| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.80690947 |
| Here , we report that XRCC 1 interacts physically and functionally with hOGG 1 , the human DNA glycosylase that initiates the repair by BER of the mutagenic oxidized base 8 oxoguanine . 0.80690947^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| We summarized here the results of published case control studies that have examined the effects of common alleles of 15 genes , MTHFR , CYP1A1 , CYP2A6 , CYP2E1 , GSTM 1 , GSTT 1 , GSTP 1 , NAT 2 , XRCC 1 , XPD , hOGG 1 , MGMT , p 53 , CNDD 1 and L Myc , on risk of esophageal squamous cell carcinoma among Chinese . ^^^ Statistically significant differences in genotype frequencies found in case control comparisons were MTHFR C677T and A1298C polymorphisms , the XRCC 1 Arg194Trp polymorphisms , the hOGG 1 Ser326Cys polymorphism , and the p 53 Arg72Pro polymorphism . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Nasopharyngeal carcinoma and genetic polymorphisms of DNA repair enzymes XRCC 1 and hOGG 1 . ^^^ To evaluate this hypothesis , this study focused on effects of genetic polymorphisms of DNA repair genes hOGG 1 and XRCC 1 on the development of NPC . ^^^ Among subjects with putative high risk genotypes for both hOGG 1 and XRCC 1 , the OR was 3 . 0 ( 95 % CI , 1 . 0 8 . 8 ) . ^^^ Furthermore , subjects with putative high risk genotypes for hOGG 1 , XRCC 1 , and CYP2E1 had an OR of disease of 25 ( 95 % CI , 3 . 5 177 ) . ^^^ Polymorphisms of the DNA repair genes hOGG 1 ( codon 326 ) and XRCC 1 ( codon 280 ) are associated with an altered risk of NPC . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Influence of hOGG 1 , XRCC 1 and XRCC 3 genotypes on biomarkers of genotoxicity in workers exposed to cobalt or hard metal dusts . ^^^ We examined whether variations in genes involved in base excision ( hOGG 1 , XRCC 1 ) and double strand break ( XRCC 3 ) DNA repair contribute to inter individual differences in genotoxic effects induced in the lymphocytes of 21 cobalt ( Co ) exposed , 26 hard metal ( WC Co ) exposed and 26 matched control male workers . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Combining the lower activity CYP1B1 432 Leu / Leu or Leu / Val genotypes ( which may decrease the level of catechol estrogens and ROS generated ) with the hOGG 1 326 Cys / Cys genotype and the XRCC 1 399 Arg / Arg or Arg / Gln genotypes ( which may enhance BER ) resulted in an even further reduced risk in Caucasians with more aggressive disease ( OR=0 . 09 ; 95 % CI=0 . 01 0 . 56 ) . ^^^ The decreased risk we observed with the hOGG 1 326 Cys / Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 ( 432 Leu / Leu or Leu / Val ) hOGG 1 ( 326 Cys / Cys ) XRCC 1 ( Arg / Arg or Arg / Gln ) genotype combination may lend new insights to the importance of ROS generated from non receptor mediated estrogenic mechanisms in more aggressive prostate cancer . . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| This paper lists the genotype frequencies of 50 polymorphisms of 37 genes ( ALDH 2 , ADRB 2 , ADRB 3 , COMT , CD 36 , CXCR 2 , CCND 1 , COX 2 , CYP2A6 , CYP 17 , CYP 19 , IGF 1 , IL 1A , IL 1B , IL 1RN , IL 1R1 , IL 6 , IL 8 , IL 10 , LEP , Le , L myc , MPO , MTR , MTHFR , MAO A , NQO 1 , OGG 1 , p 53 , p 73 , Se , SRD5A2 , TGF B , TNF A , TNF B , XPD , and XRCC 1 ) and 6 sets of combined genotype frequencies for 241 non cancer Japanese outpatients . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Thirty studies of polymorphisms in OGG 1 , XRCC 1 , ERCC 1 , XPC , XPD , XPF , BRCA 2 , and XRCC 3 were identified in the April 30 , 2002 MEDLINE database ( National Center for Biotechnology Information . ^^^ Nonetheless , published data were consistent with associations between : ( a ) the OGG 1 S326C variant and increased risk of various types of cancer ; ( b ) the XRCC 1 R194W variant and reduced risk of various types of cancer ; and ( c ) the BRCA 2 N372H variant and increased risk of breast cancer . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Six single nucleotide polymorphisms of five DNA repair genes representing three distinct repair pathways were interrogated including : XRCC 1 ( Arg399Gln ) , APE 1 ( Asp148Glu ) , XRCC 3 ( Thr241Met ) , hOGG 1 ( Ser326Cys ) , XPD ( Asp312Asn , Lys751Gln ) . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 participates in the first step of BER by interacting with the human DNA glycosylases hOGG 1 and NEIL 1 . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Following factors were also analyzed : GSTM 1 , GSTT 1 , GSTP 1 , XPD , XRCC 1 , hOGG 1 , p 53 , MTHFR , and MS gene polymorphisms , levels of vitamins A , C , E , and folate in plasma , and level of cotinine in urine . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Enzymes involved in base excision repair ( hOGG 1 , XRCC 1 ) , in rejoining single strand breaks ( XRCC 1 ) and in repair of cross links and chromosomal double strand breaks ( XRCC 3 ) might have an impact on genotoxicity as well . ^^^ In this study we assessed the dose dependent effect of genetic polymorphisms in biotransforming ( EPHX ( Tyr113 / His113 and His139 / Arg139 ) , GSTP 1 ( Ile105 / Val105 ) , GSTM 1 and GSTT 1 ) and DNA repair enzymes ( hOGG 1 ( Ser326 / Cys326 ) , XRCC 1 ( Arg194 / Trp194 , Arg280 / His280 , Arg399 / Gln399 ) , XRCC 3 ( Thr241 / Met241 ) ) on the induced genotoxicity . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Selected SNPs belong to the following genes : ADH1B , ALDH 2 , APEX , CDKN2A , COMT , CYP1A1 , CYP1A2 , CYP1B1 , CYP2A6 , CYP2C19 , CYP2C9 , CYP2E1 , CYP3A4 , DRD 2 , DRD 4 , EPHX 1 , ERCC 1 , ERCC 2 , ERCC 4 , ERCC 5 , GRPR , GSTA 4 , GSTM 3 , GSTP 1 , GSTT 2 , LIG 3 , MDM 2 , MGMT , MPO , NAT 1 , NAT 2 , NQO 1 , OGG 1 , PCNA , POLB , SLC6A3 , SOD 2 , TP 53 , XRCC 1 , XRCC 2 , XRCC 3 , and XRCC 9 . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| No induction at the transcriptional level of any of the base excision repair genes , NTH 1 ( NTHL 1 ) , OGG 1 , NEIL 1 , NEIL 2 , NEIL 3 , APE 1 , POLB , or accessory protein genes , LIG 3 , XRCC 1 or XPG , was found at gamma radiation doses ranging from 1 cGy to 2 Gy in a 24 h period . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| DNA repair enzymes ( OGG 1 , XRCC 1 , XPD , etc . ) , 3 . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| XRCC 1 194Trp , OGG 1 326Cys and APE 1 148Glu probably have limited alterations in repair activities compared to the wild type genotypes . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Are genetic polymorphisms in OGG 1 , XRCC 1 and XRCC 3 genes predictive for the DNA strand break repair phenotype and genotoxicity in workers exposed to low dose ionising radiations . ^^^ We have conducted a study to assess the predictivity of the OGG 1 , XRCC 1 and XRCC 3 genotypes and the in vitro single strand break repair phenotype for the induction of genotoxic effects . ^^^ A combined analysis of the three genotypes , OGG 1 , XRCC 1 and XRCC 3 polymorphisms is advised in order to assess individual susceptibility to ionising radiation . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| In a nested case cohort study , we have investigated the occurrence of lung cancer in relation to polymorphisms in base excision repair genes XRCC 1 and OGG 1 . ^^^ No associations were found between the polymorphisms OGG 1 Ser326Cys , XRCC 1 Arg280His , and XRCCI Arg399Gln and risk of lung cancer . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| We examined associations among four well characterized polymorphisms of BER genes ( OGG 1 Ser326Cys , XRCC 1 Arg194Trp , XRCC 1 Arg280His , and XRCC 1 Arg399Gln ) and lung cancer risk . ^^^ The associations between the OGG 1 Cys / Cys genotype and adenocarcinoma risk and between XRCC 1 Arg194Trp polymorphism and lung cancer risk among heavy smokers remained robust given prior probabilities of 25 % ( FPRP = 0 . 238 ) and 10 % ( FPRP = 0 . 276 ) , respectively . ^^^ However , we can not exclude the possibility that the OGG 1 Ser326Cys and XRCC 1 Arg194Trp polymorphisms play minor roles in lung carcinogenesis . . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| To investigate the potential role of DNA repair polymorphisms in this variation , genotypes of DNA repair genes OGG 1 ( codon 326 ) , XPD ( codon 751 ) , XRCC 1 ( 10 ray repair cross complementing group 1 ) ( codons 194 , 280 , and 399 ) , and XRCC 3 ( 10 ray repair cross complementing group 3 ) ( codon 241 ) were determined from leukocyte DNA using polymerase chain reaction based methods . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Radiation induced damage to normal tissues after radiotherapy in patients treated for gynecologic tumors : association with single nucleotide polymorphisms in XRCC 1 , XRCC 3 , and OGG 1 genes and in vitro chromosomal radiosensitivity in lymphocytes . ^^^ PURPOSE : To examine the association of polymorphisms in XRCC 1 ( 194Arg / Trp , 280Arg / His , 399Arg / Gln , 632Gln / Gln ) , XRCC 3 ( 5 ' UTR 4 . 541A > G , IVS 5 14 17 . 893A > G , 241Thr / Met ) , and OGG 1 ( 326Ser / Cys ) with the development of late radiotherapy ( RT ) reactions and to assess the correlation between in vitro chromosomal radiosensitivity and clinical radiosensitivity . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Association of XRCC 1 Arg399Gln and OGG 1 Ser326Cys polymorphisms with the risk of cervical cancer in Japanese subjects . ^^^ OBJECTIVE : In this study , genetic polymorphisms , XRCC 1 Arg399Gln and OGG 1 Ser326Cys were examined with reference to cervical cancer risk in a population based incident case control study in Japan . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| We investigated 44 single nucleotide polymorphisms ( SNPs ) in 20 DNA repair genes including nucleotide excision repair ( NER ) genes XPA , ERCC 1 , ERCC2 / XPD , ERCC4 / XPF and ERCC5 / XPG ; base excision repair ( BER ) genes APE1 / APEX , OGG 1 , MPG , XRCC 1 , PCNA , POLB , POLiota , LIG 3 and EXO 1 ; double strand break repair ( DSB R ) genes XRCC 2 , XRCC 3 , XRCC 9 , NBS 1 and ATR ; and direct damage reversal ( DR ) gene MGMT / AGT . ^^^ Our results indicate that SNPs in the NER genes ERCC 1 ( Asn118Asn , 15310G > C , 8902G > T ) , XPA ( 4G > A ) , ERCC2 / XPD ( Lys751Gln ) and ERCC5 / XPD ( His46His ) ; the BER genes APE1 / APEX ( Ile64Val ) , OGG 1 ( Ser326Cys ) , PCNA ( 1876A > G ) and XRCC 1 ( Arg194Trp , Arg280His , Arg399Gln ) ; and the DSB R genes ATR ( Thr211Met ) , NBS 1 ( Glu185Gln ) , XRCC 2 ( Arg188His ) and XRCC 9 ( Thr297Ile ) modulate NSCLC risk . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| The authors conducted meta analyses of associations between genes in the base excision repair pathway and cancer risk , focusing on three key genes : 8 oxoguanine DNA glycosylase ( OGG 1 ) , apurinic / apyrimidinic endonuclease ( APE1 / APEX1 ) , and 10 ray repair cross complementing group 1 ( XRCC 1 ) . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| We evaluated whether genetic variation in six BER pathway genes ( XRCC 1 , ADPRT , APEX 1 , OGG 1 , LIG 3 , and MUTYH ) is associated with breast cancer risk in two large population based case control studies in the United States ( 3 , 368 cases and 2 , 880 controls ) and Poland ( 1 , 995 cases and 2 , 296 controls ) . ^^^ S . study participants with mouthwash DNA , we found no significant overall association between breast cancer risk and XRCC 1 R280H and R194W , ADPRT V726W , APEX 1 D148E , OGG 1 S326C , LIG 3 R780H , or MUTYH 5 ' untranslated region . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| The candidate genes belong to different DNA repair pathways : base excision repair ( OGG 1 , LIG 3 , APEX , POLB , XRCC 1 , PCNA , and MUTYH ) , nucleotide excision repair ( ERCC 1 , ERCC 2 , ERCC 4 , and ERCC 5 ) , double strand breaks repair ( XRCC 2 , XRCC 3 , and XRCC 9 ) , and reversion repair ( MGMT ) genes . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| Furthermore , all subjects were genotyped for XRCC 1 , OGG 1 , and XPC genes . ^^^ |
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| Interacting proteins: O15527 and P18887 |
Pubmed |
SVM Score :0.0 |
| NA |
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