPS induced osteoclast formation was also inhibited by osteoprotegerin ( OPG ) , a decoy receptor of receptor activator of NF kappaB ligand ( RANKL ) , but not by anti mouse TNFR 1 Ab or IL 1 receptor antagonist . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The other death receptor derived peptides , which are the corresponding regions of TNFR 1 and Fas , also showed specific binding to TNF alpha and FasL and inhibited the ligand induced cell death , respectively . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| It is conceivable that the multiple TNF mediated chronic inflammatory disorders differ in terms of the ligand form ( soluble TNF alpha versus membrane bound TNF alpha ) , the receptor ( TNF R 1 versus TNF R 2 ) and the downstream signaling cascades utilized . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The infected cells underwent histochemically confirmed apoptosis without lymphocyte infiltration after expressing CD 30 , CD 30 ligand ( CD30L ) , tumor necrosis factor ( TNF ) alpha , TNF receptor 1 ( TNF R 1 ) , FAS , and FAS ligand ( FAS L ) with activation of caspases 3 and 8 . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The expression of receptor activator of NF kappa B ligand ( RANKL ) and receptor activator of NF kappa B ( RANK ) , as assessed by quantitative reverse transcription polymerase chain reaction ( RT PCR ) , was also increased significantly during endochondral ossification in TNFR 1 ( / ) mice . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| TNFR 2 induced apoptosis is independent of endogenous TNF or other death inducing ligand production and subsequent activation of TNFR 1 or other death receptors . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| To identify the molecular mechanisms underlying this , we have examined the expression and potency of three major death receptors : tumor necrosis factor receptor ( TNF R ) , TNF related apoptosis inducing ligand receptor ( TRAIL R ) , and Fas in mediating cytotoxicity in four invasive pancreatic cancer cell lines . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Levels of angiogenic chemokines , CC chemokine ligand 2 / murine homologue of monocyte chemoattractant protein 1 and CXC chemokine ligand 1 3 / keratinocyte derived chemokine , were significantly lower in TNFR 1 deficient mice at days 1 and 7 after implantation , respectively . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| RESULTS : We used chemical crosslinking on the cell surface to show that WT and mutant forms of TNFRI , derived from TRAPS patients , interact in the absence of TNF ligand . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| We examined the myocardial expression of Fas , Fas ligand ( FasL ) , tumor necrosis factor ( TNF ) alpha , and TNF receptor 1 ( TNFR 1 ) , and myocardial recovery in patients from the multicenter Intervention in Myocarditis and Acute Cardiomyopathy ( IMAC ) study . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Production of soluble form of human TNF alpha ligand binding domain type 1 receptor by expression in Drosophila cells ] . 5His tagged human TNFalpha type 1 receptor ( TNFR 1 ) ligand binding domain was produced in Drosophila cells under control of metallothionein Cu inducible promoter and purified by Ni NTA affinity chromatography to homogeneity . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| The majority of genes identified are involved in cell cycle regulation and apoptosis . mRNA expression patterns further indicate that in contrast to HL , CD 30 stimulation in ALCL induces cell death via the CD 95 CD95 ligand ( CD95L ) pathway and the TNF R1 / TNF R 2 crosstalk . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| INTRODUCTION : TNF receptor 1 or 2 ( TNF RI or TNF RII ) is thought to induce its own trimerization by ligand binding ; however , recently TNF RI or TNF RII was shown to form a trimer through its extracellular domain without ligand binding . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| Cytokines such as tumor necrosis factor alpha ( TNF alpha ) , FasL , and TNF related apoptosis inducing ligand ( TRAIL ) induce apoptosis or inflammation through binding to their specific receptors , TNFR 1 , Fas , and DR 5 , respectively . ^^^ |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O75888 and P19438 |
Pubmed |
SVM Score :0.0 |
| NA |
|