| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.66901912 |
| We also present data suggesting that poly ( ADP ribose ) polymerase can interact with XRCC 1 . 0.66901912^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.87957796 |
| XRCC 1 interacts with PARP by its central region ( amino acids 301 to 402 ) , which contains a BRCT ( BRCA 1 C terminus ) module , a widespread motif in DNA repair and DNA damage responsive cell cycle checkpoint proteins . 0.87957796^^^ |
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| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Thus , we show that XRCC 1 and PARP are involved in the same pathway for the repair of SSBs . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that APTX , together with XRCC 1 and PARP 1 , plays an essential role in SSBR . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| In mammalian cells , nicks in DNA are targets of proteins such as PARP 1 or XRCC 1 that have no homologues in yeast . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Thus , poly ( ADP ribose ) polymerase 1 , DNA polymerase beta , and ligase 3 interact with 10 ray repair cross complementing protein 1 within the BER complex , which ensures that ATP is generated and specifically used for DNA ligation . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| A database search indicated that TopBP 1 possessed eight regions similar to regions of Rad 4 , Cut 5 , Ect 2 , Rev 1 and 10 ray repair cross complementing 1 ( XRCC 1 ) proteins and a region similar to auto modification sites of poly ( ADP ribose ) polymerase , suggesting that TopBP 1 supported catalytic reactions of topoisomerase 2 through transient breakages of DNA strands . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| These two regions of XRCC 1 have been shown to interact independently with DNA ligase 3 and poly ( ADP ribose ) polymerase as part of a mechanism involved in the repair of DNA single strand breaks . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 functions in the repair of single strand DNA breaks in mammalian cells and forms a repair complex with beta Pol , ligase 3 and PARP . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Using a combination of alanine scanning , polymer blot analysis , and photoaffinity labeling , we have identified poly ( ADP ribose ) binding sites in the following proteins : p 53 , p 21 ( CIP1 / WAF1 ) , xeroderma pigmentosum group A complementing protein , MSH 6 , DNA ligase 3 , XRCC 1 , DNA polymerase epsilon , DNA PK ( CS ) , Ku 70 , NF kappaB , inducible nitric oxide synthase , caspase activated DNase , and telomerase . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| These changes were associated with the upregulation of DNA repair enzymes ( poly [ ADP ribose ] polymerase 1 , p 53 , phospho p 53 [ phosphorylated at Ser 392 ] , and XRCC 1 [ 10 ray repair cross complementing 1 ] ) . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| To determine the dominant inhibitory activity of polbetaDelta , we examined interactions of purified polbetaDelta with 10 ray cross complementing group 1 ( XRCC 1 ) , poly ( ADP ribose ) polymerase ( PARP ) , and apurinic endonuclease ( Ape ) proteins . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Although Xrcc 1 has no catalytic activity , it also interacts with Pol beta and poly ( ADP ribose ) polymerase ( PARP ) , linking DNA ligase 3 alpha with BER and single strand break repair , respectively . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| X ray repair cross complementing gene 1 protein plays an important role in camptothecin resistance . 10 ray repair cross complementing gene 1 protein ( XRCC 1 ) in complex with DNA polymerase beta , DNA ligase 3 , and poly ( ADP ribose ) polymerase is important in the base excision repair process . ^^^ In this study , we found the expression levels of XRCC 1 protein in KB 100 and KB 300 were > or =5 fold more than in their respective revertant cell lines , whereas there was no difference in the expression of XRCC 1 associated proteins such as DNA polymerase beta , DNA ligase 3 , poly ( ADP ribose ) polymerase , and apurinic / apyrimidinic endonuclease . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Poly ( ADP ribose ) polymerase 2 ( PARP 2 ) is required for efficient base excision DNA repair in association with PARP 1 and XRCC 1 . ^^^ PARP 2 was also found to interact with three other proteins involved in the base excision repair pathway : 10 ray cross complementing factor 1 ( XRCC 1 ) , DNA polymerase beta , and DNA ligase 3 , already known as partners of PARP 1 . ^^^ XRCC 1 negatively regulates PARP 2 activity , as it does for PARP 1 , while being a polymer acceptor for both PARP 1 and PARP 2 . ^^^ Poly ( ADP ribose ) polymerase 2 ( PARP 2 ) is required for efficient base excision DNA repair in association with PARP 1 and XRCC 1 . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| One genetic polymorphism ( G > A , Arg > Gln at codon 399 ) occurs within a poly ( ADP ribose ) polymerase binding region and within the central breast cancer susceptibility gene 1 product COOH terminus domain of XRCC 1 . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 functions as a scaffold protein by interacting and modulating polypeptide components of the single strand break repair machinery , including AP endonuclease 1 , DNA ligase IIIalpha , poly ( ADP ribose ) polymerase , DNA polymerase beta and human polynucleotide kinase . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Simultaneously , but dependent on poly ( ADP ribosyl ) ation , XRCC 1 was translocated from throughout the nucleus , including nucleoli , to the SSB . ^^^ The BRCT 1 domain of XRCC 1 protein was indispensable for its poly ( ADP ribose ) dependent recruitment to the SSB . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| The repair of DNA single strand breaks in mammalian cells is mediated by poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , DNA ligase IIIalpha , and XRCC 1 . ^^^ This provides a mechanism for the recruitment of the DNA ligase IIIalpha XRCC 1 complex to in vivo DNA single strand breaks and suggests that the zinc finger of DNA ligase 3 enables this complex and associated repair factors to locate the strand break in the presence of the negatively charged poly ( ADP ribose ) polymer . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Using a reconstituted system including the recombinant BER proteins Pol beta , AP endonuclease 1 ( APE 1 ) , 10 ray repair cross complementing group 1 ( XRCC 1 ) , DNA ligase 3 ( Lig 3 ) , flap endonuclease 1 ( FEN 1 ) , and poly ( ADP ribose ) polymerase 1 ( PARP 1 ) , it is demonstrated that in the absence of ATP , both long patch DNA synthesis by Pol beta and poly ( ADP ribosylation ) catalysed by PARP 1 are stimulated . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| A requirement for PARP 1 for the assembly or stability of XRCC 1 nuclear foci at sites of oxidative DNA damage . ^^^ The formation of XRCC 1 foci at sites of poly ( ADP ribose ) was greatly reduced by mutation of the XRCC 1 BRCT 1 domain that physically interacts with PARP 1 . ^^^ These data demonstrate that PARP 1 is required for the assembly or stability of XRCC 1 nuclear foci after oxidative DNA damage and suggest that the formation of these foci is mediated via interaction with poly ( ADP ribose ) . ^^^ Here , we show that the single strand break repair protein XRCC 1 is rapidly assembled into discrete nuclear foci after oxidative DNA damage at sites of poly ( ADP ribose ) synthesis . ^^^ Poly ( ADP ribose ) synthesis peaks during a 10 min treatment with H2O2 and the appearance of XRCC 1 foci peaks shortly afterwards . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| In the final model , 4 SNPs , including 2 in the coding regions ( ADPRT Val762Ala and MBD 4 Glu346Lys ) and others in noncoding regions ( LIG 3 A3704G and XRCC 1 T 77C ) , remained as significant predictors for the risk of ESCC . ^^^ The adjusted odd ratios were 1 . 25 [ 95 % confidence interval ( CI ) 1 . 02 1 . 53 ] for the ADPRT 762Ala allele , 1 . 25 ( 95 % CI 1 . 02 1 . 53 ) for the MBD 4 346 Lys allele , 0 . 78 ( 95 % CI 0 . 63 0 . 97 ) for the LIG 3 3704G allele , and 1 . 38 ( 95 % CI 1 . 01 1 . 89 ) for the XRCC 1 77C allele . ^^^ In addition , we observed a significant gene gene interaction between XRCC 1 Gln399Arg and ADPRT Val762Ala . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Genetic polymorphisms in XRCC 1 gene could , through alteration of protein structure , lead to defective functioning of DNA Polbeta , PARP and LIG 3 enzymes resulting in defective DNA repair and increased risk of childhood acute lymphoblastic leukemia ( ALL ) . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in DNA repair gene XRCC 1 and increased genetic susceptibility to breast cancer . 10 ray repair cross complementing 1 ( XRCC 1 ) gene encodes for a scaffolding protein , which plays an important role in base excision DNA repair by bringing together DNA polymerase beta , DNA ligase 3 and poly ( ADP Ribose ) polymerase ( PARP ) at the site of DNA damage . