Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.65582557
In somatic cells , DNA ligase 3 alpha forms a stable complex with the DNA repair protein Xrcc 1 . 0.65582557^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.68724651
We also show that the XRCC 1 NTD binds a gapped DNA beta Pol complex . 0.68724651^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.61805431
XRCC 1 His directly interacted with human DNA ligase 3 in vitro to form a complex that was resistant to 2 M NaCl . 0.61805431^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.51974791
Here , we demonstrate that XRCC 1 is additionally associated with DNA polymerase beta in human cells and that these polypeptides also directly interact . 0.51974791^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.7636007
We show that XRCC 1 interacts directly with DNA polymerase beta using far Western blotting , affinity precipitation and yeast two hybrid analyses . 0.7636007^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.73027026
Subcloned fragments of XRCC 1 have been expressed and assayed for their ability to associate with DNA ligase 3 by far Western and affinity precipitation analyses . 0.73027026^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.53337531
XRCC 1 can interact with DNA polymerase beta , thereby suppressing strand displacement , and DNA ligase 3 , both of which have been implicated in base excision repair . 0.53337531^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.62718962
These two regions of XRCC 1 have been shown to interact independently with DNA ligase 3 and poly ( ADP ribose ) polymerase as part of a mechanism involved in the repair of DNA single strand breaks . 0.62718962^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.54085079
Lack of association between DNA base excision repair gene XRCC 1 Gln399Arg polymorphism and risk of malignant lymphoma in Japan . 0.54085079^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.53180929
The functional association between XRCC 1 and DNA PK in response to IR provides the first evidence for their involvement in a common DSB repair pathway . . 0.53180929^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
An interaction between the mammalian DNA repair protein XRCC 1 and DNA ligase 3 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Hamster EM 9 and EM C 11 cells were deficient in DNA ligase 3 activity as a consequence of mutations in the XRCC 1 gene . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 keeps DNA from getting stranded . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 plays an important role in base excision repair and in rejoining DNA strand breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The XRCC 1 DNA repair gene may facilitate DNA strand break and base excision repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We studied polymorphisms in 3 DNA repair genes : XRCC 1 , XRCC 3 , and XPD . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair gene XRCC 1 and age related disease . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In addition , DNA repair protein genes ( MLH 1 , XRCC 1 ) were increased . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 and DNA strand break repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair enzymes ( OGG 1 , XRCC 1 , XPD , etc . ) , 3 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 polymorphisms , smoking , and esophageal cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
An association of polymorphism of DNA repair genes XRCC 1 and XRCC 3 with colorectal cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The XRCC 1 , DNA polymerase beta and delta proteins were also elevated . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of the XRCC 1 DNA repair gene in head and neck cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Allelic variants of the XRCC 1 gene at codons 194 , 280 and 399 were analyzed in lymphocyte DNA by PCR RFLP . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genetic polymorphisms of XRCC 1 , XRCC 3 , and APE 1 genes were determined by PCR RFLP . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Variation in DNA repair genes ERCC 2 , XRCC 1 , and XRCC 3 and risk of follicular lymphoma . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In mammalian cells , nicks in DNA are targets of proteins such as PARP 1 or XRCC 1 that have no homologues in yeast . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The 10 ray repair cross complementing group 1 ( XRCC 1 ) gene is important in DNA base excision repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Multiplex pyrosequencing of two polymorphisms in DNA repair gene XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The prognostic value of S phase fraction evaluated from DNA histograms ( S FCM ) was studied in 69 RCC patients . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA analyses showed maternal loss of heterozygosity ( LOH ) at 11p15 region in RMS but not in RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A DNA histogram of RCC cells treated at herbimycin A showed a block in the cell cycle at the S and G2M phases . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Adjuvant interferon alpha therapy in renal cell carcinoma ( RCC ) : prognostic value of DNA cytophotometry . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genomic DNA was obtained from 173 patients with RCC and 211 controls of Caucasian origin . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : DNA and RNA were extracted from 27 sporadic RCC samples . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Fas gene mutations were examined in genomic DNA extracted from RCC lesions . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA was found in the tissues of patients with conventional RCC compared with that found in a healthy control group . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
RESULTS : All tumors except one papillary RCC generated interpretable DNA histograms . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : We extracted tumor and normal DNA from 41 RCC patients . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Somatic mutations were determined using genomic DNA extracted from RCC by direct sequencing method . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Thus , poly ( ADP ribose ) polymerase 1 , DNA polymerase beta , and ligase 3 interact with 10 ray repair cross complementing protein 1 within the BER complex , which ensures that ATP is generated and specifically used for DNA ligation . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We evaluated the expression of DNA repair proteins , redox factor 1 ( Ref 1 ) and 10 ray repair cross complementing protein 1 ( XRCC 1 ) , relevant to neurodegeneration following kainic acid induced seizures in rats . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The BRCT superfamily presently includes approximately 40 nonorthologous proteins , namely , BRCA 1 , 53BP1 , and RAD 9 ; a protein family that consists of the fission yeast replication checkpoint protein Rad 4 , the oncoprotein ECT 2 , the DNA repair protein XRCC 1 , and yeast DNA polymerase subunit DPB 11 ; DNA binding enzymes such as terminal deoxynucleotidyltransferases , deoxycytidyl transferase involved in DNA repair , and DNA ligases 3 and 4 ; yeast multifunctional transcription factor RAP 1 ; and several uncharacterized gene products . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Role of a BRCT domain in the interaction of DNA ligase 3 alpha with the DNA repair protein XRCC 1 . ^^^ BRCT domains are present in the tumour suppressor protein BRCA 1 [ 1 3 ] , and the domain is found in over 40 other proteins , defining a superfamily that includes DNA ligase 3 alpha and the essential human DNA repair protein XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The structure has been obtained from the C terminal region of the human DNA repair protein XRCC 1 , and comprises a four stranded parallel beta sheet surrounded by three alpha helices , which form an autonomously folded domain . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The DNA ligase IIIalpha BRCT domain partners with the distal BRCT domain of the DNA repair protein XRCC 1 ( X1BRCTb ) in the DNA base excision repair ( BER ) pathway . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Residues of DNA polymerase beta ( beta Pol ) that interact with the DNA repair protein XRCC 1 have been determined by NMR chemical shift mapping ( CSM ) and mutagenesis . 15N / ( 13 ) C / ( 2 ) H / ( 1 ) H , ( 13 ) C methyl ( Leu , Ile , Val ) labeled beta Pol palm thumb domain was used for assignments of the 1H , 15N , and 13C resonances used for CSM of the palm thumb on forming the 40 kDa complex with the XRCC 1 N terminal domain ( NTD ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A new report has established that casein kinase 2 ( CK 2 ) , a protein that functions in diverse cellular processes , controls the activity of the DNA repair protein XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The authors have recently demonstrated a significant gene environment interaction between vinyl chloride exposure and polymorphisms in the DNA repair protein XRCC 1 on the occurrence of mutant p 53 biomarkers of vinyl chloride induced genetic damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Alterations in expression and structure of the DNA repair gene XRCC 1 . ^^^ The repair associated gene XRCC 1 was previously cloned by complementing the hamster mutant EM 9 , which has a high rate of spontaneous SCE and hypersensitivity to DNA damaging agents . ^^^ The mRNA of XRCC 1 decreased to 20 40 % after treatment of cells with a DNA damaging agent . ^^^ These data and the high levels of XRCC 1 protein detected in testis indicate that XRCC 1 may play an important role in DNA processing during meiogenesis and recombination in germ cells . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Construction of human XRCC 1 minigenes that fully correct the CHO DNA repair mutant EM 9 . ^^^ The human gene that corrects the DNA repair defect of the CHO cell mutant EM 9 is designated XRCC 1 and is the first human gene to be cloned that has an established role in DNA strand break repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using flow sorted , chromosome specific Southern hybridization techniques , homologs of the protein kinase C beta polypeptide ( PRKCB 1 ) and the DNA repair genes ERCC 2 and XRCC 1 have been assigned to Indian muntjac chromosome 2 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Expression of the polymorphic human DNA repair gene XRCC 1 does not correlate with radiosensitivity in the cells of human head and neck tumor cell lines . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
During mammalian evolution , loci coding for glucosephosphate isomerase , peptidase D , muscle creatine kinase , and several DNA repair genes ( ERCC 1 , ERCC 2 , and XRCC 1 ) appear as a conserved syntenic group on human chromosome 19 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The genes XRCC 1 and ERCC 2 were cloned from cosmid libraries prepared from DNA transformants of the CHO mutants EM 9 and UV 5 , respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Molecular cloning of the human XRCC 1 gene , which corrects defective DNA strand break repair and sister chromatid exchange . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Refined mapping of the three DNA repair genes , ERCC 1 , ERCC 2 , and XRCC 1 , on human chromosome 19 . ^^^ Three DNA repair genes , ERCC 1 , ERCC 2 , and XRCC 1 , have been regionally mapped on human chromosome 19 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In the second analysis , DNAs from an independent hybrid panel were digested with restriction enzymes and analyzed by Southern blot hybridization using DNA probes for the three DNA repair genes that are located on human chromosome 19 : ERCC 1 , ERCC 2 , and 10 Ray Repair Cross Complementing 1 ( XRCC 1 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We have investigated both DNA ligase activities and a protein which stimulates DNA ligase activity in mutant EM 9 cells , XRCC 1 transfectant H9T3 7 1 cells and wild type AA 8 cells . ^^^ Furthermore , the AMP binding capacity of DNA ligase 3 and its enzymatic activity with the synthetic polymer were restored after transfection of EM 9 with the human XRCC 1 gene . ^^^ Immunoblotting data suggest that the XRCC 1 gene does not code for DNA ligase 3 . ^^^ In conclusion , the data indicate that the EM 9 cell strain has an altered DNA ligase 3 activity that can be restored by the XRCC 1 gene product . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The transcriptional level of c myc , c jun and XRCC 1 genes after 10 irradiation was compared in human cells originating from subjects presumably with different DNA repair abilities . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The 103 kDa product of one cDNA clone formed a characteristic complex with the XRCC 1 DNA repair protein and was identical with the previously described DNA ligase 3 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genomic sequence comparison of the human and mouse XRCC 1 DNA repair gene regions . ^^^ The XRCC 1 ( 10 ray repair cross complementing ) gene is involved in the efficient repair of DNA single strand breaks formed by exposure to ionizing radiation and alkylating agents . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Testis and somatic Xrcc 1 DNA repair gene expression . ^^^ The human XRCC 1 gene has been shown to be involved in DNA strand break repair using the Chinese hamster ovary cell mutant EM 9 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Isolation and characterization of mouse Xrcc 1 , a DNA repair gene affecting ligation . ^^^ Human DNA repair gene XRCC 1 complements the strand break rejoining defect in Chinese hamster mutant EM 9 and encodes a protein that is apparently required for optimal activity of DNA ligase 3 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Among the DNA repair / DNA metabolism genes on chromosome 19q , ERCC 1 , LIG 1 , and perhaps ERCC 2 are within the common area of deletion ; XRCC 1 is centromeric and is therefore excluded as a candidate . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Duplicated region of sequence similarity to the human XRCC 1 DNA repair gene in the Schizosaccharomyces pombe rad4 / cut5 gene . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Expression of the DNA repair gene XRCC 1 in baboon tissues . ^^^ XRCC 1 is a DNA repair gene involved in rejoining DNA strand breaks . ^^^ A mean value of 24 . 6 10 10 ( 5 ) XRCC 1 transcripts per micrograms DNA was found in testis , while 10 . 5 10 10 ( 5 ) in ovary , 9 . 8 10 10 ( 5 ) in brain , 8 . 5 10 10 ( 5 ) in liver , 6 . 8 10 10 ( 5 ) in kidney , 6 . 5 10 10 ( 5 ) in heart , 6 . 4 10 10 ( 5 ) in lymph nodes , 6 . 0 10 10 ( 5 ) in lung and 4 . 9 10 10 ( 5 ) in spleen were found . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The objective of this study was to determine the relative importance of the first six complementation groups of the nucleotide excision repair cross complementing genes ( ERCC 1 ERCC6 ) and the first complementation group of the 10 ray repair cross complementing genes ( XRCC 1 ) , in the repair of DNA damage induced by the in vitro active cyclophosphamide ( CP ) derivatives 4 hydroperoxycyclophosphamide ( 4HC ) and phosphorodiamidic mustard ( PM ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 is involved in DNA strand break repair , homologous recombination , and sister chromatid exchange and is expressed as a low abundance mRNA with elevated expression in testis . ^^^ Quantitative RNase protection assays revealed no changes in the level of Xrcc 1 expression in testis relative to DNA content among 6 , 12 , 18 , 24 , or 28 mo old mice . ^^^ The relatively abundant Xrcc 1 expression in pachytene spermatocytes and round spermatids suggests that Xrcc 1 is involved in DNA strand break repair associated with meiotic recombination in addition to its previously implicated role in strand break repair associated with base excision repair . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Sequence analysis using hydrophobic cluster analysis reveals here the presence of 50 copies of the BRCT domain in 23 different proteins , including , in addition to BRCA 1 , 53BP1 and RAD 9 , XRCC 1 , RAD 4 , Ect 2 , REV 1 , Crb 2 , RAP 1 , terminal deoxynucleotidyltransferases ( TdT ) and three eukaryotic DNA ligases . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
As reported previously , the 103 kDa DNA ligase 3 alpha interacts with the DNA strand break repair protein encoded by the human XRCC 1 gene . ^^^ In contrast , the 96 kDa DNA ligase 3 beta does not interact with XRCC 1 , indicating that DNA ligase 3 beta may play a role in cellular functions distinct from the DNA repair pathways involving the DNA ligase 3 alpha 10 XRCC 1 complex . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Involvement of XRCC 1 and DNA ligase 3 gene products in DNA base excision repair . ^^^ DNA ligase 3 and the essential protein XRCC 1 are present at greatly reduced levels in the xrcc 1 mutant CHO cell line EM C 11 . ^^^ Cell free extracts prepared from these cells were used to examine the role of the XRCC 1 gene product in DNA base excision repair in vitro . ^^^ Full complementation of the ligation defect in EM C 11 extracts was achieved by addition to the repair reaction of recombinant human DNA ligase 3 but not by XRCC 1 . ^^^ This is consistent with the notion that XRCC 1 acts as an important stabilizing factor of DNA ligase 3 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We also examined mutants with defects in the base excision repair pathway [ EM 9 ( XRCC 1 ) ] and the DNA dependent protein kinase ( DNA PK ) mediated DNA double strand break ( DSB ) repair pathway [ xrs 5 ( XRCC 5 ) ] . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The ubiqitously expressed DNA ligase 3 alpha forms a complex with the DNA single strand break repair protein XRCC 1 . ^^^ In contrast , DNA ligase 3 beta , which does not interact with XRCC 1 , is only expressed in male meiotic germ cells , suggesting a role for this isoform in meiotic recombination . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A database search indicated that TopBP 1 possessed eight regions similar to regions of Rad 4 , Cut 5 , Ect 2 , Rev 1 and 10 ray repair cross complementing 1 ( XRCC 1 ) proteins and a region similar to auto modification sites of poly ( ADP ribose ) polymerase , suggesting that TopBP 1 supported catalytic reactions of topoisomerase 2 through transient breakages of DNA strands . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Mutations in hamster single strand break repair gene XRCC 1 causing defective DNA repair . ^^^ The molecular basis for the DNA repair dysfunction observed in mutant Chinese hamster ovary cell lines of 10 ray repair cross complementing group 1 ( XRCC 1 ) is unknown and the exact role of the XRCC 1 protein remains unclear . ^^^ These mutational data indicate the importance of the putative functional regions in XRCC 1 , such as the BRCA 1 C terminal ( BRCT ) domain found in common with BRCA 1 and other DNA repair and cell cycle checkpoint proteins , and also regions necessary for interaction with DNA polymerase beta and DNA ligase III . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA ligase 3 alpha and DNA ligase 3 beta , which are generated by alternative splicing of the LIG 3 gene , can be distinguished by their ability to bind to the DNA repair protein , XRCC 1 . ^^^ The interaction between DNA ligase 3 alpha and XRCC 1 , which occurs through BRCT motifs in the C termini of these polypeptides , implicates this isoform of DNA ligase 3 in the repair of DNA single strand breaks and BER . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Rare microsatellite polymorphisms in the DNA repair genes XRCC 1 , XRCC 3 and XRCC 5 associated with cancer in patients of varying radiosensitivity . ^^^ Polymorphic microsatellites in three DNA repair genes , XRCC 1 , XRCC 3 and XRCC 5 , were analyzed for possible linkage to cancer status or clinical radiosensitivity . ^^^ XRCC 1 , 3 and 5 proteins are involved in single strand DNA break rejoining , recombinational repair , and double strand DNA break rejoining respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 is specifically associated with poly ( ADP ribose ) polymerase and negatively regulates its activity following DNA damage . ^^^ XRCC 1 interacts with PARP by its central region ( amino acids 301 to 402 ) , which contains a BRCT ( BRCA 1 C terminus ) module , a widespread motif in DNA repair and DNA damage responsive cell cycle checkpoint proteins . ^^^ Overexpression of XRCC 1 in Cos 7 or HeLa cells dramatically decreases PARP activity in vivo , reinforcing the potential protective function of PARP at DNA breaks . ^^^ Given that XRCC 1 is also associated with DNA ligase 3 via a second BRCT module and with DNA polymerase beta , our results provide strong evidence that PARP is a member of a BER multiprotein complex involved in the detection of DNA interruptions and possibly in the recruitment of XRCC 1 and its partners for efficient processing of these breaks in a coordinated manner . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The CHO XRCC 1 mutant , EM 9 , deficient in DNA ligase 3 activity , exhibits hypersensitivity to camptothecin independent of DNA replication . ^^^ Recently , EM 9 were complemented the DNA ligase 3 interactive protein , XRCC 1 . ^^^ Defective XRCC 1 apparently accounts for the low DNA ligase 3 activity that may explain the single strand break repair deficiency of EM 9 cells . ^^^ These results suggest that EM 9 cells are sensitized to camptothecin by a mechanism that is independent of DNA replication and may be a consequence of the XRCC 1 mutation or the associated deficiency in DNA ligase 3 activity . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
