| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.5251293 |
| The current evidence suggests a model where XRCC 1 is sequestered via its interaction with PCNA to sites of DNA replication factories to facilitate efficient SSBR in S phase . . 0.5251293^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These results show PCNA to be a prognostic marker for RCC . . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| These include genes involved in DNA replication and repair ( e . g . , PCNA , XRCC 1 , B MYB , and GADD 45 ) , transcriptional regulators associated with stress response , and cell cycle checkpoint control ( e . g . , YB 1 , DBPA , and ATF 4 ) , and genes for signal transduction proteins ( e . g . , protein tyrosine phosphatase 1B and regulatory subunits alpha and beta of cAMP dependent protein kinase ) . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Dramatic increases in the transcripts for selected members of the nucleotide excision repair family ( XPC , XPE and PCNA ) , mismatch repair family ( PMS 1 ) , and recombination repair family ( RAD 50 ) were found in 1 cell stage embryos sired by cyclophosphamide treated males compared to controls , while decreases in the expression of base excision repair family members ( UNG 1 , UNG 2 , and XRCC 1 ) and in recombination repair transcripts ( RAD 54 ) were observed . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Selected SNPs belong to the following genes : ADH1B , ALDH 2 , APEX , CDKN2A , COMT , CYP1A1 , CYP1A2 , CYP1B1 , CYP2A6 , CYP2C19 , CYP2C9 , CYP2E1 , CYP3A4 , DRD 2 , DRD 4 , EPHX 1 , ERCC 1 , ERCC 2 , ERCC 4 , ERCC 5 , GRPR , GSTA 4 , GSTM 3 , GSTP 1 , GSTT 2 , LIG 3 , MDM 2 , MGMT , MPO , NAT 1 , NAT 2 , NQO 1 , OGG 1 , PCNA , POLB , SLC6A3 , SOD 2 , TP 53 , XRCC 1 , XRCC 2 , XRCC 3 , and XRCC 9 . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| We investigated the association of urinary bladder cancer with genetic polymorphisms in the xeroderma pigmentosum complementation group C ( XPC ) , group D ( XPD ) and group G ( XPG ) , 10 ray repair cross complementing group 1 ( XRCC 1 ) and group 3 ( XRCC 3 ) , Nijmegen breakage syndrome 1 ( NBS 1 ) , cyclin D 1 , methylene tetrahydrofolate reductase ( MTHFR ) , NAD ( P ) H dehydrogenase quinone 1 ( NQO 1 ) , H ras and glutathione S transferase theta 1 ( GSTT 1 ) genes . ^^^ For other polymorphisms included in this study , NBS 1 Glu185Gln , XPD Lys751Gln , XPG Asp1104His , XRCC 1 Arg399Gln , XRCC 3 Thr241Met , cyclin D 1 Pro242Pro , MTHFR Ala222Val and Glu429Ala , NQO 1 Arg139Trp and Pro187Ser , no significant differences for genotype distributions and allele frequencies between the bladder cancer cases and the controls were observed in the present study . . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The frequencies for single nucleotide polymorphisms ( SNPs ) were measured in the following genes : NBS 1 , XPC , XPD , XRCC 1 , XRCC 3 , MTHFR , and cyclin D 1 . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| AS primer pairs were designed for nine candidate genetic variants in DNA repair and cell cycle / apoptotic regulatory genes , including Cyclin D 1 [ codon 870 splice site variant ( A > G ) ] ; BRCA 1 , P871L ; ERCC 2 , K751Q ; FAS 1377 ( G > A ) ; hMLH 1 93 ( G > A ) and V219I ; p 21 , S31R ; and the XRCC 1 R194W and R399Q variants . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| METHODS AND RESULTS : We analyzed the expression of apoptotic genes such as BAX , CASP 1 , FAS , FAS L , FOS , MDM 2 , NFkB 2 , P 53 , PCNA , TERT , and XRCC 1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation ( ACS ) . ^^^ Gene expression analysis showed that the proapoptotic genes ( ie , BAX , CASP 1 , FAS , FAS L , FOS , NFkB 2 , P 53 , PCNA ) were significantly more expressed ( P < 0 . 001 ) in ACS plaques , whereas the antiapoptotic genes ( ie , MDM 2 , TERT , XRCC 1 ) were more transcribed ( P < 0 . 001 ) in stable angina plaques . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| These complexes contain proteins required for both types of BER , including UNG 2 , APE 1 , POLbeta , POLdelta , XRCC 1 , PCNA and DNA ligase , the latter detected as activity . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| When constitutively expressed in uninfected T lymphocytes , IRF 4 caused reduced expression of critical DNA repair genes , including Rad 51 , XRCC 1 , Ung 1 , RPA , and proliferative cell nuclear antigen ( PCNA ) , a transcriptional phenotype with striking similarities to the profile observed in HTLV infected T lymphocytes . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| DNA from peripheral blood samples was genotyped for single nucleotide polymorphisms ( SNP ) in 12 genes : NF 2 , XRCC 1 , XRCC 3 , XRCC 5 , ERCC 2 , Ki ras , p 16 , cyclin D 1 , PTEN , E cadherin , TGFB 1 , and TGFBR 2 . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Fifteen single nucleotide polymorphisms ( SNPs ) , IL 6 174G / C , 634G / C , and 597G / A ; IL 10 1082G / A and 592C / A ; IL 1beta 511C / T ; NBS 1 exon 5 Glu185Gln ; XPC exon 15 Lys939Gln ; XPD exon 23 Lys751Gln ; XRCC 1 exon 10 Arg399Gln ; XRCC 3 exon 7 Thr241Met ; cyclin D 1 exon 4 G870A ; MTHFR exon 4 Ala222Val and exon 7 Glu429Ala ; HFE exon 4 C282Y were performed by Pyrosequencing and RFLP techniques . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| We investigated 44 single nucleotide polymorphisms ( SNPs ) in 20 DNA repair genes including nucleotide excision repair ( NER ) genes XPA , ERCC 1 , ERCC2 / XPD , ERCC4 / XPF and ERCC5 / XPG ; base excision repair ( BER ) genes APE1 / APEX , OGG 1 , MPG , XRCC 1 , PCNA , POLB , POLiota , LIG 3 and EXO 1 ; double strand break repair ( DSB R ) genes XRCC 2 , XRCC 3 , XRCC 9 , NBS 1 and ATR ; and direct damage reversal ( DR ) gene MGMT / AGT . ^^^ Our results indicate that SNPs in the NER genes ERCC 1 ( Asn118Asn , 15310G > C , 8902G > T ) , XPA ( 4G > A ) , ERCC2 / XPD ( Lys751Gln ) and ERCC5 / XPD ( His46His ) ; the BER genes APE1 / APEX ( Ile64Val ) , OGG 1 ( Ser326Cys ) , PCNA ( 1876A > G ) and XRCC 1 ( Arg194Trp , Arg280His , Arg399Gln ) ; and the DSB R genes ATR ( Thr211Met ) , NBS 1 ( Glu185Gln ) , XRCC 2 ( Arg188His ) and XRCC 9 ( Thr297Ile ) modulate NSCLC risk . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| We analyzed 13 polymorphisms in seven DNA repair genes belonging to different repair pathways [ 10 ray repair cross complementing group 1 ( XRCC 1 ) : 26304C > T , 26651A > G , 28152A > G ; xeroderma pigmentosum D ( XPD ) : 23591A > G , 35931A > C ; excision repair complementing defective in Chinese hamster , group 1 ( ERCC 1 ) : 19007C > T ; XRCC 3 : 4541T > C , 17893A > G , 18067C > T ; proliferating cell nuclear antigen ( PCNA ) : 6084G > C ; ERCC 4 : 30028C > T , 30147A > G ; and XRCC 2 31479A > G ] in 317 incident bladder cancer patients and 317 controls . ^^^ After adjustment for age and smoking , the PCNA 6084C variant was significantly associated with an increased risk of bladder cancer [ CC + CG versus GG , odds ratio ( OR ) , 1 . 61 ; 95 % confidence interval ( 95 % CI ) , 1 . 00 2 . 61 ] , as well as the XRCC 1 26651G variant ( GG+AG versus AA : OR , 1 . 73 ; 95 % CI , 1 . 17 2 . 56 ) . ^^^ Our results suggest that polymorphisms and / or haplotypes in XRCC 3 , XRCC 1 , and PCNA genes and spanning XPD ERCC 1 region may modulate bladder cancer risk and that some of these effects may preferentially affect current smokers . . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The candidate genes belong to different DNA repair pathways : base excision repair ( OGG 1 , LIG 3 , APEX , POLB , XRCC 1 , PCNA , and MUTYH ) , nucleotide excision repair ( ERCC 1 , ERCC 2 , ERCC 4 , and ERCC 5 ) , double strand breaks repair ( XRCC 2 , XRCC 3 , and XRCC 9 ) , and reversion repair ( MGMT ) genes . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Mutational analysis and binding studies revealed that DNA Ligase 1 was recruited to DNA repair sites by interaction with PCNA while DNA Ligase 3 was recruited via its BRCT domain mediated interaction with XRCC 1 . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Proliferating cell nuclear antigen ( PCNA ) expression evaluated by IHC using the monoclonal antibody PC 10 ( PCNA IHC ) in 68 RCC patients , showed the mean PCNA index to be 4 . 9 % , and values being significantly greater in aneuploid than in diploid tumors . ^^^ Proliferating cell nuclear antigen ( PCNA ) expression evaluated by IHC using the monoclonal antibody PC 10 ( PCNA IHC ) in 68 RCC patients , showed the mean PCNA index to be 4 . 9 % , and values being significantly greater in aneuploid than in diploid tumors . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Proliferating cell nuclear antigen ( PCNA ) expression in renal cell carcinoma ( RCC ) was determined by immunohistochemical staining using the PC 10 clone . ^^^ PCNA indices ranged from 2 . 