| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :1.0034867 |
| The absence of an in vivo association between Syk and PLC gamma 2 in platelets is in contrast with that for PLC gamma 1 and Syk in B cells . 1.0034867^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 ( PLC gamma 1 ; EC 3 . 1 . 4 . 11 ) hydrolyzes phosphatidylinositol 4 , 5 bisphosphate to generate diacylglycerol and inositol 1 , 4 , 5 trisphosphate and is activated in response to growth factor stimulation and tyrosine phosphorylation . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ; EC 3 . 1 . 4 . 11 ) hydrolyzes phosphatidylinositol 4 , 5 bisphosphate to generate diacylglycerol and inositol 1 , 4 , 5 trisphosphate and is activated in response to growth factor stimulation and tyrosine phosphorylation . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Dissociation of tyrosine phosphorylation and activation of phosphoinositide phospholipase C induced by the protein kinase C inhibitor Ro 31 8220 in Swiss 3T3 cells treated with platelet derived growth factor . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Moreover , PDGF stimulated Tiam 1 phosphorylation was markedly reduced by 72 + / 10 % in PLC gamma 1 deficient mouse fibroblasts , compared to wild type cells , indicating that phosphoinositide phospholipase C is involved . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Inducible expression of human phospholipase C gamma 2 and its activation by platelet derived growth factor B chain homodimer and platelet derived growth factor A chain homodimer in transfected NIH 3T3 fibroblasts . ^^^ Growth factors such as platelet derived growth factor ( PDGF ) have been shown to activate phospholipase C gamma 1 ( PLC gamma 1 ) . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The triggering of T or B cell antigen specific receptors is accompanied by rapid tyrosine phosphorylation of distinct cellular substrates , one of which is the gamma 1 isoform of inositol phospholipid specific phospholipase C ( PLC gamma 1 ) . ^^^ Recently , another ubiquitously expressed PLC isoform , PLC gamma 2 ( which shares 50 . 2 % amino acid homology with PLC gamma 1 ) , has been identified . ^^^ Here , we report that , in contrast to T lymphocytes that express predominantly PLC gamma 1 , the major isoform expressed in murine and human resting B cells is PLC gamma 2 . ^^^ These findings identify PLC gamma 2 as a substrate for a B cell putative protein tyrosine kinase coupled to the antigen receptor and suggest that its tyrosine phosphorylation constitutes a critical and early event in B cell activation and , furthermore , that PLC gamma 1 and PLC gamma 2 may participate in similar but distinct signal transduction pathways in lymphocytes . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 and phospholipase C gamma 2 are substrates of the B cell antigen receptor associated protein tyrosine kinase . ^^^ One possible substrate of the antigen receptor associated kinase is phospholipase C ( PLC ) . ^^^ PLC gamma 1 and PLC gamma 2 but not PLC beta 1 or PLC delta 1 were detected in human B cells . ^^^ Immunoprecipitation with antibodies against PLC gamma 1 or PLC gamma 2 and subsequent Western blotting with anti phosphotyrosine antibodies revealed that both PLC gamma 1 and PLC gamma 2 are tyrosine phosphorylated in stimulated but not in resting B cells . ^^^ This was confirmed by experiments whereby B cell lysates were immunoprecipitated with anti phosphotyrosine antibody and subsequently blotted with antibodies against PLC gamma 1 or PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| To identify the isozyme of PLC that was phosphorylated , we immunoprecipitated PLC gamma 1 or PLC gamma 2 with specific antibodies and assessed the amount of tyrosine phosphorylation of these proteins by antiphosphotyrosine immunoblotting . ^^^ In normal resting mouse B cells , there was no detectable PLC gamma 1 , but PLC gamma 2 was abundant . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Platelet derived growth factor increases the in vivo activity of phospholipase C gamma 1 and phospholipase C gamma 2 . ^^^ Upon binding to its cell surface receptor , platelet derived growth factor ( PDGF ) causes the tyrosine phosphorylation of phospholipase C gamma 1 ( PLC gamma 1 ) and stimulates the production of diacylglycerol and inositol 1 , 4 , 5 triphosphate . ^^^ Hematopoietic cells express PLC gamma 2 , a PLC isoform that is closely related to PLC gamma 1 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Collagen stimulates tyrosine phosphorylation of phospholipase C gamma 2 but not phospholipase C gamma 1 in human platelets . ^^^ Neither the collagen receptor nor the isoform of phospholipase C that is activated have been identified . ^^^ We report that collagen activation of platelets induces tyrosine phosphorylation of phospholipase C gamma 2 but not phospholipase C gamma 1 . ^^^ We also show that the platelet low affinity Fc receptor ( Fc gamma RII ) , which mediates activation of platelets by immune complexes , and wheat germ agglutinin , which binds non specifically to glycoprotein , stimulate phospholipase C gamma 2 tyrosine phosphorylation . ^^^ In contrast , we could not detect phospholipase C gamma 2 tyrosine phosphorylation in platelets stimulated by either thrombin or a stable thromboxane A 2 analogue , U46619 . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phenylarsine oxide inhibits tyrosine phosphorylation of phospholipase C gamma 2 in human platelets and phospholipase C gamma 1 in NIH 3T3 fibroblasts . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Induction via CD 20 of tyrosine phosphorylation and activation of phospholipase C gamma 1 and PLC phospholipase C gamma 2 . ^^^ Both phospholipase C gamma 1 and gamma 2 were phosphorylated on tyrosine after cross linking of CD 20 bound mAb , and this correlated with increases in intracellular calcium that were partially resistant to depletion of extracellular calcium with EGTA . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 2 ( Plcg 2 ) and phospholipase C gamma 1 ( Plcg 1 ) map to distinct regions in the human and mouse genomes . ^^^ The phospholipase C gamma 2 ( Plcg 2 ) gene encodes an enzyme that plays a crucial role in intracellular signal transduction pathways . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| These kinases act directly or indirectly to phosphorylate and / or activate effector proteins including p 42 ( microtubule associated protein kinase ) ( MAPK ) , phospholipases C gamma 1 ( PLC gamma 1 ) and C gamma 2 ( PLC gamma 2 ) , phosphatidylinositol 3 kinase ( PI 3 K ) , and p21ras GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Differentiated ( granulocytic ) HL 60 cells did not have detectable levels of PLC gamma 1 but had substantial PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Fc epsilon RI aggregation induced tyrosine phosphorylation of the beta and gamma subunits of the receptor , but no increase in the tyrosine phosphorylation of phospholipase C gamma 1 and phospholipase C gamma 2 and no detectable increase in intracellular free Ca2+ concentration . ^^^ In these reconstituted cells , Fc epsilon RI aggregation induced tyrosine phosphorylation of phospholipase C gamma 1 and phospholipase C gamma 2 , an increase in intracellular free Ca2+ and histamine release . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Translocation of phospholipase C gamma 2 induced by in vitro activation of protein tyrosine kinase activity in mast cell lysates . ^^^ Aggregation of the high affinity receptor for IgE ( Fc eta RI ) on the surface of intact or permeabilized rodent mast cells results in tyrosine phosphorylation of phospholipase C gamma 1 ( PLC gamma 1 ) and PLC gamma 2 , and translocation of both isozymes to the particulate fraction . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phosphatidylinositol specific phospholipase C isoform expression in pregnant and nonpregnant rat myometrial tissue . ^^^ Phospholipase C is an essential molecular component of this signaling pathway . ^^^ These studies sought to characterize the expression of phospholipase C isoform messenger ribonucleic acid in both pregnant and nonpregnant rat myometrium . ^^^ After deoxyribonuclease treatment to ensure removal of genomic deoxyribonucleic acid , as well as resolution on formaldehyde 1 % agarose horizontal slab gels to rule out degradation , the ribonucleic acid was used for semiquantitative competitive reverse transcriptase polymerase chain reaction studies to evaluate the expression of five of the reported phospholipase C isoforms . ^^^ RESULTS : These reverse transcriptase polymerase chain reaction studies have confirmed expression of the phospholipase C beta1a , phospholipase C beta 3 , phospholipase C gamma 1 , phospholipase C beta 2 , and phospholipase C delta 1 isoforms in rat myometrial tissue . