| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.84545975 |
| Thus , we describe a regulated interaction between Emt and PLC gamma 1 , and based on our studies with individual Emt and PLC gamma 1 SH2 / SH3 domains , we propose a mechanism for this association . . 0.84545975^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| However , phospholipase Cgamma 1 ( PLCgamma 1 ) and LAT were strikingly hypophosphorylated in CD 148 expressing cells following TCR stimulation , whereas the phosphorylation levels of Slp 76 and Itk were modestly reduced . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Moreover , the phosphorylation levels of Itk and a downstream substrate of Itk , PLCgamma 1 , are increased in Jurkat T cells that have been treated with cyclosporin A . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Subsequently , Itk activates phospholipase C gamma 1 , leading to calcium mobilization and extracellular signal regulated kinase / mitogen activated protein kinase activation . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this deletion reduces the ability of the Src family kinase Lck to activate ITK , as well as to induce the ITK mediated tyrosine phosphorylation of its substrate PLCgamma 1 . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Rosmarinic acid inhibits Ca2+ dependent pathways of T cell antigen receptor mediated signaling by inhibiting the PLC gamma 1 and Itk activity . ^^^ Tyrosine phosphorylation of PLC gamma 1 is largely dependent on 3 kinds of protein tyrosine kinases ( PTKs ) , ie , Lck , ZAP 70 , and Itk . ^^^ Therefore , we conclude that RosA inhibits TCR signaling leading to Ca ( 2+ ) mobilization and NF AT activation by blocking membrane proximal events , specifically , the tyrosine phosphorylation of inducible T cells kinase ( Itk ) and PLC gamma 1 . . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| The TCR signaling proteins that are subject to regulation by PI3K include Akt , phospholipase Cgamma 1 ( PLCgamma 1 ) , protein kinase C zeta ( PKC zeta ) , Itk , Tec and Vav , all of which play critical roles in T cell activation . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Biochemical studies indicate that TCR induced inositol 1 , 4 , 5 tris phosphate ( IP 3 ) generation and phospholipase C gamma 1 tyrosine phosphorylation are substantially reduced in Itk / T cells . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| The PTEN deficient cells were also hyperresponsive to T cell receptor ( TCR ) stimulation , as measured by Itk kinase activity , tyrosine phosphorylation of phospholipase C gamma 1 , and activation of Erk compared to those in PTEN replete cells . ^^^ |
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| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| The Tec family kinase Itk plays a critical role in signal transduction downstream of the T cell antigen receptor and has been implicated in the activation of phospholipase C gamma 1 , a key regulator of calcium mobilization and extracellular signal regulated kinase ( ERK ) activation . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| The Tec family tyrosine kinase , Itk , is critical for PLC gamma 1 activation downstream of the TCR . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| Itk , a member of the Tec family of tyrosine kinases , is critical for TCR signaling , leading to the activation of phospholipase C gamma 1 . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| In additions , we provide evidence that ZAP 70 is the primary in vivo kinase for LAT tyrosine 191 and that Itk plays a role in the phosphorylation of tyrosine 783 on phospholipase C gamma 1 . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| These proteins are involved in the regulation of signaling processes downstream of the TCR in CD 4 ( + ) T cells , particularly in the phosphorylation of phospholipase C gamma 1 after TCR activation ; furthermore , both Itk and Rlk are important in CD 4 ( + ) T cell development , differentiation , function , and homeostasis . ^^^ These studies demonstrate that the loss of Itk and Rlk impairs TCR dependent signaling , causing defects in phospholipase C gamma 1 , p 38 , and ERK activation as well as defects in calcium flux and cytokine production in vitro and expansion and effector cytokine production by CD 8 ( + ) T cells in response to viral infection . ^^^ |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|