4 to 53 . 1 per cent with mean indices of 12 . 6 , 19 . 0 , and 31 . 6 per cent for grades 1 to 3 RCC and 31 . 9 per cent for sarcomatoid RCC . ^^^ Proliferating cell nuclear antigen ( PCNA ) expression in renal cell carcinoma ( RCC ) was determined by immunohistochemical staining using the PC 10 clone . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| One hundred seven cases of RCC were investigated by immunohistochemical analysis using two different monoclonal antibodies : PC 10 , which recognizes a proliferating cell nuclear antigen ( PCNA ) , and MIB 1 , which identifies the Ki 67 antigen in formalin fixed , paraffin embedded material . ^^^ |
|
| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The aim of this study is to compare TPF as determined by Proliferating Cell Nuclear Antigen ( PCNA ) and Flow Cytometry ( FC ) in 36 consecutive patients affected by Renal Cell Carcinoma ( RCC ) . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The relationship between the proliferating cell nuclear antigen ( PCNA ) expression in renal cell carcinoma ( RCC ) determined by immunohistochemical staining using the PC 10 clone , and the preoperative serum interleukin 6 ( IL 6 ) value determined by ELISA was examined . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Histological examination of RCC tumors from mice treated with C 225 showed a substantial decrease in proliferating cell nuclear antigen staining and an increase in tumor cell apoptosis . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : This study was designed to examine the immunohistochemical expression of bcl 2 , p 53 , and proliferating cell nuclear antigen ( PCNA ) and the relation of this expression to clinicopathological characteristics and prognosis in renal cell carcinoma ( RCC ) . ^^^ PCNA seems to be a good objective and quantitative marker of the biological malignant potential in RCC , although the assessment of malignant potential in combination with conventional pathological parameters is indispensable . . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The biologic behavior of multifocal RCC compared with that of unifocal RCC is not well investigated , and the relevance of p 53 and the proliferation markers MIB 1 and proliferating cell nuclear antigen ( PCNA ) to multifocal RCC is not yet established . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVES : To identify the dysplastic changes in tubules adjacent to or remote from renal cell carcinoma ( RCC ) and to assess proliferating cell nuclear antigen ( PCNA ) expression of normal tubule and carcinoma cells . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| CD44s , E cadherin and PCNA play an important role in the tumorigenesis of renal cell carcinoma ( RCC ) , although their significance in the clinical progression of RCC is still not clear . ^^^ In n = 137 cases of operatively resected RCC the expression of CD44s , E cadherin and PCNA was semiquantitatively analyzed by the APAAP immunohistochemical method . ^^^ A high CD44s / E cadherin ratio and an above average PCNA expression were identified as independent prognostic parameters for the progression tendency of RCC . . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Since very little is known about aberrations in the G 1 S transition in human renal cell carcinoma ( RCC ) , we have characterized the expression of cyclin D 1 in 80 human renal cell carcinomas and 12 normal kidney cortex tissues using Western blotting . ^^^ Although it is difficult to define aberrant expression of cyclin D 1 , the results might indicate that the proto oncogene was activated in a sub set of RCC . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| We investigated 40 cases of renal cell carcinoma ( RCC ) to study the polysomy 7 status in papillary and clear cell types ( nonpapillary RCC ) and relationship with clinical , pathological , and biological features such as grade , stage , tumor proliferation rate ( PCNA expression ) and epidermal growth factor receptor ( EGFr ) expression and thereby to understand the prognostic significance of polysomy 7 and EGFr expression . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| These 14 differentially expressed genes , only 6 of which have previously been associated with RCC , are related to tumour growth / survival ( EGFR , cyclin D 1 , insulin like growth factor binding protein 1 and a MLRQ sub unit homologue of the NADH : ubiquinone oxidoreductase complex ) , angiogenesis ( vascular endothelial growth factor , endothelial PAS domain protein 1 , ceruloplasmin , angiopoietin related protein 2 ) and cell adhesion / motility ( protocadherin 2 , cadherin 6 , autotaxin , vimentin , lysyl oxidase and semaphorin G ) . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| METHODS : Expression of p 27 and the related cyclins ( cyclin A , cyclin E , and cyclin D 1 ) was examined immunohistochemically in 67 patients with of clear cell RCC . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| To assess the proliferative activity of renal cell carcinoma ( RCC A ) in patients with acquired cystic disease of the kidney ( ACDK ) after long term hemodialysis , we analyzed cell cycle , DNA ploidy , and S phase fraction by flow cytometry ( FCM ) and proliferating cell nuclear antigen ( PCNA ) labeling index by immunohistochemistry . ^^^ The PCNA labeling index was statistically significantly lower in the RCC As ( 24 . 01 % + / 13 . 4 % ; P < . 05 ) than in tRCCs ( 42 . 27 % + / 26 . 1 % ) . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| Few G1 / S studies have been performed on renal cell carcinoma ( RCC ) and therefore in this study the cyclin D 3 protein content in 80 RCCs and that in 12 corresponding normal kidney cortex tissues are characterized using Western blotting . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| We have therefore analyzed the cyclin E content , using Western blotting , in 79 RCC and 12 corresponding kidney cortex tissues as well as the fraction of p 27 positive cells in 73 RCCs , using immunohistochemistry . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| The mean PCNA index in the 41 patients with RCC was ( 29 . 5 + / 17 . 6 ) % , which was ( 49 . 6 + / 21 . 5 ) % in the group with extra pseudocapsule cancer lesions and ( 24 . 6 + / 12 . 7 ) % in the group without ( t = 3 . 162 , P = 0 . 013 ) . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| To test this hypothesis , we investigated TCF 4 splicing isoforms , beta catenin , and Wnt signal pathway ( cyclin D 1 , c myc , c jun , and MMP 7 ) in three RCC cell lines ( A 498 , Caki 1 , and Caki 2 ) , 38 primary RCCs , and 29 normal kidney samples . ^^^ In these 8 RCC samples , down regulation of cyclin D 1 , c myc , c jun , and MMP 7 expression was observed at the mRNA level . ^^^ We also analyzed the relationship between TCF 4 gene splicing isoforms , proliferation ( proliferating cell nuclear antigen labeling index ) , and apoptosis [ antiapoptotic factors ( Bcl 2 and Bcl 10 ( L ) ) , proapoptotic factors ( Bak and Bax ) , and caspase 3 ] in RCC samples . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| To investigate the relationship of bcl 2 , p 53 , proliferating cell nuclear antigen ( PCNA ) to cell proliferation , apoptosis and pathological parameters , the patterns of cell growth and turnover in renal cell carcinoma ( RCC ) , formalin fixed and paraffin embedded tissue blocks from 34 patients with RCC were examined . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| In VHL defective RCC cells , we demonstrate that the protumorigenic genes encoding cyclin D 1 , transforming growth factor alpha , and vascular endothelial growth factor respond specifically to HIF 2alpha and that the proapoptotic gene encoding BNip 3 responds positively to HIF 1alpha and negatively to HIF 2alpha , indicating that HIF 1alpha and HIF 2alpha have contrasting properties in the biology of RCC . ^^^ |
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| Interacting proteins: P18887 and P12004 |
Pubmed |
SVM Score :0.0 |
| To clarify the role of cyclin B 1 in the pathogenesis and prognosis of renal cell carcinoma ( RCC ) , protein expression was compared with clinicopathological characteristics of patients as well as the long term survival after surgical therapy . ^^^ Increased intratumoral cyclin B 1 positivity and aberrant localization of signals within the cytoplasm of tumor cells is positively correlated with the tendency towards tumor progression , indicating the significant role of cyclin B 1 in the development and pathogenesis of RCC . ^^^ The result of uni and multivariate statistical analysis suggests the prognostic value of cyclin B 1 for RCC patients . . ^^^ |
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