As DNA breaks were reported to occur in PA , we determined mRNA levels of two genes representing DNA nucleotide excision repair , ERCC 2 and ERCC 3 , and a DNA repair gene involved in the repair of oxidation mediated DNA damage , XRCC 1 . mRNAs for HIF 1 were not detectable following 5 20 minutes of asphyxia . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Cloning and characterization of the promoter of baboon XRCC 1 , a gene involved in DNA strand break repair . ^^^ The DNA repair gene XRCC 1 was the first cloned human DNA repair gene involved in resistance to ionizing radiation . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The other proteins involved in base excision repair , polymerase beta , XRCC 1 , and DNA ligase 3 , do not affect the dissociation of thymine DNA glycosylase from the apurinic site . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The assay has been validated on cellular systems with known repair defects such as xeroderma pigmentosum defective in nucleotide excision repair , on mutant rodent cell lines defective in DNA single strand break rejoining ( XRCC 1 ) ( alkaline version ) or DNA double strand breaks rejoining ( XRCC5 / Ku80 and XRCC7 / DNAPKcs ) ( neutral conditions ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Increased expression of human DNA repair genes , XRCC 1 , XRCC 3 and RAD 51 , in radioresistant human KB carcinoma cell line N 10 . ^^^ The radioresistant N 10 and parental KB cell lines were examined for the expression of human DNA repair genes which were related to the repair of radiation induced DNA damage by northern blot analysis using five kinds of DNA probes ( XRCC 1 , XRCC 3 , XRCC 5 , RAD 51 , RAD 52 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 mRNA expression in peripheral blood mononuclear cells was analyzed , using the reverse transcriptase polymerase chain reaction , in 8 patients and was suppressed during etoposide infusion in 2 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Requirement for the Xrcc 1 DNA base excision repair gene during early mouse development . ^^^ Xrcc 1 / cell lines derived from mutant embryos were hypersensitive to mutagen induced DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Increased steady state mRNA levels of DNA repair genes XRCC 1 , ERCC 2 and ERCC 3 in brain of patients with Down syndrome . ^^^ As one of the hypotheses for the pathogenesis of brain damage in DS is oxidative stress and cells of patients with DS are more susceptible to ionizing irradiation , we decided to study ERCC 2 , ERCC 3 and XRCC 1 , representatives of repair genes known to be involved in the repair of oxidative DNA damage . mRNA steady state levels of ERCC 2 , ERCC 3 , XRCC 1 , a transcription activator ( TAF DBP ) and an elongation factor ( EF1A ) were determined and normalized versus the housekeeping gene beta actin in five individual brain regions of nine controls and nine DS patients . ^^^ We showed that DNA repair genes ERCC 2 and ERCC 3 ( excision repair cross complementing ) for nucleotide excision repair and XRCC 1 ( 10 ray repair cross complementing ) for 10 ray repair , were increased at the transcriptional level with the possible biological meaning that this increase may be compatible with permanent ( oxidative ? ) DNA damage . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
H , 15N , and 13C resonance assignments for the N terminal 20 kDa domain of the DNA single strand break repair protein XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Expression of PADPRP or molecules involved in the BER system [ 3 methylpurine DNA glycosylase ( MPG ) and 10 ray repair cross complementing 1 ( XRCC 1 ) ] , have been explored . ^^^ This could suggest that in the presence of PADPRP inhibitor , persistence of DNA damage triggers XRCC 1 transcription . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 polymorphisms : effects on aflatoxin B 1 DNA adducts and glycophorin A variant frequency . ^^^ We explored the relationship between polymorphisms in the DNA repair enzyme , XRCC 1 ( codons 194 , 280 , and 399 ) , and genotoxic end points measured in two populations : ( a ) placental aflatoxin B 1 DNA ( AFB 1 DNA ) adducts in a group of Taiwanese maternity subjects ( n = 120 ) ; and ( b ) somatic glycophorin A ( GPA ) variants in erythrocytes from a group of North Carolina smokers and nonsmokers ( n = 59 ) . ^^^ The XRCC 1 399Gln allele was significantly associated with higher levels of both AFB 1 DNA adducts and GPA NN mutations . ^^^ These results suggest that the Arg399Gln amino acid change may alter the phenotype of the XRCC 1 protein , resulting in deficient DNA repair . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The mammalian 10 ray cross complementing group 1 protein ( XRCC 1 ) is an important player in base excision repair of damaged DNA . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of DNA repair gene XRCC 1 in squamous cell carcinoma of the head and neck . ^^^ The findings support the hypothesis that a polymorphic XRCC 1 DNA repair gene contributes to risk of developing SCCHN . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Early decrease of XRCC 1 , a DNA base excision repair protein , may contribute to DNA fragmentation after transient focal cerebral ischemia in mice . ^^^ The 10 ray repair cross complementing group 1 ( XRCC 1 ) protein plays a central role in the DNA base excision repair pathway by interacting with DNA ligase 3 and DNA polymerase beta . ^^^ The present study examined the protein expression of XRCC 1 and DNA fragmentation before and after transient focal cerebral ischemia ( FCI ) . ^^^ The spatial relationship between XRCC 1 expression and DNA damage was examined by double staining with XRCC 1 and TUNEL after FCI . ^^^ CONCLUSIONS : These results suggest that the early decrease of XRCC 1 and the failure of the DNA repair mechanism may contribute , at least in part , to DNA fragmentation after FCI . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Consistent with the early hepatocyte entry into S phase , regenerating transgenic livers exhibited earlier expression of DNA repair genes ( XRCC 1 , mHR21spA , and mHR23B ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The alpha exon encodes the interaction domain with a scaffold DNA repair protein , XRCC 1 , while the beta exon encoded C terminal does not . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A cell cycle specific requirement for the XRCC 1 BRCT 2 domain during mammalian DNA strand break repair . ^^^ XRCC 1 protein is essential for viability in mammals and is required for efficient DNA single strand break repair and genetic stability following DNA base damage . ^^^ We report here that XRCC 1 dependent strand break repair in G ( 1 ) phase of the cell cycle is abolished by mutations created within the XRCC 1 BRCT domain that interact with DNA ligase 3 . ^^^ In contrast , XRCC 1 dependent DNA strand break repair in S phase is largely unaffected by these mutations . ^^^ These data describe a cell cycle specific role for a BRCT domain , and we conclude that the XRCC 1 DNA ligase 3 complex is required for DNA strand break repair in G ( 1 ) phase of the cell cycle but is dispensable for this process in S phase . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Domain specific interaction in the XRCC 1 DNA polymerase beta complex . ^^^ XRCC 1 ( 10 ray cross complementing group 1 ) is a DNA repair protein that forms complexes with DNA polymerase beta ( beta Pol ) , DNA ligase 3 and poly ADP ribose polymerase in the repair of DNA single strand breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair genes XRCC 1 and ERCC 2 and biomarkers of DNA damage in human blood mononuclear cells . ^^^ To determine whether variation in DNA repair genes is related to host DNA damage , we studied the association between polymorphisms in XRCC 1 ( codon 399 ) and ERCC 2 ( codon 751 ) and two markers of DNA damage , sister chromatid exchange ( SCE ) frequencies ( n = 76 ) and polyphenol DNA adducts ( n = 61 ) . ^^^ We also observed a possible gene dosage effect for XRCC 1 399Gln and detectable DNA adducts , and significantly more adducts among older subjects who were carriers of the 399Gln allele than in younger subjects with the 399Arg / Arg genotype . ^^^ Our results suggest that carriers of the polymorphic XRCC 1 399Gln allele may be at greater risk for tobacco and age related DNA damage . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Reduction of the DNA base excision repair protein , XRCC 1 , may contribute to DNA fragmentation after cold injury induced brain trauma in mice . ^^^ The 10 ray repair cross complementing group 1 ( XRCC 1 ) protein plays a central role in the DNA base excision repair pathway by interacting with DNA ligase 3 and DNA polymerase beta . ^^^ The present study examined the protein expression of XRCC 1 and DNA fragmentation before and after cold injury induced brain trauma ( CIBT ) in mice , in which apoptosis is assumed to participate . ^^^ DNA fragmentation was also observed after CIBT , and double staining with XRCC 1 immunohistochemistry and terminal deoxynucleotidyl transferase mediated uridine 5 ' triphosphate biotin nick end labeling showed a spatial relationship between XRCC 1 loss and DNA fragmentation 24 h after CIBT . ^^^ These data indicate that early decrease of XRCC 1 and failure of the DNA repair mechanism may contribute to DNA damaged neuronal cell death after CIBT . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The 399Gln polymorphism in the DNA repair gene XRCC 1 modulates the genotoxic response induced in human lymphocytes by the tobacco specific nitrosamine NNK . ^^^ In the current study , we explored the relationship between two polymorphisms in the DNA repair gene XRCC 1 ( polymorphisms in codons 194 and 399 ) and the genotoxic response induced by the tobacco specific nitrosamine , 4 ( methylnitrosamino ) 1 ( 3 pyridyl ) 1 butanone ( NNK ) . ^^^ These data suggest that the Arg399Gln amino acid change may alter the phenotype of the XRCC 1 protein , resulting in deficient DNA repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC 1 are associated with increased risk of early onset colorectal carcinoma in Egypt . ^^^ In a pilot case control study , we tested the hypothesis that polymorphisms in the gene for the DNA repair enzyme XRCC 1 are associated with increased risk of colorectal cancer among Egyptians . ^^^ Using a multiplex polymerase chain reaction restriction fragment length polymorphism ( PCR RFLP ) methodology , allelic variants of the XRCC 1 gene at codons 194 ( Arg > Trp ) ( 194Trp ) and 399 ( Arg > Gln ) ( 399Gln ) , were analyzed in DNA from lymphocytes of 48 newly diagnosed colorectal cancer cases and 48 age and sex matched controls . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
These include genes involved in DNA replication and repair ( e . g . , PCNA , XRCC 1 , B MYB , and GADD 45 ) , transcriptional regulators associated with stress response , and cell cycle checkpoint control ( e . g . , YB 1 , DBPA , and ATF 4 ) , and genes for signal transduction proteins ( e . g . , protein tyrosine phosphatase 1B and regulatory subunits alpha and beta of cAMP dependent protein kinase ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using a combination of alanine scanning , polymer blot analysis , and photoaffinity labeling , we have identified poly ( ADP ribose ) binding sites in the following proteins : p 53 , p 21 ( CIP1 / WAF1 ) , xeroderma pigmentosum group A complementing protein , MSH 6 , DNA ligase 3 , XRCC 1 , DNA polymerase epsilon , DNA PK ( CS ) , Ku 70 , NF kappaB , inducible nitric oxide synthase , caspase activated DNase , and telomerase . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Mitochondrial DNA ligase 3 function is independent of Xrcc 1 . ^^^ Hamster EM 9 cells , which lack Xrcc 1 protein , have reduced levels of DNA ligase 3 and are defective in nuclear base excision repair . ^^^ The Xrcc 1 protein stabilizes DNA ligase 3 and may even play a direct role in catalyzing base excision repair . ^^^ Since DNA ligase 3 is also thought to function in mitochondrial base excision repair , it seemed likely that mitochondrial DNA ligase 3 function would also be dependent upon Xrcc 1 . ^^^ Thus , mitochondrial DNA ligase 3 function is independent of the Xrcc 1 protein . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of the DNA repair gene XRCC 1 and risk of gastric cancer in a Chinese population . ^^^ In the present study , we described an association between 2 polymorphisms of the DNA repair gene XRCC 1 and risk of gastric cancer in a Chinese population . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The DNA single strand break repair protein XRCC 1 contains a BRCT domain that binds and stabilizes intracellular DNA ligase 3 protein . ^^^ Mutations that disrupt the BRCT domain and prevent DNA ligase 3 interaction abolished XRCC 1 dependent repair in serum starved Chinese hamster ovary cells , and reentry into cell cycle induced by readdition of serum restored repair . ^^^ Elevating DNA ligase 3 levels in XRCC 1 mutant cells using proteosome inhibitors or by expressing XRCC 1 protein in which the BRCT domain is disrupted but can still bind DNA ligase 3 failed to restore repair in noncycling cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Defects in the repair and maintenance of DNA increase risk for cancer . 10 ray cross complementing group 1 protein ( XRCC 1 ) is involved with the repair of DNA single strand breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The BRCT regions of tumor suppressor BRCA 1 and of XRCC 1 show DNA end binding activity with a multimerizing feature . ^^^ The recombinant second BRCT of XRCC 1 ( 10 ray repair cross complementing group 1 ) , whose folding was determined by 10 ray crystallography , also showed similar DNA end binding images . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 stimulates human polynucleotide kinase activity at damaged DNA termini and accelerates DNA single strand break repair . ^^^ XRCC 1 protein is required for DNA single strand break repair and genetic stability but its biochemical role is unknown . ^^^ Here , we report that XRCC 1 interacts with human polynucleotide kinase in addition to its established interactions with DNA polymerase beta and DNA ligase 3 . ^^^ Strikingly , XRCC 1 stimulates the DNA kinase and DNA phosphatase activities of polynucleotide kinase at damaged DNA termini and thereby accelerates the overall repair reaction . ^^^ These data identify a novel pathway for mammalian single strand break repair and demonstrate a concerted role for XRCC 1 and PNK in the initial step of processing damaged DNA ends . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of the DNA repair gene XRCC 1 and lung cancer risk . ^^^ We explored the association between polymorphisms of the DNA repair gene XRCC 1 ( codons 194 , 280 , and 399 ) and lung cancer risk in a case control study nested within a cohort of tin miners . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 polymorphisms , smoking , and bladder cancer risk . ^^^ The XRCC 1 gene protein plays an important role in BER by serving as a scaffold for other repair enzymes and by recognizing single strand DNA breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair gene XRCC 1 and breast cancer . 10 ray repair cross complementing group 1 ( XRCC 1 ) encodes a protein involved in base excision repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
These changes were associated with the upregulation of DNA repair enzymes ( poly [ ADP ribose ] polymerase 1 , p 53 , phospho p 53 [ phosphorylated at Ser 392 ] , and XRCC 1 [ 10 ray repair cross complementing 1 ] ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In a case control study of 124 bladder cancer patients and 85 hospital controls ( urological and non urological ) , 3 DNA polymorphisms localized in 3 genes of different repair pathways ( XRCC 1 Arg399Gln , exon 10 ; XRCC 3 Thr241Met , exon 7 ; XPD Lys751Gln , exon 23 ) have been analyzed . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