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Analysis of platelet derived growth factor induced phospholipase D activation in mouse embryo fibroblasts lacking phospholipase C gamma 1 . ^^^ In order to investigate a role for phospholipase C gamma 1 ( PLC gamma 1 ) , we used targeted disruption of the Plcg 1 gene in the mouse to develop Plcg 1 ( + / + ) and Plcg 1 ( / ) cell lines . ^^^ The PDGF induced inositol phosphate formation and the PLD activity that remained in the Plcg 1 ( / ) cells could be attributed to the presence of phospholipase C gamma 2 ( PLC gamma 2 ) in the Plcg 1 ( / ) cells . ^^^ The PLC gamma 2 expressed in the Plcg 1 ( / ) cells was phosphorylated on tyrosine in response to PDGF treatment , and a small but significant fraction of the Plcg 1 ( / ) cells showed Ca2+ mobilization in response to PDGF , suggesting that the PLC gamma 2 expressed in the Plcg 1 ( / ) cells was activated in response to PDGF . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Interestingly , these early embryos do express phospholipase C gamma 2 , however , it is unable to substitute for the absence of phospholipase C gamma 1 , which can be detected in its tyrosine phosphorylated state . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Impaired antigen receptor induced calcium mobilization in a phospholipase C gamma 1 deficient B cell line . ^^^ B lymphocytes express phospholipase C gamma ( 1 ) ( PLC gamma ( 1 ) ) and phospholipase C gamma ( 2 ) ( PLC gamma ( 2 ) ) isozymes . ^^^ Mature splenic B lymphocytes and a panel of cell lines representing pre B , immature and mature B cell stages expressed phospholipase C gamma ( PLC gamma ) , but not the beta or delta isoforms of phospholipase C ( PLC ) . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| This was accompanied by enhanced tyrosine phosphorylation and enzymatic activity of phospholipase C gamma 1 and phospholipase C gamma 2 , resulting in elevated levels of inositol 1 , 4 , 5 trisphosphate and free intracellular Ca2+ . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Five clones of pLC 1 , pLC 2 , pLC 3 , pLC 4 , and pLC 5 obtained from the 5 respective bands were analysed by restriction endonuclease mapping and Southern blot hybridization using gene specific probes of FeLV . ^^^ The results have clearly demonstrated that pLC 4 and pLC 5 contained large deletions in the pol and part of gag regions , while the full length proviruses could be observed in pLC 1 and pLC 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| PLC 4 is distinct from the other three types of rat PLC ( PLC 1 , 2 , and 3 ) with respect to primary structure and tissue distribution of its mRNAs . ^^^ PLC 4 contains two homologous regions included commonly in PLC 1 , 2 , and 3 and is most similar to PLC 2 ( identity : 50 . 2 % ) . ^^^ Various truncation experiments of the PLC 4 cDNA revealed that the src related domain is not necessary for catalytic activity while both domains homologous among PLC 1 4 are essential . ^^^ PLC 4 , in common with PLC 2 , has a sequence homologous to the N terminal regulatory domains of nonreceptor tyrosine kinases of the src family of oncogenes . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Based on the paradigm provided by the receptor tyrosine kinases , we investigated whether PLC gamma 1 and / or PLC gamma 2 are expressed in NK cells , and whether the PLC gamma isoforms are tyrosine phosphorylated in response to Fc gamma R stimulation . ^^^ Immunoblotting analyses with PLC gamma 1 and PLC gamma 2 specific antisera demonstrate that both isoforms are expressed in human NK cells . ^^^ Furthermore , Fc gamma R crosslinking triggers the tyrosine phosphorylation of both PLC gamma 1 and PLC gamma 2 in these cells . ^^^ Pretreatment with herbimycin A , a PTK inhibitor , blocked the Fc gamma R induced tyrosine phosphorylation of PLC gamma 1 and PLC gamma 2 , and the subsequent release of inositol phosphates . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| In order to examine physiological function of the SH2 / SH3 region of phospholipase C gamma ( Z region ) , we independently expressed cDNA fragments corresponding to the SH2 / SH3 region of PLC gamma 1 and PLC gamma 2 in Escherichia coli . ^^^ The molecular mass of the proteins was 45 kDa ( derived from PLC gamma 1 and designated as rP45Z ) and 38 kDa ( derived from PLC gamma 2 and designated as rP38Z ) , which was consistent with that as expected from inserted cDNA . ^^^ We determined the effect of purified rP45Z or rP38Z on PIP 2 hydrolyzing activity of either PLC gamma 1 or PLC gamma 2 and found that these proteins strongly suppressed the rate of PLC dependent PIP 2 hydrolysis . