| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :1.0430881 |
| Here , we demonstrate that XRCC 1 is additionally associated with DNA polymerase beta in human cells and that these polypeptides also directly interact . 1.0430881^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :1.1667633 |
| We show that XRCC 1 interacts directly with DNA polymerase beta using far Western blotting , affinity precipitation and yeast two hybrid analyses . 1.1667633^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :1.2254379 |
| XRCC 1 can interact with DNA polymerase beta , thereby suppressing strand displacement , and DNA ligase 3 , both of which have been implicated in base excision repair . 1.2254379^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| A novel role of XRCC 1 in the functions of a DNA polymerase beta variant . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| The XRCC 1 , DNA polymerase beta and delta proteins were also elevated . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| These mutational data indicate the importance of the putative functional regions in XRCC 1 , such as the BRCA 1 C terminal ( BRCT ) domain found in common with BRCA 1 and other DNA repair and cell cycle checkpoint proteins , and also regions necessary for interaction with DNA polymerase beta and DNA ligase III . . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Given that XRCC 1 is also associated with DNA ligase 3 via a second BRCT module and with DNA polymerase beta , our results provide strong evidence that PARP is a member of a BER multiprotein complex involved in the detection of DNA interruptions and possibly in the recruitment of XRCC 1 and its partners for efficient processing of these breaks in a coordinated manner . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| The 10 ray repair cross complementing group 1 ( XRCC 1 ) protein plays a central role in the DNA base excision repair pathway by interacting with DNA ligase 3 and DNA polymerase beta . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Domain specific interaction in the XRCC 1 DNA polymerase beta complex . ^^^ XRCC 1 ( 10 ray cross complementing group 1 ) is a DNA repair protein that forms complexes with DNA polymerase beta ( beta Pol ) , DNA ligase 3 and poly ADP ribose polymerase in the repair of DNA single strand breaks . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| The 10 ray repair cross complementing group 1 ( XRCC 1 ) protein plays a central role in the DNA base excision repair pathway by interacting with DNA ligase 3 and DNA polymerase beta . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Thus , poly ( ADP ribose ) polymerase 1 , DNA polymerase beta , and ligase 3 interact with 10 ray repair cross complementing protein 1 within the BER complex , which ensures that ATP is generated and specifically used for DNA ligation . . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| X ray repair cross complementing gene 1 protein plays an important role in camptothecin resistance . 10 ray repair cross complementing gene 1 protein ( XRCC 1 ) in complex with DNA polymerase beta , DNA ligase 3 , and poly ( ADP ribose ) polymerase is important in the base excision repair process . ^^^ In this study , we found the expression levels of XRCC 1 protein in KB 100 and KB 300 were > or =5 fold more than in their respective revertant cell lines , whereas there was no difference in the expression of XRCC 1 associated proteins such as DNA polymerase beta , DNA ligase 3 , poly ( ADP ribose ) polymerase , and apurinic / apyrimidinic endonuclease . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| PARP 2 was also found to interact with three other proteins involved in the base excision repair pathway : 10 ray cross complementing factor 1 ( XRCC 1 ) , DNA polymerase beta , and DNA ligase 3 , already known as partners of PARP 1 . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 functions as a scaffold protein by interacting and modulating polypeptide components of the single strand break repair machinery , including AP endonuclease 1 , DNA ligase IIIalpha , poly ( ADP ribose ) polymerase , DNA polymerase beta and human polynucleotide kinase . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Mapping of the interaction interface of DNA polymerase beta with XRCC 1 . ^^^ Residues of DNA polymerase beta ( beta Pol ) that interact with the DNA repair protein XRCC 1 have been determined by NMR chemical shift mapping ( CSM ) and mutagenesis . 15N / ( 13 ) C / ( 2 ) H / ( 1 ) H , ( 13 ) C methyl ( Leu , Ile , Val ) labeled beta Pol palm thumb domain was used for assignments of the 1H , 15N , and 13C resonances used for CSM of the palm thumb on forming the 40 kDa complex with the XRCC 1 N terminal domain ( NTD ) . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Human 10 ray cross complementing group 1 ( XRCC 1 ) is a single strand DNA break repair protein which forms a base excision repair ( BER ) complex with DNA polymerase beta ( beta Pol ) . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Interestingly the amino terminus of the long form aprataxin is homologous with polynucleotidekinase 3 ' phosphatase , which has been demonstrated to be involved in base excision repair , a subtype of single strand DNA break repair , through interaction with XRCC 1 , DNA polymerase beta , and DNA ligase 3 . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 DNA polymerase beta interaction is required for efficient base excision repair . 10 ray repair cross complementing protein 1 ( XRCC 1 ) deficient cells are sensitive to DNA damaging agents and have delayed processing of DNA base lesions . ^^^ In support of its role in base excision repair , it was found that XRCC 1 forms a tight complex with DNA ligase IIIalpha and also interacts with DNA polymerase beta ( Pol beta ) and other base excision repair ( BER ) proteins . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we characterized repair pathways by using repair defective mammalian cells and found that DNA polymerase beta accumulated at single strand breaks and oxidative base damage by means of its 31 and 8 kDa domains , respectively , and that XRCC 1 is essential for both polymerase beta dependent and proliferating cell nuclear antigen dependent repair pathways of single strand breaks . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Polymorphisms in DNA repair gene XRCC 1 and increased genetic susceptibility to breast cancer . 10 ray repair cross complementing 1 ( XRCC 1 ) gene encodes for a scaffolding protein , which plays an important role in base excision DNA repair by bringing together DNA polymerase beta , DNA ligase 3 and poly ( ADP Ribose ) polymerase ( PARP ) at the site of DNA damage . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 and DNA polymerase beta interaction contributes to cellular alkylating agent resistance and single strand break repair . 10 ray cross complementing 1 ( XRCC 1 ) protein has been suggested to bind to DNA single strand breaks ( SSBs ) and organize protein interactions that facilitate efficient DNA repair . ^^^ Using four site specifically modified human XRCC 1 mutant expression systems and functional complementation assays in Chinese hamster ovary ( CHO ) XRCC 1 deficient EM 9 cells , we evaluated the cellular contributions of XRCC1s proposed N terminal domain ( NTD ) DNA binding and DNA polymerase beta ( POLbeta ) interaction activities . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Radiosensitization by a dominant negative to DNA polymerase beta is DNA polymerase beta independent and XRCC 1 dependent . ^^^ BACKGROUND AND PURPOSE : DNA base damages and single strand breaks after ionizing radiation are repaired by base excision repair ( BER ) and single strand break repair ( SSBR ) , with both DNA polymerase beta ( polbeta ) and XRCC 1 playing key roles . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| DNA polymerase beta promotes recruitment of DNA ligase 3 alpha XRCC 1 to sites of base excision repair . ^^^ We find that after dissociation of AP endonuclease from the incised abasic site , both DNA polymerase beta ( Pol beta ) and the DNA ligase IIIalpha XRCC 1 heterodimer efficiently bind / cross link to the substrate DNA . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Employing a reconstituted BER complex containing among others DNA polymerase beta ( Pol beta ) , DNA ligase 3 ( Lig 3 ) and XRCC 1 , here we show that Lig 3 and XRCC 1 are essential mediators of this regulation . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| Selected SNPs belong to the following genes : ADH1B , ALDH 2 , APEX , CDKN2A , COMT , CYP1A1 , CYP1A2 , CYP1B1 , CYP2A6 , CYP2C19 , CYP2C9 , CYP2E1 , CYP3A4 , DRD 2 , DRD 4 , EPHX 1 , ERCC 1 , ERCC 2 , ERCC 4 , ERCC 5 , GRPR , GSTA 4 , GSTM 3 , GSTP 1 , GSTT 2 , LIG 3 , MDM 2 , MGMT , MPO , NAT 1 , NAT 2 , NQO 1 , OGG 1 , PCNA , POLB , SLC6A3 , SOD 2 , TP 53 , XRCC 1 , XRCC 2 , XRCC 3 , and XRCC 9 . ^^^ |
|
| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| No induction at the transcriptional level of any of the base excision repair genes , NTH 1 ( NTHL 1 ) , OGG 1 , NEIL 1 , NEIL 2 , NEIL 3 , APE 1 , POLB , or accessory protein genes , LIG 3 , XRCC 1 or XPG , was found at gamma radiation doses ranging from 1 cGy to 2 Gy in a 24 h period . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| The differentially expressed genes between diffuse and nodular samples included some related to DNA stability and repair ( TALDO 1 , PRDX 2 , DDB 1 , XRCC 1 , and POLB ) , RNA stability and degradation ( OASL and AUF 1 ) , protein synthesis and processing ( PFDN 5 , HSPD 1 , and NACA ) , cell growth ( CDC25C and GRPR ) , and tumorigenesis and cell cycle ( VIL 2 and TPD 52 ) . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| We investigated 44 single nucleotide polymorphisms ( SNPs ) in 20 DNA repair genes including nucleotide excision repair ( NER ) genes XPA , ERCC 1 , ERCC2 / XPD , ERCC4 / XPF and ERCC5 / XPG ; base excision repair ( BER ) genes APE1 / APEX , OGG 1 , MPG , XRCC 1 , PCNA , POLB , POLiota , LIG 3 and EXO 1 ; double strand break repair ( DSB R ) genes XRCC 2 , XRCC 3 , XRCC 9 , NBS 1 and ATR ; and direct damage reversal ( DR ) gene MGMT / AGT . ^^^ |
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| Interacting proteins: P06746 and P18887 |
Pubmed |
SVM Score :0.0 |
| The candidate genes belong to different DNA repair pathways : base excision repair ( OGG 1 , LIG 3 , APEX , POLB , XRCC 1 , PCNA , and MUTYH ) , nucleotide excision repair ( ERCC 1 , ERCC 2 , ERCC 4 , and ERCC 5 ) , double strand breaks repair ( XRCC 2 , XRCC 3 , and XRCC 9 ) , and reversion repair ( MGMT ) genes . ^^^ |
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