| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| The BRCT regions of tumor suppressor BRCA 1 and of XRCC 1 show DNA end binding activity with a multimerizing feature . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 possesses two BRCA 1 carboxyl terminal ( BRCT ) protein interaction domains , denoted BRCT 1 and 2 . ^^^ |
|
| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| The BRCT superfamily presently includes approximately 40 nonorthologous proteins , namely , BRCA 1 , 53BP1 , and RAD 9 ; a protein family that consists of the fission yeast replication checkpoint protein Rad 4 , the oncoprotein ECT 2 , the DNA repair protein XRCC 1 , and yeast DNA polymerase subunit DPB 11 ; DNA binding enzymes such as terminal deoxynucleotidyltransferases , deoxycytidyl transferase involved in DNA repair , and DNA ligases 3 and 4 ; yeast multifunctional transcription factor RAP 1 ; and several uncharacterized gene products . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| BRCT domains are present in the tumour suppressor protein BRCA 1 [ 1 3 ] , and the domain is found in over 40 other proteins , defining a superfamily that includes DNA ligase 3 alpha and the essential human DNA repair protein XRCC 1 . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis using hydrophobic cluster analysis reveals here the presence of 50 copies of the BRCT domain in 23 different proteins , including , in addition to BRCA 1 , 53BP1 and RAD 9 , XRCC 1 , RAD 4 , Ect 2 , REV 1 , Crb 2 , RAP 1 , terminal deoxynucleotidyltransferases ( TdT ) and three eukaryotic DNA ligases . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| These mutational data indicate the importance of the putative functional regions in XRCC 1 , such as the BRCA 1 C terminal ( BRCT ) domain found in common with BRCA 1 and other DNA repair and cell cycle checkpoint proteins , and also regions necessary for interaction with DNA polymerase beta and DNA ligase III . . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 interacts with PARP by its central region ( amino acids 301 to 402 ) , which contains a BRCT ( BRCA 1 C terminus ) module , a widespread motif in DNA repair and DNA damage responsive cell cycle checkpoint proteins . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| Based on the XRCC 1 BRCT structure , we have constructed a model for the C terminal BRCT domain of BRCA 1 , which frequently is mutated in familial breast and ovarian cancer . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| The XRCC 1 DNA repair protein contains two regions of approximately 100 amino acids each that share homology with the BRCT ( BRCA 1 carboxyl terminus ) domain superfamily . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| These data are biologically plausible since codon 399 is located within the BRCA 1 C terminus functional domain and codon 194 is in the linker region of the XRCC 1 N terminal functional domain . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| Thus , 19 single nucleotide polymorphisms ( SNPs ) in eight genes involved in base excision repair ( XRCC 1 , APEX , POLD 1 ) , BRCA 1 protein interaction ( BRIP 1 , ZNF 350 , BRCA 2 ) , and growth regulation ( TGFss 1 , IGFBP 3 ) were evaluated . ^^^ CONCLUSION : Some variants in genes within the base excision repair pathway ( XRCC 1 ) and BRCA 1 interacting proteins ( BRIP 1 ) may play a role as low penetrance breast cancer risk alleles . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| AS primer pairs were designed for nine candidate genetic variants in DNA repair and cell cycle / apoptotic regulatory genes , including Cyclin D 1 [ codon 870 splice site variant ( A > G ) ] ; BRCA 1 , P871L ; ERCC 2 , K751Q ; FAS 1377 ( G > A ) ; hMLH 1 93 ( G > A ) and V219I ; p 21 , S31R ; and the XRCC 1 R194W and R399Q variants . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| Additionally , we summarized breast cancer risk associated with the following genetic factors : breast cancer susceptibility high penetrance genes ( BRCA 1 , BRCA 2 , p 53 , PTEN , ATM , NBS 1 or LKB 1 ) and low penetrance genes such as cytochrome P 450 genes ( CYP1A1 , CYP2D6 , CYP 19 ) , glutathione S transferase family ( GSTM 1 , GSTP 1 ) , alcohol and one carbon metabolism genes ( ADH1C and MTHFR ) , DNA repair genes ( XRCC 1 , XRCC 3 , ERCC4 / XPF ) and genes encoding cell signaling molecules ( PR , ER , TNFalpha or HSP 70 ) . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| Increasing evidence suggests that cells have evolved scaffolding proteins to orchestrate and control the assembly of these repair complexes , typified in mammalian cells by several BRCT motif containing proteins , such as Brca 1 , Xrcc 1 , and 53BP1 . ^^^ |
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| Interacting proteins: P18887 and P38398 |
Pubmed |
SVM Score :0.0 |
| We analyzed 49 SNPs in BRCA 1 , BRCA 2 , ESR 1 , XRCC 1 , XRCC 2 , XRCC 3 , NBN , RAD 51 , RAD 52 , LIG 4 , ATM , BCL 2 , TGFB 1 , MSH 6 , ERCC 2 , XPF , NR3C1 , CYP1A1 , CYP2C9 , CYP2C19 , CYP3A5 , CYP2D6 , CYP11B2 , and CYP17A1 genes using the Pyrosequencing technique . ^^^ |
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