| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| A new link between the c Abl tyrosine kinase and phosphoinositide signalling through PLC gamma 1 . ^^^ Here we show that functional phospholipase C gamma 1 ( PLC gamma 1 ) is required for c Abl activation by PDGFR . ^^^ Decreasing cellular levels of phosphatidylinositol 4 , 5 bisphosphate ( PtdIns ( 4 , 5 ) P 2 ) by PLC gamma 1 mediated hydrolysis or dephosphorylation by an inositol polyphosphate 5 phosphatase ( Inp 54 ) results in increased Abl kinase activity . c Abl functions downstream of PLC gamma 1 , as expression of kinase inactive c Abl blocks PLC gamma 1 induced chemotaxis towards PDGF BB . ^^^ PLC gamma 1 and c Abl form a complex in cells that is enhanced by PDGF stimulation . ^^^ After activation , c Abl phosphorylates PLC gamma 1 and negatively modulates its function in vivo . ^^^ |
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| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| This domain is shared by a number of signal transduction proteins including nonreceptor tyrosine kinases such as Abl , Fps , Src , and Src family members , the transforming protein Crk , phospholipase C gamma 1 , PI 3 ( phosphatidylinositol ) kinase , and guanosine triphosphatase activating protein ( GAP ) . ^^^ |
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| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| In addition , Tec and Lyn were shown to phosphorylate Dok 1 , whereas phosphorylated Dok 1 was demonstrated to bind to the SH 2 domains of several signaling molecules activated by SCF , including Abl , CrkL , SHIP , and PLCgamma 1 , but not those of Vav and Shc . ^^^ |
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| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| Previously , we showed that Abl kinases are activated downstream of growth factor receptors , Src family kinases , and phospholipase Cgamma 1 ( PLCgamma 1 ) in fibroblasts and influence growth factor mediated proliferation , membrane ruffling , and migration . ^^^ |
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| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P00519 and P19174 |
Pubmed |
SVM Score :0.0 |
| NA |
|