| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.66901912 |
| We also present data suggesting that poly ( ADP ribose ) polymerase can interact with XRCC 1 . 0.66901912^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| A database search indicated that TopBP 1 possessed eight regions similar to regions of Rad 4 , Cut 5 , Ect 2 , Rev 1 and 10 ray repair cross complementing 1 ( XRCC 1 ) proteins and a region similar to auto modification sites of poly ( ADP ribose ) polymerase , suggesting that TopBP 1 supported catalytic reactions of topoisomerase 2 through transient breakages of DNA strands . . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 is specifically associated with poly ( ADP ribose ) polymerase and negatively regulates its activity following DNA damage . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| These two regions of XRCC 1 have been shown to interact independently with DNA ligase 3 and poly ( ADP ribose ) polymerase as part of a mechanism involved in the repair of DNA single strand breaks . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Thus , poly ( ADP ribose ) polymerase 1 , DNA polymerase beta , and ligase 3 interact with 10 ray repair cross complementing protein 1 within the BER complex , which ensures that ATP is generated and specifically used for DNA ligation . . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Using a combination of alanine scanning , polymer blot analysis , and photoaffinity labeling , we have identified poly ( ADP ribose ) binding sites in the following proteins : p 53 , p 21 ( CIP1 / WAF1 ) , xeroderma pigmentosum group A complementing protein , MSH 6 , DNA ligase 3 , XRCC 1 , DNA polymerase epsilon , DNA PK ( CS ) , Ku 70 , NF kappaB , inducible nitric oxide synthase , caspase activated DNase , and telomerase . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| To determine the dominant inhibitory activity of polbetaDelta , we examined interactions of purified polbetaDelta with 10 ray cross complementing group 1 ( XRCC 1 ) , poly ( ADP ribose ) polymerase ( PARP ) , and apurinic endonuclease ( Ape ) proteins . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Although Xrcc 1 has no catalytic activity , it also interacts with Pol beta and poly ( ADP ribose ) polymerase ( PARP ) , linking DNA ligase 3 alpha with BER and single strand break repair , respectively . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| METHODS : Polyadenylated RNA [ Poly ( A ) + RNA ] was isolated from tissues of RCC and normal kidney , and single strand cDNAs and double strand cDNAs were synthesized in turn . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| X ray repair cross complementing gene 1 protein plays an important role in camptothecin resistance . 10 ray repair cross complementing gene 1 protein ( XRCC 1 ) in complex with DNA polymerase beta , DNA ligase 3 , and poly ( ADP ribose ) polymerase is important in the base excision repair process . ^^^ In this study , we found the expression levels of XRCC 1 protein in KB 100 and KB 300 were > or =5 fold more than in their respective revertant cell lines , whereas there was no difference in the expression of XRCC 1 associated proteins such as DNA polymerase beta , DNA ligase 3 , poly ( ADP ribose ) polymerase , and apurinic / apyrimidinic endonuclease . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Poly ( ADP ribose ) polymerase 2 ( PARP 2 ) is required for efficient base excision DNA repair in association with PARP 1 and XRCC 1 . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| One genetic polymorphism ( G > A , Arg > Gln at codon 399 ) occurs within a poly ( ADP ribose ) polymerase binding region and within the central breast cancer susceptibility gene 1 product COOH terminus domain of XRCC 1 . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 functions as a scaffold protein by interacting and modulating polypeptide components of the single strand break repair machinery , including AP endonuclease 1 , DNA ligase IIIalpha , poly ( ADP ribose ) polymerase , DNA polymerase beta and human polynucleotide kinase . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Simultaneously , but dependent on poly ( ADP ribosyl ) ation , XRCC 1 was translocated from throughout the nucleus , including nucleoli , to the SSB . ^^^ The BRCT 1 domain of XRCC 1 protein was indispensable for its poly ( ADP ribose ) dependent recruitment to the SSB . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| METHODS : Poly A ( + ) RNA was isolated from RCC lines 786 O ( tester ) and renal cell ( RC ) lines HK 2 ( driver ) , respectively . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| These changes were associated with the upregulation of DNA repair enzymes ( poly [ ADP ribose ] polymerase 1 , p 53 , phospho p 53 [ phosphorylated at Ser 392 ] , and XRCC 1 [ 10 ray repair cross complementing 1 ] ) . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| The repair of DNA single strand breaks in mammalian cells is mediated by poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , DNA ligase IIIalpha , and XRCC 1 . ^^^ This provides a mechanism for the recruitment of the DNA ligase IIIalpha XRCC 1 complex to in vivo DNA single strand breaks and suggests that the zinc finger of DNA ligase 3 enables this complex and associated repair factors to locate the strand break in the presence of the negatively charged poly ( ADP ribose ) polymer . . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Using a reconstituted system including the recombinant BER proteins Pol beta , AP endonuclease 1 ( APE 1 ) , 10 ray repair cross complementing group 1 ( XRCC 1 ) , DNA ligase 3 ( Lig 3 ) , flap endonuclease 1 ( FEN 1 ) , and poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , it is demonstrated that in the absence of ATP , both long patch DNA synthesis by Pol beta and poly ( ADP ribosylation ) catalysed by PARP 1 are stimulated . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Here , we show that the single strand break repair protein XRCC 1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly ( ADP ribose ) synthesis . ^^^ Poly ( ADP ribose ) synthesis peaks during a 10 min treatment with H2O2 and the appearance of XRCC 1 foci peaks shortly afterwards . ^^^ Both sites of poly ( ADP ribose ) and XRCC 1 foci decrease to background levels during subsequent incubation in drug free medium , consistent with the rapidity of the single strand break repair process . ^^^ The formation of XRCC 1 foci at sites of poly ( ADP ribose ) was greatly reduced by mutation of the XRCC 1 BRCT 1 domain that physically interacts with PARP 1 . ^^^ These data demonstrate that PARP 1 is required for the assembly or stability of XRCC 1 nuclear foci after oxidative DNA damage and suggest that the formation of these foci is mediated via interaction with poly ( ADP ribose ) . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in DNA repair gene XRCC 1 and increased genetic susceptibility to breast cancer . 10 ray repair cross complementing 1 ( XRCC 1 ) gene encodes for a scaffolding protein , which plays an important role in base excision DNA repair by bringing together DNA polymerase beta , DNA ligase 3 and poly ( ADP Ribose ) polymerase ( PARP ) at the site of DNA damage . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Using genomic DNA extracted from blood samples , we identified wild type and polymorphic variants of XPD ( Arg156Arg and Lys751Gln ) , XRCC 1 ( Arg194Trp and Arg399Gln ) and XRCC 3 ( Thr241Met ) , and the poly ( AT ) insertion / deletion of XPC ( PAT ) . ^^^ |
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| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| A number of proteins , including histones , DNA topoisomerases , DNA methyltransferase 1 as well as DNA damage repair and checkpoint proteins ( p 23 , p 21 , DNA PK , NF kB , XRCC 1 , and others ) can be targeted in this manner ; the interaction involves a specific poly ( ADP ribose ) binding sequence motif of 20 26 amino acids in the target domains . . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| Here , we characterized the interactions of four purified BRCT domains , two from XRCC 1 and their two partners from DNA ligase IIIalpha and poly ( ADP ribosyl ) polymerase 1 . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| As an amplified DNA damage signal , auto poly ( ADP ribosyl ) ation of PARP 1 triggers the recruitment of XRCC 1 , which coordinates and stimulates the repair process , to the DNA damage sites in less than 15 s in living cells ( Okano et al . , 2003 ) . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| BRCT 1 is required for the immediate poly ( ADP ribose ) dependent recruitment of XRCC 1 to DNA breaks and is essential for survival after DNA damage . ^^^ |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGN5 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|