| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.7625417 |
| From transient expression studies , we could demonstrate that the SH 3 domain of PLC gamma 1 is necessary for the association with SOS 1 in vivo . 0.7625417^^^ The carboxyl terminal proline rich domain of SOS 1 is involved in the interaction with the PLC gamma 1 SH3 domain . 0.51283572^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| HGF stimulated Gab 1 association with c Met , Grb 2 , SHP 2 , PI3K , Shc , Crk isoforms and CrkL , but not with PLCgamma 1 . ^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation stimulates PI3K and PLCgamma 1 enzymatic activity , and on ShcA creates binding sites for Grb 2 with its associated Sos 1 and Gab 1 . ^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| METHODS : Sections of postnatal 5 day old and adult rat , and aged human retina , and cell cultures prepared from selected cell populations of young rat retina , were immunolabeled with specific antisera to FGFR ( FGFR 1 , 2 , 3 , and 4 ) or candidate signaling molecules [ phospholipase Cg 1 ( PLCg 1 ) , son of sevenless 1 and 2 ( SOS 1 , SOS 2 ) , extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , protein tyrosine phosphatase ( SH PTP 2 ) and SH 2 containing protein ( Shc ) ] , and with multiple retinal cell type specific antibodies . ^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : Phospholipase C ( PLC ) gamma is a cytosolic enzyme activated by several growth factor ( GF ) receptors ( epidermal GF receptor [ EGFR ] , platelet derived GF receptor , and insulin like GF 1 receptor ) , and its activation is associated with increased cell motility ( but not cell proliferation ) in nonglioma cell lines . ^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| In contrast to the neocortical cells , HGF did not enhance phosphorylation of PLC gamma 1 in primary astrocytes . ^^^ These findings suggest that HGF exerts neurotrophic effects through selective phosphorylation of PLC gamma 1 and activation of distinct PKC subspecies in neocortical cells , most likely neurons . . ^^^ |
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| Interacting proteins: Q07889 and P19174 |
Pubmed |
SVM Score :0.0 |
| Under the same condition , phospholipase Cgamma 1 ( PLCgamma 1 ) , which is another signal mediator of c Met , was not tyrosine phosphorylated during HGF stimulation . ^^^ However , treatment of the cells with orthovanadate , a tyrosine phosphatase inhibitor , restored the HGF induced tyrosine phosphorylation of PLCgamma 1 . ^^^ A tyrosine phosphatase , SHP 1 , was associated with both PI 3 kinase and PLCgamma 1 before HGF stimulation , but it was dissociated only from PI 3 kinase after the stimulation . ^^^ Furthermore , transfectants of catalytically inactive mutant of SHP 1 showed tyrosine phosphorylation of PLCgamma 1 and mitogenic responses to HGF , and the mitogenic response was blocked with , an inhibitor of phosphatidylinositol specific PLC , and calphostin C , an inhibitor of protein kinase C downstream of the PLCgamma 1 . ^^^ These results indicate that PLCgamma 1 is selectively prevented from being a signal mediator by constitutive association of SHP 1 , and that this selective inhibition of PLCgamma 1 may determine the cellular response of astrocytes to HGF . . ^^^ |
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