| Interacting proteins: Q12913 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q12913 and P19174 |
Pubmed |
SVM Score :0.0 |
| Cell growth inhibition was associated with down regulation of extracellular signal regulated kinase 1 / 2 activity , with increased levels of the cell cycle inhibitor p 27 ( kip 1 ) protein and with dephosphorylation of PLCgamma 1 , a substrate of DEP 1 , the human homologue of r PTPeta . ^^^ |
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| Interacting proteins: Q12913 and P19174 |
Pubmed |
SVM Score :0.0 |
| However , phospholipase Cgamma 1 ( PLCgamma 1 ) and LAT were strikingly hypophosphorylated in CD 148 expressing cells following TCR stimulation , whereas the phosphorylation levels of Slp 76 and Itk were modestly reduced . ^^^ Based on these results , we propose that CD 148 negatively regulates TCR signaling by interfering with the phosphorylation and function of PLCgamma 1 and LAT . . ^^^ |
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