BRCT domain interactions in the heterodimeric DNA repair protein XRCC 1 DNA ligase 3 . ^^^ The heterodimer of the DNA repair proteins , XRCC 1 and DNA ligase 3 , was the first example of a functional interaction via BRCT modules . ^^^ Key amino acid residues mediating the interaction with DNA ligase 3 were identified here by targeted mutagenesis of the XRCC 1 BRCT domain . ^^^ A structural model of the DNA ligase 3 BRCT domain was constructed and similarly tested by mutation of corresponding residues required for the interaction with XRCC 1 . ^^^ These data identify the XRCC 1 DNA ligase 3 heterodimer interface and provide the first demonstration of the surface contacts coordinating a functional BRCT BRCT protein interaction . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Amino acid substitution variants of APE 1 and XRCC 1 genes associated with ionizing radiation sensitivity . ^^^ PCR restriction fragment length polymorphism ( RFLP ) assays were used to determine four genotypes : 10 ray repair cross complementing group 1 ( XRCC 1 , exon 6 , C / T , 194 Arg / Trp and exon 10 , G / A , 399 Arg / Gln ) , XRCC group 3 ( XRCC 3 , exon 7 , C / T , 241 Thr / Met ) and apurinic / apyrimidinic endonuclease 1 ( APE 1 , exon 5 , T / G , 148 Asp / Glu ) . ^^^ There was a significant interaction between family history ( FH ) and APE 1 ( exon 5 ) genotype ( P = 0 . 007 ) as well as FH and XRCC 1 ( exon 10 ) genotype ( P = 0 . 005 ) in mitotic delay . ^^^ Lastly , prolonged cell cycle delay was significantly associated with number of variant alleles when APE 1 Asp148Glu and XRCC 1 Arg399Gln genotypes were evaluated in a four level model ( chi ( 2 ) for linear trend = 10 . 9 ; P = 0 . 001 ) . ^^^ These results suggest that amino acid substitution variants of XRCC 1 and APE 1 may contribute to IR hypersensitivity . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To determine the dominant inhibitory activity of polbetaDelta , we examined interactions of purified polbetaDelta with 10 ray cross complementing group 1 ( XRCC 1 ) , poly ( ADP ribose ) polymerase ( PARP ) , and apurinic endonuclease ( Ape ) proteins . ^^^ A novel role of XRCC 1 in the functions of a DNA polymerase beta variant . ^^^ However , this binary complex not only suppresses gap filling synthesis activity of WT polbeta but also binds more strongly to gapped DNA than WT polbeta bound to XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
After 6 h , expression of a variety of genes related to growth regulation ( e . g . p 21 ( WAF 1 ) , notch 4 , and smoothened ) , apoptosis ( e . g . caspase 10 , hTRIP , and CRAF 1 ) , DNA repair ( ERCC 1 , XRCC 1 ) , cytokines ( e . g . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 , XRCC 3 , XPD gene polymorphisms , smoking and ( 32 ) P DNA adducts in a sample of healthy subjects . ^^^ In 308 healthy Italian individuals belonging to the prospective European project EPIC , we have investigated the relationship between DNA damage , as measured by ( 32 ) P DNA adduct levels , and three genetic polymorphisms in different repair genes : XRCC 1 Arg399Gln ( exon 10 ) , XRCC 3 Thr241Met ( exon 7 ) and XPD Lys751Gln ( exon 23 ) . ^^^ The XRCC 3 241Met variant was significantly associated with higher DNA adduct levels , whereas XRCC 1 399Gln and XPD 751Gln were associated with higher DNA adduct levels only in never smokers . ^^^ Never smoking XRCC 1 399Gln homozygotes had an average DNA adduct level of 15 . 60 + / 5 . 42 compared with 6 . 16 + / 0 . 97 in Gln / Arg heterozygotes and 6 . 78 + / 1 . 10 in Arg / Arg homozygotes ( F = 5 . 237 , P = 0 . 007 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MAPK dependence of DNA damage repair : ionizing radiation and the induction of expression of the DNA repair genes XRCC 1 and ERCC 1 in DU 145 human prostate carcinoma cells in a MEK1 / 2 dependent fashion . ^^^ PURPOSE : To examine the role of mitogen activated protein kinase ( MAPK ) signalling on the induction by ionizing radiation of the nucleotide excision repair gene ( ERCC 1 ) , the 10 ray cross complementing group 1 protein ( XRCC 1 ) and the repair of radiation induced DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We report here that XRCC 1 , another essential protein involved in the maintenance of genome stability , physically interacts with APE 1 and stimulates its enzymatic activities . ^^^ A truncated form of APE 1 , lacking the first 35 amino acids , although catalytically proficient , loses the affinity for XRCC 1 and is not stimulated by XRCC 1 . ^^^ XRCC 1 coordinates the initial and late stages of DNA abasic site repair through protein protein interactions . ^^^ The interaction described extends the coordinating role of XRCC 1 to the initial step of the repair of DNA abasic sites . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Human XPA and XRCC 1 DNA repair proteins expressed in yeast , Saccharomyces cerevisiae . ^^^ Human XPA and XRCC 1 DNA repair proteins have been expressed in a series of novel yeast episomal vectors . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Recently , it has been demonstrated that the Arg399Gln substitution in the XRCC 1 gene is associated with increased levels of markers of DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Recently discovered polymorphisms affecting DNA repair may be expected to be of special importance in modulating genotoxic effects ; the first available studies have suggested that the exon 10 Arg399Gln polymorphism of XRCC 1 gene ( 10 ray repair cross complementing group 1 ) could affect individual genotoxic response . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Homology search also reveals that HERV K derived sequences are interspersed , amongst others , in the tumor suppressor gene BRCA 2 and the DNA repair gene XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 , a protein directly involved in the repair of DNA base damage , contains at least three common polymorphisms . ^^^ Exposure information was derived from a detailed interviewer administered questionnaire , and XRCC 1 genotype was determined from blood derived DNA using a PCR RFLP method . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
X ray repair cross complementing gene 1 protein plays an important role in camptothecin resistance . 10 ray repair cross complementing gene 1 protein ( XRCC 1 ) in complex with DNA polymerase beta , DNA ligase 3 , and poly ( ADP ribose ) polymerase is important in the base excision repair process . ^^^ In this study , we found the expression levels of XRCC 1 protein in KB 100 and KB 300 were > or =5 fold more than in their respective revertant cell lines , whereas there was no difference in the expression of XRCC 1 associated proteins such as DNA polymerase beta , DNA ligase 3 , poly ( ADP ribose ) polymerase , and apurinic / apyrimidinic endonuclease . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphism of the DNA repair gene XRCC 1 and risk of primary lung cancer . ^^^ Recently , three coding polymorphisms in 10 ray cross complementing group 1 ( XRCC 1 ) DNA repair gene have been identified , and it is possible that these polymorphisms may affect DNA repair capacity and thus modulate cancer susceptibility . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In this report , we investigated the association between the repair phenotype of ultraviolet ( UV ) induced damage and genotypes of three DNA repair genes , XPC and XPD [ involved in nucleotide excision repair ( NER ) ] and XRCC 1 [ involved in base excision repair ( BER ) ] . ^^^ We also typed these subjects for five polymorphisms in these three DNA repair genes ( at intron 9 of XPC ; exons 6 , 10 and 23 of XPD and exon 10 of XRCC 1 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We investigated the relationship between the risk of relapse in ALL patients and functional polymorphisms in genes encoding carcinogen metabolizing enzymes , including CYP1A1 , CYP2D6 , CYP2E1 , MPO , GSTM 1 , GSTT 1 , GSTP 1 , NAT 1 , NAT 2 , NQO 1 , as well as DNA repair enzymes hMLH 1 , hMSH 3 , XRCC 1 , XPF , and APE . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Central role for the XRCC 1 BRCT 1 domain in mammalian DNA single strand break repair . ^^^ The DNA single strand break repair ( SSBR ) protein XRCC 1 is required for genetic stability and for embryonic viability . ^^^ However , the naturally occurring human polymorphism in BRCT 1 supported XRCC 1 dependent SSBR and cell survival after DNA alkylation equally well . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
PCR restriction fragment length polymorphism ( RFLP ) assays were used to determine four genotypes of three DNA repair genes : XRCC 1 , 194 Arg / Trp and 399 Arg / Gln ; XRCC 3 , 241 Thr / Met ; and APE 1 , 148 Asp / Glu . ^^^ In controls , prolonged cell cycle delay was significantly associated with the number of variant alleles in APE 1 Asp148Glu and XRCC 1 Arg399Gln genotypes ( P ( trend ) = 0 . 001 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Poly ( ADP ribose ) polymerase 2 ( PARP 2 ) is required for efficient base excision DNA repair in association with PARP 1 and XRCC 1 . ^^^ PARP 2 was also found to interact with three other proteins involved in the base excision repair pathway : 10 ray cross complementing factor 1 ( XRCC 1 ) , DNA polymerase beta , and DNA ligase 3 , already known as partners of PARP 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Although based on relatively few individuals , our results suggest that bleomycin sensitivity is partially explained by genetic polymorphisms affecting DNA repair ( XRCC 1 ) and in vitro metabolism of bleomycin ( BLHX ) . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
These include the overexpressed genes ABL 2 , Notch 4 and SOD 1 , as well as XRCC 1 , a DNA repair gene whose transcript was found downregulated . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To determine whether variations in DNA repair genes are related to host DNA damage , we investigated the association between polymorphism in the XPD gene ( codon 199 , 312 , 751 ) and the XRCC 1 gene ( codon 194 , 399 ) and the presence of benzo ( a ) pyrene diolepoxide adducts to lymphocyte DNA ( BPDE DNA ) in a group of male patients with incident lung cancer , all current smokers . ^^^ XRCC 1 and XPD genotypes did not affect the levels and proportion of detectable BPDE DNA adducts . ^^^ This is the first study analysing the specific BPDE DNA adduct in vivo with regard to polymorphic repair genes ( XPD , XRCC 1 ) and xenobiotic metabolizing gene ( GSTM 1 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of DNA repair genes XRCC 1 and XPD and their associations with risk of esophageal squamous cell carcinoma in a Chinese population . ^^^ We therefore investigated the associations between genetic polymorphisms in the DNA repair genes XRCC 1 ( Arg194Trp and Arg399Gln ) and XPD ( Asp312Asn and Lys751Gln ) and risk of ESCC in an at risk Chinese population . ^^^ These findings suggest that DNA repair gene XRCC 1 but not XPD might play a role in esophageal carcinogenesis and might represent a genetic determinant in the development of the cancer . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 and XPD polymorphisms and risk of lung cancer in a Chinese population . 10 ray repair cross complementing group 1 ( XRCC 1 ) and xeroderma pigmentosum group D ( XPD ) are mainly involved in base excision repair ( BER ) and nucleotide excision repair ( NER ) of DNA repair pathways , respectively . ^^^ Polymorphisms of DNA repair gene XRCC 1 and XPD has recently been identified , and there is a growing body of evidence that these polymorphisms may have some phenotypic significance . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Effects on sister chromatid exchange frequency of polymorphisms in DNA repair gene XRCC 1 in smokers . ^^^ To investigate if the polymorphisms of metabolic traits and DNA repair modulate smoking related DNA damage , we used sister chromatid exchange ( SCE ) as a marker of genetic damage to explore the relationship of microsomal epoxide hydrolase ( mEH ) , glutathione S transferase M 1 ( GSTM 1 ) , and 10 ray cross complementing group 1 ( XRCC 1 ) and cigarette smoking induced SCE . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair gene XRCC 1 and susceptibility to alcoholic liver cirrhosis in older Southeastern Brazilians . ^^^ In this study , we tested the hypothesis that polymorphisms in the DNA repair gene XRCC 1 are associated with increased risk of liver cirrhosis in Southeastern Brazilians . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 ( 10 ray repair cross complementing group 1 ) is a base excision repair protein that plays a central role in the repair of DNA strand breaks and base damage from a variety of endogenous and exogenous oxidants including tobacco smoke . ^^^ The variant 399Gln allele of XRCC 1 has been associated with elevated biomarkers of DNA damage in human cells . ^^^ We conducted an analysis of the Arg399Gln polymorphism in XRCC 1 using genomic DNA , and questionnaire information from 309 cases of pancreatic adenocarcinoma and 964 controls that were part of a population based , case control study conducted in the San Francisco Bay Area between 1994 and 2001 . ^^^ Because smoking and obesity are known and suspected pancreas cancer risk factors , and have been associated with DNA damage and oxidative stress in target tissues , we estimated odds ratios ( ORs ) , interaction contrast ratios ( ICRs ) , and 95 % confidence intervals for the combined effects of XRCC 1 genotype and smoking or body mass index ( in kg / m ( 2 ) ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 functions as a scaffold protein by interacting and modulating polypeptide components of the single strand break repair machinery , including AP endonuclease 1 , DNA ligase IIIalpha , poly ( ADP ribose ) polymerase , DNA polymerase beta and human polynucleotide kinase . ^^^ XRCC 1 protein is required for the repair of DNA single strand breaks and genetic stability , and is essential for viability in mammals . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 3 codon 241 polymorphism , its interaction with smoking and XRCC 1 polymorphisms , and bladder cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Coding polymorphisms of the DNA repair gene XRCC 1 have been shown to affect the DNA repair capacity and to be associated with genetic susceptibility to carcinogenesis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We discuss the clinical significance of polymorphisms in TS , MTHFR , and FCGR3A , as well as the polymorphic DNA repair genes XPD and XRCC 1 , in influencing response to chemotherapy and survival outcomes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Human 10 ray cross complementing group 1 ( XRCC 1 ) is a single strand DNA break repair protein which forms a base excision repair ( BER ) complex with DNA polymerase beta ( beta Pol ) . ^^^ Mutant proteins defective in XRCC 1 NTD interaction with beta Pol and with a beta Pol gapped DNA complex were determined by gel filtration chromatography and a gel mobility shift assay . ^^^ Establishing the direct contacts in the beta Pol XRCC 1 complex is a critical step in understanding how XRCC 1 fulfills its numerous functions in DNA BER . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The DNA repair proteins XPD and XRCC 1 are involved in the nucleotide and base excision repair of DNA lesions induced by many tobacco and environmental carcinogens . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We used a case control study design ( 162 cases and 302 controls ) to test the association between three amino acid substitution variants of DNA repair genes ( XRCC 1 Arg194Trp , XRCC 1 Arg399Gln , and XRCC 3 Thr241Met ) and breast cancer susceptibility . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Because base excision repair ( BER ) is a major DNA repair pathway for SSB induced by chemical agents and ionizing radiation , we initially assessed the role of BER in modulating IdUrd cytotoxicity and radiosensitization using genetically matched Chinese hamster ovary cells , with ( AA 8 cells ) and without ( EM 9 cells ) XRCC 1 expression . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 is a unique DNA repair protein containing two BRCT motifs , recently identified in several DNA repair and cell cycle regulating proteins . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair genes XPD , XRCC 1 , XRCC 3 , and APE / ref 1 , and the risk of lung cancer among male smokers in Finland . ^^^ Associations between lung cancer risk and common polymorphisms in the DNA repair genes xeroderma pigmentosum complementation group D ( XPD ) , 10 ray repair cross complementing group 1 ( XRCC 1 ) , XRCC 3 and apurinic / apyrimidinic endonuclease / redox factor 1 were examined within a randomized clinical trial designed to determine whether alpha tocopherol , beta carotene , or both would reduce cancer incidence among male smokers in Finland . ^^^ We found no direct association between lung cancer risk and any of the DNA repair genotypes studied , however , the association between XPD codon 751 genotype and lung cancer was modified by alpha tocopherol supplementation , and the association between XRCC 1 codon 399 genotype and lung cancer was modified by the amount of smoking . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Epidermal growth factor and ionizing radiation up regulate the DNA repair genes XRCC 1 and ERCC 1 in DU 145 and LNCaP prostate carcinoma through MAPK signaling . ^^^ This work examined the importance of radiation induced and ligand induced EGFR ERK signaling for the regulation of DNA repair proteins XRCC 1 and ERCC 1 in prostate carcinoma cells , DU 145 ( TP 53 ( mut ) ) , displaying EGFR TGFA dependent autocrine growth and high MAPK ( ERK1 / 2 ) activity , and LNCaP ( TP 53 ( wt ) ) cells expressing low constitutive levels of ERK1 / 2 activity . ^^^ Using quantitative RT PCR and Western analyses , we determined that ionizing radiation activated the DNA repair genes XRCC 1 and ERCC 1 in an ERK1 / 2 dependent fashion for each cell line . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Gene environment interactions between the codon 194 polymorphism of XRCC 1 and antioxidants influence lung cancer risk . 10 ray repair cross complementing group 1 ( XRCC 1 ) is a DNA repair gene whose polymorphisms appear to influence the risk of lung cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair genes XRCC 1 and ERCC 2 , smoking , and lung cancer risk . ^^^ XRCC 1 ( 10 ray cross complementing group 1 ) and ERCC 2 ( excision repair cross complementing group 2 ) are two major DNA repair proteins . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A DNA repair gene , 10 ray repair cross complementing group 1 ( XRCC 1 , exon 10 ) , may also be implicated in the process of VCM related carcinogenesis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The 399Gln polymorphism in the DNA repair gene XRCC 1 has been indicated to have a contributive role in DNA adduct formation , sister chromatid exchange , and an increased risk of cancer development . ^^^ The findings support the hypothesis that XRCC 1 Arg399Gln amino acid change may alter the phenotype of the XRCC 1 protein , resulting in a DNA repair deficiency . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The objective of this study is to investigate the relationship between the polymorphisms of two DNA repair genes , the nucleotide excision repair xeroderma pigmentosum group D ( XPD ) gene ( codons 312 and 751 ) and the base excision repair 10 ray repair cross complementing group 1 ( XRCC 1 ) gene ( codon 399 ) , and p 53 mutations among lung cancer patients . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The 10 ray repair cross complementing group 1 ( XRCC 1 ) gene plays a critical role in the repair of DNA single strand breaks . ^^^ A polymorphism at codon 399 of the XRCC 1 gene ( Arg to Gln ) is associated with increased DNA adduct binding and an increase in sister chromatid exchanges after exposure to tobacco carcinogens and may be linked with an increased risk of lung cancer . ^^^ To further define the interaction between tobacco carcinogens , XRCC 1 mediated DNA repair and DNA damage , we examined the role of the XRCC 1 codon 399 polymorphism in mutation of the p 53 gene in non small cell lung cancer ( NSCLC ) . ^^^ The XRCC 1 gene may play a role in the repair of cigarette smoking induced DNA damage . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The repair of DNA single strand breaks in mammalian cells is mediated by poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , DNA ligase IIIalpha , and XRCC 1 . ^^^ XRCC 1 not only forms a stable complex with DNA ligase IIIalpha but also interacts with several other DNA repair factors . ^^^ This provides a mechanism for the recruitment of the DNA ligase IIIalpha XRCC 1 complex to in vivo DNA single strand breaks and suggests that the zinc finger of DNA ligase 3 enables this complex and associated repair factors to locate the strand break in the presence of the negatively charged poly ( ADP ribose ) polymer . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 stimulates the formation of the hOGG 1 Schiff base DNA intermediate without interfering with the endonuclease activity of APE 1 , the second enzyme in the pathway . ^^^ The data presented support a model by which XRCC 1 will pass on the DNA intermediate from hOGG 1 to the endonuclease APE 1 . ^^^ Role of XRCC 1 in the coordination and stimulation of oxidative DNA damage repair initiated by the DNA glycosylase hOGG 1 . ^^^ XRCC 1 participates in DNA single strand break and base excision repair ( BER ) to preserve genetic stability in mammalian cells . ^^^ Here , we report that XRCC 1 interacts physically and functionally with hOGG 1 , the human DNA glycosylase that initiates the repair by BER of the mutagenic oxidized base 8 oxoguanine . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Association of XRCC 1 and tyrosyl DNA phosphodiesterase ( Tdp 1 ) for the repair of topoisomerase 1 mediated DNA lesions . ^^^ XRCC 1 complementation enhanced survival to CPT induced DNA lesions produced independently of DNA replication . ^^^ CPT induced comparable levels of Top 1 cleavage complexes ( single strand break ( SSB ) and DNA protein cross links ( DPC ) ) in both XRCC 1 deficient and XRCC 1 complemented cells . ^^^ However , XRCC 1 complemented cells repaired Top 1 induced DNA breaks faster than XRCC 1 deficient cells , and exhibited enhanced tyrosyl DNA phosphodiesterase ( Tdp 1 ) and polynucleotide kinase phosphatase ( PNKP ) activities . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using a reconstituted system including the recombinant BER proteins Pol beta , AP endonuclease 1 ( APE 1 ) , 10 ray repair cross complementing group 1 ( XRCC 1 ) , DNA ligase 3 ( Lig 3 ) , flap endonuclease 1 ( FEN 1 ) , and poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , it is demonstrated that in the absence of ATP , both long patch DNA synthesis by Pol beta and poly ( ADP ribosylation ) catalysed by PARP 1 are stimulated . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A requirement for PARP 1 for the assembly or stability of XRCC 1 nuclear foci at sites of oxidative DNA damage . ^^^ Here , we show that the single strand break repair protein XRCC 1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly ( ADP ribose ) synthesis . ^^^ These data demonstrate that PARP 1 is required for the assembly or stability of XRCC 1 nuclear foci after oxidative DNA damage and suggest that the formation of these foci is mediated via interaction with poly ( ADP ribose ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
An arginine ( Arg ) to glutamine ( Gln ) polymorphism at codon 399 in the XRCC 1 gene is putatively associated with DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC 1 and hOGG 1 . ^^^ To evaluate this hypothesis , this study focused on effects of genetic polymorphisms of DNA repair genes hOGG 1 and XRCC 1 on the development of NPC . ^^^ Polymorphisms of the DNA repair genes hOGG 1 ( codon 326 ) and XRCC 1 ( codon 280 ) are associated with an altered risk of NPC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Selected SNPs belong to the following genes : ADH1B , ALDH 2 , APEX , CDKN2A , COMT , CYP1A1 , CYP1A2 , CYP1B1 , CYP2A6 , CYP2C19 , CYP2C9 , CYP2E1 , CYP3A4 , DRD 2 , DRD 4 , EPHX 1 , ERCC 1 , ERCC 2 , ERCC 4 , ERCC 5 , GRPR , GSTA 4 , GSTM 3 , GSTP 1 , GSTT 2 , LIG 3 , MDM 2 , MGMT , MPO , NAT 1 , NAT 2 , NQO 1 , OGG 1 , PCNA , POLB , SLC6A3 , SOD 2 , TP 53 , XRCC 1 , XRCC 2 , XRCC 3 , and XRCC 9 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The aim of this study was to examine a common polymorphism in the DNA repair gene XRCC 1 as a potential biomarker of susceptibility modifying this relationship , consistent with the known mechanism of production of p 53 mutations via vinyl chloride induced etheno DNA adducts , which are repaired by XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We report data on the population distribution of potentially functional variants in XRCC 1 , APEX 1 , ERCC 2 , ERCC 4 , hMLH 1 , and hMSH 3 genes among groups representing individuals of European , Middle Eastern , African , Southeast Asian and North American descent . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We have genotyped polymorphic DNA repair genes preferentially involved with base excision repair ( BER ) and nucleotide excision repair ( NER ) activities ( XRCC 1 , XRCC 3 , APE 1 , XPD ) corresponding to the repair of 10 ray and UV light induced DNA damage , respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Xrcc 1 knockout embryos show increased DNA breakage and apoptosis in tissues of the embryo proper prior to death at embryonic day E6 . 5 . ^^^ The greatly reduced XRCC 1 protein level destabilized the XRCC 1 partner protein DNA ligase 3 ( LIG 3 ) but still allowed for successful mouse development and healthy , fertile adults . ^^^ Thus , a large reduction of both XRCC 1 and DNA ligase 3 has no observable effect on mouse embryogenesis and post natal development , and no significant effect on cellular sensitivity to DNA alkylation . ^^^ The presence of XRCC 1 , even at reduced levels of expression , is therefore capable of supporting mouse development and DNA repair . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
SNPs in TGFB 1 ( codons 10 , 25 and position 509 ) , SOD 2 ( codon 16 ) , XRCC 3 ( codon 241 ) , XRCC 1 ( codon 399 ) and APEX ( codon 148 ) were analyzed by PCR and single nucleotide primer extension . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA repair gene XRCC 1 , breast cancer risk , and response to radiotherapy . ^^^ The study goal was to examine the association of three polymorphisms in the XRCC 1 gene ( Arg194Trp , Arg280His , and Arg399Gln ) involved in repairing DNA damage produced by ionizing radiation , a known breast cancer ( BC ) risk factor , with BC incidence and the possibility of developing an adverse radiotherapy response . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using samples collected in an ongoing , clinic based , case control study ( 253 cases and 268 controls ) , we tested whether breast cancer risk is associated with four amino acid substitution variants in three DNA repair genes , including XRCC 1 Arg194Trp and XRCC 1 Arg399Gln in base excision repair , XRCC 3 Thr241Met in homologous recombination repair , and ERCC4 / XPF Arg415Gln in nucleotide excision repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of the DNA repair genes XRCC 1 , XRCC 3 , XPD , interaction with environmental exposures , and bladder cancer risk in a case control study in northern Italy . ^^^ A hospital based case control study was conducted in Brescia , Italy , to assess the relationship between polymorphisms in DNA repair genes XRCC 1 ( Arg ( 399 ) Gln ) , XRCC 3 ( Thr ( 241 ) Met ) , and XPD ( Lys ( 751 ) Gln ) and bladder cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A population based case control study of the Arg399Gln polymorphism in DNA repair gene XRCC 1 and risk of breast cancer . ^^^ XRCC 1 ( 10 ray repair cross complementing group 1 ) is a base excision repair protein that plays a central role in the repair of DNA base damage and strand breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This study investigates variation in somatic mutation frequency , as measured by the glycophorin A ( GPA ) somatic mutation assay , in relation to polymorphic variation among 435 newborn babies in DNA repair genes XRCC 1 , XRCC 3 and XRCC 4 and gender , parental age , social class and smoking habits . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : Genotyping for glutathione S transferase micro 1 ( GSTM 1 ) , glutathione S transferase theta 1 ( GSTT 1 ) , myeloperoxidase ( MPO ) ( C ( ) 463T ) , nicotinamide adenine dinucleotide phosphate : quinone oxidoreductase ( NQO 1 ) ( C609T ) , 5 , 10 methylenetetrahydrofolate reductase ( MTHFR ) ( C677T ) , MTHFR ( A1298C ) , methionine synthase reductase ( MTRR ) ( A66G ) , 10 ray repair cross complementing 1 ( XRCC 1 ) 194 ( Arg194Trp ) , XRCC 1 280 ( Arg280His ) , and XRCC 1 399 ( Arg399Gln ) alleles was performed by TaqMan analysis using DNA isolated from newborn heel stick spots provided by the Minnesota Department of Health . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We analysed the associations between genetic polymorphisms in genes coding for DNA repair enzymes XPD ( exon 23 A > C , K751Q ) , XPG ( exon 15 G > C , D1104H ) , XPC ( exon 15 A > C , K939Q ) , XRCC 1 ( exon 10 G > A , R399Q ) and XRCC 3 ( exon 7 C > T , T 241 M ) and the levels of chromosomal aberrations ( CAs ) and single strand breaks ( SSBs ) in peripheral lymphocytes in a central European population . ^^^ SSBs in DNA , on the other hand , were modulated by XPD ( F = 4 . 3 , P = 0 . 023 ) , XPG ( F = 4 . 3 , P = 0 . 024 ) and XRCC 1 genotypes ( F = 3 . 0 , P = 0 . 064 ) . ^^^ Irradiation specific DNA repair rates ( reflecting mainly base excision repair activity ) were affected by XRCC 1 ( F = 5 . 9 , P = 0 . 010 ) and XPC polymorphisms ( F = 4 . 2 , P = 0 . 046 , MANOVA ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 and XPD polymorphisms and risk of prostate cancer . ^^^ The 10 ray repair cross complementing group 1 ( XRCC 1 ) and xeroderma pigmentosum group D ( XPD ) genes are involved in base excision repair and nucleotide excision repair of DNA repair pathways , respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Interestingly the amino terminus of the long form aprataxin is homologous with polynucleotidekinase 3 ' phosphatase , which has been demonstrated to be involved in base excision repair , a subtype of single strand DNA break repair , through interaction with XRCC 1 , DNA polymerase beta , and DNA ligase 3 . ^^^ These results strongly support the possibility that aprataxin and XRCC 1 constitute a multiprotein complex and are involved in single strand DNA break repair , and furthermore , that accumulation of unrepaired damaged DNA underlies the pathophysiological mechanisms of EAOH . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
No induction at the transcriptional level of any of the base excision repair genes , NTH 1 ( NTHL 1 ) , OGG 1 , NEIL 1 , NEIL 2 , NEIL 3 , APE 1 , POLB , or accessory protein genes , LIG 3 , XRCC 1 or XPG , was found at gamma radiation doses ranging from 1 cGy to 2 Gy in a 24 h period . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Gene environment interactions between the smoking habit and polymorphisms in the DNA repair genes , APE 1 Asp148Glu and XRCC 1 Arg399Gln , in Japanese lung cancer risk . ^^^ APE 1 ( apurinic / apyrimidinic endonuclease 1 ) and XRCC 1 ( 10 ray cross complementing group 1 ) are DNA repair proteins that play important roles in the base excision repair ( BER ) pathway . ^^^ In the present case control study with 178 Japanese incident lung cancer cases and 449 age and sex matched controls , we investigated the gene environment interaction among APE 1 Asp148Glu , XRCC 1 Arg399Gln and smoking habit in lung cancer risk . ^^^ When APE 1 Asp148Glu and XRCC 1 Arg399Gln polymorphisms were evaluated together , the adjusted odds ratios for the current smokers with 0 1 , 2 and 3 4 of APE 1 148Glu or XRCC 1 399Gln alleles as compared with never smokers with the 0 of these alleles were 2 . 96 ( 95 % CI 1 . 57 5 . 58 , P = 0 . 001 ) , 3 . 86 ( 95 % CI 1 . 85 8 . 05 , P < 0 . 001 ) and 6 . 01 ( 95 % CI 2 . 25 16 . 1 , P < 0 . 001 ) , respectively . ^^^ The gene environment interaction between current smoking and three or more APE 1 148Glu or XRCC 1 399Gln alleles was statistically significant ( OR 2 . 44 , 95 % CI 1 . 00 9 . 22 , P = 0 . 049 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We show that this essential protein kinase phosphorylates the scaffold protein XRCC 1 and thereby enables the assembly and activity of DNA single strand break repair protein complexes in vitro and at sites of chromosomal breakage . ^^^ Moreover , we show that inhibiting XRCC 1 phosphorylation by mutation of the CK 2 phosphorylation sites or preventing CK 2 activity using a highly specific inhibitor ablates the rapid repair of cellular DNA single strand breaks by XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This study investigates the role of two nonsynonymous single nucleotide polymorphisms in DNA repair genes , 10 ray repair cross complementing group 1 ( XRCC 1 ) R399Q and 10 ray repair cross complementing group 3 ( XRCC 3 ) T241M , in breast cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To further define the contribution of XRCC 1 to DNA metabolism , we determined the in vivo localization pattern of this protein and searched for novel protein interactors . ^^^ We report here that XRCC 1 co localizes with proliferating cell nuclear antigen ( PCNA ) at DNA replication foci , observed exclusively in the S phase of undamaged HeLa cells . ^^^ The current evidence suggests a model where XRCC 1 is sequestered via its interaction with PCNA to sites of DNA replication factories to facilitate efficient SSBR in S phase . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Thus , 19 single nucleotide polymorphisms ( SNPs ) in eight genes involved in base excision repair ( XRCC 1 , APEX , POLD 1 ) , BRCA 1 protein interaction ( BRIP 1 , ZNF 350 , BRCA 2 ) , and growth regulation ( TGFss 1 , IGFBP 3 ) were evaluated . ^^^ No associations with breast cancer were observed for : APEX Q51H ; XRCC 1 R280H ; IGFPB 3 202A > C ; TGFss 1 L10P , P25R , and T263I ; BRCA 2 N289H and T1915M ; BRIP 1 64A > C ; and ZNF 350 ( or ZBRK 1 ) 1845C > T , L66P , R501S , and S472P . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 DNA polymerase beta interaction is required for efficient base excision repair . 10 ray repair cross complementing protein 1 ( XRCC 1 ) deficient cells are sensitive to DNA damaging agents and have delayed processing of DNA base lesions . ^^^ In support of its role in base excision repair , it was found that XRCC 1 forms a tight complex with DNA ligase IIIalpha and also interacts with DNA polymerase beta ( Pol beta ) and other base excision repair ( BER ) proteins . ^^^ We have isolated wild type XRCC 1 DNA ligase IIIalpha heterodimer and mutated XRCC 1 DNA ligase IIIalpha complex that does not interact with Pol beta and tested their activities in BER reconstituted with human purified proteins . ^^^ We find that a point mutation in the XRCC 1 protein which disrupts functional interaction with Pol beta , affected the ligation efficiency of the mutant XRCC 1 DNA ligase IIIalpha heterodimer in reconstituted BER reactions . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
AS primer pairs were designed for nine candidate genetic variants in DNA repair and cell cycle / apoptotic regulatory genes , including Cyclin D 1 [ codon 870 splice site variant ( A > G ) ] ; BRCA 1 , P871L ; ERCC 2 , K751Q ; FAS 1377 ( G > A ) ; hMLH 1 93 ( G > A ) and V219I ; p 21 , S31R ; and the XRCC 1 R194W and R399Q variants . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : We used polymerase chain reaction restriction fragment length polymorphism to evaluate genetic polymorphisms of the XPD ( Asp312Asn ) and XRCC 1 ( Arg399Gln ) DNA repair genes in 103 patients with stage 3 ( 54 % ) and 4 ( 46 % ) NSCLC treated with platinum based chemotherapy . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Together with data from the present study on DNA repair genes , we did not observe significant associations between any single variant genotype for several DNA repair and chemical metabolizing genes ( XPD [ or ERCC 2 ] , XRCC 1 , XRCC 3 , GSTM 1 , GSTT 1 , MPO , and mEH [ or EPHX 1 ] ) and lung cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA samples were extracted from peripheral blood specimens and genetic polymorphisms of p 53 and XRCC 1 were determined by polymerase chain reaction restriction fragment length polymorphism . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Some of the genes known to display polymorphic differences include FLT 3 receptor tyrosine kinase , FCG3RA IgG FC receptor , thymidylate synthase , methylenetetrahydrofolate reductase , thiopurine S methyltransferase , dihydropyrimidine dehydrogenase , aldehyde dehydrogenase , glutathione S transferase , uridine diphosphate glyuronosyl transferases , N acetyl transferases , cytochrome P 450 , and the DNA repair enzymes XPD and XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The Arg399Gln polymorphism in the DNA base excision repair gene XRCC 1 is associated with several phenotypic markers of reduced DNA repair capacity . ^^^ Our data are consistent with a potential role of the XRCC 1 Arg399Gln polymorphism in bladder cancer susceptibility and further suggest that there may be DNA lesions important in bladder carcinogenesis , repaired by the base excision repair mechanism , that are not directly associated with tobacco smoking . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This study examined the association between genetic polymorphisms of DNA repair gene XRCC 1 and response to cisplatin or carboplatin based chemotherapy of advanced non small cell lung cancer ( NSCLC ) . ^^^ XRCC 1 genotypes were determined by PCR RFLP methods using DNA samples isolated from peripheral blood collected before treatment . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We found previously that glioma patients were susceptible to gamma ray induced chromosomal breaks , which may be influenced by genetic variation in genes involved in DNA strand breaks , such as XRCC 1 in single strand break repair , XRCC 3 and RAD 51 in homologous recombination repair , and XRCC 7 in nonhomologous end joining double strand break repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Several polymorphisms in DNA repair genes have been reported to be associated with lung cancer risk including XPA ( 4G / A ) , XPD ( Lys751Gln and Asp312Asn ) , XRCC 1 ( Arg399Gln ) , APE 1 ( Asp148Glu ) and XRCC 3 ( Thr241Met ) . ^^^ Combinations of polymorphisms in genes involved in the same repair pathway ( XPA + XPD or XRCC 1 + APE 1 ) affected lung cancer risk only in patients with SCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Expression of phospho extracellular signal regulated kinase ( ERK ) 1 / 2 and phospho epidermal growth factor receptor ( EGFR ) and the DNA repair proteins XRCC 1 and ERCC 1 were determined by Western analyses . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Furthermore , we characterized repair pathways by using repair defective mammalian cells and found that DNA polymerase beta accumulated at single strand breaks and oxidative base damage by means of its 31 and 8 kDa domains , respectively , and that XRCC 1 is essential for both polymerase beta dependent and proliferating cell nuclear antigen dependent repair pathways of single strand breaks . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : In the current study , the authors investigated the association between polymorphisms in 3 genes glutathione S transferase M 1 ( GSTM 1 ) , glutathione S transferase T 1 ( GSTT 1 ) , and XRCC 1 , with roles in protection from a variety of DNA damaging agents and the risk of subsequent malignancy in 650 survivors of HD enrolled in the Childhood Cancer Survivor Study who had received radiotherapy . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The ataxia oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC 1 and XRCC 4 . ^^^ Strikingly , however , aprataxin physically interacts in vitro and in vivo with the DNA strand break repair proteins XRCC 1 and XRCC 4 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genotypes of DNA repair genes 10 ray repair cross complementation group 1 ( XRCC 1 codons 194 , 280 , 399 ) and 3 ( XRCC 3 codon 241 [ corrected ] ) , and XME genes glutathione S transferase ( GST ) M 1 and T 1 and N acetyl transferase 2 ( NAT 2 ) were determined using polymerase chain reaction ( PCR ) and restriction fragment length polymorphism ( RFLP ) based methods . ^^^ Our results are in line with earlier findings on the influence of NAT 2 , GSTT 1 , and GSTM 1 polymorphisms on the level of lymphocyte chromosome damage and suggest that also XRCC 1 polymorphism affects CA frequencies , thus apparently influencing DNA repair phenotype . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Moreover , repair of normal abasic sites in wild type and 10 ray cross complementing gene 1 ( XRCC 1 ) DNA ligase IIIalpha immunodepleted cell extracts involved similar proportions of short and long patch repair events . ^^^ This suggests that DNA ligase 1 was able to efficiently substitute the XRCC 1 DNA ligase IIIalpha complex during short patch repair . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