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| In order to study the regulatory mechanisms of phospholipase C gamma ( PLC gamma ) via the intrinsic SH2 / SH3 region ( Z region ) , two recombinant Z proteins , rP45Z and rP38Z , derived from rat PLC gamma 1 and PLC gamma 2 , respectively , were purified from the inclusion bodies of Escherichia coli . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Receptor ligation triggers the activation of multiple receptor associated src family kinases leading to phosphorylation and activation of PLC gamma 1 and PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The PI PLC pathway in T cells was not stimulated by tyrosine phosphorylation of PLC gamma 2 , a homologue of PLC gamma 1 , demonstrating the strict regulation of PLC gamma isoform usage in CD 3 stimulated T cells . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Comparison of the amino acid sequence of the predicted protein with those of five mammalian phospholipase C isoforms ( PLC beta 1 , PLC gamma 1 , PLC gamma 2 , PLC delta 1 , and PLC delta 2 ) revealed that the new enzyme is most closely related to PLC beta 1 with an overall amino acid sequence identity of 48 % . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The genomic loci of four distinct phospholipase C genes ( PLC beta , PLC gamma 1 , PLC delta and PLC gamma 2 ) were examined for restriction fragment length polymorphisms ( RFLPs ) between the genomes of three normotensive [ Sprague Dawley , Donryu and Wistar Kyoto ( WKY ) ] and two closely related hypertensive [ spontaneously hypertensive ( SHR ) and SHR stroke prone ( SHR SP ) ] rat strains . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| PLC gamma 1 mRNA expression was lower than that observed for PLC alpha or PLC gamma 2 mRNA and varied widely among different cell lines . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Chem . 264 , 21885 21890 ] respectively ] and delta type of the enzyme , but PLC gamma 1 is separated from the PLC gamma 2 pool by the first DEAE cellulose column chromatography . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The receptor PTK subsequently phosphorylates PLC gamma , of which two distinct isozymes , PLC gamma 1 and PLC gamma 2 , have been identified . ^^^ Although the specific kinases are not known , one or more of these enzymes phosphorylate and activate PLC gamma 1 and PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| In studies reported here , we show that co cross linking of Fc gamma RII with sIg prevents the influx of extracellular Ca2+ without significantly affecting the tyrosine phosphorylation of substrates including PLC gamma 1 , PLC gamma 2 , and Syk or the mobilization of Ca2+ from intracellular stores . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| In vitro tyrosine phosphorylation of PLC gamma 1 and PLC gamma 2 by src family protein tyrosine kinases . ^^^ The phosphorylation of purified phospholipase C gamma 1 ( PLC gamma 1 ) and PLC gamma 2 by src family protein tyrosine kinases ( PTKs ) P56lck , p53 / 56lyn , p59hck , p59fyn , and p60src was studied in vitro . ^^^ All five PTKs phosphorylated PLC gamma 1 and PLC gamma 2 , suggesting that both PLC gamma isozymes can be phosphorylated in cells by any of the src family PTKs in response to the activation of cell surface receptors . ^^^ Comparison of the in vitro phosphorylation rates revealed no distinct specificity between PLC gamma 1 and PLC gamma 2 , or between the five PTKs . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Activated syk then phosphorylates and activates PLC gamma 1 and PLC gamma 2 , resulting in their activation and translocation to the membrane . ^^^ The presence of active PLC gamma 1 and PLC gamma 2 on the cell membrane results in hydrolysis of membrane phosphatidyl inositol and the production of 1 , 4 , 5 inositol triphosphate . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The enzyme activity and protein level of PLC gamma 1 were markedly decreased in the human histiocytic leukemia U 937 cell line during the differentiation process which is induced by phorbol 12 myristate 13 acetate ( PMA ) but those of PLC gamma 2 were not altered . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Six mammalian phospholipase C isozymes ( PLC beta 1 , PLC beta 2 , PLC gamma 1 , PLC gamma 2 , PLC delta 1 , and PLC delta 2 ) have been identified at both protein and DNA levels . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Cross linking of Fc gamma RIIIA on natural killer cells results in tyrosine phosphorylation of PLC gamma 1 and PLC gamma 2 . ^^^ The NK cell line NK3 . 