| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| CD 28 receptor crosslinking induces tyrosine phosphorylation of PLC gamma 1 . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| Both the phosphorylation of phospholipase C gamma 1 at tyrosine and the rise in [ Ca2+ ] 1 induced by CD 28 cross linking in preactivated T cells were blocked by herbimycin A . ^^^ We conclude that CD 28 costimulatory signals augment superantigen induced TCR signals by converging onto common TCR effector pathways involving the activation of phospholipase C gamma 1 and PKC and by generating a cyclosporin A sensitive pathway . . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| In addition to activation of phospholipase C gamma 1 , ligation of this receptor also seems to activate a calcium independent , CD 28 specific pathway . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| CD 28 receptor ligation induces tyrosine phosphorylation of specific substrates , including phospholipase C gamma 1 , and triggers both calcium dependent and calcium independent signals . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| These studies demonstrate that the PLC gamma 1 SH2 ( N ) and SH 2 ( C ) domains play functionally distinct roles during TCR mediated signaling and identify a non Ca ( 2+ ) related signaling function linked to the SH 2 ( C ) domain , which couples TCR plus phorbol ester CD 28 costimulation to the activation of the IL 2 promoter in T lymphocytes . . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| CD 28 crosslinking on YT Indy cl 43 enhanced tyrosine phosphorylation of PLC gamma 1 . ^^^ The simultaneous ligation of KIR2DL2 with mAb resulted in a decrease in CD 28 induced tyrosine phosphorylation of PLC gamma 1 confirming that dephosphorylation of this protein is involved in the KIR2DL2 induced inhibition of CD 28 mediated cytotoxicity . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| Moreover , the signal supplied by CD 28 does not lead to increased Zap 70 and Lat phosphorylation , but amplifies PLCgamma 1 activation and Ca ( 2+ ) response . ^^^ Our data suggest that CD 28 binding to B 7 contributes to setting the level of TCR induced phosphorylated Lat for recruiting signaling complexes , whereas the CD 28 signal boosts multiple pathways by facilitating PLCgamma 1 activation . ^^^ |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10747 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|