After 24 h of repair , lower residual DNA damage was found in individuals homozygous for XRCC 1 Arg ( 194 ) ( P = 0 . 013 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In the present study , we investigated markers of genotoxicity [ chromosomal aberrations ( CAs ) and single strand breaks ( SSBs ) ] in a cohort of 110 tire plant workers engaged in jobs with different levels of xenobiotic exposure in relation to various polymorphisms in genes coding for biotransformation enzymes ( CYP1A1 , CYP2E1 , EPHX 1 , GSTM 1 , GSTP 1 , and GSTT 1 ) and in genes involved in DNA repair ( XPD exon 23 , XPG exon 15 , XPC exon 15 , XRCC 1 exon 10 , and XRCC 3 exon 7 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 194Trp , OGG 1 326Cys and APE 1 148Glu probably have limited alterations in repair activities compared to the wild type genotypes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
These complexes contain proteins required for both types of BER , including UNG 2 , APE 1 , POLbeta , POLdelta , XRCC 1 , PCNA and DNA ligase , the latter detected as activity . ^^^ Neutralizing antibodies to APE 1 and POLbeta , and depletion of XRCC 1 strongly reduced short patch BER , and a fraction of long patch repair was POLbeta dependent . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Are genetic polymorphisms in OGG 1 , XRCC 1 and XRCC 3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations . ^^^ Analysis of the total population revealed that genetic polymorphisms in XRCC 1 resulted in higher residual DNA ( RDNA ) values and the Met / Met variant of XRCC 3 resulted in an increased frequency of micronuclei . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In a nested case cohort study that originated from two cancer prevention trials in Linxian , we examined the relationship between these cancers and two polymorphisms in the DNA repair gene XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Manganese superoxide dismutase ( SOD 2 ) catalyzes the dismutation of superoxide radicals , a major type of ROS , into hydrogen peroxide . p 53 is a tumor suppressor gene , and 10 ray cross complementing group 1 ( XRCC 1 ) is involved in the base excision repair of ROS induced DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In our previous study , we found that APTX interacts with 10 ray repair cross complementing group 1 ( XRCC 1 ) , a scaffold protein with an essential role in single strand DNA break repair ( SSBR ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 polymorphisms in childhood acute lymphoblastic leukemia . ^^^ Genetic polymorphisms in XRCC 1 gene could , through alteration of protein structure , lead to defective functioning of DNA Polbeta , PARP and LIG 3 enzymes resulting in defective DNA repair and increased risk of childhood acute lymphoblastic leukemia ( ALL ) . ^^^ The role of DNA repair gene XRCC 1 in susceptibility to childhood ALL has , however , not been widely studied and no data exists from Indian children . ^^^ In this pilot study , through the use of PCR and RFLP , further confirmed by DNA sequencing , we have shown an increased risk of ALL among children with XRCC 1 codons 194 and 399 variant genotypes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The distribution of polymorphic variants of XPD , XRCC 1 and XRCC 3 DNA repair genes in the group of laryngeal cancer subjects ( n = 293 ) , subjects with second primary tumours ( n = 84 ) and in the matched controls ( n = 322 ) was estimated by PCR based genotyping . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Biophysical characterization of human XRCC 1 and its binding to damaged and undamaged DNA . ^^^ XRCC 1 bound both nicked and 1 nucleotide gapped DNA substrates tightly in a stoichiometric manner ( 1 : 1 ) with K ( d ) values of 65 and 34 nM , respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
APE 1 overexpression in XRCC 1 deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability . ^^^ To further define the defects leading to genetic instability in XRCC 1 deficient cells , we overexpressed the AP endonuclease APE 1 , shown previously to interact with and be stimulated by XRCC 1 . ^^^ Here , we report that the overexpression of APE 1 can compensate for the impaired capability of XRCC 1 deficient cells to repair SSBs induced by oxidative DNA damage , both in vivo and in whole cell extracts . ^^^ Conversely , APE 1 overproduction resulted in a 3 fold increase in the sensitivity of XRCC 1 deficient cells to an alkylating agent , most probably due to the accumulation of SSBs . ^^^ Finally , the overproduction of APE 1 results in increases of 40 % in the frequency of micronuclei and 33 % in sister chromatid exchanges of XRCC 1 cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Translocation of XRCC 1 and DNA ligase IIIalpha from centrosomes to chromosomes in response to DNA damage in mitotic human cells . ^^^ Here , we show that XRCC 1 and its partner protein , DNA ligase IIIalpha , localize at the centrosomes and their vicinity in metaphase cells and disappear during anaphase . ^^^ On treatment of metaphase cells with H2O2 , XRCC 1 and DNA ligase IIIalpha translocate immediately from the centrosomes to mitotic chromosomes . ^^^ These results show for the first time that the repair of SSBs is present in the early mitotic chromosomes and that there is a dynamic response of XRCC 1 and DNA ligase IIIalpha to SSBs , in which these proteins are recruited from the centrosomes , where metaphase dependent activation of PAR polymerase occurs , to mitotic chromosomes , by SSBs dependent activation of PAR polymerase . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in DNA repair gene XRCC 1 and increased genetic susceptibility to breast cancer . 10 ray repair cross complementing 1 ( XRCC 1 ) gene encodes for a scaffolding protein , which plays an important role in base excision DNA repair by bringing together DNA polymerase beta , DNA ligase 3 and poly ( ADP Ribose ) polymerase ( PARP ) at the site of DNA damage . ^^^ In the present study we sought to determine whether these genetic variants of the XRCC 1 gene was associated with any increased risk of breast cancer among the South Indian women in a hospital based case control study using PCR RFLP and DNA sequencing techniques . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
BACKGROUND : The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens ( GSTT 1 , GSTM 1 , GSTP 1 ) and one polymorphism of a DNA repair gene ( XRCC 1 ) for patients diagnosed with squamous cell carcinoma ( SCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This study was designed to examine the polymorphisms associated with three DNA repair genes , namely : XRCC 1 Arg399Gln , XRCC 3 Thr241Met and XPD Lys751Gln , and investigate their role as susceptibility markers for colorectal cancer . ^^^ METHODS : We conducted a case control study including 727 cases of cancer and 736 hospital based age and sex matched healthy controls to examine the role of genetic polymorphisms of three DNA repair genes ( XRCC 1 , XRCC 3 and XPD ) in the context of colorectal cancer risk for the Taiwanese population . ^^^ Genomic DNA isolated from 10 ml whole blood was used to genotype XRCC 1 Arg399Gln , XRCC 3 Thr241Met and XPD Lys751Gln by means of polymerase chain reaction ( PCR ) and restriction fragment length polymorphism ( RFLP ) analysis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
When constitutively expressed in uninfected T lymphocytes , IRF 4 caused reduced expression of critical DNA repair genes , including Rad 51 , XRCC 1 , Ung 1 , RPA , and proliferative cell nuclear antigen ( PCNA ) , a transcriptional phenotype with striking similarities to the profile observed in HTLV infected T lymphocytes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in DNA base excision repair genes ADPRT and XRCC 1 and risk of lung cancer . ^^^ Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are two major DNA base excision repair ( BER ) proteins and act interactively in stimulating and executing BER processes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Cytokine gene polymorphisms for IFN gamma ( +874A > T ) and IL 10 ( 1082G > A ) were assessed . 10 ray repair cross complementing gene 1 ( XRCC 1 ; Arg399Gln ) , xeroderma pigmentosum complementary group D ( XPD ; Lys751Gln ) , and excision repair cross complementing gene 1 ( ERCC 1 ; codon 118 ) DNA repair polymorphisms were also determined . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in XRCC 1 modify the association between polycyclic aromatic hydrocarbon DNA adducts , cigarette smoking , dietary antioxidants , and breast cancer risk . ^^^ The variability in DNA repair capacity of the general population may depend in part upon common variants in DNA repair genes . 10 ray repair cross complementing group 1 ( XRCC 1 ) is an important DNA base excision repair gene and exhibits polymorphic variation . ^^^ Using the Long Island Breast Cancer Study Project , a population based case control study , we evaluated the hypothesis that two common single nucleotide polymorphisms of XRCC 1 ( codon 194 Arg > Trp and 399 Arg > Gln ) influence breast cancer susceptibility and interact with polycyclic aromatic hydrocarbon ( PAH ) DNA adducts , cigarette smoking , and intake of fruits and vegetables and antioxidants . ^^^ However , there is evidence for interactions between the two XRCC 1 single nucleotide polymorphisms and PAH DNA adducts or fruit and vegetable and antioxidant intake on breast cancer risk . ^^^ Further understanding of the biological function of XRCC 1 variants and their interactions with PAH DNA adducts , antioxidants , and other genes in the pathway are needed . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We investigated genetic polymorphisms in carcinogen metabolizing ( GSTM 1 , GSTT 1 , HYL1 * 2 ) and DNA repair ( XRCC 1 ) enzymes in a hospital based case control study . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We examined whether variations in genes involved in base excision ( hOGG 1 , XRCC 1 ) and double strand break ( XRCC 3 ) DNA repair contribute to inter individual differences in genotoxic effects induced in the lymphocytes of 21 cobalt ( Co ) exposed , 26 hard metal ( WC Co ) exposed and 26 matched control male workers . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Therefore , we also analyzed whether environmental and genetic factors associated with DNA damage , i . e . smoking and polymorphisms in the genes involved in the metabolism of genotoxic carcinogens ( EPHX 1 , GSTA 1 , GSTM 1 , GSTP 1 , GSTT 1 , NAT 1 , NAT 2 and NQO 1 ) or DNA repair ( APE 1 , NBS 1 , XPC , XPD , XRCC 1 , XRCC 3 and XRCC 4 ) , could modify the association between telomere length and cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA repair gene XRCC 1 Arg399Gln polymorphism is associated with increased risk of uterine leiomyoma . ^^^ BACKGROUND : DNA repair gene XRCC 1 Arg399Gln polymorphism has been associated with the risk of several human tumours . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Associations between XRCC 1 and ERCC 2 polymorphisms and DNA damage in peripheral blood lymphocyte among coke oven workers . ^^^ In this study , alkaline comet assay was used to detect the DNA damage in peripheral blood lymphocytes among 143 coke oven workers and 50 non coke oven workers , and the effects of genetic polymorphisms of XRCC 1 and ERCC 2 genes on DNA damage were evaluated . ^^^ The study showed that the alkaline comet assay is a suitable biomarker in the detection of DNA damage among coke oven workers and it suggested that the A allele of G27466A polymorphism of XRCC 1 may be associated with decreased DNA repair capacity toward PAH induced base damage and strand breaks . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To investigate whether two of these polymorphisms directly influence their repair ability , we established Chinese hamster ovary ( CHO ) EM 9 cell lines transfected with XRCC 1 ( WT ) , XRCC 1 ( R194W ) , or XRCC 1 ( R280H ) genes and analyzed the DNA repair ability of these cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Additionally , we summarized breast cancer risk associated with the following genetic factors : breast cancer susceptibility high penetrance genes ( BRCA 1 , BRCA 2 , p 53 , PTEN , ATM , NBS 1 or LKB 1 ) and low penetrance genes such as cytochrome P 450 genes ( CYP1A1 , CYP2D6 , CYP 19 ) , glutathione S transferase family ( GSTM 1 , GSTP 1 ) , alcohol and one carbon metabolism genes ( ADH1C and MTHFR ) , DNA repair genes ( XRCC 1 , XRCC 3 , ERCC4 / XPF ) and genes encoding cell signaling molecules ( PR , ER , TNFalpha or HSP 70 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We evaluated how three XRCC 1 polymorphisms , Arg194Trp , Arg280His and Arg399Gln , affect the extent of DNA damage and repair using the micronucleus assay . ^^^ Only XRCC 1 cDNA containing the Arg399Gln polymorphism did not fully correct the DNA repair defect in EM 9 cells . ^^^ These results indicate that the Arg399Gln polymorphism , but not the Arg194Trp or Arg280His polymorphism , influences the ability of XRCC 1 to repair DNA . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms in the DNA base excision repair genes APEX 1 and XRCC 1 and lung cancer risk in Xuan Wei , China . ^^^ Homozygous carriers of the APEX 1 148Glu variant had an increased risk ( OR , 2 . 13 ; 95 % CI , 0 . 96 4 . 74 ) , whereas persons with the XRCC 1 399Gln allele had a decreased risk ( OR , 0 . 60 ; 95 % CI , 0 . 35 1 . 02 ) of lung cancer compared with wild type carriers . ^^^ Subjects with both at risk genotypes ( APEX 1 Glu148Glu and XRCC 1 Arg399Arg ) had a higher risk of lung cancer ( OR : 3 . 34 ; 95 % CI : 1 . 16 9 . 67 ) . ^^^ We found genetic variants in APEX 1 and XRCC 1 may alter the risk of lung cancer in a special population in China . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA from peripheral blood samples was genotyped for single nucleotide polymorphisms ( SNP ) in 12 genes : NF 2 , XRCC 1 , XRCC 3 , XRCC 5 , ERCC 2 , Ki ras , p 16 , cyclin D 1 , PTEN , E cadherin , TGFB 1 , and TGFBR 2 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 and DNA polymerase beta interaction contributes to cellular alkylating agent resistance and single strand break repair . 10 ray cross complementing 1 ( XRCC 1 ) protein has been suggested to bind to DNA single strand breaks ( SSBs ) and organize protein interactions that facilitate efficient DNA repair . ^^^ Using four site specifically modified human XRCC 1 mutant expression systems and functional complementation assays in Chinese hamster ovary ( CHO ) XRCC 1 deficient EM 9 cells , we evaluated the cellular contributions of XRCC1s proposed N terminal domain ( NTD ) DNA binding and DNA polymerase beta ( POLbeta ) interaction activities . ^^^ Our data favor a model where the interaction of XRCC 1 with POLbeta contributes to efficient DNA repair in vivo , whereas its interactions with target DNA is biologically less relevant . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 is required for DNA single strand break repair in human cells . ^^^ The 10 ray repair cross complementing 1 ( XRCC 1 ) protein is required for viability and efficient repair of DNA single strand breaks ( SSBs ) in rodents . ^^^ XRCC 1 deficient mouse or hamster cells are hypersensitive to DNA damaging agents generating SSBs and display genetic instability after such DNA damage . ^^^ A reduction in XRCC 1 protein levels resulted in decreased SSBR capacity as measured by the comet assay and intracellular NAD ( P ) H levels , hypersensitivity to the cell killing effects of the DNA damaging agents methyl methanesulfonate ( MMS ) , hydrogen peroxide and ionizing radiation and enhanced formation of micronuclei following exposure to MMS . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using genomic DNA extracted from blood samples , we identified wild type and polymorphic variants of XPD ( Arg156Arg and Lys751Gln ) , XRCC 1 ( Arg194Trp and Arg399Gln ) and XRCC 3 ( Thr241Met ) , and the poly ( AT ) insertion / deletion of XPC ( PAT ) . ^^^ The protective effect of the homozygous variant of XRCC 1 Arg399Gln for GERD and BE suggests that base excision repair alterations may occur early in progression to EADC , likely in response to GERD induced endogenous oxidative or inflammatory DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The differentially expressed genes between diffuse and nodular samples included some related to DNA stability and repair ( TALDO 1 , PRDX 2 , DDB 1 , XRCC 1 , and POLB ) , RNA stability and degradation ( OASL and AUF 1 ) , protein synthesis and processing ( PFDN 5 , HSPD 1 , and NACA ) , cell growth ( CDC25C and GRPR ) , and tumorigenesis and cell cycle ( VIL 2 and TPD 52 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Six single nucleotide polymorphisms of five DNA repair genes representing three distinct repair pathways were interrogated including : XRCC 1 ( Arg399Gln ) , APE 1 ( Asp148Glu ) , XRCC 3 ( Thr241Met ) , hOGG 1 ( Ser326Cys ) , XPD ( Asp312Asn , Lys751Gln ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