3 was found to contain PLC gamma 1 and an especially high concentration of PLC gamma 2 , but PLC beta 1 and PLC delta 1 were not detected . ^^^ Cross linking of Fc gamma RIIIA on NK3 . 3 cells induced a rapid phosphorylation of PLC gamma 1 and PLC gamma 2 on tyrosine residues . ^^^ Pretreatment of NK3 . 3 cells with a tyrosine kinase inhibitor , herbimycin A , prevented the tyrosine phosphorylation of both PLC gamma 1 and PLC gamma 2 . ^^^ These results indicate that activation of Fc gamma RIIIA on NK3 . 3 cells is coupled either directly or indirectly to a nonreceptor tyrosine kinase , which phosphorylates , and thereby activates PLC gamma 1 and PLC gamma 2 . . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The amount of these isoforms in normal platelets decreased in the order PLC gamma 2 > PLC beta 2 > PLC beta 3 > PLC beta 1 > PLC gamma 1 > PLC delta 1 > PLC beta 4 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| On the other hand , PLC beta 4 , PLC gamma 1 and PLC gamma 2 were distributed almost equally among the regions for the rats of both ages . ^^^ When compared with WKY rats at 12 weeks of age , the amounts of PLC beta 1 , PLC beta 3 , PLC gamma 1 , PLC gamma 2 , and PLC delta 1 in the inner medulla of SHRs were significantly lower , and the amount of PLC delta 1 in the inner stripe of the outer medulla was also significantly lower . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Moreover , LPA and ET 1 treatment of PLCgamma1+ / + and PLCgamma 1 / cells did not cause tyrosine phosphorylation of PLC gamma 1 or PLC gamma 2 . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Whereas tyrosine phosphorylation of Fc ( epsilon ) RI , Syk , and Vav was intact in LAT deficient BMMCs following Fc ( epsilon ) RI engagement , tyrosine phosphorylation of SLP 76 , PLC gamma 1 , and PLC gamma 2 and calcium mobilization were dramatically reduced . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| We used antibodies against the various PLC isoforms to show that only PLC beta 1 and PLC beta 3 were involved in the Ca ( 2+ ) mobilization and InsP ( 3 ) formation induced by both progestins in female and male osteoblasts , whereas PLC beta 2 , PLC gamma 1 , and PLC gamma 2 were not . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| On immunohistochemistry , the immunoreactivities of PLC isozymes except for PLC gamma 1 were observed as follows : PLC beta 1 , in both the exocrine and endocrine tissues ; PLC beta 2 , mainly in the periphery of the islet and acinar cells ; PLC beta 3 , in the periphery of the islet and in some ductal epithelium ; PLC beta 4 , through the islet of Langerhans and ductal epithelium ; PLC gamma 1 , not detected in pancreatic tissue ; PLC gamma 2 , mainly in acinar cells ; PLC delta 1 and delta 2 , in the islet and in ductal epithelium . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| RNA interference to deplete either PLC gamma 1 or PLC gamma 2 in PC 12 and A7r5 cells inhibited ACE . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| Although enzymatic activities of PLC gamma 1 and PLC gamma 2 were also up regulated , amounts of inositol 1 , 4 , 5 trisphosphate , mobilization of intracellular calcium and degranulation were suppressed . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| The enzymatic activity and protein level of PLC gamma 1 were significantly increased in the human monocyte derived DCs by GM CSF / IL 4 , but the protein levels of PLC gamma 2 were unaltered . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| It has been assumed that PLC gamma 1 and PLC gamma 2 have redundant functions and that the receptors can use whichever PLC gamma isoform is preferentially expressed in a cell of a given hemopoietic lineage . ^^^ In this study , we demonstrate that ITAM containing immune recognition receptors can use either PLC gamma 1 or PLC gamma 2 , whereas the novel NK cell activating receptor NKG2D preferentially couples to PLC gamma 2 . ^^^ Experimental models evaluating signals from either endogenous receptors ( FcR vs NKG2D DAP 10 ) or ectopically expressed chimeric receptors ( with ITAM containing cytoplasmic tails vs DAP 10 containing cytoplasmic tails ) demonstrate that PLC gamma 1 and PLC gamma 2 both regulate the functions of ITAM containing receptors , whereas only PLC gamma 2 regulates the function of DAP 10 coupled receptors . ^^^ |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16885 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|