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in DNA base excision repair genes ADPRT and XRCC 1 and risk of lung cancer . ^^^ Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are two major DNA base excision repair ( BER ) proteins and act interactively in stimulating and executing BER processes . ^^^ Polymorphisms of ADPRT Val762Ala and XRCC 1 Arg399Gln have been associated with altered protein function and BER activity . ^^^ Gene gene interaction of ADPRT and XRCC 1 polymorphisms increased risk of lung cancer in a supermultiplicative manner ( OR for the presence of both ADPRT 762Ala / Ala and XRCC 1 399Gln / Gln genotypes , 5 . 91 ; 95 % CI , 2 . 09 16 . 72 ) , although the XRCC 1 polymorphism itself was not associated with the risk . ^^^ In conclusion , the ADPRT Val762Ala polymorphism plays an important role in smoking related lung cancer and the XRCC 1 Arg399Gln polymorphism may serve as a risk modifier . . ^^^ |
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| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Using genomic DNA extracted from blood samples , we identified wild type and polymorphic variants of XPD ( Arg156Arg and Lys751Gln ) , XRCC 1 ( Arg194Trp and Arg399Gln ) and XRCC 3 ( Thr241Met ) , and the poly ( AT ) insertion / deletion of XPC ( PAT ) . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| A number of proteins , including histones , DNA topoisomerases , DNA methyltransferase 1 as well as DNA damage repair and checkpoint proteins ( p 23 , p 21 , DNA PK , NF kB , XRCC 1 , and others ) can be targeted in this manner ; the interaction involves a specific poly ( ADP ribose ) binding sequence motif of 20 26 amino acids in the target domains . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Here , we characterized the interactions of four purified BRCT domains , two from XRCC 1 and their two partners from DNA ligase IIIalpha and poly ( ADP ribosyl ) polymerase 1 . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Genetic polymorphisms in XRCC 1 , APE 1 , ADPRT , XRCC 2 , and XRCC 3 and risk of chronic benzene poisoning in a Chinese occupational population . ^^^ Because benzene induced DNA damage includes single and double strand breaks , we hypothesized that single nucleotide polymorphisms in 10 ray repair cross complementing group 1 ( XRCC 1 ) , apurinic / apyrimidinic endonuclease ( APE 1 ) , ADP ribosyltransferase ( ADPRT ) , 10 ray repair cross complementing group 2 ( XRCC 2 ) , and 10 ray repair cross complementing group 3 ( XRCC 3 ) are associated with risk of CBP . ^^^ We genotyped single nucleotide polymorphisms at codons 194 , 280 , and 399 of XRCC 1 , codon 148 of APE 1 , codon 762 of ADPRT , codon 188 of XRCC 2 , and codon 241 of XRCC 3 in 152 CBP patients and 152 healthy workers frequency matched on age and sex among those who were occupationally exposed to benzene . ^^^ |
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| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms of ADPRT Val762Ala and XRCC 1 Arg399Glu and risk of breast cancer in Chinese women : a case control analysis . ^^^ Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are two major base excision repair ( BER ) proteins and act cooperatively in the BER processes . ^^^ Polymorphisms of ADPRT Val762Ala and XRCC 1 Arg399Gln may alter their protein functions and BER activity , and were therefore hypothesized to be associated with breast cancer susceptibility . ^^^ We found that the variant genotypes of both ADPRT Val762Ala and XRCC 1 Arg399Gln were not significantly associated with the risk of breast cancer ( adjusted OR 0 . 87 , 95 % CI 0 . 64 to 1 . 19 for ADPRT Val / Ala + Ala / Ala ; adjusted OR 0 . 82 , 95 % CI 0 . 61 to 1 . 11 for XRCC 1 Arg / Gln + Gln / Gln ; and adjusted OR 0 . 70 , 95 % CI 0 . 45 to 1 . 10 for these two combined variant genotypes . ^^^ These findings suggest that the ADPRT Val762Ala and XRCC 1 Arg399Gln polymorphisms may not play a role in the etiology of breast cancer . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| BRCT 1 is required for the immediate poly ( ADP ribose ) dependent recruitment of XRCC 1 to DNA breaks and is essential for survival after DNA damage . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Correlation of genetic polymorphisms in DNA repair genes ADPRT and XRCC 1 to risk of gastric cancer ] . ^^^ BACKGROUND & OBJECTIVE : Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are 2 major DNA base excision repair ( BER ) proteins and act interactively in stimulating and executing BER processes . ^^^ Polymorphisms of ADPRT 762Val > Ala and XRCC 1 399Arg > Gln have been verified to associate with altered protein function and BER activity . ^^^ Gene gene interaction of ADPRT and XRCC 1 polymorphisms increased the risk of gastric cancer in a super multiplicative manner , with an OR of 5 . 32 ( 95 % CI=1 . 12 28 . 