| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| During arsenite treatment of PC 12 cells , we observed enhanced binding of ATF 4 to the C / EBP ATF site at 2 h as Gadd 153 mRNA levels increased , and enhanced binding of ATF 3 complexes at 6 h as Gadd 153 expression declined . ^^^ We further demonstrated that ATF 4 activates , while ATF 3 represses , Gadd 153 promoter activity through the C / EBP ATF site . ^^^ ATF 3 also repressed ATF 4 mediated transactivation and arsenite induced activation of the Gadd 153 promoter . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| Proteasome inhibitor induced gene expression profiles reveal overexpression of transcriptional regulators ATF 3 , GADD 153 and MAD 1 . ^^^ Two of the most prominently induced genes encoded the growth arrest and DNA damage inducible protein Gadd 153 and the activating transcription factor ATF 3 , both transcription factors of the CCAAT / enhancer binding protein ( C / EBP ) family . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| Induction of GADD 153 , NF IL 6 and ATF 3 was confirmed by Western analysis . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| ATF 3 contributes to induction of the CHOP transcriptional factor in response to amino acid starvation , and loss of ATF 3 function significantly lowers stress induced expression of GADD 34 , an eIF 2 protein phosphatase regulatory subunit implicated in feedback control of the eIF 2 kinase stress response . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| This included induction of transcription factors GADD 153 , ATF 4 , and ATF 3 ; amino acid metabolic enzymes ; proteasome components ; and certain ER chaperones . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| Notably , stress induced transcription factors such as ATF 3 , ATF 4 , CHOP , and C / EBP beta were robustly up regulated , yet exhibited unique kinetic patterns . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| ATF 4 also enhances the expression of additional transcription factors , ATF 3 and CHOP ( CCAAT / enhancer binding protein homologous protein ) / GADD153 ( growth arrest and DNA damage inducible protein ) , that assist in the regulation of genes involved in metabolism , the redox status of the cells and apoptosis . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| ATF 3 expression precedes death of spinal motoneurons in amyotrophic lateral sclerosis SOD 1 transgenic mice and correlates with c Jun phosphorylation , CHOP expression , somato dendritic ubiquitination and Golgi fragmentation . ^^^ Furthermore , the majority of ATF 3 and phospho c Jun positive motoneurons were also immunoreactive for CHOP ( GADD 153 ) and showed Golgi fragmentation . ^^^ |
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| Interacting proteins: P18847 and P35638 |
Pubmed |
SVM Score :0.0 |
| Dramatic increases in the mRNA levels of ATF 3 and CHOP genes , both of which were reported to play roles in the ER stress mediated apoptosis pathway , were observed from 1h after the CHX treatment . ^^^ |
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