X ray repair cross complementing group 1 polymorphisms and cancer risks in Asian populations : a mini review . 10 ray repair cross complementing group 1 ( XRCC 1 ) is an important DNA repair protein . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The polymorphisms of genes involved in carcinogen metabolic activation ( CYP1A1 , CYP2E1 ) , detoxication ( GSTM 1 , GSTT 1 , GSTM 3 , NAT 2 , ) and DNA repair ( XPD / A35931C exon 23 and C22541A exon 6 / , XRCC 1 / G28152A exon 10 and C26304T exon 6 / , XRCC3 / C18067T / ) were studied by PCR based techniques to analyze genotypes and allele distribution in 84 patients with MPT correlated with 182 subjects with a single tumor of head and neck and 143 cancer free male volunteers recruited from healthy smokers . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This hospital based case control study examined whether polymorphic DNA repair genes : XRCC 1 Arg399Gln , XRCC 3 Thr241Met and XPD Lys751Gln , play a role in the susceptibility to colorectal cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 interactions with multiple DNA glycosylases : a model for its recruitment to base excision repair . ^^^ XRCC 1 participates in the first step of BER by interacting with the human DNA glycosylases hOGG 1 and NEIL 1 . ^^^ To analyze the possibility of a general mechanism involving the interaction of XRCC 1 with DNA glycosylases we used XRCC 1 to pull down DNA glycosylases activities from human cell extracts . ^^^ XRCC 1 co purifies with DNA glycosylase activities capable of excising hypoxanthine and dihydrothymine , in addition to 8 oxoguanine , but not uracil . ^^^ In vivo localization studies show that after genotoxic treatments these DNA glycosylases can be found associated with XRCC 1 foci . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A number of proteins , including histones , DNA topoisomerases , DNA methyltransferase 1 as well as DNA damage repair and checkpoint proteins ( p 23 , p 21 , DNA PK , NF kB , XRCC 1 , and others ) can be targeted in this manner ; the interaction involves a specific poly ( ADP ribose ) binding sequence motif of 20 26 amino acids in the target domains . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A promoter polymorphism ( 77T > C ) of DNA repair gene XRCC 1 is associated with risk of lung cancer in relation to tobacco smoking . 10 ray repair cross complementing group 1 ( XRCC 1 ) is one of the major DNA repair proteins involved in the base excision repair pathway . ^^^ Functional Polymorphisms in the XRCC 1 gene may lead to decreased DNA repair capacity and thus confer inherited predisposition to cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To investigate the potential role of DNA repair polymorphisms in this variation , genotypes of DNA repair genes OGG 1 ( codon 326 ) , XPD ( codon 751 ) , XRCC 1 ( 10 ray repair cross complementing group 1 ) ( codons 194 , 280 , and 399 ) , and XRCC 3 ( 10 ray repair cross complementing group 3 ) ( codon 241 ) were determined from leukocyte DNA using polymerase chain reaction based methods . ^^^ Our data suggest that the XRCC 1 280His and XRCC 3 241Met alleles affect individual CA levels , most probably via influencing the DNA repair phenotype . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Specificity of protein interactions mediated by BRCT domains of the XRCC 1 DNA repair protein . ^^^ Common to these pathways is the essential XRCC 1 DNA repair protein , which interacts with at least nine other proteins and DNA . ^^^ Here , we characterized the interactions of four purified BRCT domains , two from XRCC 1 and their two partners from DNA ligase IIIalpha and poly ( ADP ribosyl ) polymerase 1 . ^^^ A structural model for a XRCC 1 10 DNA ligase IIIalpha heterotetramer is proposed as a core base excision repair complex , which constitutes a scaffold for higher order complexes to which other repair proteins and DNA are brought into proximity . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Association between polymorphisms in the DNA repair genes , XRCC 1 , APE 1 , and XPD and acute side effects of radiotherapy in breast cancer patients . ^^^ We evaluated the association of six polymorphisms in the DNA repair genes : XRCC 1 ( Arg194Trp , Arg280His , and Arg399Gln ) , APE 1 ( Asp148Glu ) , and XPD ( Lys751Gln and Asp312Asn ) , with the risk of acute skin reactions following radiotherapy . ^^^ Among normal weight patients only , both carriers of the APE 1 148Glu and the XRCC 1 399Gln alleles had decreased risk of acute skin reactions after radiotherapy ( HR , 0 . 49 and 0 . 51 , respectively ) . ^^^ When considering joint effects , we observed that compared with homozygote carriers of the wild type allele in both genes , the risk was most strongly reduced in carriers of both APE 1 148Glu and XRCC 1 399Gln alleles with normal weight [ HR , 0 . 19 ; 95 % confidence interval ( 95 % CI ) , 0 . 06 0 . 56 ] but not in those with overweight ( HR , 1 . 39 ; 95 % CI , 0 . 56 3 . 45 ; Pinteraction = 0 . 009 ) . ^^^ CONCLUSION : The XRCC 1 399Gln or APE 1 148Glu alleles may be protective against the development of acute side effects after radiotherapy in patients with normal weight . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Radiosensitization by a dominant negative to DNA polymerase beta is DNA polymerase beta independent and XRCC 1 dependent . ^^^ BACKGROUND AND PURPOSE : DNA base damages and single strand breaks after ionizing radiation are repaired by base excision repair ( BER ) and single strand break repair ( SSBR ) , with both DNA polymerase beta ( polbeta ) and XRCC 1 playing key roles . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Pooling data and DNA specimens from three case control studies in western Washington State , North Carolina , and Puerto Rico , totaling 555 cases ( 430 whites ) and 792 controls ( 695 whites ) , we studied the risk of head and neck cancer in relation to common nonsynonymous single nucleotide polymorphisms in four DNA repair genes : MGMT ( Leu84Phe and Ile143Val ) , XRCC 1 ( Arg399Gln ) , XPD ( Lys751Gln ) , and XRCC 3 ( Thr241Met ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Several potential functional polymorphisms ( Arg194Trp , Arg280His , Arg399Gln ) in the DNA base excision repair gene 10 ray repair cross complementing group 1 ( XRCC 1 ) have been implicated in cancer risk . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In a subgroup of 32 nonsmokers and 31 smokers we also studied polymorphisms in XPD ( Lys751Gln ) , XRCC 1 ( Arg399Gln ) and XRCC 3 ( Thr241Val ) because they are part of DNA repair pathways involved in the repair of tobacco related DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Influence of polymorphisms in DNA repair genes XPD , XRCC 1 and MGMT on DNA damage induced by gamma radiation and its repair in lymphocytes in vitro . ^^^ DNA single strand breaks ( SSBs ) were quantified by single cell gel electrophoresis and micronucleated and apoptotic cells were quantified by microscopic assays in peripheral blood lymphocytes after irradiation on ice with 2 Gy of 60Co gamma radiation , and their association with polymorphisms of genes that encode proteins of different DNA repair pathways and influence cancer risk ( XPD codon 312Asp > Asn and 751Lys > Gln , XRCC 1 399Arg > Gln , and MGMT 84Leu > Phe ) was studied . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We investigated in a central European population , the association between genetic polymorphisms in several genes coding for xenobiotic metabolizing enzymes ( CYP1A1 , CYP2E1 , EPHX 1 , GSTP 1 , GSTM 1 and GSTT 1 ) and in DNA repair genes ( XPD , XPG , XPC and XRCC 1 ) and the levels of single strand breaks ( SSBs ) and SSB endonuclease 3 sensitive sites ( endoIII sites ) in peripheral blood lymphocytes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The role of individual polymorphisms has been evaluated for several genes including the CYP and glutathione s transferase superfamilies , and the NAT genes ; DNA repair genes such as XPD ( nucleotide excision pathway ) , XRCC 1 ( base excision pathway ) , and MGMT ; and tumor suppressor or cell cycle genes such as p 53 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA polymerase beta promotes recruitment of DNA ligase 3 alpha XRCC 1 to sites of base excision repair . ^^^ We find that after dissociation of AP endonuclease from the incised abasic site , both DNA polymerase beta ( Pol beta ) and the DNA ligase IIIalpha XRCC 1 heterodimer efficiently bind / cross link to the substrate DNA . ^^^ We also find that the cross linking efficacy of the DNA ligase IIIalpha XRCC 1 heterodimer was decreased about 2 fold in the Pol beta deficient cell extract but was rescued by addition of purified wild type but not a mutant Pol beta protein that does not interact with the DNA ligase IIIalpha XRCC 1 heterodimer . ^^^ We further demonstrate that Pol beta and the DNA ligase IIIalpha XRCC 1 heterodimer are present at equimolar concentrations in whole cell extracts and that Pol beta has a 7 fold higher affinity to the incised abasic site containing substrate than DNA ligase IIIalpha . ^^^ Using gel filtration of whole cell extracts prepared at physiological salt conditions ( 0 . 15 M NaCl ) , we find no evidence for a stable preexisting complex of DNA Pol beta with the DNA ligase IIIalpha XRCC 1 heterodimer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Microsatellite polymorphisms in DNA repair genes XRCC 1 , XRCC 3 and XRCC 5 in patients with gynecological tumors : association with late clinical radiosensitivity and cancer incidence . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Three coding polymorphisms at codons 194 , 280 , and 399 in 10 ray cross complementing group 1 ( XRCC 1 ) DNA repair gene have been identified , and it is possible that these polymorphisms may affect DNA repair capacity and thus modulate cancer susceptibility . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
APE 1 and XRCC 1 protein expression levels predict cancer specific survival following radical radiotherapy in bladder cancer . ^^^ We therefore investigated the prognostic value of the DNA repair proteins APE 1 and XRCC 1 in patients with muscle invasive bladder cancer treated by radical radiotherapy . ^^^ MATERIALS AND METHODS : The tumors of 90 patients with muscle invasive transitional cell carcinoma and known clinical outcomes were immunostained with APE 1 and XRCC 1 antibodies . ^^^ RESULTS : The median percentage of nuclear staining for APE 1 was 98 . 7 % ( range , 42 . 2 100 % ) and for XRCC 1 was 96 . 5 % ( range , 0 . 6 99 . 6 % ) . ^^^ High expression levels of APE 1 or XRCC 1 ( > or = 95 % positivity ) were associated with improved patient cancer specific survival ( log rank , P = 0 . 02 and 0 . 006 , respectively ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We investigated 44 single nucleotide polymorphisms ( SNPs ) in 20 DNA repair genes including nucleotide excision repair ( NER ) genes XPA , ERCC 1 , ERCC2 / XPD , ERCC4 / XPF and ERCC5 / XPG ; base excision repair ( BER ) genes APE1 / APEX , OGG 1 , MPG , XRCC 1 , PCNA , POLB , POLiota , LIG 3 and EXO 1 ; double strand break repair ( DSB R ) genes XRCC 2 , XRCC 3 , XRCC 9 , NBS 1 and ATR ; and direct damage reversal ( DR ) gene MGMT / AGT . ^^^ The variant alleles of XRCC 1 ( Arg280His ) , XRCC 1 ( Arg399Gln ) , ERCC 1 ( G8092T ) , ERCC 5 ( His46His ) and MGMT / AGT ( Lys178Arg ) were more frequent in patients with PAH DNA adduct levels lower than the mean whereas the XRCC 1 ( Arg194Trp ) variant was more frequent in cases with higher adduct levels than the mean . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
PURPOSE : The 10 ray repair cross complementing Group 1 ( XRCC 1 ) protein is involved mainly in the base excision repair of the DNA repair process . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The authors conducted meta analyses of associations between genes in the base excision repair pathway and cancer risk , focusing on three key genes : 8 oxoguanine DNA glycosylase ( OGG 1 ) , apurinic / apyrimidinic endonuclease ( APE1 / APEX1 ) , and 10 ray repair cross complementing group 1 ( XRCC 1 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Risk assessment of welders using analysis of eight metals by ICP MS in blood and urine and DNA damage evaluation by the comet and micronucleus assays ; influence of XRCC 1 and XRCC 3 polymorphisms . ^^^ The XRCC 1 variant allele coding Gln amino acid at position 399 was found to be associated with a higher number of DNA breaks as revealed by the comet assay . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA damage levels and biochemical repair capacities associated with XRCC 1 deficiency . ^^^ Base excision repair ( BER ) is the major corrective pathway for most spontaneous , oxidative , and alkylation DNA base and sugar damage . 10 ray cross complementing 1 ( XRCC 1 ) has been suggested to function at nearly every step of this repair process , primarily through direct protein protein interactions . ^^^ Using whole cell extract ( WCE ) repair assays and DNA damage measurement techniques , we examined systematically the quantitative contribution of XRCC 1 to specific biochemical steps of BER and single strand break repair ( SSBR ) . ^^^ Abasic site incision activity was found to be normal in XRCC 1 deficient cell extracts , as were the levels of abasic sites in isolated chromosomal DNA from mutant cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In this study , we evaluated if polymorphisms in DNA repair genes XRCC 1 ( Arg280His , Arg399Gln ) and XPD ( Lys751Gln ) modify individual breast cancer risk , with emphasis on tobacco smoking . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We analyzed 13 polymorphisms in seven DNA repair genes belonging to different repair pathways [ 10 ray repair cross complementing group 1 ( XRCC 1 ) : 26304C > T , 26651A > G , 28152A > G ; xeroderma pigmentosum D ( XPD ) : 23591A > G , 35931A > C ; excision repair complementing defective in Chinese hamster , group 1 ( ERCC 1 ) : 19007C > T ; XRCC 3 : 4541T > C , 17893A > G , 18067C > T ; proliferating cell nuclear antigen ( PCNA ) : 6084G > C ; ERCC 4 : 30028C > T , 30147A > G ; and XRCC 2 31479A > G ] in 317 incident bladder cancer patients and 317 controls . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genetic polymorphisms in XRCC 1 , APE 1 , ADPRT , XRCC 2 , and XRCC 3 and risk of chronic benzene poisoning in a Chinese occupational population . ^^^ Because benzene induced DNA damage includes single and double strand breaks , we hypothesized that single nucleotide polymorphisms in 10 ray repair cross complementing group 1 ( XRCC 1 ) , apurinic / apyrimidinic endonuclease ( APE 1 ) , ADP ribosyltransferase ( ADPRT ) , 10 ray repair cross complementing group 2 ( XRCC 2 ) , and 10 ray repair cross complementing group 3 ( XRCC 3 ) are associated with risk of CBP . ^^^ We genotyped single nucleotide polymorphisms at codons 194 , 280 , and 399 of XRCC 1 , codon 148 of APE 1 , codon 762 of ADPRT , codon 188 of XRCC 2 , and codon 241 of XRCC 3 in 152 CBP patients and 152 healthy workers frequency matched on age and sex among those who were occupationally exposed to benzene . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This domain interacts with threonine phosphorylated XRCC 1 and XRCC 4 , proteins responsible for the recruitment of PNK to sites of DNA strand break repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
CONCLUSIONS : Polymorphisms in the DNA repair enzyme gene XRCC 3 241Met was associated with an increased risk of second neoplasms , and polymorphisms of the XRCC 1 399Gln gene were associated with a decreased risk of all cause mortality in patients with primary OSCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Nine known single nucleotide polymorphisms ( SNPs ) in five common DNA repair genes were investigated : XRCC 1 ( Arg194Trp and Arg399Gln ) ; XRCC 3 ( Thr241Met ) ; XPC ( PAT and Lys939Gln ) ; XPD ( exon 6 , and Lys751Gln ) ; and MGMT ( Trp65Cys and Leu84Phe ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In this study we assessed the dose dependent effect of genetic polymorphisms in biotransforming ( EPHX ( Tyr113 / His113 and His139 / Arg139 ) , GSTP 1 ( Ile105 / Val105 ) , GSTM 1 and GSTT 1 ) and DNA repair enzymes ( hOGG 1 ( Ser326 / Cys326 ) , XRCC 1 ( Arg194 / Trp194 , Arg280 / His280 , Arg399 / Gln399 ) , XRCC 3 ( Thr241 / Met241 ) ) on the induced genotoxicity . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC 1 to risk of gastric cancer ] . ^^^ BACKGROUND & OBJECTIVE : Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are 2 major DNA base excision repair ( BER ) proteins and act interactively in stimulating and executing BER processes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Association between polymorphisms in the DNA repair genes XRCC 1 and APE 1 , and the risk of prostate cancer in white and black Americans . ^^^ PURPOSE : XRCC 1 and APE 1 are enzymes involved in the repair of DNA strand breaks and base damage that arise from various endogenous and exogenous oxidants . ^^^ We determined whether polymorphisms in XRCC 1 and APE 1 increase the risk of prostate cancer . ^^^ Polymorphisms at codon 399 in XRCC 1 , and at codons 51 and 148 in APE 1 were determined using an restriction fragment length polymorphism method . ^^^ When APE 1 and XRCC 1 polymorphisms were evaluated together , we found an increased risk of the XRCC 1 ( 399Arg / Gln+Gln / Gln ) / APE1 ( 51Gln / Gln ) ( OR 4 . 0 , 95 % CI 1 . 3 to 12 . 5 ) and XRCC 1 ( 399Arg / Gln+Gln / Gln ) / APE1 ( 148Asp / Asp ) ( OR 2 . 9 , 95 % CI 1 . 4 to 6 . 1 ) genotypes in white men . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms of DNA repair genes XRCC 1 and XRCC 3 , interaction with environmental exposure and risk of chronic gastritis and gastric cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Roles of DNA ligase 3 and XRCC 1 in regulating the switch between short patch and long patch BER . ^^^ Employing a reconstituted BER complex containing among others DNA polymerase beta ( Pol beta ) , DNA ligase 3 ( Lig 3 ) and XRCC 1 , here we show that Lig 3 and XRCC 1 are essential mediators of this regulation . ^^^ XRCC 1 stimulates Pol beta strand displacement activity and releases inhibition of Pol beta by DNA bound Lig 3 if ligation is prevented . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
