| Interacting proteins: P15173 and P19387 |
Pubmed |
SVM Score :0.0 |
| The alpha like RNA polymerase 2 core subunit 3 ( RPB 3 ) is involved in tissue specific transcription and muscle differentiation via interaction with the myogenic factor myogenin . ^^^ It is of interest that an interaction between RPB 3 and the myogenic transcription factor myogenin was identified . ^^^ Although RPB 3 contacts the basic helix loop helix ( HLH ) region of myogenin , it does not bind other HLH myogenic factors such as MyoD , Myf 5 , and MRF 4 . ^^^ Coimmunoprecipitation experiments indicate that myogenin contacts the pol 2 complex and that the RPB 3 subunit is responsible for this interaction . ^^^ Exogenous expression of RPB 3 slightly promotes myogenin transactivation activity and muscle differentiation , whereas the region of RPB 3 that contacts myogenin , when used as a dominant negative molecule ( Sud ) , counteracts these effects . ^^^ |
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| Interacting proteins: P15173 and P19387 |
Pubmed |
SVM Score :0.0 |
| We previously employed the yeast two hybrid system and identified an interaction between RPB 3 and the myogenic transcription factor myogenin , demonstrating an involvement of this subunit in muscle differentiation . ^^^ We found that the intensity of the interaction between RPB 3 and ATF 4 is similar to the one between RPB 3 and myogenin . ^^^ |
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| Interacting proteins: P15173 and P19387 |
Pubmed |
SVM Score :0.0 |
| We have recently demonstrated that the expression of RPB 3 is regulated during muscle differentiation and that , inside RNA polymerase 2 ( RNAP 2 ) , it is directly involved in contacting regulatory proteins such as the myogenic transcription factor Myogenin and activating transcription factor ATF 4 . ^^^ |
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