| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.89956534 |
| Association of VEGFR 2 with PLCgamma 1 was mainly established between tyrosine 1006 and the C terminal SH 2 domain of PLCgamma 1 in vitro and in vivo . 0.89956534^^^ |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| A tyrosine mutant VEGFR 2 , defective in PLC gamma 1 activation underwent down regulation efficiently in response to ligand stimulation , suggesting that activation of classical PKCs are not involved in VEGFR 2 down regulation . ^^^ |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| Assays for the following receptors VEGFR 1 ( Flt 1 ) , VEGFR 2 ( KDR / Flk 1 ) and PDGFR beta were performed by immunoprecipitation , while PLCgamma 1 , Akt 1 / 2 , and phospholamban B phosphorylation were assessed with Western immunoblotting . ^^^ |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| The data showed that VEGF stimulates complex formation of the flk 1 / kinase insert domain containing receptor ( KDR ) VEGF receptor with c Src and that Src activation is required for VEGF induction of phospholipase C gamma 1 activation and inositol 1 , 4 , 5 trisphosphate formation . ^^^ This effect is mediated by a signaling cascade initiated by flk 1 / KDR activation of c Src , leading to phospholipase C gamma 1 activation , inositol 1 , 4 , 5 trisphosphate formation , release of [ Ca ( 2+ ) ] ( 1 ) and nitric oxide synthase activation . ^^^ |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P35968 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|