| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.81816366 |
| Examination of the PLC gamma 1 phosphorylation pattern during early Xenopus development and its association with FGFR 1 revealed that maximum phosphorylation and association of these two proteins occurred during early to mid blastula stages , concurrent with mesoderm induction in vivo . 0.81816366^^^ In explants , PLC gamma 1 became associated with FGFR 1 during mesoderm induction by FGF or by vegetal cells , the source of the natural inducer . 0.75533179^^^ PLC gamma 1 was also associated with FGFR 1 in Xenopus blastulae and this association was specific to presumptive mesoderm cells . 0.66004665^^^ PLC gamma 1 was also associated with FGFR 1 in Xenopus blastulae and this association was specific to presumptive mesoderm cells . 0.51807815^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| Exposure of the cells to bFGF resulted not only in FGFR 1 tyrosine phosphorylation , but also in tyrosine phosphorylation of phospholipase C gamma , one of the initial enzymes in the intracellular signaling cascade initiated by FGFR activation . ^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| We analysed ligand induced migration and proliferation of porcine aortic endothelial cells expressing wild type FGFR 1 , point mutated Y766F FGFR 1 , unable to activate phospholipase C gamma 1 ( PLC gamma 1 ) , or carboxyl terminally truncated FGFR 1 , lacking either 48 ( from amino acid 774 in the FGFR 1 sequence ) or 63 ( from amino acid 759 ) amino acid residues of the C terminal tail . ^^^ The defect in migration capacity of CT 63 was not due to loss of Y 766 , and thereby PLC gamma 1 activation , since cells expressing the mutant Y766F FGFR 1 migrated as efficiently as the wild type receptor cells . ^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| Upon binding to FGFR 1 , basic FGF stimulates cytosolic form of phospholipase A 2 ( cPLA 2 ) , phospholipase C gamma 1 ( PLC gamma 1 ) and phospholipase D ( PLD ) , the key enzymes for the production of various lipid second messengers , in a tyrosine kinase dependent manner . ^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| In the present study , we examined a potential role for PLC gamma 1 in the basic fibroblast growth factor ( bFGF ) induced PAK translocation using stable PC 12 cell lines that overexpress in a tetracycline inducible manner either the wild type FGFR 1 or the Y766F FGFR 1 mutant . ^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| METHODS : Sections of postnatal 5 day old and adult rat , and aged human retina , and cell cultures prepared from selected cell populations of young rat retina , were immunolabeled with specific antisera to FGFR ( FGFR 1 , 2 , 3 , and 4 ) or candidate signaling molecules [ phospholipase Cg 1 ( PLCg 1 ) , son of sevenless 1 and 2 ( SOS 1 , SOS 2 ) , extracellular signal regulated kinase 1 and 2 ( ERK1 / 2 ) , protein tyrosine phosphatase ( SH PTP 2 ) and SH 2 containing protein ( Shc ) ] , and with multiple retinal cell type specific antibodies . ^^^ |
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| Interacting proteins: P11362 and P19174 |
Pubmed |
SVM Score :0.0 |
| A tyrosine phosphorylated carboxy terminal peptide of the fibroblast growth factor receptor ( Flg ) is a binding site for the SH 2 domain of phospholipase C gamma 1 . ^^^ Phospholipase C gamma ( PLC gamma ) is a substrate of the fibroblast growth factor receptor ( FGFR ; encoded by the flg gene ) and other receptors with tyrosine kinase activity . ^^^ |
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