INTRODUCTION : The gene XRCC 1 ( 10 ray repair cross complementing group 1 ) encodes a protein involved in DNA base excision repair . ^^^ Two non synonymous polymorphisms in XRCC 1 ( Arg194Trp and Arg399Gln ) have been shown to alter DNA repair capacity in some studies in vitro . ^^^ We also examined whether factors associated with DNA damage , such as smoking and antioxidant intake , modified the association between XRCC 1 polymorphisms and breast cancer . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymorphisms have been identified in several DNA repair genes , such as XRCC 1 , XPD , XRCC 3 , and RAD 51 , but the influence of specific genetic variants on repair phenotype and cancer risk has not yet been clarified . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We evaluated whether genetic variation in six BER pathway genes ( XRCC 1 , ADPRT , APEX 1 , OGG 1 , LIG 3 , and MUTYH ) is associated with breast cancer risk in two large population based case control studies in the United States ( 3 , 368 cases and 2 , 880 controls ) and Poland ( 1 , 995 cases and 2 , 296 controls ) . ^^^ S . study participants with mouthwash DNA , we found no significant overall association between breast cancer risk and XRCC 1 R280H and R194W , ADPRT V726W , APEX 1 D148E , OGG 1 S326C , LIG 3 R780H , or MUTYH 5 ' untranslated region . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To test this hypothesis , DNA samples from 112 cases of renal cell cancer and healthy controls ( n=180 ) were analyzed by PCR RFLP to determine the genotypic frequency of six different polymorphic loci on five DNA repair genes ( XRCC 1 , XPC , ERCC 1 , XRCC 3 , and XRCC 7 ) . ^^^ This is the first report on SNPs of DNA repair genes in renal cell carcinoma that suggests XRCC 1 399Gln polymorphism may be a risk factor for RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Tobacco smoke produces oxidative and alkylative DNA damage that necessitates repair by base excision repair coordinated by 10 ray cross complementing gene 1 ( XRCC 1 ) . ^^^ We investigated whether polymorphisms in XRCC 1 alter DNA repair capacity and modify breast cancer risk associated with smoking . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : We used a case control study design ( 157 carcinomas , 983 adenomas and 399 controls ) to test the association between five polymorphisms in these DNA repair genes ( XRCC 1 Arg194Trp , Arg280His , Arg399Gln , XRCC 3 Thr241Met and XPD Lys751Gln ) , and risk of colorectal adenomas and carcinomas in a Norwegian cohort . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Three coding polymorphisms at codons 194 , 280 , and 399 in 10 ray cross complementing group 1 ( XRCC 1 ) DNA repair gene have been identified that may affect DNA repair and alter cancer susceptibility . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Condensin 1 interacts with the PARP 1 XRCC 1 complex and functions in DNA single strand break repair . ^^^ Consistent with this , DNA damage rapidly stimulates the chromatin association of PARP 1 , condensin 1 , and XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Mouse models of XRCC 1 DNA repair polymorphisms and cancer . ^^^ XRCC 1 is an excellent prototype to provide a forum for determining how epidemiological cancer association studies with DNA repair gene polymorphisms can be validated or refuted . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In addition , we find that ERCC 1 , XRCC 1 and DNA PKcs defective cells are hypersensitive to Cr [ 6 ] , indicating that several repair pathways cooperate in repairing Cr [ 6 ] induced DNA damage . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In a nationwide population based case control study , we examined associations of polymorphisms in the DNA repair genes XPD , XPC , XRCC 1 and XRCC 3 with risk of esophageal adenocarcinoma , squamous cell carcinoma ( SCC ) and gastric cardia adenocarcinoma , and paid special attention to possible interactions with symptomatic reflux or body mass . ^^^ DNA was extracted and polymorphisms in XPD codon 751 ( Lys > Gln ) , codon 312 ( Asp > Asn ) , C insertion in intron 10 of XPD , XPC codon 939 ( Lys > Gln ) , XRCC 1 codon 399 ( Arg > Gln ) and XRCC 3 codon 241 ( Thr > Met ) were examined using PCR RFLP . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
XRCC 1 is involved in the repair of DNA single strand breaks formed by exposure to ionizing radiation and alkylating agents . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The candidate genes belong to different DNA repair pathways : base excision repair ( OGG 1 , LIG 3 , APEX , POLB , XRCC 1 , PCNA , and MUTYH ) , nucleotide excision repair ( ERCC 1 , ERCC 2 , ERCC 4 , and ERCC 5 ) , double strand breaks repair ( XRCC 2 , XRCC 3 , and XRCC 9 ) , and reversion repair ( MGMT ) genes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Genetic variants of the ADPRT , XRCC 1 and APE 1 genes and risk of cutaneous melanoma . ^^^ Sunlight causes various kinds of DNA damage , including oxidative lesions that are removed effectively by the base excision repair ( BER ) pathway , in which ADPRT , XRCC 1 and APE 1 play a key role . ^^^ We hypothesized that ADPRT , XRCC 1 and APE 1 polymorphisms are associated with risk of cutaneous melanoma ( CM ) . ^^^ However , we found that , compared with the APE 1 Asp / Asp genotype , a significantly decreased risk of CM was associated with the APE 1 Asp / Glu [ adjusted odds ratio ( OR ) , 0 . 60 ; 95 % confidence interval ( CI ) , 0 . 41 0 . 86 ] , Glu / Glu ( OR , 0 . 58 ; 95 % CI , 0 . 38 0 . 88 ) and combined APE 1 Asp / Glu+Glu / Glu ( OR , 0 . 59 ; 95 % CI , 0 . 42 0 . 83 ) genotypes , but not for other XRCC 1 variant genotypes . ^^^ Moreover , there was evidence for a possible gene gene interaction between XRCC 1 and APE 1 variants in the association with risk of CM ( P=0 . 030 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A novel T 77C polymorphism in DNA repair gene XRCC 1 contributes to diminished promoter activity and increased risk of non small cell lung cancer . 10 ray repair cross complementing 1 ( XRCC 1 ) plays a key role in DNA base excision repair and cells lacking its activity are hypersensitive to DNA damage . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The assay was used successfully to demonstrate base and nucleotide excision repair deficiency in certain polymorphic DNA repair genes , namely XRCC 1 751Gln and XPD 312Asn , respectively . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The DNA samples are screened using denaturing high performance liquid chromatography ( DHPLC ) and the Surveyor nuclease assay for variants in ATM , TGFB 1 , XRCC 1 , XRCC 3 , SOD 2 , and hHR 21 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
As an amplified DNA damage signal , auto poly ( ADP ribosyl ) ation of PARP 1 triggers the recruitment of XRCC 1 , which coordinates and stimulates the repair process , to the DNA damage sites in less than 15 s in living cells ( Okano et al . , 2003 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We have also evaluated the possible influence of DNA repair genetic polymorphisms ( XRCC 1 codons 194 and 399 , XRCC 3 codon 241 and APE 1 codon 148 ) on susceptibility to the genotoxic effects evaluated . ^^^ Among exposed individuals , carriers of the variant alleles XRCC 1 399Gln and APE 1 148Glu have shown altered DNA damage with regard to wild type homozygotes , suggesting exposure genotype interactions . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In order to elucidate the influence of a few widely studied DNA repair polymorphisms on individual levels of DNA damage and their possible interaction with lifestyle and environmental exposures , 171 subjects from a well characterized human population enrolled in a previous study on genetic effects of air pollution were genotyped for the XRCC 1 Arg280His and Arg399Glu , XRCC 3 Thr241Met and ERCC 2 Lys751Gln polymorphisms . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Mutational analysis and binding studies revealed that DNA Ligase 1 was recruited to DNA repair sites by interaction with PCNA while DNA Ligase 3 was recruited via its BRCT domain mediated interaction with XRCC 1 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
BACKGROUND & AIMS : Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are major DNA base excision repair proteins acting interactively in repair processes . ^^^ METHODS : The ADPRT XRCC 1 interaction in cells transfected with ADPRT and XRCC 1 variant complementary DNA ( cDNA ) constructs were examined by immunoprecipitation and immunoblotting analysis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : A polymerase chain reaction restriction fragment length polymorphism ( RFLP ) approach was used to determine the frequency of the SNPs : XPD Asp312Asn , XPD Lys751Gln , ERCC 1 C8092A , and XRCC 1 Arg399Gln in DNA from peripheral lymphocytes of 103 stage 4 SCCHN patients . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Aprataxin associates with the DNA repair proteins XRCC 1 and XRCC 4 , which are partners of DNA ligase 3 and ligase 4 , respectively , suggestive of a role in DNA repair . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
RESULTS : After 10 ray irradiation , persons bearing XRCC 1 homozygous variant ( codon 399 ) genotype exhibited significantly lower Tail DNA values than those bearing wild type and heterozygous genotypes . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In order to obtain biochemical indicators for histopathological , biological and clinical malignancy of renal cell carcinoma ( RCC ) , concentrations of protein , RNA , DNA and polyamines in 14 samples of RCC were measured and examined on their histopathological properties and clinical malignancies . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The association of RCC with nephrosclerosis is shown by a high proportion ( 82 . 7 % ) of the RCC development against the background of nephrosclerosis ; the dependence of the so called cortical adenoma development on the degree of nephrosclerosis ; epithelial proliferation in the nephrosclerotic foci with the appearance of undifferentiated cells with the altered DNA content and the expression of cytokeratins and vimentine . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymerase chain reaction methods using genomic DNA from normal kidneys and RCC and primers specific for the GPS human FN gene showed two products of identical size , indicating that genomic amplification did not cause activation of the human FN gene in RCC to produce GPS . ^^^ Restriction fragment length analysis demonstrated identical patterns in DNA extracted from both normal kidneys and RCC , suggesting that chromosomal rearrangements did not activate the GPS human FN gene . ^^^ This study showed that genetic changes detectable only by DNA sequencing can explain the activation of the normal human FN gene to produce GPS , a product important for autologous growth stimulation of RCC . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The DNA sequences for Ha , Ki , and N ras were determined in six cell lines derived from independent rat hereditary renal cell carcinomas ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Clinical , histopathological and DNA cytometric parameters were analyzed before treatment in 57 patients with metastatic renal cell carcinoma ( RCC ) with regard to their ability to predict objective response to treatment with interferon alpha ( IFN ) with or without vinblastine ( VB ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Recent studies have shown that the deletion of chromosome 3p or the loss of DNA sequences at 3p is generally associated with the development of renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using a rabbit antiserum to a synthetic undecapeptide deduced from a cloned human retroviral gag gene related DNA sequence , we found a specific immunohistochemical reaction in all of 42 tested renal cell adenocarcinomas ( RCC ) , while none of 17 similarly tested Wilms ' tumors and 65 carcinomas at other sites were positive . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Furthermore , the DNA synthesis in lymphocytes ( monitored by measuring the uptake of tritiated thymidine ) on contact with phytohemagglutinin ( PHA ) was depressed in 9 of 21 ( 43 % ) patients with RCC as compared with healthy controls . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To study the possible involvement of reactive oxygen species ( ROS ) in the tumor biology of human renal cell carcinoma ( RCC ) , we analyzed 35 cases of RCC for 2 parameters of oxidative damage : 8 hydroxy 2 ' deoxyguanosine ( 8 OHdG ) , a mutation prone DNA base modified product , was measured by means of high performance liquid chromatography ( HPLC ) with an electrochemical ( EC ) detector , and 4 hydroxy 2 nonenal ( HNE ) modified proteins were measured with a polyclonal antibody against HNE modified proteins . ^^^ A 54 % higher content of 8 OHdG was found in RCC than in the corresponding non tumorous kidney , suggesting that the DNA of RCC is more exposed to ROS than is the DNA of non tumorous kidneys . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We conclude that ( a ) LOH on 3p is not restricted to the clear cell type of RCC , ( b ) the most common LOH were telomeric to D3S32 locus at the 3p21 region , and ( c ) no statistical correlation between the LOH at 3p and histologic grade , DNA ploidy , or clinical stage was found in this series . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Southern blot analysis of genomic DNA extracted from normal and neoplastic tissue indicated no amplification of the thymosin beta 10 gene in RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Amplification of DNA from the harvested tumor cells demonstrated a loss of heterozygosity at the VHL gene in five RCC specimens obtained from two patients . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Cytogenetic and DNA deletion analyses show that both sporadic and familial RCC tumors arise as the result of chromosomal deletions in the 3p13 p 26 region . von Hippel Lindau ( VHL ) disease is a hereditary , multifocal syndrome that includes , among several affected organs , multiple , bilateral renal cysts and RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Cell material from 49 cases of archival paraffin embedded tumor specimens of newly diagnosed renal cell carcinoma ( RCC ) was studied retrospectively using rapid flow cytofluorometric ( propidium iodide ) DNA analysis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The prognostic value of flow cytometric analysis of DNA content is contradictory in renal cell carcinoma ( RCC ) . ^^^ Flow cytometric analysis was performed on 72 patients with RCC , and the relationship between the DNA content and pathologic or clinical features was investigated . ^^^ DNA ploidy assessed with one sample is not a prognostic factor , and heterogeneity between different samples of a given tumor indicates that one sample is not enough for DNA flow cytometry in RCC . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Based on the variations in DNA indices within a single tumor , RCC were divided into three groups : 1 ) tumors with stable DNA indices ( variation within the range of the measurement error ) , including all DNA diploid tumors ( n = 8 ) , all hyperdiploid tumors ( n = 3 ) , a hypodiploid tumor ( n = 1 ) , and only 2 of 11 tetraploid and hypotetraploid tumors ; 2 ) tumors with moderate variations in DNA indices , which were all close to tetraploidy ( n = 5 ) ; and 3 ) tumors with large variations of DNA indices . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVE : To determine the utility of deoxyribonucleic acid ( DNA ) ploidy pattern , detected by flow cytometry , in predicting the outcome of renal cell carcinoma ( RCC ) . ^^^ CONCLUSION : While DNA content might be of considerable predictive value for patients with RCC , these results showed that there was no difference in mortality rate , recurrence rate , or type of renal parenchymal sparing surgery used between aneuploid and diploid tumours . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The MIB 1 indices and DNA data were found not only to be significantly correlated with various other morphologic parameters , but also to the clinical behavior of RCC . ^^^ In addition to tumor grade and stage , both a high MIB 1 index and a noneuploid or aneuploid DNA histogram of a given RCC have the potential to identify tumor patients with an impaired prognosis . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A combination of Southern blot analysis on a panel of tumor derived somatic cell hybrids and fluorescence in situ hybridization ( FISH ) techniques was used to map a series of DNA markers relative to the 1q21 breakpoint of the renal cell carcinoma ( RCC ) associated ( 10 ; 1 ) ( p 11 ; q 21 ) translocation . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We analyzed Southern blots of HINF 1 digested DNA of a large number of renal cell carcinomas ( RCC ) including different tumor areas , secondary tumors and metastases ( 76 cases with 142 tumor samples ) for changes in the length of telomeric repeats using the oligonucleotide probe ( TTAGGG ) 3 and found telomere shortening in 54 % , suggesting that a reduction of the telomeric repeat length is not a general characteristic in RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Polymerase chain reaction ( PCR ) was used to analyze a rarely deleted region of mitochondrial DNA ( mtDNA ) from 39 human renal cell carcinomas ( RCC ) and matched normal kidney tissue removed during radical nephrectomy . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In conclusion , apoptosis can be easily and reliably recognized by the in situ end labeling of fragmented DNA and may help predict the outcome of RCC . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
With the help of the deparaffination technique described by Heldly , it has become possible to conduct large scale flow cytometric ( FCM ) studies , including retrospective DNA analysis of renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We suggest that unstable DNA sequences at chromosome 3p11 . 2 serve as a genetic basis for deletions and homologous and non homologous recombinations to remove distal 3p sequences with one copy of RCC gene ( s ) in different types of tumors . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The FHIT gene , encoded by 10 exons in a 1 . 1 kb transcript , encompasses approximately 1 Mb of genomic DNA , which includes the hereditary RCC t ( 3 ; 8 ) translocation break at 3p14 . 2 , the FRA3B common fragile region , and homozygous deletions in various cancer derived cell lines . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Molecular genetic studies suggest that VHL is a tumor suppressor gene ; correspondingly , reintroduction of a VHL complementary DNA ( cDNA ) into RCC cells inhibits their ability to form tumors in nude mice . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This resistance could not be explained by mutations in two `` hot spot ' ' regions of the type 2 receptor gene ( bp 622 to 795 and bp 1868 to 2019 ) , as was demonstrated by DNA sequencing in the TGF beta 1 resistant RCC cell lines . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Findings of selective renal tumor biopsy for RCC coincided with those of surgical specimen in 27 / 39 ( accuracy 69 % , kappa 0 . 398 ) in cell types , 29 / 39 ( accuracy 74 % , kappa 0 . 432 ) in structural types , 26 / 39 ( accuracy 67 % , kappa 0 . 341 ) in gradings and 27 / 39 ( accuracy 69 % , kappa 0 . 532 ) in ploidy patterns . ( CONCLUSION ) : It was assumed that DNA histograms might help the histological diagnosis by biopsy . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
BACKGROUND : The prognostic values of intratumoral microvessel density ( iMVD ) , tumor cell proliferation rate , DNA content ( ploidy ) , and p 53 protein expression are controversial or have not been well studied in patients with renal cell carcinoma ( RCC ) confined to the kidney . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Alignment of class 1 hybridizing cosmids from an R 21 ( AlBlDlEugrc+ ) genomic DNA library gave two contigs : one [ 150 kilobases ( kb ) ] encompassed the E / C region , or a large part thereof , and the other ( 110 kb ) contained the grc region which has genes influencing resistance to chemical carcinogens ( rcc ) , fertility ( ft ) , and growth ( dw 3 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
