| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| Other GST fusion proteins containing the SH 2 domain of p 85 of phosphatidylinositol 3 kinase , phospholipase C gamma 1 , and ras GAP also precipitated c Kit . ^^^ |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that c kit is present in mature sperm , and its binding to SCF may result in the activation of PLC gamma 1 and PI3K , leading to receptor autophosphorylation , and ultimately may play a role in capacitation and / or the acrosome reaction . . ^^^ |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| Microinjection of a truncated form of the c kit tyrosine kinase present in mouse spermatozoa ( tr kit ) activates mouse eggs parthenogenetically , and tr kit induced egg activation is inhibited by preincubation with an inhibitor of phospholipase C ( PLC ) ( Sette , C . , A . ^^^ |
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| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| Microinjection in mouse eggs of tr kit , a truncated form of the c kit tyrosine kinase present in mouse spermatozoa , causes resumption of meiosis through activation of phospholipase Cgamma 1 ( PLCgamma 1 ) and Ca ( 2+ ) mobilization from intracellular stores . ^^^ |
|
| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| In normal mast cells , Steel induces Kit to autophosphorylate on tyrosine and bind to phosphatidylinositol 3 ' kinase ( PI3K ) and phospholipase C gamma 1 but not detectably to Ras GTPase activating protein . ^^^ |
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| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| Kit signaling inhibits the sphingomyelin ceramide pathway through PLC gamma 1 : implication in stem cell factor radioprotective effect . ^^^ Beyond the scope of Kit expressing cells , it suggests that PLC gamma 1 status could greatly influence the post DNA damage cellular response to IR , and perhaps , to other genotoxic agents . . ^^^ |
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| Interacting proteins: P10721 and P19174 |
Pubmed |
SVM Score :0.0 |
| Additionally , a truncated product , tr kit , expressed in haploid spermatids and mature spermatozoa can induce parthenogenetic activation when microinjected into mouse eggs , through the activation of PLCgamma 1 . ^^^ Interestingly , we also found that , in wild type testis , PLCgamma 1 is specifically phosphorylated in condensing spermatids , coincident with the timing of expression of tr kit in spermiogenesis . ^^^ We propose that alterations of PLCgamma 1 activity artificially promoted by ectopic Kit ( D814Y ) expression are related to the abnormalities of spermiogenesis . ^^^ |
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