| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :1.4245954 |
| Using immunoprecipitation , PI 3 kinase and tyrosine phosphorylated PLC gamma 1 and SHC were shown to be associated with tyrosine phosphorylated TrkB in response to both BDNF and NT 4 . 1.4245954^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| Identification of TrkB autophosphorylation sites and evidence that phospholipase C gamma 1 is a substrate of the TrkB receptor . ^^^ Following activation of TrkB , phospholipase C gamma 1 is phosphorylated on Tyr 783 , Tyr 771 , and Tyr 1254 . ^^^ Phospholipase C gamma 1 also forms a complex with TrkB in response to neurotrophin 3 treatment , consistent with the possibility that one of the TrkB autophosphorylation sites provides a binding site for the phospholipase C gamma 1 SH 2 domains , as is the case for other receptor protein tyrosine kinases . ^^^ We conclude that phospholipase C gamma 1 is directly phosphorylated by TrkB . ^^^ Since phosphorylation of Tyr 783 and Tyr 1254 results in activation of phospholipase C gamma 1 , we predict that neurotrophin 3 leads to activation of phospholipase C gamma 1 following binding to TrkB in Rat 2 cells . . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| Exogenous BDNF induces tyrosine phosphorylation of TRK B as well as phosphorylation of phospholipase C gamma 1 , the extracellular signal regulated kinases 1 and 2 , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| Signal proteins such as phosphatidylinositol 3 kinase , phospholipase C gamma 1 , Shc , and mitogen activated protein kinase seem to be involved in both TrkA and TrkB mediated signaling pathways . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| Monoamine activated alpha2M also blocks tyrosine phosphorylation of phospholipase C gamma 1 and extracellular signal regulated protein kinase ( ERK ) 1 , which are key intracellular proteins involved in trkB signal transduction . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| TrkB mutated at the Shc binding site supported survival and growth poorly relative to wild type TrkB , whereas TrkB mutated at the PLC gamma 1 binding site supported growth and survival well . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| SIN 1 treatment induced tyrosine phosphorylation of phospholipase C gamma 1 ( PLC gamma 1 ) and induced its binding with activated TrkB , similar to that seen with BDNF downstream signaling pathways . ^^^ |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q16620 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|