| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| The 47 kDa protein coimmunoprecipitated with phospholipase C ( PLC ) gamma 1 by anti PLC gamma 1 monoclonal antibodies is proved to be Nck , a protein composed almost exclusively of one SH 2 and three SH 3 domains . ^^^ Nck and PLC gamma 1 are recognized by certain anti PLC gamma 1 monoclonal antibodies because Nck and PLC gamma 1 share an epitope that likely is located in their SH 3 domains . ^^^ The expression levels of Nck remains unchanged during the development of rat brain , whereas PLC gamma 1 decreases during the same developmental period . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| Two of these proteins represented the tyrosine kinase fyn and the mouse homologue of phospholipase C gamma 1 , whereas two genes encoded proteins similar to 5 crk and NCK . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| We compared the phosphorylation of Nck and PLC gamma 1 in several cell lines transformed by oncogenes with different modes of transformation . ^^^ Although PLC gamma 1 and Nck have significant amino acid identity , particularly in their SH 3 regions , and both associate with growth factor receptors in a ligand dependent manner , they were not always phosphorylated on tyrosine in a coincident manner . . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| In addition , we demonstrate that phospholipase C gamma 1 , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , and Src family tyrosine kinases , but not Ras GTPase activating protein , Vav , or Nck , physically associate with the Flk2 / Flt3 cytoplasmic domain . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this study we examine the ability of tyrosine phosphorylated proteins from Jurkat T cells stimulated by CD 2 or T cell receptor CD 3 to interact with the src homology 2 or src homology 3 domains from eight different proteins involved in signal transduction in lymphocytes : Vav , Shc , Nck , phosphatidylinositol 3 kinase , phospholipase C gamma 1 , Ras GTPase activating protein , c Crk and Grb 2 . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| The in vivo interaction with the EGFr / p185c neu heterodimer of several signal transduction proteins , including phospholipase C gamma 1 ( PLC gamma 1 ) , the p 85 subunit of phosphotidylinositol 3 kinase , the ras GTPase activating protein , SHC , NCK , p72RAF , and the tyrosine phosphatase SHPTP 2 , was measured by coimmunoprecipitation . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this study , we isolated Nck cDNA from mouse thymus by screening a phase expression library using monoclonal antibody ( mAb ) B 16 5 which recognizes the SH 3 domain of phospholipase C gamma 1 . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| A mouse thymus cDNA expression library was screened with monoclonal antibody ( mAb ) , B 16 5 which binds to common epitope in SH 3 domains of phospholipase C gamma 1 ( PLC gamma 1 ) and Nck . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| In a previous report , we demonstrated that PLC gamma 1 , Grb 2 , SOS and Nck were associated with activated FGFR1s in a signaling complex in Xenopus blastulae . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| Expression of a partially activated A Raf mutant resulted in decreased tyrosine phosphorylation of the PDGFR , specifically on Y 857 ( autophosphorylation site ) and Y 1021 ( phospholipase Cgamma 1 ( PLCgamma 1 ) binding site ) , but not the binding sites for other signalling proteins ( Nck , phosphatidylinositol 3 ' kinase ( PI3K ) , RasGAP , Grb 2 , SHP ) . ^^^ |
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| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P16333 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
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