| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.80507887 |
| After NGF treatment , NGF was bound to TrkA in endocytic organelles , and TrkA was tyrosine phosphorylated and bound to PLC gamma 1 , suggesting that these receptors were competent to initiate signal transduction . 0.80507887^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.53073139 |
| Both amino and carboxyl terminal SH 2 domains of PLC gamma 1 are necessary for the association of pp 38 with PLC gamma 1 , although each SH 2 domain is sufficient for the association of pp140c trk with PLC gamma 1 . 0.53073139^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.5142202 |
| Our findings identify PLC gamma 1 as a likely substrate for the trk encoded tyrosine kinase , and they provide a link between NGF dependent activation of p140trk and the stimulation of intracellular second messenger pathways . . 0.5142202^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.99378068 |
| Following exposure to NGF , pp140c trk undergoes a rapid autophosphorylation on tyrosine residues , and concomitantly phosphorylates and associates with phospholipase C gamma 1 ( PLC gamma 1 ) , through interaction with its src homology domains . 0.99378068^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Ras was not required for NGF induced activation of Trk or tyrosine phosphorylation of PLC gamma 1 . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| NGF induced phosphorylation of the trkA receptor , activated a cascade of cellular intermediaries such as phospholipase C gamma 1 and ERK proteins , and stimulated c fos gene transcription in all trkA expressing clones . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Mutation of the Trk A residue Tyr 490 to phenylalanine prevents the association with Shc , while similar mutations at Tyr 751 or Tyr 785 are reported to prevent interaction of Trk A with the p 85 subunit of inositol phospholipid 3 kinase and phospholipase C gamma 1 , respectively . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Nerve growth factor induces a multimeric TrkA receptor complex in neuronal cells that includes Crk , SHC and PLC gamma 1 but excludes P130CAS . ^^^ Using receptor activated immunoprecipitation followed by analysis of the immune complexes by SDS PAGE and immunoblotting , we show that NGF induces the association of TrkA with c Crk 2 in a multimeric complex that also includes SHC and PLC gamma 1 . ^^^ While the tyrosine phosphorylation of TrkA , SHC and PLC gamma 1 increased with time in the presence of NGF and was inhibited by the tyrosine kinase inhibitor K252a , the state of tyrosine phosphorylation of c Crk 2 did not appear to change with NGF treatment . ^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| The K 252b and NT 3 induced [ 3H ] thymidine incorporation correlated with an increase in the tyrosine autophosphorylation of the trkA receptor as well as tyrosine phosphorylation of trk associated phospholipase C gamma 1 and SH 2 containing proteins . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Signal proteins such as phosphatidylinositol 3 kinase , phospholipase C gamma 1 , Shc , and mitogen activated protein kinase seem to be involved in both TrkA and TrkB mediated signaling pathways . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| To the tyrosine phosphorylated sites of TrkA several proteins , such as phospholipase C gamma 1 , the adaptor protein SHC , the phosphotyrosine phosphatase SH PTP 2 ( SYP ) associate via their SH 2 phosphotase SH PTP 2 domain . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| The neurotrophic activity of APP was independent of the TrkA NGF receptor because neither phospholipase C gamma 1 nor TrkA exhibited tyrosine phosphorylations with APP treatment . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| We used recombinant glutathione S transferase ( GST ) PLCgamma 1 SH2 domain fusion proteins to study the site of interaction of TrkA receptors with PLCgamma 1 . ^^^ TrkA receptors derived from DRG neuronal cultures bound preferentially to the amino terminal Src homology 2 ( SH 2 ) domain of PLCgamma 1 , but there was enhanced binding with tandemly expressed amino and carboxy terminal SH 2 domains . ^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Herein , we demonstrate that acidic substitution of the activation loop tyrosines is sufficient to induce allosteric changes required for constitutive TrkA kinase activity as well as phosphorylation of TrkA signaling proteins such as Shc , PLCgamma 1 , FRS 2 and erk1 / 2 . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Activation of signal transduction pathways involving trkA , PLCgamma 1 , PKC isoforms and ERK 1 / 2 by tetanus toxin . ^^^ In the present work the differential activation of PKC isoforms and of signal transduction pathways , including nerve growth factor receptor trkA , phospholipase Cgamma 1 ( PLCgamma 1 ) , and extracellular regulated kinases 1 and 2 ( ERK 1 / 2 ) by TeTx in a synaptosome enriched P ( 2 ) fraction from rat brain is reported . ^^^ Immunoprecipitation assays against phosphotyrosine show an increase of trkA and PLCgamma 1 phosphorylation . ^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Phospholipase C gamma 1 directly associates with the p 70 trk oncogene product through its src homology domains . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) was also found to be constitutively tyrosine phosphorylated in trk transformed cells and the trk protein co immunoprecipitated with PLC gamma . ^^^ Phospholipase C gamma 1 ( PLC gamma 1 ) was also found to be constitutively tyrosine phosphorylated in trk transformed cells and the trk protein co immunoprecipitated with PLC gamma . ^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| However , by comparison MA alpha 2M is more effective in inhibiting the activation of phospholipase C gamma 1 than trk . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| A Trk nerve growth factor ( NGF ) receptor point mutation affecting interaction with phospholipase C gamma 1 abolishes NGF promoted peripherin induction but not neurite outgrowth . ^^^ Tyr 785 is required for phospholipase C gamma 1 to interact with Trk and to become tyrosine phosphorylated in response to NGF . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| To transmit NGF signals , NGF activated Trk rapidly associates with the cytoplasmic proteins , SHC , PI 3 kinase , and PLC gamma 1 . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Maximal inhibition of VGF mRNA induction was achieved using K 252a , an inhibitor of the NGF receptor Trk tyrosine kinase , and by mutating both Y 490 ( SHC association site ) and Y 785 ( PLC gamma 1 association site ) of Trk . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Trk receptors use redundant signal transduction pathways involving SHC and PLC gamma 1 to mediate NGF responses . ^^^ To determine the role of SHC and other Trk substrates in NGF signaling , Trk receptors with mutations in Y 490 and Y 785 ( the PLC gamma 1 association site ) were introduced into PC12nnr5 cells . ^^^ We postulate that Trk receptors can activate Erk 1 by either SHC or PLC gamma 1 dependent signaling pathways . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Exogenous BDNF induces tyrosine phosphorylation of TRK B as well as phosphorylation of phospholipase C gamma 1 , the extracellular signal regulated kinases 1 and 2 , and phosphatidylinositol 3 kinase . ^^^ |
|
| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| K 252b , a compound known to inhibit selectively neutrophin actions by interfering with the phosphorylation of trk type neutrophin receptors , prevented the BDNF and NT 3 stimulated phosphorylation of PLC gamma 1 . ^^^ Receptors of the trk type were coprecipitated with anti PLC gamma 1 antibodies . ^^^ |
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| Interacting proteins: P04629 and P19174 |
Pubmed |
SVM Score :0.0 |
| Substitution of the phospholipase Cgamma 1 ( PLCgamma 1 ) binding site of the EGFR by the PLCgamma binding domain of Trk renders the EGFR induced Ca2+ influx insensitive to the expression of Asn 17 Ha Ras , whereas the Ca2+ signal induced by Trk carrying the PLC binding site of EGFR is Ras dependent and abrogated by the dominant negative Ras mutant . ^^^ |
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