PATIENTS AND METHODS : Tumour cytogenetics , histomorphology , DNA ploidy and S phase fraction , stage , size , and grade were related to survival in 50 consecutive patients with RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Considering the fact that the DNA sequence of this VTR region contains a target area for transcription and other regulation factors of H ras gene expression , these findings could be of importance as regards the involvement of this gene in the process of carcinogenesis in RCC . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
RFLP studies have indicated a duplication of DNA sequences at the chromosome 5q22 region and showed a breakpoint cluster between the apc and mcc genes in nonpapillary renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The genomic DNAs extracted from 5 human RCC cell lines were examined by restriction landmark genomic scanning ( RLGS ) , a two dimensional gel analysis which allows evaluation of approximately 2 , 000 radiolabelled DNA fragments . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA losses were most prevalent at 13q ( 75 per cent ) and 4q ( 50 per cent ) , suggesting that inactivation of tumour suppressor genes at chromosomes 13q and 4q may be linked to sarcomatoid growth of RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Control samples included RCC DNA from 107 patients without known TRI exposure and lymphocyte DNA from 97 healthy subjects . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Whereas these cells did not display DNA breaks when freshly isolated or after culture for 24 h in medium , peripheral blood T cells from RCC patients underwent activation induced cell death after stimulation with either phorbol 12 myristate 13 acetate / ionomycin or anti CD3 / CD28 antibodies . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We report on a prospective DNA cytophotometric study of 66 patients with renal tumors , 61 of whom had renal cell carcinoma ( RCC ) ( pT 1 pT4 , G 1 G3 ) . 16 of the patients had a metastasis at the time of diagnosis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To this end , Feulgen stained RCC cell nuclei were characterized by means of 38 variables describing nuclear DNA ploidy levels and morphology . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : DNA was extracted from 33 Japanese sporadic RCC samples , and examined for loss of heterozygosity ( LOH ) and RERs by amplification of 14 microsatellite regions . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This was approached in vitro on four human renal cell carcinoma ( RCC ) lines by means of the highly specific mouse G 250 monoclonal antibody ( mAb ) chemically conjugated to a plasmid DNA conveying a reporter activity . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
CONCLUSIONS : Stratification of organ confined RCC according to tumor size and DNA content could possibly provide more information that could be useful in the selection of individuals with significantly different risks of disease progression . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Using PCR single strand conformation polymorphism and DNA direct sequencing , we examined the presence of genetic alterations within the third exon of beta catenin , which are frequently observed in other tumors , in transitional cell cancer ( TCC ) and renal cell cancer ( RCC ) cell lines , and in tumor specimens . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In clear cell RCC , DNA losses were frequently observed on 3p ( 66 % ) , 6q ( 56 % ) , 9p and 4q ( 44 % each ) and 2q ( 33 % ) . ^^^ DNA gains were identified on chromosome 7 and 17 in papillary RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Therefore , we introduced the complementary DNA ( cDNA ) encoding human IFNgamma into a well characterized RCC line that has been selected for development of an allogeneic tumor cell vaccine for treatment of patients with metastatic disease . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA from normal and tumor tissue from 40 patients at various stages of RCC was analyzed for LOH at three microsatellites mapped to 3p ( 3p14 . 1 14 . 3 ; 3p21 . 2 21 . 3 and 3p25 ) by polymerase chain reaction ) . 42 . 5 % of the tumors studied showed LOH on at least one locus . 30 % showed LOH on only one locus ; 5 % on two loci and 7 . 5 % on the three loci tested . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To determine whether the abnormal expression and activating mutations in exon 3 of the beta catenin gene are implicated in renal cell carcinogenesis , 52 renal cell carcinomas ( RCC ) were analyzed by immunohistochemistry , polymerase chain reaction single strand conformational polymorphism analysis ( PCR SSCP ) , and direct DNA sequencing . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The objective was to study the prognostic value of Deoxyribonucleic Acid ( DNA ) ploidy status in small renal cell carcinomas ( RCC ) . ^^^ DNA ploidy is an inaccurate predictor of tumor behavior in patients with RCC , even in small tumors . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MATERIAL AND METHODS : The nuclear accumulation of p 53 protein was determined by immunohistochemical analysis in RCC specimens from 90 patients and was correlated with clinical stage , grade , DNA ploidy , S phase fraction and cancer specific survival . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In preclinical efficacy studies in a murine model of renal cell carcinoma ( RCC ) , the direct intratumoral administration of an IL 2 plasmid DNA / DMRIE / DOPE complex resulted in the generation of tumor specific lymphocytes and complete tumor regression in the majority of the mice . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The authors evaluated the predictive value of DNA ploidy in patients who underwent resection because of RCC . ^^^ CONCLUSIONS : The results of this study suggest that DNA ploidy is a significant and independent predictor for survival of patients afflicted from RCC and superior to tumor classification and grade . ^^^ DNA ploidy is a reliable prognostic factor for RCC and yields considerable information for patient management and predicting clinical outcome . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
We applied fluorescent microsatellite analysis ( MSA ) to detect serum DNA alterations in patients with RCC . ^^^ After DNA extraction , we performed MSA with a total of 9 markers from the chromosomal regions 3p , 5q , 7p , 7q , 9p , 13q , 17p and 17q to identify tumour specific serum DNA alterations in Group 1 ( n= 53 RCC ) ; 11 additional markers were used in the first 23 RCCs ( Group 2 ) in order to increase sensitivity ; and 20 healthy controls were investigated with 10 markers . ^^^ In RCC , the microsatellite analysis has a high sensitivity in the detection of serum DNA alterations when a sufficient number of markers from various chromosomal regions are used . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
To assess the proliferative activity of renal cell carcinoma ( RCC A ) in patients with acquired cystic disease of the kidney ( ACDK ) after long term hemodialysis , we analyzed cell cycle , DNA ploidy , and S phase fraction by flow cytometry ( FCM ) and proliferating cell nuclear antigen ( PCNA ) labeling index by immunohistochemistry . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The common region of deletion 3p14 . 2 suggests the presence of unstable sequences of DNA that play an important role in the pathogenesis of nonpapillary RCC . 4 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
This study was designed to define the clinical potential of the DNA hypomethylating agent 5 aza 2 ' deoxycytidine ( 5 AZA CdR ) in human RCC , through its control of the expression of `` therapeutic targets ' ' of the cancer testis antigen ( CTA ) family , and of the tumor associated antigen RAGE 1 , in RCC cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Comparative genomic hybridization ( CGH ) and conventional cytogenetic karyotyping were used to screen for losses and gains of DNA sequences along chromosomes in ten renal tumors ( RCC ) of different histologic types ( clear cell RCC , papillary RCC , and one oncocytoma ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Deletion of DNA ( loss of heterozeigosity : LOH ) is seen with a high frequency in human RCC of all 6 types at chromosome 3p 14 25 . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Although numerous studies on the prognostic value of DNA aneuploidy in RCC have been reported , the in vivo DNA aneuploidization during RCC expansion has not been revealed . ^^^ The present study was undertaken to observe the DNA aneuploidization during RCC expansion . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
PURPOSE : 5 Fluorouracil ( 5 FU ) is an anticancer agent clinically used against various cancers including renal cell carcinoma ( RCC ) . 5 FU inhibits thymidylate synthase ( TS ) and blocks DNA synthesis . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
METHODS : We estimated methylation status in the promoter region of Cx 32 gene in the RCC cell by DNA digestion with methylation sensitive restriction enzyme and PCR , and methylation specific PCR ( MSP ) . ^^^ We also checked the recovery of Cx 32 gene expression in the RCC cell treated with a DNA methyltranferase inhibitor , 5 Aza 2 ' deoxycytidine ( 5 Aza CdR ) . ^^^ Hypermethylation of the Cx 32 promoter region in the RCC cell was confirmed by DNA digestion with methylation sensitive restriction enzyme and PCR , and MSP . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MN / CA9 , cadherin 6 , vimentin , mucin 1 and DNA content are particularly useful for the diagnosis and / or prognosis of clear cell RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA was extracted from peripheral blood and normal tissue of 119 patients with conventional renal cell carcinoma ( RCC ) and from 210 age and sex matched healthy volunteers . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : We analyzed VHL gene mutations by direct DNA sequencing and methylation specific polymerase chain reaction in 31 paired RCC tissue samples . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Tumor stage remains the most important prognostic factor for RCC , but compelling data have also been accumulated in support of various clinical signs and symptoms , tumor grade , size , histologic subtype , and DNA content and nuclear morphometry . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : To identify the origin of these unknown events , separate populations of mononuclear cells and polymorphonuclear neutrophils ( PMNs ) ( prepared by density gradient centrifugation ) were spiked into leucocyte depleted red cell concentrates ( RCC ) to a concentration of 150 cells / microl and assessed , using LeucoCount and DNA Prep reagents , by flow cytometry . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNFalpha ) and TNFalpha receptor mRNA expression , the effects of TNFalpha on DNA synthesis and cell proliferation as well as its effects on interleukin 6 ( IL 6 ) production and expression in renal cell carcinoma ( RCC ) were studied using RCC cell lines . ^^^ The effects of TNFalpha on DNA synthesis and IL 6 production were also studied using short term established RCC cell lines . ^^^ As for the 10 short term established RCC cell lines , DNA synthesis and IL 6 production were induced with the addition of TNFalpha . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
A somatic missense mutation ( Ala444Ser ) with loss of the wild type allele ( consistent with a two hit mechanism of tumorigenesis ) was detected in a primary clear cell RCC , and a further missense mutation ( Ala238Val ) was identified in a clear cell RCC cell line for which matched normal DNA was not available . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The objective of this study was to compare DNA ploidy and proliferation index of renal cell carcinoma ( RCC ) with renal vein ( RV ) thrombus and RCC with inferior vena cava ( IVC ) thrombus and to investigate a correlation between these markers and Fuhrman grade and patient survival . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In fact , all four RCC derived cell lines we tested maintained wild type p 53 but were not capable of transactivating p 53 responsive reporters and endogenous p 53 responsive genes . p 53 protein in RCC showed normal response to genotoxic stress , including accumulation , nuclear translocation , and activation of specific DNA binding . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Two RCC cell lines were treated with 50 micromol / L troglitazoned for and evaluated for the effects of antidiabetic thiazolidinediones ( TZDs ) on the cells apoptosis by fluorescence microscopy and DNA ladder assay . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Expression of caspase activated DNase , DFF 40 accountable for characteristic ladder pattern was easily detectable in Jurkat but not renal cancer cells , providing one possible explanation for the lack of oligonucleosomal DNA fragmentation in apoptotic RCC cells . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVE : The number of DNA losses found using comparative genomic hybridization ( CGH ) and the proliferation index MIB 1 have been shown to be prognostic factors in renal cell carcinoma ( RCC ) . ^^^ CONCLUSION : CGH gives an overview of DNA changes in RCC and helps to locate targets for more precise genetic evaluation . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The frequency of these polymorphisms was studied in 160 nontumor DNA samples from patients with renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVES : To determine whether the degree of oxidative DNA damage in renal cell carcinoma ( RCC ) can be used as a useful prognostic predictor for patients who undergo radical nephrectomy . ^^^ METHODS : We measured 8 hydroxy 2 ' deoxyguanosine ( 8 OHdG ) , one of the most commonly used markers for evaluating oxidative stress , in DNA isolated from 72 RCC specimens , as well as adjacent normal kidney tissue using a quantitative sandwich enzyme linked immunosorbent assay . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
STUDY DESIGN : Blood and urine samples were obtained in weekly intervals and the following markers were determined : ( 1 ) IgG and IgM antibodies in serum using immunofluorescence and ELISA tests ; ( 2 ) viral shedding in urine by rapid centrifugation culture ( RCC ) ; ( 3 ) viral antigen ( pp 65 ) in peripheral blood leukocytes ( PBL ) by immunofluorescence and ( 4 ) viral DNA in PBL by nested PCR ( NPCR ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : Genomic DNA and total RNA were extracted from three renal cancer cell lines ( A 498 , Caki 1 , and Caki 2 ) and 54 RCC tissue samples with their corresponding normal kidney tissue samples . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
DNA sequencing detected a p 53 gene mutation in two out of eight RCC cell lines , i . e . in exon 8 ( cell line clearCa 6 ) , and in exon 9 ( cell line clearCa 5 ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
For a case control study , DNA samples from 200 nonpapillary RCC patients and 200 healthy control subjects were analyzed using the TaqMan technique . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
AIM : The aim of the present study was to correlate bcl 2 protein expression and DNA ploidy status with established prognostic parameters in renal cell carcinoma ( RCC ) and to examine their impact on disease progression and patient survival . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVE : The prognostic value of deoxyribonucleic acid ( DNA ) ploidy in renal cell carcinoma ( RCC ) is not well defined among modern surgical nephrectomy series . ^^^ METHODS : We reviewed all patients from 1992 to 2000 , who prospectively had DNA ploidy analysis of their primary tumor determined at the time of nephrectomy for nonmetastatic RCC . ^^^ CONCLUSIONS : In the modern era , DNA ploidy is not an independent predictor of either overall survival or recurrence free survival in patients with nonmetastatic RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Evaluation of the DNA content in clear cell RCC appears to significantly improve the predictive value of the TNM staging system , especially in the pT1a and pT1b categories . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
The objective of this study was to evaluate the role of DNA ploidy , p 53 , and Ki 67 ( MIB 1 ) as individual and combined prognostic factors for survival in patients with renal cell carcinoma ( RCC ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVE : To investigate the prognostic value of DNA ploidy , Ki 67 index and p 53 expression in relation to disease related survival in a consecutive series of patients with renal cell carcinoma ( RCC ) . ^^^ CONCLUSION : The results indicate that DNA ploidy has relevant prognostic value in RCC , adding useful information to the classic histopathological indicators of clinical outcome . . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Resistance of human renal cell carcinoma ( RCC ) and melanoma to the apoptosis inducing effects of IFNs was postulated to result from epigenetic silencing of genes by DNA methylation , a common feature of human cancers . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Based on recent indications of a potential relationship between mismatch repair genes and renal cell carcinoma ( RCC ) , we were interested in investigating the existence of promoter hypermethylation of the hMLH 1 gene in tumor DNA samples from patients with sporadic RCC . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Treatment of human ACHN renal cell carcinoma ( RCC ) and A 375 melanoma cells with the DNA demethylating nucleoside analog 5 AZA 2 ' deoxycytidine ( 5 AZA dC ) synergistically augmented antiproliferative effects of IFN alpha ( alpha ) 2 and IFN beta ( beta ) . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
In a cross sectional survey of 128 men treated for RCC ( 55 with disseminated disease and 73 with a local disease ) , they were genotyped using DNA extracted from freshly drawn blood , and central clinical data were recorded . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
OBJECTIVE : To examine differences in gene expression levels between renal cell carcinoma ( RCC ) tissue and ' normal ' appearing renal tissue using a commercially available DNA macroarray . ^^^ A commercially available DNA macroarray coupled with the significance analysis of macroarrays allowed the identification of sets of differentially expressed cancer related genes that were characteristic of RCC , compared with apparently normal renal tissue , and which distinguished among subgroups divided according to tumour grade and histological subtype . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
Moreover , VHL deleted RCC cells showed attenuated apoptosis or abnormal cell cycle arrest upon DNA damage , but became normal when pVHL was restored . ^^^
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA
Interacting proteins: P18887 and P27695	Pubmed	SVM Score :0.0
NA