| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| These data identify a novel pathway for mammalian single strand break repair and demonstrate a concerted role for XRCC 1 and PNK in the initial step of processing damaged DNA ends . . ^^^ |
|
| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| However , XRCC 1 complemented cells repaired Top 1 induced DNA breaks faster than XRCC 1 deficient cells , and exhibited enhanced tyrosyl DNA phosphodiesterase ( Tdp 1 ) and polynucleotide kinase phosphatase ( PNKP ) activities . ^^^ XRCC 1 immunoprecipitates contained Tdp 1 polypeptide , and both Tdp 1 and PNKP activities , indicating a functional connection between the XRCC 1 single strand break repair pathway and the repair of Top 1 covalent complexes by Tdp 1 and PNKP . . ^^^ |
|
| Interacting proteins: P18887 and Q96T60 |
Pubmed |
SVM Score :0.0 |
| This domain interacts with threonine phosphorylated XRCC 1 and XRCC 4 , proteins responsible for the recruitment of PNK to sites of DNA strand break repair . ^^^ |
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