57 ) for the presence of both ADPRT 762Ala / Ala and XRCC 1 399Gln / Gln genotypes , although the XRCC 1 polymorphism itself was not associated with the risk of gastric cancer . ^^^ CONCLUSION : The ADPRT 762Val > Ala polymorphism plays an important role in the development of gastric cancer , and the XRCC 1 399Arg > Gln polymorphism may serve as a risk modifier . . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| We evaluated whether genetic variation in six BER pathway genes ( XRCC 1 , ADPRT , APEX 1 , OGG 1 , LIG 3 , and MUTYH ) is associated with breast cancer risk in two large population based case control studies in the United States ( 3 , 368 cases and 2 , 880 controls ) and Poland ( 1 , 995 cases and 2 , 296 controls ) . ^^^ S . study participants with mouthwash DNA , we found no significant overall association between breast cancer risk and XRCC 1 R280H and R194W , ADPRT V726W , APEX 1 D148E , OGG 1 S326C , LIG 3 R780H , or MUTYH 5 ' untranslated region . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Condensin 1 interacts with the PARP 1 XRCC 1 complex and functions in DNA single strand break repair . ^^^ We show that the association between condensin 1 , PARP 1 , and the base excision repair ( BER ) factor XRCC 1 increases dramatically upon single strand break damage ( SSB ) induction . ^^^ Consistent with this , DNA damage rapidly stimulates the chromatin association of PARP 1 , condensin 1 , and XRCC 1 . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Genetic variants of the ADPRT , XRCC 1 and APE 1 genes and risk of cutaneous melanoma . ^^^ Sunlight causes various kinds of DNA damage , including oxidative lesions that are removed effectively by the base excision repair ( BER ) pathway , in which ADPRT , XRCC 1 and APE 1 play a key role . ^^^ We hypothesized that ADPRT , XRCC 1 and APE 1 polymorphisms are associated with risk of cutaneous melanoma ( CM ) . ^^^ In a hospital based case control study of 602 CM patients and 603 cancer free control subjects frequency matched on age , sex and ethnicity , we genotyped for three non synonymous single nucleotide polymorphisms ( SNPs ) ( i . e . the ADPRT Val762Ala , XRCC 1 Arg399Gln and APE1Asp148Glu ) and assessed their associations with risk of CM . ^^^ |
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| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| As an amplified DNA damage signal , auto poly ( ADP ribosyl ) ation of PARP 1 triggers the recruitment of XRCC 1 , which coordinates and stimulates the repair process , to the DNA damage sites in less than 15 s in living cells ( Okano et al . , 2003 ) . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND & AIMS : Adenosine diphosphate ribosyl transferase ( ADPRT ) and 10 ray repair cross complementing 1 ( XRCC 1 ) are major DNA base excision repair proteins acting interactively in repair processes . ^^^ This study examined the effects of ADPRT Val762Ala and XRCC 1 Arg399Gln polymorphisms on ADPRT XRCC 1 interaction in vitro in cells and their contributions to gastric cardia adenocarcinoma ( GCA ) risk . ^^^ METHODS : The ADPRT XRCC 1 interaction in cells transfected with ADPRT and XRCC 1 variant complementary DNA ( cDNA ) constructs were examined by immunoprecipitation and immunoblotting analysis . ^^^ RESULTS : Interactions between ADPRT 762Val and XRCC 1 399Arg or XRCC 1 399Gln were robust , but interactions between ADPRT 762Ala and either XRCC 1 399Arg or XRCC 1 399Gln were very weak . ^^^ A case control analysis showed ORs of 2 . 17 ( 95 % CI , 1 . 55 3 . 04 ) and 1 . 61 ( 95 % CI , 1 . 06 2 . 44 ) for GCA in the ADPRT Ala / Ala or XRCC 1 Gln / Gln genotype carriers , respectively , compared with noncarriers . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| METHODS : Polyadenylated RNA [ Poly ( A ) + RNA ] was isolated from tissues of RCC and normal kidney , and single strand cDNAs and double strand cDNAs were synthesized in turn . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| METHODS : Poly A ( + ) RNA was isolated from RCC lines 786 O ( tester ) and renal cell ( RC ) lines HK 2 ( driver ) , respectively . ^^^ |
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| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| Apoptosis in RCC 91 cells was accompanied by activation of caspases 3 and 9 ; cleavage of PARP and DFF 45 proteins ; typical apoptotic nuclei fragmentation and mitochondrial collapse . ^^^ |
|
| Interacting proteins: P18887 and P09874 |
Pubmed |
SVM Score :0.0 |
| IFNalpha sensitised SK RC 44 to anti Fas and induced PARP cleavage confirming that IFNalpha has a cytotoxic effect on RCC lines by induction of the Fas antigen . ^^^ |
|