| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| In addition , Tec and Lyn were shown to phosphorylate Dok 1 , whereas phosphorylated Dok 1 was demonstrated to bind to the SH 2 domains of several signaling molecules activated by SCF , including Abl , CrkL , SHIP , and PLCgamma 1 , but not those of Vav and Shc . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| Coexpression in HEK 293T cells of PLCgamma 1 HA with Lck or the Tec family kinase Rlk resulted in preferential phosphorylation of raft targeted PLCgamma 1 over wild type PLCgamma 1 . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| This complex couples the T cell receptor to Ras through a novel pathway involving PLC gamma 1 , Tec family kinases , and RasGRP . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| Furthermore , mice possessing mutations in signaling molecules upstream of PLC gamma 1 , such as Src homology 2 ( SH 2 ) domain containing phosphoprotein of 76 kDa ( SLP 76 ) , linker for activation of T cells ( LAT ) and Vav 1 , or in members of the nuclear factor for activated T cells ( NFAT ) family of transcription factors , which are downstream of PLC gamma 1 , have been found to have similar phenotypes to Tec family deficient mice , emphasizing the importance of this pathway in regulating T cell activation , differentiation and homeostasis . . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| The TCR signaling proteins that are subject to regulation by PI3K include Akt , phospholipase Cgamma 1 ( PLCgamma 1 ) , protein kinase C zeta ( PKC zeta ) , Itk , Tec and Vav , all of which play critical roles in T cell activation . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| The Tec family kinase Itk plays a critical role in signal transduction downstream of the T cell antigen receptor and has been implicated in the activation of phospholipase C gamma 1 , a key regulator of calcium mobilization and extracellular signal regulated kinase ( ERK ) activation . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| Regulation of PLCgamma 1 signaling by PKCtheta required the tyrosine kinase Tec since a dominant negative Tec mutant blocked PKCtheta induced AP 1 ( but not NF kappaB ) activation . ^^^ These findings define a novel PKCtheta initiated pathway that regulates Ca ( 2+ ) signaling and AP 1 activation via Tec and PLCgamma 1 . ^^^ |
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| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| The Tec family tyrosine kinase , Itk , is critical for PLC gamma 1 activation downstream of the TCR . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| Itk , a member of the Tec family of tyrosine kinases , is critical for TCR signaling , leading to the activation of phospholipase C gamma 1 . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| Finally , we have imaged isolated T cell membranes by confocal microscopy , confirming the membrane proximal location of Tec vesicles , as well as demonstrating overlap of these vesicles with the tyrosine kinase Lck , the Tec substrate PLC gamma 1 , and the early endosomal antigen 1 marker EEA1 . . ^^^ |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42680 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|