| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.55571026 |
| Moreover , LTD ( 4 ) induced an increased association of c Src with PLC gamma 1 , and the selective Src family tyrosine kinase inhibitor PP 1 blocked both LTD ( 4 ) induced tyrosine phosphorylation of PLC gamma 1 and the association of PLC gamma 1 with Gbetagamma subunits . 0.55571026^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.89794649 |
| In addition , it was confirmed that PLC gamma 1 purified from rat liver was phosphorylated at a tyrosine residue and associated with viral src kinase and that src kinases associated with the recombinant SH 2 region of PLC gamma 1 , expressed in Escherichia coli , depending upon phosphorylation of tyrosine residues . 0.89794649^^^ Phospholipase C gamma 1 associates with viral and cellular src kinases . 0.57627511^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The cellular tyrosine kinase c src appears to play a critical role in the angiotensin 2 stimulated tyrosine phosphorylation of PLC gamma 1 and the generation of 1 , 4 , 5 IP 3 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| PDGF induced activation of c Src is blocked , as is the induction of c Myc and c Fos , while tyrosine phosphorylation of the PDGFbeta receptor , PLCgamma 1 and induction of c Jun are intact . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The data showed that VEGF stimulates complex formation of the flk 1 / kinase insert domain containing receptor ( KDR ) VEGF receptor with c Src and that Src activation is required for VEGF induction of phospholipase C gamma 1 activation and inositol 1 , 4 , 5 trisphosphate formation . ^^^ This effect is mediated by a signaling cascade initiated by flk 1 / KDR activation of c Src , leading to phospholipase C gamma 1 activation , inositol 1 , 4 , 5 trisphosphate formation , release of [ Ca ( 2+ ) ] ( 1 ) and nitric oxide synthase activation . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| These data indicate that calcium activates PLC gamma 1 via increased PIP 3 formation mediated by c src and fyn activated PI3K . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| These results show for the first time that thrombin , acting through PAR 1 and PAR 4 , activates the phosphoinositide phospholipase C / PKC alpha / c Src / IKK alphabeta signaling pathway to induce NF kappaB activation , which in turn induces IL 8 / CXCL8 expression and release in human lung EC . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Stimulation of platelets by PAF increased the association and phosphorylation of both pp60c src ( 60 kDa ) and phospholipase C gamma 1 ( 145 kDa ) . ^^^ This study provides the first evidence in platelets for a direct and specific involvement of pp60c src in PAF mediated phospholipase C activation and aggregation response . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Electroporation of pp60c src antibodies inhibits the angiotensin 2 activation of phospholipase C gamma 1 in rat aortic smooth muscle cells . ^^^ Angiotensin 2 stimulated tyrosine phosphorylation of phospholipase C gamma 1 was eliminated by the anti pp60c src antibodies but not by anti mouse IgG or bovine serum albumin . ^^^ Electroporation of RASM cells with anti pp60c src antibodies had no effect on platelet derived growth factor stimulated tyrosine phosphorylation of PLC gamma 1 . ^^^ These data provide the first evidence for a direct involvement of pp60c src kinase in angiotensin 2 mediated PLC gamma 1 phosphorylation and activation . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Gastrin induces IP 3 formation through phospholipase C gamma 1 and pp60c src kinase . ^^^ The results provide direct evidence that gastrin regulates IP 3 level by a signaling mechanism that involves PLC gamma 1 and pp60c src kinase . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Presence of SH 2 domains of phospholipase C gamma 1 enhances substrate phosphorylation by increasing the affinity toward the epidermal growth factor receptor . src homology region 2 and 3 ( SH 2 and SH 3 ) domains are conserved noncatalytic regions originally described in cytoplasmic tyrosine kinases and subsequently identified in phospholipase C gamma 1 ( PLC gamma 1 ) , GTPase activating protein of ras , and other signaling proteins . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The binding of cytoplasmic signaling proteins such as phospholipase C gamma 1 and Ras GTPase activating protein to autophosphorylated growth factor receptors is directed by their noncatalytic Src homology region 2 ( SH 2 ) domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Neither beta nor gamma subunit of Fc epsilon RI nor src family PTK was coprecipitated with the PLC gamma 1 anti PLC gamma 1 complexes . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Direct analysis of the binding of Src homology 2 domains of phospholipase C to the activated epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Nerve growth factor stimulates the tyrosine phosphorylation of a 38 kDa protein that specifically associates with the src homology domain of phospholipase C gamma 1 . ^^^ In both PC 12 and 3T3 c trk cells , NGF rapidly stimulates the association of pp140c trk and pp 38 with a fusion protein containing the src homology ( SH ) domains of PLC gamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src homology 2 domains bind to tyrosine phosphorylated growth factor receptors and are found in proteins that serve as substrates for tyrosine kinases , such as phospholipase C gamma 1 and ras GTPase activating protein . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| These phosphoproteins include phospholipase C gamma 1 , the beta and gamma subunits of the Fc epsilon RI , the Src family protein tyrosine kinase Lyn , and a 72 kDa protein that coimmunoprecipitates from lysates of antigen stimulated cells with antibody to the receptor beta subunit . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| An identical pattern of proteins precipitate with TrpE fusion proteins that contain the Src homology ( SH ) 2 domains of PLC gamma 1 , indicating that these regions of PLC gamma 1 are responsible for binding . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| This involves association with , and tyrosine phosphorylation by , the ligand bound epidermal growth factor and platelet derived growth factor receptors , probably by means of the PLC gamma 1 specific src homology ( SH 2 ) domain . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| This domain is shared by a number of signal transduction proteins including nonreceptor tyrosine kinases such as Abl , Fps , Src , and Src family members , the transforming protein Crk , phospholipase C gamma 1 , PI 3 ( phosphatidylinositol ) kinase , and guanosine triphosphatase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Since other studies have implicated two members of the src family of PTKs in TCR mediated signal transduction , our findings suggest that the induction of tyrosine phosphorylation of PLC gamma 1 by a mechanism involving a src like kinase may be the means by which the TCR regulates PLC activity in T cells . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Nerve growth factor binds to the 140 kd trk proto oncogene product and stimulates its association with the src homology domain of phospholipase C gamma 1 . ^^^ Following exposure to NGF , pp140c trk undergoes a rapid autophosphorylation on tyrosine residues , and concomitantly phosphorylates and associates with phospholipase C gamma 1 ( PLC gamma 1 ) , through interaction with its src homology domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| WT EGF receptor from EGF treated cells bound well to bacterially expressed src homology ( SH ) regions of PLC gamma 1 and to a lesser extent to bacterially expressed GTPase activating protein SH regions . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 directly associates with the p 70 trk oncogene product through its src homology domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Binding of SH 2 domains of phospholipase C gamma 1 , GAP , and Src to activated growth factor receptors . ^^^ Both PLC gamma 1 and GAP contain two adjacent copies of the noncatalytic Src homology 2 ( SH 2 ) domain . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that Raf 1 associated with the SH 2 domain of Fyn ( a member of the Src tyrosine kinase family ) but not with the SH 2 domains of phospholipase C gamma 1 , the p 85 alpha subunit of phosphatidylinositol 3 kinase , and SH 2 containing protein tyrosine phosphatase 2 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src family kinases have been shown to phosphorylate PLC gamma 1 and to be activated by G protein coupled receptors . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Herbimycin A , a specific inhibitor of Src family tyrosine kinase , dose dependently inhibited PDGF induced PLD activation ( IC 50 of 8 micrograms / ml ) without affecting PLC gamma 1 activation and significantly reduced PDGF induced tyrosine phosphorylations of 40 46 kD and 60 kD proteins in PLC gamma 1 overexpressing NIH 3T3 gamma 1 cells . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| We show that phospholipase C gamma 1 , Ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , Vav , Fyn , and Src are components of the Flk2 / Flt3 signal transduction pathway . ^^^ In addition , we demonstrate that phospholipase C gamma 1 , the p 85 subunit of phosphatidylinositol 3 ' kinase , Shc , Grb 2 , and Src family tyrosine kinases , but not Ras GTPase activating protein , Vav , or Nck , physically associate with the Flk2 / Flt3 cytoplasmic domain . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Association of p72syk with the src homology 2 ( SH 2 ) domains of PLC gamma 1 in B lymphocytes . ^^^ We have used a fusion protein containing the tandem src homology 2 ( SH 2 ) domains of phospholipase C gamma 1 ( PLC gamma 1 ) to identify B cell kinases which associate with PLC gamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Differentiation of peptide molecular recognition by phospholipase C gamma 1 Src homology 2 domain and a mutant Tyr phosphatase PTP1bC215S . ^^^ Activated epidermal growth factor receptor ( EGFR ) undergoes autophosphorylation on several cytoplasmic tyrosine residues , which may then associate with the src homology 2 ( SH 2 ) domains of effector proteins such as phospholipase C gamma 1 ( PLC gamma 1 ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Association of p 62 , a multifunctional SH 2 and SH 3 domain binding protein , with src family tyrosine kinases , Grb 2 , and phospholipase C gamma 1 . src family tyrosine kinases contain two noncatalytic domains termed src homology 3 ( SH 3 ) and SH 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| METHODS : Immunodetection was used to compare the expression and tyrosine phosphorylation state of PLC gamma 1 , EGFR , phosphatidylinositol 3 kinase ( PI 3 kinase ) , ras guanosine triphosphatase activating protein ( GAP ) , and src homologous collagen like protein ( SHC ) in the postnatal rat intestine . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The two regions are split by a Z region that comprises two src homology 2 and one src homology 3 domains and is characteristic of gamma type mammalian PLC ( PLC gamma 1 and gamma 2 ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Receptor association , as measured by coimmunoprecipitation , has been determined for phospholipase C gamma 1 , the ras GTPase activating protein , the p 85 subunit of phosphatidylinositol 3 kinase , and the src homology and collagen protein . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| This striking difference from Src and Lck reflects the fact that the PLC gamma 1 complex involves binding of a phosphopeptide with predominantly hydrophobic residues C terminal to the pTyr and therefore serves as a prototype for a second class of SH 2 phosphopeptide interactions . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this study we examine the ability of tyrosine phosphorylated proteins from Jurkat T cells stimulated by CD 2 or T cell receptor CD 3 to interact with the src homology 2 or src homology 3 domains from eight different proteins involved in signal transduction in lymphocytes : Vav , Shc , Nck , phosphatidylinositol 3 kinase , phospholipase C gamma 1 , Ras GTPase activating protein , c Crk and Grb 2 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| PLC gamma 1 Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts . ^^^ To test other regions of PLC gamma 1 for DNA synthesis inducing activity , cDNA fragments encoding Src homology ( SH ) and pleckstrin homology ( PH ) domains were subcloned into the bacterial expression plasmid pGEX 2TK , and the GST fusion proteins were purified . ^^^ PLC gamma 1 Src homology domain induces mitogenesis in quiescent NIH 3T3 fibroblasts . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Following binding of platelet derived growth factor ( PDGF ) , the PDGF alpha receptor ( alphaPDGFR ) becomes tyrosine phosphorylated and associates with a number of signal transduction molecules , including phospholipase Cgamma 1 ( PLCgamma 1 ) , phosphatidylinositol 3 kinase ( PI3K ) , the phosphotyrosine phosphatase SHP 2 , Grb 2 , and Src . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| By using a glutathione S transferase fusion protein containing the src homology 2 domains of phospholipase C gamma 1 to specifically recognize tyrosine 992 on the EGF receptor ( Tyr ( P ) 992 ) , we have found differences in this subpopulation of receptors . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Fc epsilon RI ligation induces association of tyrosine phosphorylated proteins with Src homology 2 domains of phospholipase C gamma 1 in RBL 2H3 rat basophilic leukemia cells . ^^^ In this study , we examined the possibility that phospholipase C gamma 1 associates with protein tyrosine kinases and tyrosine phosphorylated molecules as a result of activation of RBL 2H3 cells , and that this association involves the Src homology 2 domains of phospholipase C gamma 1 . ^^^ Tyrosine phosphorylation of phospholipase C gamma 1 was observed in 1 min following IgE receptor stimulation . several proteins ( 72 , 50 , 40 , and 33 kDa ) were identified to be tyrosine phosphorylated and specifically associated with phospholipase C gamma 1 by its Src homology 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation experiments with specific antibodies against potential candidate proteins in the molecular mass range around 130kDa revealed positive results for the focal adhesion kinase FAK and the p 130 Src substrate while negative results were obtained for the GTPase activating protein GAP , the phospholipase C gamma 1 , the Janus kinase JAK 1 and vinculin . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In membrane binding assays , fusion proteins containing the Src homology 2 domains of phospholipase C gamma 1 , Shc , Syk , and Lyn directly bound the tyrosine phosphorylated ITAM peptides . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Purified amino terminal Src homology 2 ( SH 2 ) domains of GAP , PLCgamma 1 and the p85alpha subunit of PI 3 kinase , as well as the carboxy terminal SH 2 domain of the latter protein and the unique SH 2 domain of Grb 2 , were injected into full grown , stage 6 Xenopus laevis oocytes . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this report , direct binding assays were carried out to study which fragment of PLC gamma 1 Src homology region has been able to bind to the actin cytoskeleton . ^^^ Using GST fusion proteins containing various deletions of the PLC gamma 1 Src homology region , it was found that PLC gamma 1 binds to the actin cytoskeleton directly via its C terminal SH 2 domain but not the SH 3 domain in vitro . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In the nontransformed intestinal cell line IEC 6 , expression of EGFR , Src homology and collagen protein ( SHC ) , phospholipase C gamma 1 ( PLC gamma ) , and their tyrosine phosphorylation in response to EGF was assayed by immunoblot . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| From our binding studies using synthetic peptides , we conclude that 3 phosphohistidine can not replace phosphotyrosine in conferring high affinity binding to the phosphotyrosine binding domain of shc or the src homology 2 domain of phospholipase C gamma1 . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In this study , we have established rat 3Y1 fibroblasts that overexpress whole PLC gamma 1 and src homology 2 ( SH 2 ) SH 2 SH3 domain of PLC gamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Interaction of phospholipase C gamma 1 via its COOH terminal SRC homology 2 domain with synaptojanin . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The PLCgamma 1 AT1 receptor interaction appears to depend on phosphorylation of tyrosine 319 in a YIPP motif in the C terminal intracellular domain of the AT 1 receptor and binding of the phosphorylated receptor by the most C terminal of two Src homology 2 domains in PLCgamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Proteins that also underwent redistribution in response to the tyrosine phosphatase inhibitor included paxillin , phospholipase C gamma 1 , mitogen activated protein kinase , and the tyrosine kinases Src and Fyn . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Mutations that disrupted the binding of mT to Src kinases or PLC gamma 1 abrogated the ability of mT to deliver the signals needed for IL 2 promoter activation . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The amino terminal Src homology 2 domain of phospholipase C gamma 1 is essential for TCR induced tyrosine phosphorylation of phospholipase C gamma 1 . ^^^ PLC gamma 1 contains a pair of Src homology 2 ( SH 2 ) domains whose function is that of promoting protein interactions by binding phosphorylated tyrosine and adjacent amino acids . ^^^ PLC gamma 1 contains a pair of Src homology 2 ( SH 2 ) domains whose function is that of promoting protein interactions by binding phosphorylated tyrosine and adjacent amino acids . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| We conclude that : ( 1 ) EPO induced stimulation of 1 pS Ca2+ channels is mediated via a cytosolic Src TK in glomerular mesangial cells . ( 2 ) Stimulation of this Ca 2 ( + ) activated , Ca 2 ( + ) permeable channel is dependent on the tyrosine phosphorylation / activation of PLC gamma 1 . ( 3 ) This cascade provides a possible mechanism for the vasoconstriction and hypertension observed with clinical EPO use for the treatment of chronic anemias . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src homology domains of phospholipase C gamma 1 inhibit nerve growth factor induced differentiation of PC 12 cells . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Thus , we examined the interactions of various SH 2 containing molecules like PLC gamma 1 , rasGAP , p 85 subunit of PI 3 kinase , Src , Fyn , Crk , Nck , Grb 2 and Shc with HEK 2 using in vitro binding assays , immunoprecipitations and yeast Two Hybrid assays . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| TrkA receptors derived from DRG neuronal cultures bound preferentially to the amino terminal Src homology 2 ( SH 2 ) domain of PLCgamma 1 , but there was enhanced binding with tandemly expressed amino and carboxy terminal SH 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Evidence that a starfish egg Src family tyrosine kinase associates with PLC gamma 1 SH2 domains at fertilization . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| SLM 1 bound the SH 2 and SH 3 domains of p 59 ( fyn ) , Grb 2 , phospholipase Cgamma 1 ( PLCgamma 1 ) , and / or p 120 ( rasGAP ) , suggesting it may function as a multifunctional adapter protein for Src during mitosis . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| We found that , besides SHP 1 and SHP 2 , platelet endothelial cell adhesion molecule 1 binds the cytoplasmic signalling proteins SHIP and PLC gamma 1 via their Src homology 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Finally , the structure of Grb 2 SH2 domain was compared with those of the complexes of Src and phospholipase C gamma 1 with their cognate peptides , showing that the specific conformation of the peptide was required for binding to the SH 2 domains . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Here evidence is presented that the FAK autophosphorylation site Tyr 397 mediates a direct interaction with the C terminal Src homology 2 domain of phospholipase C ( PLC ) gamma 1 and that this is required for both adhesion dependent association of the two molecules and increased inositol phosphate production in mouse embryo fibroblasts . ^^^ These observations suggest a role for FAK in recruiting PLC gamma 1 to the plasma membrane at sites of cell matrix adhesion and there promoting its enzymatic activity , possibly by releasing the repression caused by intramolecular interactions of the PLC gamma 1 Src homology domains and / or by positioning it for phosphorylation by associated Src family kinases . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| PURPOSE : To determine the cellular localization of the Src homology ( SH ) 2 and SH 3 domains of PLC gamma 1 and their cytoplasmic binding partners , living corneal endothelial cells were microinjected with the fusion proteins containing SH domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The two SH 2 ( Src homology domain 2 ) domains present in phospholipase C gamma 1 ( PLC gamma 1 ) were assayed for their capacities to recognize the five autophosphorylation sites in the epidermal growth factor receptor . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| These events are preceded by the ligand induced tyrosine phosphorylation of the receptor and its association with SH 2 containing signaling enzymes including Src family members ( Src ) , the phosphotyrosine phosphatase SHP 2 , phosphatidylinositol 3 kinase ( PI3K ) , and phospholipase C gamma 1 ( PLCgamma ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Functional independence and interdependence of the Src homology domains of phospholipase C gamma 1 in B cell receptor signal transduction . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Differential roles of the Src homology 2 domains of phospholipase C gamma 1 ( PLC gamma 1 ) in platelet derived growth factor induced activation of PLC gamma 1 in intact cells . ^^^ Upon stimulation of cells with platelet derived growth factor ( PDGF ) , phospholipase C gamma 1 ( PLC gamma 1 ) binds to the tyrosine phosphorylated PDGF receptor through one or both of its Src homology 2 ( SH 2 ) domains , is phosphorylated by the receptor kinase , and is thereby activated to hydrolyze phosphatidylinositol 4 , 5 bisphosphate . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of the platelet derived growth factor ( PDGF ) receptor triggers intracellular signaling cascades as a result of recruitment of Src homology 2 domain containing enzymes , including phosphatidylinositol 3 kinase ( PI3K ) , the GTPase activating protein of Ras ( GAP ) , the protein tyrosine phosphatase SHP 2 , and phospholipase C gamma 1 ( PLC gamma 1 ) , to specific phosphotyrosine residues . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| To directly define the role of phospholipase Cgamma 1 ( PLCgamma 1 ) in NF kappaB activation , NF kappaB promoted luciferase reporter gene plasmid ( pNF kappaB Luc ) was transfected into rat 3Y1 fibroblasts that overexpress whole PLCgamma 1 ( PLCgamma 1 3Y1 ) , src homology domains SH 2 SH2 SH 3 of PLCgamma 1 ( SH 223 3Y1 ) and 5 src ( Src 3Y1 ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Upon T cell activation , LAT becomes highly phosphorylated on tyrosine residues , and Grb 2 , Gads , and phospholipase C ( PLC ) gamma 1 bind LAT via Src homology 2 domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| PymT , a membrane associated scaffold , recruits and activates Src family tyrosine kinases , and , once tyrosine phosphorylated , binds proteins with PTB and SH 2 domains such as ShcA , phosphatidylinositol 3 kinase ( PI3K ) and phospholipase Cgamma 1 ( PLCgamma 1 ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| We showed that Src family kinases were activated by pervanadate , and that InsPs production and phosphorylation of both PLC gamma 1 and the PDGF receptor were blocked by PP 1 , an Src inhibitor . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| In particular , we demonstrate a down regulation of phosphatidylinositol 3 kinase , Src homology phosphatase 2 , and phospholipase C gamma 1 binding but not of MAPK activation . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this deletion reduces the ability of the Src family kinase Lck to activate ITK , as well as to induce the ITK mediated tyrosine phosphorylation of its substrate PLCgamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| However , the specific Src kinase inhibitor PP 2 inhibited Gbeta subunit co precipitation with PLCgamma 1 , suggesting a possible role for Src in activation of PLCgamma 1 and interaction between two distinct o HA induced signaling pathways . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src homology 2 domain containing leukocyte phosphoprotein of 76 kDa and phospholipase C gamma 1 are required for NF kappa B activation and lipid raft recruitment of protein kinase C theta induced by T cell costimulation . ^^^ Because Vav 1 inducibly associates with further proteins including phospholipase C ( PLC ) gamma 1 and Src homology 2 domain containing leukocyte phosphoprotein of 76 kDa ( SLP 76 ) , we investigated their role for NF kappaB activation in Jurkat leukemia T cell lines deficient for expression of these two proteins . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Identification of p 115 as a PLCgamma 1 binding protein and the role of Src homology domains of PLCgamma 1 in the vesicular transport . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Furthermore , mice possessing mutations in signaling molecules upstream of PLC gamma 1 , such as Src homology 2 ( SH 2 ) domain containing phosphoprotein of 76 kDa ( SLP 76 ) , linker for activation of T cells ( LAT ) and Vav 1 , or in members of the nuclear factor for activated T cells ( NFAT ) family of transcription factors , which are downstream of PLC gamma 1 , have been found to have similar phenotypes to Tec family deficient mice , emphasizing the importance of this pathway in regulating T cell activation , differentiation and homeostasis . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The results of in vitro binding analysis and co immunoprecipitation analysis in COS 7 cells show that the Src homology ( SH ) 3 domain of PLC gamma 1 binds to the proline rich motif within the Phox homology ( PX ) domain of PLD 2 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| This interaction requires Src kinase activity as well as the association of this kinase with PLC gamma 1 , suggesting a G beta gamma mediated recruitment of proteins to the plasma membrane and formation of a signaling complex which is essential for the downstream Ca2+ signal . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Collagen and CRP stimulate tyrosine phosphorylation of PLCgamma 1 at its regulatory site , Tyr 783 , in murine but not in human platelets through a Src kinase dependent pathway . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src kinase mediates the regulation of phospholipase C gamma activity by glycosphingolipids . ^^^ The Src inhibitor , PP 2 , significantly blocked EGF induced tyrosine phosphorylation of phospholipase C gamma 1 in control cells , whereas in glucosylceramide depleted cells , suppression of Src kinase activity by PP 2 toward EGF induced tyrosine phosphorylation of phospholipase C gamma 1 was less significant . ^^^ Thus the activation of Src kinase by depletion of glucosylceramide based glycosphingolipids in cultured ECV 304 cells is a critical up stream event in the activation of phospholipase C gamma1 . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 ( PLC gamma 1 ) plays pivotal roles in cellular growth and proliferation through its two Src homology ( SH ) 2 domains and its single SH 3 domain , which interact with signaling molecules in response to various growth factors and hormones . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) plays pivotal roles in cellular growth and proliferation through its two Src homology ( SH ) 2 domains and its single SH 3 domain , which interact with signaling molecules in response to various growth factors and hormones . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| This association was found to be independent of PLCgamma 1 Src homology 2 domains , and instead required the pleckstrin homology ( PH ) EF hand domain . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Here , we identify several putative signalling motifs in the C terminus of human SR BII , which are absent from SR BI , and hypothesize that these motifs interact with signalling molecules to mobilize stored cholesteryl esters and / or promote the efflux of intracellular free cholesterol . ' Pull down ' assays using a panel of tagged SH 3 ( Src homology 3 ) domains showed that cytoplasmic SR BII , but not cytoplasmic SR BI , bound the SH 3 domain of phospholipase C gamma 1 ; this interaction was not , however , detected under more physiological conditions . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| PAF activated PLC beta 3 through its G alpha ( q ) protein coupled receptor , whereas activation of phospholipase C gamma 1 ( PLC gamma 1 ) by PAF was independent of G proteins but required the involvement of Src at prolonged PAF exposure ( 60 min ) . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Depletion of cholesterol by methyl beta cyclodextrin disrupted the raft localization of EGFR and Src , as well as bradykinin induced translocation of PLCgamma 1 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the related kinase Arg is activated downstream of PDGFRs in a manner dependent on Src family kinases and phospholipase C gamma 1 ( PLC gamma 1 ) mediated phosphatidylinositol 4 , 5 bisphosphate ( PIP 2 ) hydrolysis , as we showed previously for c Abl . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 ( PLC gamma 1 ) , which interacts with a variety of signaling molecules through its two Src homology ( SH ) 2 domains and a single SH 3 domain has been implicated in the regulation of many cellular functions . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) , which interacts with a variety of signaling molecules through its two Src homology ( SH ) 2 domains and a single SH 3 domain has been implicated in the regulation of many cellular functions . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Also the FcepsilonRI mediated tyrosine phosphorylation of PLCgamma 1 was more sensitive to the inhibitors of Src and Syk kinases . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| To elucidate the function of PLCgamma 1 , we have investigated the proteins that bind to its SH ( Src homology ) domain . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| To investigate the roles of Src homology domain 2 and domain 3 of PLCgamma 1 in PLCgamma 1 mediated cell signaling , we characterized some proteins binding to these domains in the MCF 7 and MDA MB 231 breast cancer cell lines . ^^^ Our results suggest that betaPix a binds to the Src homology domain 3 of PLCgamma 1 and promotes tumor growth in breast cancer by enhancing the activity PLCgamma1 . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Adhesion to fibronectin induced PLC gamma 1 tyrosine phosphorylation that was inhibited by a Src kinase inhibitor , but not an epidermal growth factor receptor kinase inhibitor . ^^^ Moreover , in cells null for Src family members , but not in cells null for FAK family members , integrin dependent PLC gamma 1 tyrosine phosphorylation was greatly reduced . ^^^ Finally , the data demonstrated that PLC gamma 1 co immunoprecipitated with Src following fibronectin induced integrin activation , and this association did not depend on FAK expression . . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Intramolecular interaction between phosphorylated tyrosine 783 and the C terminal Src homology 2 domain activates phospholipase C gamma 1 . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) contains two tandem Src homology 2 ( SH 2 ) domains . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) contains two tandem Src homology 2 ( SH 2 ) domains . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Src homology domains in phospholipase C gamma 1 mediate its anti apoptotic action through regulating the enzymatic activity . ^^^ However , the biological function of Src homology ( SH ) domains of PLC gamma 1 in promoting cell survival remains elusive . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Upstream of PLCgamma 1 activity , beta 1 integrin and Src kinase are demonstrated to be essential for phosphorylation of PLCgamma 1 , formation of protein complexes and accumulation of intracellular calcium . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Analysis of the light fraction indicated that both PLC gamma 1 and IP 3 receptors ( isoforms 2 and 3 , IP3R2 and IP3R3 ) were coenriched with the Na / K ATPase , caveolin 1 and Src . ^^^ Second , ouabain induced phosphorylation of PLC gamma 1 at Tyr ( 783 ) and activated PLC gamma 1 in a Src dependent manner , resulting in increased hydrolysis of PIP 2 . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| The mechanism of PLCgamma 1 recruitment and the role of PLCgamma 1 Src homology ( SH ) domains in this process remain incompletely understood . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C ( PLC ) gamma is unique among the PLC enzymes because each PLC gamma isozyme contains a split pleckstrin homology ( PH ) domain with an SH2SH2SH3 tandem repeat insertion ( where SH indicates Src homology domain ) in the middle of its sequence . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that the interaction is mediated by the binding of PLC gamma 1 Src homology ( SH ) 3 domain to Akt proline rich motifs . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that Abl kinases are activated downstream of growth factor receptors , Src family kinases , and phospholipase Cgamma 1 ( PLCgamma 1 ) in fibroblasts and influence growth factor mediated proliferation , membrane ruffling , and migration . ^^^ Growth factor receptors , Src kinases , and PLCgamma 1 are deregulated in many solid tumors and drive tumor invasion and metastasis . ^^^ |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P12931 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|