| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| We showed that overexpression of activating transcription factor 3 ( ATF 3 ) , ATF 4 , ATF 5 , c Jun , JunD and caspase 3 is associated with sensitivity to bortezomib induced apoptosis , whereas overexpression of heat shock protein ( HSP ) 27 , HSP 70 , HSP 90 and T cell factor 4 is associated with bortezomib resistance . . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| The protein complexes interacting with CREL were not recognized by antibodies specific for CRE binding proteins CREB 1 and CREB 2 , or activating transcription factors ATF 1 , ATF 2 and ATF 3 . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| During arsenite treatment of PC 12 cells , we observed enhanced binding of ATF 4 to the C / EBP ATF site at 2 h as Gadd 153 mRNA levels increased , and enhanced binding of ATF 3 complexes at 6 h as Gadd 153 expression declined . ^^^ We further demonstrated that ATF 4 activates , while ATF 3 represses , Gadd 153 promoter activity through the C / EBP ATF site . ^^^ ATF 3 also repressed ATF 4 mediated transactivation and arsenite induced activation of the Gadd 153 promoter . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| We will then review three members of the ATF / CREB family of proteins : ATF 3 , ATF 4 and ATF 6 . ^^^ ATF 3 homodimer is a transcriptional repressor and ATF 4 has been reported to be either an activator or a repressor . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| Increased expression of ATF 3 protein occurs early in response to stress by a mechanism requiring the related bZIP transcriptional regulator ATF 4 . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| In addition to genes previously reported to be induced by type 1 or type 2 IFNs , many novel genes were found to be upregulated , including transcription factors , such as ATF 3 , ATF 4 , properdin , a key regulator of the complement pathway , a homeobox gene ( HESX 1 ) , and an RNA editing enzyme ( apobec 3 ) . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| This included induction of transcription factors GADD 153 , ATF 4 , and ATF 3 ; amino acid metabolic enzymes ; proteasome components ; and certain ER chaperones . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| Notably , stress induced transcription factors such as ATF 3 , ATF 4 , CHOP , and C / EBP beta were robustly up regulated , yet exhibited unique kinetic patterns . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| Immediately following amino acid removal , the kinetics of binding for ATF 4 , ATF 3 , and C / EBPbeta itself to the 93 bp regulatory region were similar to those observed for the amino acid responsive asparagine synthetase gene . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| ATF 4 also enhances the expression of additional transcription factors , ATF 3 and CHOP ( CCAAT / enhancer binding protein homologous protein ) / GADD153 ( growth arrest and DNA damage inducible protein ) , that assist in the regulation of genes involved in metabolism , the redox status of the cells and apoptosis . ^^^ |
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| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| Eight out of twelve genes with known functions encoded transcription factors linked to two major cellular processes ; inhibition of cell growth ( ATF 3 , ATF 4 , KLF 4 , KLF 6 and ELK 3 ) and immune response ( NR4A1 and CEBPB ) , indicating that the earliest consequences of an adenovirus infection are growth arrest and induction of an immune response . ^^^ |
|
| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P18847 and P18848 |
Pubmed |
SVM Score :0.0 |
| NA |
|